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Parmi ceux-ci, les lysosomes, longtemps consid\u00e9r\u00e9s comme des compartiments uniquement d\u00e9gradatifs, sont d\u00e9sormais reconnus comme des r\u00e9gulateurs cl\u00e9s du m\u00e9tabolisme, de la signalisation et de l\u2019invasion tumorale. Nous discutons ici de la mani\u00e8re dont leur localisation intracellulaire influence leur fonction, leur signalisation et leur s\u00e9cr\u00e9tion. Dans le m\u00e9lanome, leur distribution p\u00e9riph\u00e9rique favorise l\u2019agressivit\u00e9 des cellules tumorales et les m\u00e9tastases. L\u2019existence de changements similaires dans d\u2019autres cancers souligne le r\u00f4le du trafic lysosomal en tant que facteur de malignit\u00e9 et en tant que biomarqueur prometteur pour le diagnostic et le traitement.<\/jats:p>","DOI":"10.1051\/medsci\/2026033","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T08:54:57Z","timestamp":1773996897000},"page":"258-262","source":"Crossref","is-referenced-by-count":0,"title":["Quand la position des organites favorise la progression du cancer"],"prefix":"10.1051","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4734-6458","authenticated-orcid":false,"given":"Katerina","family":"Jerabkova-Roda","sequence":"first","affiliation":[{"name":"Tumor Biomechanics Lab, Inserm UMRS1109","place":["France"]},{"name":"Universit\u00e9 de Strasbourg","place":["France"]},{"name":"F\u00e9d\u00e9ration de m\u00e9decine translationnelle de Strasbourg (FMTS)","place":["France"]},{"name":"\u00c9quipe 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