{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T08:44:43Z","timestamp":1777020283218,"version":"3.51.4"},"reference-count":12,"publisher":"EDP Sciences","issue":"4","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":23,"URL":"https:\/\/www.edpsciences.org\/en\/authors\/copyright-and-licensing"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Sci (Paris)"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:p>Les connaissances d\u00e9montrant l\u2019implication de m\u00e9canismes de propagation des anomalies de repliement prot\u00e9ique dans la progression de la maladie de Parkinson ouvrent la voie \u00e0 de nouvelles perspectives th\u00e9rapeutiques. Cet article illustre cette possibilit\u00e9 au travers de deux publications majeures r\u00e9centes. La premi\u00e8re \u00e9tude porte sur un nouveau r\u00e9cepteur (FAM171A2) de la prot\u00e9ine \u03b1-synucl\u00e9ine anormalement repli\u00e9e, qui permet d\u2019envisager son blocage, limitant ainsi la propagation, de cellule \u00e0 cellule, de la prot\u00e9ine pathologique. La seconde \u00e9tude montre que les extr\u00e9mit\u00e9s non structur\u00e9es de cette prot\u00e9ine pr\u00e9sentent des positions variables susceptibles d\u2019influencer sa pathog\u00e9nicit\u00e9 ainsi que sa capacit\u00e9 de propagation. La modification de ce positionnement par l\u2019action d\u2019une substance, telle qu\u2019un anticorps, pourrait constituer une approche permettant de freiner la progression de la maladie.<\/jats:p>","DOI":"10.1051\/medsci\/2026058","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T08:00:10Z","timestamp":1777017610000},"page":"385-388","source":"Crossref","is-referenced-by-count":0,"title":["Un \u00ab\u00a0m\u00e9canisme prion\u00a0\u00bb impliqu\u00e9 dans la progression de la maladie de Parkinson : vers des approches th\u00e9rapeutiques innovantes ?"],"prefix":"10.1051","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5396-7707","authenticated-orcid":false,"given":"Thierry","family":"Baron","sequence":"first","affiliation":[{"name":"Agence nationale de s\u00e9curit\u00e9 sanitaire (ANSES), Universit\u00e9 de Lyon, Unit\u00e9 Maladies neuro-d\u00e9g\u00e9n\u00e9ratives et du neurod\u00e9veloppement (MN2D)","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"250","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"383","DOI":"10.3233\/JPD-240002","volume":"14","author":"Borghammer","year":"2024","journal-title":"J Parkinsons Dis"},{"key":"R2","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/s41591-024-03469-7","volume":"31","author":"Soto","year":"2025","journal-title":"Nat Med"},{"key":"R3","doi-asserted-by":"crossref","first-page":"106101","DOI":"10.1016\/j.parkreldis.2024.106101","volume":"122","author":"Horsager","year":"2024","journal-title":"Parkinsonism Relat Disord"},{"key":"R4","doi-asserted-by":"crossref","first-page":"375","DOI":"10.3390\/cells10020375","volume":"10","author":"Bras","year":"2021","journal-title":"Cells"},{"key":"R5","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1126\/science.adp3645","volume":"387","author":"Wu","year":"2025","journal-title":"Science"},{"key":"R6","doi-asserted-by":"crossref","first-page":"eabb3063","DOI":"10.1126\/sciadv.abb3063","volume":"6","author":"Xu","year":"2020","journal-title":"Sci Adv"},{"key":"R7","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1126\/science.1227157","volume":"338","author":"Luk","year":"2012","journal-title":"Science"},{"key":"R8","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s13024-025-00797-1","volume":"20","author":"Kuo","year":"2025","journal-title":"Mol Neurodegener"},{"key":"R9","doi-asserted-by":"crossref","first-page":"28282","DOI":"10.1021\/jacs.4c08869","volume":"146","author":"Zhang","year":"2024","journal-title":"J Am Chem Soc"},{"key":"R10","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1016\/j.neuron.2025.03.019","volume":"113","author":"Han","year":"2025","journal-title":"Neuron"},{"key":"R11","doi-asserted-by":"crossref","first-page":"104712","DOI":"10.1016\/j.nbd.2019.104712","volume":"136","author":"Henderson","year":"2020","journal-title":"Neurobiol Dis"},{"key":"R12","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1111\/nan.12402","volume":"43","author":"Covell","year":"2017","journal-title":"Neuropathol Appl Neurobiol"}],"container-title":["m\u00e9decine\/sciences"],"original-title":[],"link":[{"URL":"https:\/\/www.medecinesciences.org\/10.1051\/medsci\/2026058\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T08:01:13Z","timestamp":1777017673000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.medecinesciences.org\/10.1051\/medsci\/2026058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":12,"journal-issue":{"issue":"4"},"alternative-id":["medsci20250152"],"URL":"https:\/\/doi.org\/10.1051\/medsci\/2026058","relation":{},"ISSN":["0767-0974","1958-5381"],"issn-type":[{"value":"0767-0974","type":"print"},{"value":"1958-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]}}}