{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T08:56:24Z","timestamp":1763542584438,"version":"3.45.0"},"reference-count":53,"publisher":"EDP Sciences","issue":"10","license":[{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"vor","delay-in-days":49,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Sci (Paris)"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:p>\n                    Le carcinome s\u00e9reux de haut grade repr\u00e9sente la forme la plus agressive et la plus fr\u00e9quente du cancer de l\u2019ovaire. Il est caract\u00e9ris\u00e9 par une forte h\u00e9t\u00e9rog\u00e9n\u00e9it\u00e9 g\u00e9n\u00e9tique, une r\u00e9sistance aux chimioth\u00e9rapies conventionnelles bas\u00e9es sur l\u2019utilisation de complexes de platine, et pr\u00e9sente un pronostic souvent d\u00e9favorable. Face \u00e0 ces d\u00e9fis th\u00e9rapeutiques, les complexes polypyridyles de ruth\u00e9nium (Ru) apparaissent comme une alternative prometteuse aux compos\u00e9s \u00e0 base de platine. En effet, dot\u00e9s de propri\u00e9t\u00e9s physico-chimiques uniques, ces complexes pr\u00e9sentent une activit\u00e9 anticanc\u00e9reuse significative tout en affichant une toxicit\u00e9 r\u00e9duite pour les cellules saines. Leurs m\u00e9canismes d\u2019action, encore en cours d\u2019\u00e9lucidation, incluent l\u2019induction de stress oxydant, la perturbation de la fonction mitochondriale et l\u2019intercalation dans l\u2019ADN. L\u2019encapsulation covalente de ces complexes dans des nanovecteurs polym\u00e9riques constitue une strat\u00e9gie innovante permettant d\u2019am\u00e9liorer leur solubilit\u00e9, leur stabilit\u00e9\n                    <jats:italic>in vivo<\/jats:italic>\n                    et leur distribution cibl\u00e9e vers les cellules tumorales. Cet article revient sur les principales caract\u00e9ristiques des complexes polypyridyles de ruth\u00e9nium Ru d\u00e9velopp\u00e9s dans nos laboratoires et met en lumi\u00e8re nos r\u00e9sultats pr\u00e9cliniques encourageants concernant le d\u00e9veloppement d\u2019une m\u00e9thode originale d\u2019encapsulation covalente de ces complexes.\n                  <\/jats:p>","DOI":"10.1051\/medsci\/2025141","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T08:52:04Z","timestamp":1763542324000},"page":"753-759","source":"Crossref","is-referenced-by-count":0,"title":["Lib\u00e9ration s\u00e9lective et contr\u00f4l\u00e9e d\u2019agents th\u00e9rapeutiques \u00e0 base de ruth\u00e9nium : une arme cibl\u00e9e contre le cancer de l\u2019ovaire"],"prefix":"10.1051","volume":"41","author":[{"given":"Axia","family":"Marlin","sequence":"first","affiliation":[{"name":"Chimie ParisTech, Universit\u00e9 PSL, CNRS, Institut de chimie pour les sciences de la vie et de la sant\u00e9 (UMR 8060)","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Didier","family":"Decaudin","sequence":"first","affiliation":[{"name":"D\u00e9partement de recherche translationnelle, Laboratoire d\u2019investigation pr\u00e9clinique, Universit\u00e9 PSL, Institut Curie","place":["France"]},{"name":"D\u00e9partement d\u2019oncologie m\u00e9dicale, Institut Curie","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe M.","family":"Thomas","sequence":"first","affiliation":[{"name":"Chimie ParisTech, Universit\u00e9 PSL, CNRS, Institut de Recherche de Chimie Paris (UMR 8247)","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilles","family":"Gasser","sequence":"first","affiliation":[{"name":"Chimie ParisTech, Universit\u00e9 PSL, CNRS, Institut de chimie pour les sciences de la vie et de la sant\u00e9 (UMR 8060)","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"250","published-online":{"date-parts":[[2025,11,19]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"S48","DOI":"10.1038\/d41586-021-03719-5","volume":"600","author":"Fiscutean","year":"2021","journal-title":"Nature"},{"key":"R2","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.3390\/medicina59071183","volume":"59","author":"Arnaoutoglou","year":"2023","journal-title":"Medicina"},{"key":"R3","first-page":"100629","volume":"33","author":"Sambasivan","year":"2022","journal-title":"Cancer Treat Res Commun"},{"key":"R4","unstructured":"Arora T, Mullangi S, Vadakekut ES, et al. Epithelial ovarian cancer. StatPearls. Treasure Island (FL) : StatPearls Publishing, 2025 :"},{"key":"R5","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.3390\/ijms25031845","volume":"25","author":"Tavares","year":"2024","journal-title":"Inter J Mol