{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T08:07:52Z","timestamp":1784275672101,"version":"3.55.0"},"reference-count":32,"publisher":"EDP Sciences","issue":"6-7","license":[{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"vor","delay-in-days":46,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Sci (Paris)"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:p>\n                    Le prix Nobel de physiologie ou m\u00e9decine 2025 a \u00e9t\u00e9 attribu\u00e9 conjointement \u00e0 Mary Brunkow, Fred Ramsdell et Shimon Sakaguchi, pour la caract\u00e9risation des lymphocytes T r\u00e9gulateurs et l\u2019identification du g\u00e8ne\n                    <jats:italic>FOXP3<\/jats:italic>\n                    comme \u00ab\u00a0chef d\u2019orchestre\u00a0\u00bb de ces cellules. Ces travaux ont r\u00e9habilit\u00e9 le concept, alors controvers\u00e9, de lymphocytes T suppresseurs et ont fond\u00e9 le champ de la tol\u00e9rance immunitaire p\u00e9riph\u00e9rique. Cet article retrace bri\u00e8vement l\u2019histoire de cette d\u00e9couverte et les contributions respectives des trois laur\u00e9ats, avant de se concentrer sur l\u2019essor de cette th\u00e9matique de recherche, en mettant en lumi\u00e8re le r\u00f4le d\u00e9terminant de Beno\u00eet Salomon dans son introduction et son d\u00e9veloppement en France \u00e0 partir des ann\u00e9es 2000.\n                  <\/jats:p>","DOI":"10.1051\/medsci\/2026109","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T07:58:36Z","timestamp":1784275116000},"page":"608-615","source":"Crossref","is-referenced-by-count":0,"title":["Prix Nobel de physiologie ou m\u00e9decine 2025: Les lymphocytes T r\u00e9gulateurs, des \u00ab\u00a0cellules immunosuppressives\u00a0\u00bb longtemps oubli\u00e9es"],"prefix":"10.1051","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5077-6726","authenticated-orcid":false,"given":"Jos\u00e9 L.","family":"Cohen","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris-Est Cr\u00e9teil, Inserm U955, Institut Mondor et AP-HP, H\u00f4pital Henri Mondor, Centre d\u2019investigation clinique en bioth\u00e9rapie","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"250","published-online":{"date-parts":[[2026,7,17]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","unstructured":"Glick B, Chang T, Jaap G. 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