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Les neurones du syst\u00e8me olfactif stimulent les aires c\u00e9r\u00e9brales impliqu\u00e9es dans les \u00e9motions, la m\u00e9moire et le plaisir, et qui sont li\u00e9es \u00e0 l\u2019alimentation. Ils sont modul\u00e9s par le niveau du m\u00e9tabolisme \u00e9nerg\u00e9tique corporel, qu\u2019ils r\u00e9gulent en retour. La sensibilit\u00e9 olfactive diminue dans l\u2019ob\u00e9sit\u00e9 et la chirurgie bariatrique la r\u00e9tablit. Dans le diab\u00e8te de type 2, l\u2019apparition de troubles olfactifs peut pr\u00e9dire les troubles cognitifs. Enfin, dans un mod\u00e8le murin de l\u2019ob\u00e9sit\u00e9, l\u2019activation locale du syst\u00e8me\n                    <jats:italic>glucagon-like peptide-1<\/jats:italic>\n                    (GLP-1) dans le bulbe olfactif, premi\u00e8re structure c\u00e9r\u00e9brale codant les odeurs, induit une meilleure r\u00e9gulation de la glyc\u00e9mie et de la prise alimentaire. Le recrutement de cette nouvelle voie neurom\u00e9tabolique menant jusqu\u2019au pancr\u00e9as provoque une augmentation de la lib\u00e9ration d\u2019insuline et de la sensibilit\u00e9 \u00e0 cette hormone.\n                  <\/jats:p>","DOI":"10.1051\/medsci\/2026014","type":"journal-article","created":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T08:51:14Z","timestamp":1771923074000},"page":"153-163","source":"Crossref","is-referenced-by-count":0,"title":["Interr\u00e9gulations entre olfaction et m\u00e9tabolisme \u00e9nerg\u00e9tique dans l\u2019ob\u00e9sit\u00e9 et le diab\u00e8te de type 2"],"prefix":"10.1051","volume":"42","author":[{"given":"Mireia","family":"Montaner","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Unit\u00e9 de biologie fonctionnelle et adaptative (BFA), CNRS UMR 8251","place":["France"]},{"name":"Institute of Metabolic Science-Metabolic Research Laboratories & MRC-Metabolic Diseases Unit, University of 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