Sci"},{"key":"R6","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1021\/acscentsci.3c01340","volume":"10","author":"Casini","year":"2024","journal-title":"ACS Cent Sci"},{"key":"R7","doi-asserted-by":"crossref","first-page":"4540","DOI":"10.1021\/cr400460s","volume":"114","author":"Mjos","year":"2014","journal-title":"Chem Rev"},{"key":"R8","doi-asserted-by":"crossref","first-page":"216319","DOI":"10.1016\/j.ccr.2024.216319","volume":"526","author":"Wei","year":"2025","journal-title":"Coordi Chem Rev"},{"key":"R9","doi-asserted-by":"crossref","first-page":"102925","DOI":"10.1016\/j.bioorg.2019.102925","volume":"88","author":"Ghosh","year":"2019","journal-title":"Bioorg Chem"},{"key":"R10","unstructured":"Gold JM, Raja A. Cisplatin. StatPearls. Treasure Island (FL) : StatPearls Publishing, 2025 :"},{"key":"R11","doi-asserted-by":"crossref","first-page":"303","DOI":"10.2147\/JEP.S267383","volume":"13","author":"Tchounwou","year":"2021","journal-title":"J Exp Pharmacol"},{"key":"R12","doi-asserted-by":"crossref","unstructured":"Rossi A. Relapsed small-cell lung cancer: platinum re-challenge or not. J Thor Dis 2016 ; 8.","DOI":"10.21037\/jtd.2016.09.28"},{"key":"R13","doi-asserted-by":"crossref","first-page":"22639","DOI":"10.1073\/pnas.2007285117","volume":"117","author":"Balfourier","year":"2020","journal-title":"Proc Natl Acad Sci USA"},{"key":"R14","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1021\/jm061081y","volume":"50","author":"Groessl","year":"2007","journal-title":"J Med Chem"},{"key":"R15","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1200\/JCO.2024.42.3_suppl.143","volume":"42","author":"Spratlin","year":"2024","journal-title":"JCO"},{"key":"R16","doi-asserted-by":"crossref","first-page":"8802","DOI":"10.1039\/C5CS00486A","volume":"44","author":"Jaouen","year":"2015","journal-title":"Chem Soc Rev"},{"key":"R17","doi-asserted-by":"crossref","first-page":"114202","DOI":"10.1016\/j.ejmech.2022.114202","volume":"234","author":"Wang","year":"2022","journal-title":"Eur J Med Chem"},{"key":"R18","doi-asserted-by":"crossref","first-page":"e653","DOI":"10.1038\/cddis.2013.185","volume":"4","author":"Maillet","year":"2013","journal-title":"Cell Death Dis"},{"key":"R19","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1002\/ejic.201101175","volume":"2012","author":"Dieckmann","year":"2012","journal-title":"Eur J Inorg Chem"},{"key":"R20","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.chempr.2019.10.013","volume":"6","author":"Boros","year":"2020","journal-title":"Chem"},{"key":"R21","doi-asserted-by":"crossref","first-page":"116211","DOI":"10.1016\/j.biopha.2024.116211","volume":"171","author":"Adhikari","year":"2024","journal-title":"Biomed Pharmacother"},{"key":"R22","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.3390\/molecules24101995","volume":"24","author":"Alessio","year":"2019","journal-title":"Molecules"},{"key":"R23","doi-asserted-by":"crossref","first-page":"587","DOI":"10.3390\/cancers12030587","volume":"12","author":"Chen","year":"2020","journal-title":"Cancers"},{"key":"R24","doi-asserted-by":"crossref","first-page":"111289","DOI":"10.1016\/j.jinorgbio.2020.111289","volume":"214","author":"Oliveira","year":"2021","journal-title":"J Inorg Biochem"},{"key":"R25","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1021\/acs.molpharmaceut.2c01027","volume":"20","author":"Sumithaa","year":"2023","journal-title":"Mol Pharm"},{"key":"R26","doi-asserted-by":"crossref","first-page":"5568","DOI":"10.1021\/acs.jmedchem.0c00431","volume":"63","author":"Notaro","year":"2020","journal-title":"J. Med. Chem."},{"key":"R27","doi-asserted-by":"crossref","first-page":"5505","DOI":"10.1021\/acs.chemrev.3c00705","volume":"124","author":"Beach","year":"2024","journal-title":"Chem. Rev."},{"key":"R28","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.3390\/pharmaceutics14071506","volume":"14","author":"Dantas","year":"2022","journal-title":"Pharmaceutics"},{"key":"R29","doi-asserted-by":"crossref","unstructured":"Kumar Sahu AK, Kashyap P, Yadav R, et al. Properties and Applications of Ruthenium. In : Seehra MS, Bristow AD, eds. Noble and Precious Metals - Properties, Nanoscale Effects and Applications. Rijeka : IntechOpen, 2018.","DOI":"10.5772\/intechopen.76393"},{"key":"R30","doi-asserted-by":"crossref","unstructured":"Lin K, Zhao Z-Z, Bo H-B, et al. Applications of ruthenium complex in tumor diagnosis and therapy. Front Pharmacol 2018 ; 