{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T08:07:10Z","timestamp":1780042030690,"version":"3.53.1"},"reference-count":29,"publisher":"EDP Sciences","issue":"5","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":28,"URL":"https:\/\/www.edpsciences.org\/en\/authors\/copyright-and-licensing"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Sci (Paris)"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:p>Apr\u00e8s trois si\u00e8cles de ravages caus\u00e9s par la fi\u00e8vre jaune, un vaccin vivant att\u00e9nu\u00e9 a \u00e9t\u00e9 finalement mis au point et demeure encore utilis\u00e9 aujourd\u2019hui. Son \u00e9laboration s\u2019est inscrite dans un contexte marqu\u00e9 par les rivalit\u00e9s entre les puissances commerciales et coloniales europ\u00e9ennes et am\u00e9ricaines. Largement utilis\u00e9 aussi bien dans les zones d\u2019end\u00e9mie que chez les voyageurs, son utilisation a \u00e9t\u00e9 encadr\u00e9e par le R\u00e8glement sanitaire international, et int\u00e9gr\u00e9e aux programmes de vaccination pr\u00e9ventive des enfants dans les r\u00e9gions end\u00e9miques. La p\u00e9nurie provoqu\u00e9e par la reprise d\u2019\u00e9pid\u00e9mies en Afrique et en Am\u00e9rique latine a conduit \u00e0 allonger la dur\u00e9e de validit\u00e9 de la vaccination et \u00e0 r\u00e9duire la dose administr\u00e9e. De nombreuses incertitudes persistent n\u00e9anmoins quant \u00e0 l\u2019ampleur et aux m\u00e9canismes de ses effets ind\u00e9sirables, parfois mortels. La mise au point d\u2019un vaccin plus facile \u00e0 produire, tout en \u00e9tant aussi efficace, mais associ\u00e9 \u00e0 moins d\u2019effets secondaires, se trouve au c\u0153ur de l\u2019histoire pr\u00e9sente et future de ce vaccin presque centenaire.<\/jats:p>","DOI":"10.1051\/medsci\/2026067","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T07:54:38Z","timestamp":1780041278000},"page":"501-505","source":"Crossref","is-referenced-by-count":0,"title":["L\u2019aventure du vaccin contre la fi\u00e8vre jaune"],"prefix":"10.1051","volume":"42","author":[{"given":"\u00c9ric","family":"Pichard","sequence":"first","affiliation":[{"name":"Soci\u00e9t\u00e9 francophone de m\u00e9decine tropicale et sant\u00e9 internationale, Institut Pasteur","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"250","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.lpm.2022.104132","volume":"51","author":"Rodhain","year":"2022","journal-title":"Presse Med"},{"key":"R2","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1001\/jama.1928.02690310005002","volume":"90","author":"Stokes","year":"1928","journal-title":"JAMA"},{"key":"R3","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1084\/jem.65.6.801","volume":"65","author":"Smith","year":"1937","journal-title":"J Exp Med"},{"key":"R4","first-page":"1609","volume":"194","author":"Sellards","year":"1932","journal-title":"CR Acad Sci Paris"},{"key":"R5","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1084\/jem.65.6.787","volume":"65","author":"Theiler","year":"1937","journal-title":"J Exp Med"},{"key":"R6","first-page":"77","volume":"83","author":"Frierson","year":"2010","journal-title":"Yale J Biol Med"},{"key":"R7","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1093\/oxfordjournals.aje.a118911","volume":"39","author":"Sawyer","year":"1944","journal-title":"Am J Epidemiol"},{"key":"R8","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.2105\/AJPH.2021.306313","volume":"111","author":"Lowy","year":"2021","journal-title":"Am J Public Health"},{"key":"R9","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1126\/science.177.4043.76","volume":"177","author":"Waters","year":"1972","journal-title":"Science"},{"key":"R10","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1051\/medsci\/2024002","volume":"40","author":"Dieu-Nosiean","year":"2024","journal-title":"Med Sci (Paris)"},{"key":"R11","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S2214-109X(23)00556-9","volume":"12","author":"Schnyder","year":"2024","journal-title":"Lancet Glob Health"},{"key":"R12","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1007\/s13149-011-0135-7","volume":"104","author":"Coulange Bodilis","year":"2011","journal-title":"Bull Soc Pathol Exot"},{"key":"R13","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/S1473-3099(19)30323-8","volume":"19","author":"Domingo","year":"2019","journal-title":"Lancet Infect Dis"},{"key":"R14","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1177\/2051013613498954","volume":"1","author":"Jonker","year":"2013","journal-title":"Ther Adv Vaccines"},{"key":"R15","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S1473-3099(23)00809-5","volume":"24","author":"Doshi","year":"2024","journal-title":"Lancet Infect Dis"},{"key":"R16","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/s41541-021-00318-3","volume":"6","author":"Bakoa","year":"2021","journal-title":"NPJ Vaccines"},{"key":"R17","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1016\/j.vaccine.2013.01.054","volume":"1","author":"Breugelmans","year":"2013","journal-title":"Vaccine"},{"key":"R18","doi-asserted-by":"crossref","unstructured":"Lindsey NP, Rabe IB, Miller ER et al. 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