{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T08:07:53Z","timestamp":1784275673245,"version":"3.55.0"},"reference-count":44,"publisher":"EDP Sciences","issue":"6-7","license":[{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"vor","delay-in-days":46,"URL":"https:\/\/www.edpsciences.org\/en\/authors\/copyright-and-licensing"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Sci (Paris)"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:p>Le diab\u00e8te de type 1 est une maladie chronique due \u00e0 la destruction auto-immune des cellules b\u00eata du pancr\u00e9as qui produisent de l\u2019insuline. La transplantation de ces cellules, selon le protocole d\u2019Edmonton, offre de nouvelles perspectives pour restaurer une production physiologique d\u2019insuline et r\u00e9duire les risques de comorbidit\u00e9s. Les progr\u00e8s dans la diff\u00e9renciation et la transplantation de cellules souches sont prometteurs pour surmonter les d\u00e9fis li\u00e9s au protocole d\u2019Edmonton et am\u00e9liorer la probabilit\u00e9 de r\u00e9mission. Dans cette revue, nous analysons les donn\u00e9es cliniques afin de pr\u00e9senter les avantages et les d\u00e9fis de ce protocole, vingtcinq ans apr\u00e8s sa mise en place.<\/jats:p>","DOI":"10.1051\/medsci\/2026111","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T07:58:36Z","timestamp":1784275116000},"page":"630-636","source":"Crossref","is-referenced-by-count":0,"title":["Le protocole de transplantation d\u2019Edmonton, 25 ans plus tard : vers la r\u00e9mission du diab\u00e8te de type 1 ?"],"prefix":"10.1051","volume":"42","author":[{"given":"Meriem","family":"Fassy El Fehri","sequence":"first","affiliation":[{"name":"Facult\u00e9 Saint-Jean, Universit\u00e9 de l\u2019Alberta","place":["Canada"]},{"name":"Alberta Diabetes Institute, Universit\u00e9 de l\u2019Alberta","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7636-0959","authenticated-orcid":false,"given":"Mourad","family":"Ferdaoussi","sequence":"additional","affiliation":[{"name":"Facult\u00e9 Saint-Jean, Universit\u00e9 de l\u2019Alberta","place":["Canada"]},{"name":"Alberta Diabetes Institute, Universit\u00e9 de l\u2019Alberta","place":["Canada"]},{"name":"Women and Children\u2019s Health Research Institute, Universit\u00e9 de l\u2019Alberta","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"250","published-online":{"date-parts":[[2026,7,17]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"533","DOI":"10.3390\/biomedicines12030533","volume":"12","author":"Lambert","year":"2024","journal-title":"Biomedicines"},{"key":"R2","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.jcjd.2022.06.003","volume":"46","author":"Morrison","year":"2022","journal-title":"Can J Diabetes"},{"key":"R3","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1007\/s00125-005-0082-6","volume":"49","author":"Skrivarhaug","year":"2006","journal-title":"Diabetologia"},{"key":"R4","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1056\/NEJM200007273430401","volume":"343","author":"Shapiro","year":"2000","journal-title":"N Engl J Med"},{"key":"R5","first-page":"175","volume":"72","author":"Ballinger","year":"1972","journal-title":"Surgery"},{"key":"R6","doi-asserted-by":"crossref","unstructured":"Bretzel RG, Hering BJ, Schultz AO, et al. 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