9.","DOI":"10.3389\/fphar.2018.01323"},{"key":"R31","doi-asserted-by":"crossref","first-page":"5805","DOI":"10.1021\/acs.jmedchem.7b01689","volume":"61","author":"Thota","year":"2018","journal-title":"J Med Chem"},{"key":"R32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00280-010-1293-1","volume":"66","author":"Antonarakis","year":"2010","journal-title":"Cancer Chemother Pharmacol"},{"key":"R33","doi-asserted-by":"crossref","first-page":"5771","DOI":"10.1039\/C7CS00195A","volume":"46","author":"Zeng","year":"2017","journal-title":"Chem Soc Rev"},{"key":"R34","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.ejmech.2017.07.066","volume":"139","author":"Wan","year":"2017","journal-title":"Eur J Med Chem"},{"key":"R35","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1021\/ar700135m","volume":"41","author":"Hoye","year":"2008","journal-title":"Acc Chem Re."},{"key":"R36","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1002\/cbic.200900185","volume":"10","author":"Yousif","year":"2009","journal-title":"Chembiochem"},{"key":"R37","doi-asserted-by":"crossref","first-page":"5957","DOI":"10.1039\/D3DT03701K","volume":"53","author":"Zhang","year":"2024","journal-title":"Dalton Trans"},{"key":"R38","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.drup.2006.05.002","volume":"9","author":"Brabec","year":"2006","journal-title":"Drug Resist Updat"},{"key":"R39","doi-asserted-by":"crossref","first-page":"3864","DOI":"10.1021\/om050293a","volume":"24","author":"Bruce","year":"2005","journal-title":"Organometallics"},{"key":"R40","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1136\/jcp.36.5.539","volume":"36","author":"Gatter","year":"1983","journal-title":"J Clin Pathol"},{"key":"R41","doi-asserted-by":"crossref","first-page":"6066","DOI":"10.1021\/jacs.9b12464","volume":"142","author":"Notaro","year":"2020","journal-title":"J Am Chem Soc"},{"key":"R42","doi-asserted-by":"crossref","first-page":"544","DOI":"10.3109\/10837450.2012.751408","volume":"18","year":"2013","journal-title":"Pharmaceutical Development and Technology"},{"key":"R43","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1007\/s12325-018-0707-z","volume":"35","author":"Schwartzberg","year":"2018","journal-title":"Adv Ther"},{"key":"R44","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s40824-020-00190-7","volume":"24","author":"Sung","year":"2020","journal-title":"Biomater Res"},{"key":"R45","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.bmt.2023.09.001","volume":"5","author":"Elumalai","year":"2024","journal-title":"Biomed Tech"},{"key":"R46","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.3390\/nano10101970","volume":"10","author":"Idrees","year":"2020","journal-title":"Nanomaterials (Basel)"},{"key":"R47","doi-asserted-by":"crossref","first-page":"2401950","DOI":"10.1002\/adfm.202401950","volume":"34","author":"Redrado","year":"2024","journal-title":"Adv Funct Mater"},{"key":"R48","doi-asserted-by":"crossref","first-page":"362","DOI":"10.3390\/ph16030362","volume":"16","author":"Klojdov\u00e1","year":"2023","journal-title":"Pharmaceutic"},{"key":"R49","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/s41570-019-0088-0","volume":"3","author":"Villemin","year":"2019","journal-title":"Nat Rev Chem"},{"key":"R50","doi-asserted-by":"crossref","first-page":"0024","DOI":"10.34133\/bmef.0024","volume":"4","author":"Karges","year":"2023","journal-title":"BME Frontiers"},{"key":"R51","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1039\/D2SC05693C","volume":"14","author":"Ant\u00f3nio","year":"2023","journal-title":"Chem Sci"},{"key":"R52","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1039\/C9SC05976H","volume":"11","author":"Soliman","year":"2020","journal-title":"Chem Sci"},{"key":"R53","doi-asserted-by":"crossref","first-page":"961","DOI":"10.3390\/pharmaceutics12100961","volume":"12","author":"Soliman","year":"2020","journal-title":"Pharmaceutics"}],"container-title":["m\u00e9decine\/sciences"],"original-title":[],"link":[{"URL":"https:\/\/www.medecinesciences.org\/10.1051\/medsci\/2025141\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T08:52:48Z","timestamp":1763542368000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.medecinesciences.org\/10.1051\/medsci\/2025141"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":53,"journal-issue":{"issue":"10"},"alternative-id":["medsci20250017"],"URL":"https:\/\/doi.org\/10.1051\/medsci\/2025141","relation":{},"ISSN":["0767-0974","1958-5381"],"issn-type":[{"value":"0767-0974","type":"print"},{"value":"1958-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]}}}