{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T08:07:51Z","timestamp":1784275671125,"version":"3.55.0"},"reference-count":46,"publisher":"EDP Sciences","issue":"6-7","license":[{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"vor","delay-in-days":46,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Sci (Paris)"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:p>\n                    Les synucl\u00e9inopathies regroupent trois maladies diff\u00e9rentes, la maladie de Parkinson, la d\u00e9mence \u00e0 corps de Lewy, et l\u2019atrophie multisyst\u00e9matis\u00e9e, qui impliquent toutes l\u2019agr\u00e9gation pathologique d\u2019une prot\u00e9ine appel\u00e9e alpha-synucl\u00e9ine (\u03b1-syn). Dans le but de poser un diagnostic pr\u00e9cis de ces maladies pour mieux orienter leur prise en charge th\u00e9rapeutique ou leur inclusion dans des essais th\u00e9rapeutiques, des m\u00e9thodes bas\u00e9es sur l\u2019amplification\n                    <jats:italic>in vitro<\/jats:italic>\n                    de l\u2019\u03b1-syn pathologique ont \u00e9t\u00e9 d\u00e9velopp\u00e9es. Dans cette synth\u00e8se, nous discutons du d\u00e9veloppement historique de ces techniques, de leurs avantages et de l\u2019espoir qu\u2019elles offrent aux patients en vue d\u2019un d\u00e9pistage pr\u00e9coce par voie sanguine.\n                  <\/jats:p>","DOI":"10.1051\/medsci\/2026095","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T07:58:36Z","timestamp":1784275116000},"page":"600-607","source":"Crossref","is-referenced-by-count":0,"title":["Apports des techniques d\u2019amplification pour le diagnostic des synucl\u00e9inopathies"],"prefix":"10.1051","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-2519-1512","authenticated-orcid":false,"given":"Emma","family":"Lamard","sequence":"first","affiliation":[{"name":"\u00c9tablissement fran\u00e7ais du sang Occitanie","place":["France"]},{"name":"Pathogen\u00e8se et contr\u00f4le des infections chroniques et \u00e9mergentes (PCCEI), Universit\u00e9 de Montpellier, 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