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Il est principalement m\u00e9tabolis\u00e9 via les voies de la kynur\u00e9nine, des indoles et de la s\u00e9rotonine, ce qui conduit \u00e0 la production de m\u00e9tabolites aux effets protecteurs ou d\u00e9l\u00e9t\u00e8res selon le contexte physiologique et tissulaire. La d\u00e9r\u00e9gulation de ces voies contribue \u00e0 l\u2019ob\u00e9sit\u00e9, au diab\u00e8te et aux maladies cardiovasculaires. 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