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Les techniques de s\u00e9quen\u00e7age de nouvelle g\u00e9n\u00e9ration, qui permettent une caract\u00e9risation compl\u00e8te de ces s\u00e9quences virales, montrent que, dans 80 % des cas, l\u2019insertion virale se fait dans des g\u00e8nes cellulaires, ce qui entra\u00eene une alt\u00e9ration de leur niveau d\u2019expression. Environ un tiers de ces g\u00e8nes correspondent \u00e0 des cibles th\u00e9rapeutiques potentielles. L\u2019analyse de l\u2019ADN viral circulant par s\u00e9quen\u00e7age de nouvelle g\u00e9n\u00e9ration a permis des d\u00e9veloppements dans le diagnostic et le suivi th\u00e9rapeutique des cancers dus aux papillomavirus. Ces progr\u00e8s devraient \u00e9galement b\u00e9n\u00e9ficier au d\u00e9veloppement de th\u00e9rapeutiques innovantes ciblant les s\u00e9quences virales int\u00e9gr\u00e9es.<\/jats:p>","DOI":"10.1051\/medsci\/2026055","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T08:00:10Z","timestamp":1777017610000},"page":"365-372","source":"Crossref","is-referenced-by-count":0,"title":["Caract\u00e9risation des g\u00e9nomes de papillomavirus humains int\u00e9gr\u00e9s au g\u00e9nome cellulaire"],"prefix":"10.1051","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5992-2083","authenticated-orcid":false,"given":"Xavier","family":"Sastre-Garau","sequence":"first","affiliation":[{"name":"Laboratoire de pathologie, Centre hospitalier intercommunal de Cr\u00e9teil","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abir Al","family":"Ghuzlan","sequence":"additional","affiliation":[{"name":"Laboratoire de pathologie, Centre Antoine Lacassagne","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rana","family":"Mitri-Frangieh","sequence":"additional","affiliation":[{"name":"Laboratoire de pathologie, Centre hospitalier intercommunal de Cr\u00e9teil","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"250","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0738-081X(97)00008-4","volume":"15","author":"Favre","year":"1997","journal-title":"Clin Dermatol"},{"key":"R2","unstructured":"Orth G, Breitburd F, Favre M, et al. 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