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In this study, we evaluated the histological and immunological differences between two forms of CL described in Tunisia: zoonotic cutaneous leishmaniasis (ZCL) caused by<jats:italic>L. major<\/jats:italic>and sporadic cutaneous leishmaniasis (SCL) caused by<jats:italic>L. infantum<\/jats:italic>. Histological analysis showed a mild to moderate infiltrate within ZCL lesions. In contrast, massive infiltration of the dermis was observed within SCL lesions. Contrary to ZCL, infiltrates within SCL lesions were organized and showed granuloma composed of macrophages and lymphocytes. In addition, immunohistochemical analysis showed a predominance of CD4<jats:sup>+<\/jats:sup>T cells within both CL forms. Furthermore, expression of interferon-\u03b3, interleukin (IL)-10, IL-8, IL-13 and monocyte chemotactic protein (MCP)-1 was evaluated using real-time quantitative polymerase chain reaction (RT-qPCR). MCP-1 and IL-10 were expressed at comparable levels in ZCL and SCL lesions. Interestingly, IL-8 mRNA levels were significantly higher in ZCL lesions compared to SCL lesions, but interferon-\u03b3 was significantly higher in SCL lesions than in ZCL lesions.<\/jats:p>","DOI":"10.1051\/parasite\/2019007","type":"journal-article","created":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T09:29:18Z","timestamp":1551259758000},"page":"9","source":"Crossref","is-referenced-by-count":19,"title":["Histological and immunological differences between zoonotic cutaneous leishmaniasis due to<i>Leishmania major<\/i>and sporadic cutaneous leishmaniasis due to<i>Leishmania infantum<\/i>"],"prefix":"10.1051","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9827-6440","authenticated-orcid":false,"given":"Thouraya","family":"Boussoffara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed 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