{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T19:58:51Z","timestamp":1777579131952,"version":"3.51.4"},"reference-count":36,"publisher":"EDP Sciences","license":[{"start":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T00:00:00Z","timestamp":1543968000000},"content-version":"vor","delay-in-days":338,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite"],"accepted":{"date-parts":[[2018,11,19]]},"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>The efficacy of NexGard<jats:sup>\u00ae<\/jats:sup> and NexGard Spectra<jats:sup>\u00ae<\/jats:sup> against sarcoptic mange in dogs was evaluated in a clinical field study. Skin scrapings from dogs presenting signs suggestive of sarcoptic mange were examined to confirm infestation. A total of 106 dogs were screened at eight sites in Portugal and Germany. In all, 80 dogs that had demonstrated \u22655 live <jats:italic>Sarcoptes<\/jats:italic> mites in five skin scrapings were enrolled, scored for specific clinical signs (pruritus; papules and crusts; alopecia), and allocated at random to receive either NexGard<jats:sup>\u00ae<\/jats:sup> or NexGard Spectra<jats:sup>\u00ae<\/jats:sup> twice, one month apart per label instructions. To determine efficacy, live <jats:italic>Sarcoptes<\/jats:italic> mites in five skin scrapings per dog were counted, and clinical signs were scored one month and two months after first treatment and compared to pre-treatment (baseline) values. Based on compliance, 65 dogs were determined to be evaluable cases at the end of the study. The efficacy, in terms of reduction of geometric mean live <jats:italic>Sarcoptes<\/jats:italic> mite counts, was 98.9% and 99.7% for NexGard<jats:sup>\u00ae<\/jats:sup>-treated (<jats:italic>n<\/jats:italic>\u00a0=\u00a038) and 99.6% and 100% for NexGard Spectra<jats:sup>\u00ae<\/jats:sup>-treated dogs (<jats:italic>n<\/jats:italic>\u00a0=\u00a027) at one month and two months after treatment initiation (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001, both treatments). Both treatments resulted in a significant improvement in pruritus, papules and crusts, and alopecia one month and two months after treatment initiation (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.0001, both treatments). In conclusion, this field study confirms that both NexGard<jats:sup>\u00ae<\/jats:sup> and NexGard Spectra<jats:sup>\u00ae<\/jats:sup> administered twice one month apart provide an effective and safe treatment against sarcoptic mange in dogs.<\/jats:p>","DOI":"10.1051\/parasite\/2018064","type":"journal-article","created":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T09:45:42Z","timestamp":1544003142000},"page":"63","source":"Crossref","is-referenced-by-count":26,"title":["Treatment of canine sarcoptic mange with afoxolaner (NexGard<sup>\u00ae<\/sup>) and afoxolaner plus milbemycin oxime (NexGard Spectra<sup>\u00ae<\/sup>) chewable tablets: efficacy under field conditions in Portugal and Germany"],"prefix":"10.1051","volume":"25","author":[{"given":"Verena","family":"Hampel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Knaus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Sch\u00e4fer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederic","family":"Beugnet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffen","family":"Rehbein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"250","published-online":{"date-parts":[[2018,12,5]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.meegid.2013.04.018","volume":"17","author":"Alasaad","year":"2015","journal-title":"Infection, Genetics and Evolution"},{"key":"R2","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1146\/annurev.en.34.010189.001035","volume":"34","author":"Arlian","year":"1989","journal-title":"Annual Reviews of Entomology"},{"key":"R3","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1186\/s13071-017-2234-1","volume":"10","author":"Arlian","year":"2017","journal-title":"Parasites & Vectors"},{"key":"R4","unstructured":"Baker AS. 1999. 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