{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T08:57:17Z","timestamp":1764320237410,"version":"3.46.0"},"reference-count":30,"publisher":"EDP Sciences","license":[{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"vor","delay-in-days":27,"URL":"https:\/\/www.edpsciences.org\/en\/authors\/copyright-and-licensing"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Sci (Paris)"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:p>Malgr\u00e9 les traitements immunomodulateurs, une proportion importante de patients atteints de myopathies inflammatoires (MI), m\u00eame lorsque l\u2019activit\u00e9 de la maladie est faible, pr\u00e9sentent un handicap persistant. Cette condition, appel\u00e9e \u00ab\u00a0dommage\u00a0\u00bb, est fr\u00e9quente et corr\u00e9l\u00e9e \u00e0 la mortalit\u00e9.<\/jats:p>\n                  <jats:p>\n                    Notre \u00e9tude a examin\u00e9 l\u2019association entre le d\u00e9s\u00e9quilibre de diverses myokines, mesur\u00e9es \u00e0 l\u2019inclusion, et le \u00ab\u00a0dommage total\u00a0\u00bb d\u2019\u00e9tendue et celui de s\u00e9v\u00e9rit\u00e9, \u00e9valu\u00e9s gr\u00e2ce aux scores de l\u2019IMACS (\n                    <jats:italic>International Myositis Assessment and Clinical Studies<\/jats:italic>\n                    ), et le \u00ab\u00a0dommage global\u00a0\u00bb \u00e9tabli par un m\u00e9decin. \u00c0 cette fin, ont \u00e9t\u00e9 inclus 40 patients adultes atteints de MI, avec une dur\u00e9e de maladie de 12 mois et plus, une activit\u00e9 de la maladie faible depuis au moins 6 mois, et 30 volontaires sains (VS).\n                  <\/jats:p>\n                  <jats:p>\n                    Le taux s\u00e9rique de FABP-3 (\n                    <jats:italic>fatty acid-binding protein 3<\/jats:italic>\n                    ) \u00e9tait 1,8 fois plus \u00e9lev\u00e9 chez les patients atteints de MI par rapport aux VS, et positivement corr\u00e9l\u00e9 aux scores de dommage total (\u00e9tendue et s\u00e9v\u00e9rit\u00e9), ainsi qu\u2019au score de dommage global. Parmi les domaines de l\u2019IMACS, les associations les plus fortes ont \u00e9t\u00e9 observ\u00e9es pour les atteintes gastro-intestinales, cardiovasculaires et musculaires.\n                  <\/jats:p>\n                  <jats:p>En conclusion, un taux circulant \u00e9lev\u00e9 de FABP-3 est un biomarqueur candidat de dommages dans les MI. Compte tenu du r\u00f4le de FABP-3 dans le m\u00e9tabolisme \u00e9nerg\u00e9tique et la trophicit\u00e9 musculaires, il pourrait \u00e9galement jouer un r\u00f4le dans la physiopathologie de cette condition. Ces r\u00e9sultats pourraient donc avoir un impact sur la quantification et le d\u00e9veloppement de traitements pharmacologiques pour les dommages associ\u00e9s aux MI.<\/jats:p>","DOI":"10.1051\/medsci\/2025182","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T08:52:58Z","timestamp":1764319978000},"page":"58-63","source":"Crossref","is-referenced-by-count":0,"special_numbering":"Hors s\u00e9rie n\u00b0 2","title":["Augmentation des taux circulants de la prot\u00e9ine 3 de liaison aux acides gras (FABP-3)"],"prefix":"10.1051","volume":"41","author":[{"given":"Margherita","family":"Giannini","sequence":"first","affiliation":[{"name":"Physiologie et explorations fonctionnelles musculaires, H\u00f4pitaux universitaires de Strasbourg","place":["France"]},{"name":"UR3072 \u00ab\u00a0Mitochondrie, stress oxydant et plasticit\u00e9 musculaire\u00a0\u00bb, Centre de recherche en biom\u00e9decine, Universit\u00e9 de Strasbourg","place":["France"]},{"name":"Centre de r\u00e9f\u00e9rence des maladies auto-immunes syst\u00e9miques rares","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e9a","family":"Debrut","sequence":"additional","affiliation":[{"name":"UR3072 \u00ab\u00a0Mitochondrie, stress oxydant et plasticit\u00e9 musculaire\u00a0\u00bb, Centre de recherche en biom\u00e9decine, Universit\u00e9 de Strasbourg","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Geny","sequence":"additional","affiliation":[{"name":"UR3072 \u00ab\u00a0Mitochondrie, stress oxydant et plasticit\u00e9 musculaire\u00a0\u00bb, Centre de recherche en biom\u00e9decine, Universit\u00e9 de Strasbourg","place":["France"]},{"name":"Physiologie et explorations fonctionnelles musculaires, H\u00f4pitaux universitaires de Strasbourg","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"Meyer","sequence":"additional","affiliation":[{"name":"Physiologie et explorations fonctionnelles musculaires, H\u00f4pitaux universitaires de Strasbourg","place":["France"]},{"name":"UR3072 \u00ab\u00a0Mitochondrie, stress oxydant et plasticit\u00e9 musculaire\u00a0\u00bb, Centre de recherche en biom\u00e9decine, Universit\u00e9 de Strasbourg","place":["France"]},{"name":"Centre de r\u00e9f\u00e9rence des maladies auto-immunes syst\u00e9miques rares","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"250","published-online":{"date-parts":[[2025,11,28]]},"reference":[{"issue":"1","key":"R1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jbspin.2017.03.005","volume":"85","author":"Meyer","year":"2018","journal-title":"Joint Bone Spine"},{"issue":"12","key":"R2","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1002\/acr.22068","volume":"65","author":"Alemo Munters","year":"2013","journal-title":"Arthritis & Rheumatism"},{"issue":"11","key":"R3","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1093\/rheumatology\/40.11.1262","volume":"40","author":"Miller","year":"2001","journal-title":"Rheumatology"},{"issue":"6","key":"R4","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1097\/00002281-199611000-00002","volume":"8","author":"Rider","year":"1996","journal-title":"Current Opinion in Rheumatology"},{"issue":"12","key":"R5","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1093\/rheumatology\/kep302","volume":"48","author":"Sanner","year":"2009","journal-title":"Rheumatology (Oxford)"},{"issue":"1","key":"R6","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3109\/03009742.2011.608376","volume":"41","author":"Mathiesen","year":"2012","journal-title":"Scand J Rheumatol."},{"issue":"11","key":"R7","doi-asserted-by":"crossref","first-page":"3425","DOI":"10.1002\/art.24904","volume":"60","author":"Rider","year":"2009","journal-title":"Arthritis Rheum."},{"issue":"11","key":"R8","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1136\/ard.2005.045690","volume":"65","author":"Bronner","year":"2006","journal-title":"Annals of the Rheumatic Diseases"},{"issue":"5","key":"R9","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1002\/art.22780","volume":"57","author":"Alexanderson","year":"2007","journal-title":"Arthritis Rheum."},{"key":"R10","doi-asserted-by":"crossref","unstructured":"Loell I, Lundberg I. 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