{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T05:24:28Z","timestamp":1741238668286,"version":"3.38.0"},"reference-count":33,"publisher":"JLE","issue":"1","license":[{"start":{"date-parts":[[2019,4,17]],"date-time":"2019-04-17T00:00:00Z","timestamp":1555459200000},"content-version":"vor","delay-in-days":47,"URL":"https:\/\/www.edpsciences.org\/en\/authors\/copyright-and-licensing"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orthod Fr"],"accepted":{"date-parts":[[2019,2,10]]},"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:p><jats:bold>Introduction :<\/jats:bold> Des observations r\u00e9centes effectu\u00e9es dans le service d\u2019ODF de la Piti\u00e9-Salp\u00eatri\u00e8re \u00e0 Paris montrent une augmentation des alt\u00e9rations de l\u2019\u00e9ruption des molaires permanentes non-familiales. Nos travaux r\u00e9cents au laboratoire montrent l\u2019implication des ost\u00e9oclastes (OC) dans les processus d\u2019\u00e9ruption et de r\u00e9tention dentaires avec implication de la voie de signalisation RANKL\/RANK\/OPG. Ces faits nous ont amen\u00e9s \u00e0 \u00e9mettre l\u2019hypoth\u00e8se d\u2019une \u00e9tiologie environnementale \u00e0 l\u2019origine de ces d\u00e9fauts d\u2019\u00e9ruption qui correspondrait \u00e0 la perturbation des voies de signalisation cellulaires autocrines\/paracrines telles que la voie RANKL\/RANK\/OPG. <jats:bold>Mat\u00e9riels et m\u00e9thodes :<\/jats:bold> Des souris C57BL\/6 ont subi des injections d\u2019anticorps anti- RANKL \u00e0 intervalles r\u00e9guliers au cours des neuf premiers jours apr\u00e8s la naissance. Une comparaison ph\u00e9notypique avec les souris transg\u00e9niques RANK a permis la caract\u00e9risation fonctionnelle de la voie RANK\/RANKL. Le complexe dento-alv\u00e9olaire a \u00e9t\u00e9 analys\u00e9 par micro-CT pour la densit\u00e9 osseuse, et la coloration au trichrome de Masson pour les examens histologiques. <jats:bold>R\u00e9sultats :<\/jats:bold> L\u2019invalidation transitoire de RANKL a conduit \u00e0 un arr\u00eat du d\u00e9veloppement radiculaire des molaires et l\u2019inhibition de l\u2019\u00e9ruption dentaire contrairement au ph\u00e9notype des souris surexprimant RANK. Le recrutement et l\u2019activit\u00e9 des ost\u00e9oclastes ont \u00e9t\u00e9 fortement alt\u00e9r\u00e9s. <jats:bold>Discussion :<\/jats:bold> Ces recherches pr\u00e9sentent un int\u00e9r\u00eat clinique tant direct concernant la compr\u00e9hension des pathologies de l\u2019\u00e9ruption qu\u2019indirect pour l\u2019\u00e9tablissement des protocoles de traitements orthodontiques pour les cas particuliers.<\/jats:p>","DOI":"10.1051\/orthodfr\/2019008","type":"journal-article","created":{"date-parts":[[2019,4,17]],"date-time":"2019-04-17T08:24:29Z","timestamp":1555489469000},"page":"55-63","source":"Crossref","is-referenced-by-count":2,"title":["Effets de l\u2019inhibition post-natale de RANKL sur l\u2019\u00e9ruption et la formation radiculaire des molaires de souris 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