{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:59:25Z","timestamp":1790366365650,"version":"4.1.0"},"reference-count":30,"publisher":"EDP Sciences","issue":"12","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"vor","delay-in-days":36,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Sci (Paris)"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:p>\n                    La m\u00e9nopause correspond \u00e0 l\u2019arr\u00eat permanent des menstruations, r\u00e9sultant d\u2019une perte de l\u2019activit\u00e9 folliculaire ovarienne. Elle est connue depuis l\u2019Antiquit\u00e9, mais ce n\u2019est qu\u2019au d\u00e9but du XIX\n                    <jats:sup>e<\/jats:sup>\n                    si\u00e8cle que le terme \u00ab\u00a0m\u00e9nopause\u00a0\u00bb appara\u00eet. Au fil des \u00e2ges, la perception de la m\u00e9nopause a toujours rev\u00eatu une dimension culturelle et sociologique, diff\u00e9rente selon les pays et les ethnies. Progressivement, \u00e0 partir de la seconde moiti\u00e9 du XX\n                    <jats:sup>e<\/jats:sup>\n                    si\u00e8cle, la mise en \u00e9vidence des liens entre la carence en estrog\u00e8ne et la d\u00e9gradation de la qualit\u00e9 de vie, avec l\u2019augmentation de certaines maladies, telles que l\u2018ost\u00e9oporose ou les risques cardiovasculaires, a ouvert la voie \u00e0 une m\u00e9dicalisation de cette p\u00e9riode de la vie des femmes, qui demeure, encore aujourd\u2019hui, l\u2019objet de d\u00e9bats passionn\u00e9s.\n                  <\/jats:p>\n                  <jats:p>Les bouff\u00e9es vasomotrices, commun\u00e9ment appel\u00e9es bouff\u00e9es de chaleur, constituent l\u2019une des principales manifestations fonctionnelles li\u00e9es \u00e0 la carence en \u0153strog\u00e8ne induite par l\u2019arr\u00eat de l\u2019activit\u00e9 ovarienne. Leur physiopathologie demeure encore mal connue, bien que des progr\u00e8s r\u00e9cents aient permis d\u2019identifier le r\u00f4le de certains neurom\u00e9diateurs dans la r\u00e9gulation de la thermor\u00e9gulation, avec, sous l\u2019effet de la chute de l\u2019estradiol, une r\u00e9duction de la zone de neutralit\u00e9 thermique.<\/jats:p>","DOI":"10.1051\/medsci\/2025228","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T08:43:09Z","timestamp":1767688989000},"page":"1004-1008","source":"Crossref","is-referenced-by-count":1,"title":["Comprendre la m\u00e9nopause. Physiopathologie des bouff\u00e9es de chaleur"],"prefix":"10.1051","volume":"41","author":[{"given":"Florence","family":"Tr\u00e9molli\u00e8res","sequence":"first","affiliation":[{"name":"Centre de M\u00e9nopause, H\u00f4pital Paule de Viguier, CHU Toulouse","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"250","published-online":{"date-parts":[[2026,1,6]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"3427","DOI":"10.1210\/jc.2005-0181","volume":"90","author":"Murabito","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"R2","doi-asserted-by":"crossref","first-page":"e1002704","DOI":"10.1371\/journal.pmed.1002704","volume":"15","author":"Zhu","year":"2018","journal-title":"PLoS Med"},{"key":"R3","doi-asserted-by":"crossref","unstructured":"Beyene Y. Cultural significance and physiological manifestations of menopause. A biocultural analysis. 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