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Cette \u00e9tape diagnostique est indispensable avant de proposer l\u2019utilisation d\u2019un traitement hormonal de la m\u00e9nopause, s\u2019il existe une v\u00e9ritable indication. Si ce traitement est autoris\u00e9, l\u2019estradiol par voie transdermique associ\u00e9 \u00e0 la progest\u00e9rone naturelle constitue le traitement qui assure la meilleure s\u00e9curit\u00e9 d\u2019emploi chez les femmes n\u2019ayant pas d\u2019ant\u00e9c\u00e9dent d\u2019hyst\u00e9rectomie. La tol\u00e9rance de ce traitement, ainsi que l\u2019ensemble des facteurs de risque cardiovasculaires, doivent \u00eatre \u00e9valu\u00e9s annuellement afin d\u2019optimiser la balance b\u00e9n\u00e9fice-risque de ce traitement.<\/jats:p>","DOI":"10.1051\/medsci\/2025229","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T08:43:09Z","timestamp":1767688989000},"page":"1009-1018","source":"Crossref","is-referenced-by-count":0,"title":["M\u00e9nopause, traitement hormonal et risque cardiovasculaire"],"prefix":"10.1051","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1020-8142","authenticated-orcid":false,"given":"Genevi\u00e8ve","family":"Plu-Bureau","sequence":"first","affiliation":[{"name":"Unit\u00e9 de gyn\u00e9cologie endocrinienne, h\u00f4pital Port-Royal, Universit\u00e9 Paris Cit\u00e9, Paris, Inserm UMR 1153, Obstetrical, Perinatal, Paediatric Life course Epidemiology (OPPaLE), centre d\u2019\u00e9pid\u00e9miologie et de statistiques Sorbonne Paris Cit\u00e9 (CRESS)","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iphig\u00e9nie","family":"Cavadias","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de gyn\u00e9cologie endocrinienne, h\u00f4pital Port-Royal, Universit\u00e9 Paris Cit\u00e9, Paris, Inserm UMR 1153, Obstetrical, Perinatal, Paediatric Life course Epidemiology (OPPaLE), centre d\u2019\u00e9pid\u00e9miologie et de statistiques Sorbonne Paris Cit\u00e9 (CRESS)","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Raccah-Tebeka","sequence":"additional","affiliation":[{"name":"Maternit\u00e9 H\u00f4pital Robert Debr\u00e9","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7105-2508","authenticated-orcid":false,"given":"Manon","family":"Jouffroy","sequence":"additional","affiliation":[{"name":"Univ. 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