{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T08:07:10Z","timestamp":1780042030733,"version":"3.53.1"},"reference-count":5,"publisher":"EDP Sciences","issue":"5","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":28,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Sci (Paris)"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:p>Dans le cadre de l\u2019unit\u00e9 d\u2019enseignement \u00ab\u00a0prolif\u00e9ration et morts cellulaires\u00a0\u00bb propos\u00e9e par l\u2019universit\u00e9 de Reims Champagne-Ardenne, les \u00e9tudiants de master 1 Biologie-Sant\u00e9 ont \u00e9t\u00e9 sensibilis\u00e9s \u00e0 l\u2019\u00e9criture scientifique. Deux th\u00e9matiques ont \u00e9t\u00e9 propos\u00e9es en lien direct avec les cours magistraux dispens\u00e9s dans cette EC, le cycle cellulaire et la mort cellulaire. A partir de 2 publications originales, les \u00e9tudiants ont r\u00e9dig\u00e9s deux br\u00e8ves. La premi\u00e8re br\u00e8ve souligne le b\u00e9n\u00e9fice du ciblage de CREPT en combinaison avec une th\u00e9rapie anti-PD-1 dans le cancer du poumon \u00e0 non petites cellules et la deuxi\u00e8me br\u00e8ve permet de mettre en lumi\u00e8re la voie non canonique ATM-CHK2 dans l\u2019adaptation des cellules tumorales \u00e0 l\u2019hypoxie. Ce travail a permis aux \u00e9tudiants de comprendre l\u2019int\u00e9r\u00eat du d\u00e9cryptage des m\u00e9canismes mol\u00e9culaires du cycle cellulaire pour le d\u00e9veloppement de nouvelles strat\u00e9gies th\u00e9rapeutiques en oncologie.<\/jats:p>","DOI":"10.1051\/medsci\/2026086","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T07:54:38Z","timestamp":1780041278000},"page":"530-531","source":"Crossref","is-referenced-by-count":0,"title":["Un nouveau m\u00e9canisme de r\u00e9gulation de HIF-1\u03b1"],"prefix":"10.1051","volume":"42","author":[{"given":"Arthur","family":"Hoermann","sequence":"first","affiliation":[{"name":"Master Biologie Sant\u00e9 (BS) Universit\u00e9 de Reims Champagne Ardenne","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Souvannavong Puente","sequence":"additional","affiliation":[{"name":"Master Biologie Sant\u00e9 (BS) Universit\u00e9 de Reims Champagne Ardenne","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Mar\u00e9challe-Amant","sequence":"additional","affiliation":[{"name":"Master Biologie Sant\u00e9 (BS) Universit\u00e9 de Reims Champagne Ardenne","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rom\u00e9o","family":"Weil","sequence":"additional","affiliation":[{"name":"Master Biologie Sant\u00e9 (BS) Universit\u00e9 de Reims Champagne Ardenne","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"250","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1242\/jcs.112.8.1203","volume":"112","author":"Chilov","year":"1999","journal-title":"J Cell Sci"},{"key":"R2","first-page":"e70700","volume":"16","author":"Basheeruddin","year":"2024","journal-title":"Cureus"},{"key":"R3","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1038\/s41388-025-03336-w","volume":"44","author":"Bai","year":"2025","journal-title":"Oncogene"},{"key":"R4","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s11010-020-03917-1","volume":"476","author":"Sarkar","year":"2021","journal-title":"Mol Cell Biochem"},{"key":"R5","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.dnarep.2015.11.019","volume":"38","author":"Li","year":"2016","journal-title":"DNA Repair"}],"container-title":["m\u00e9decine\/sciences"],"original-title":[],"link":[{"URL":"https:\/\/www.medecinesciences.org\/10.1051\/medsci\/2026086\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T07:56:20Z","timestamp":1780041380000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.medecinesciences.org\/10.1051\/medsci\/2026086"}},"subtitle":["L\u2019axe ROS\u2013ATM\u2013CHK2 au c\u0153ur de l\u2019angiogen\u00e8se tumorale"],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":5,"journal-issue":{"issue":"5"},"alternative-id":["medsci20260078"],"URL":"https:\/\/doi.org\/10.1051\/medsci\/2026086","relation":{},"ISSN":["0767-0974","1958-5381"],"issn-type":[{"value":"0767-0974","type":"print"},{"value":"1958-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]}}}