{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T11:09:22Z","timestamp":1784632162383,"version":"3.55.0"},"reference-count":48,"publisher":"EDP Sciences","license":[{"start":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T00:00:00Z","timestamp":1595289600000},"content-version":"vor","delay-in-days":202,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite"],"accepted":{"date-parts":[[2020,7,3]]},"published-print":{"date-parts":[[2020]]},"abstract":"<jats:p>Excretory\/Secretory Products (ESPs) of the nematode <jats:italic>Trichinella spiralis<\/jats:italic> contain antitumor-active substances that inhibit tumor growth. Mature dendritic cells (DCs) play a critical role in the antitumor immunity of the organism. As pathogen-derived products, it ought to be discussed whether <jats:italic>T. spiralis<\/jats:italic> ESPs will reduce the antitumor effect of mature DCs from the host before it is applied to patients\u2019 tumors. Therefore, the aim of this work was to evaluate the immunological effect of DCs stimulated by <jats:italic>T. spiralis<\/jats:italic> ESPs in H22 tumor-bearing mice. H22 tumor model mice in this study were randomly divided into four groups according to the treatment: PBS control group, ESP group, DCs group, and DCs stimulated with <jats:italic>T. spiralis<\/jats:italic> ESP (ESP+DCs group). The antitumor effect was evaluated by tumor inhibition rate and cytokine detection using ELISA. The results showed significant inhibition in tumor growth in the ESP+DCs, DCs and ESP groups when compared with the PBS control group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01, and <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05, respectively). However, no significant difference was observed on tumor inhibition rates between the ESP+DCs and DCs groups. The decrease in IL-4, IL-6, and IL-10, and the increase in IFN-\u03b3 between the DCs and ESP+DCs groups were also not significant. Therefore, DCs stimulated by ESP did not reduce the antitumor effect of mature DCs, which demonstrated that the <jats:italic>T. spiralis<\/jats:italic> ESP would not affect the antitumor effect of mature DCs by modulating the immune response of the host, and that ESPs are safe in antitumor immunology when applied in a tumor model mice.<\/jats:p>","DOI":"10.1051\/parasite\/2020045","type":"journal-article","created":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T11:14:31Z","timestamp":1595330071000},"page":"47","source":"Crossref","is-referenced-by-count":4,"title":["Murine hepatoma treatment with mature dendritic cells stimulated by <i>Trichinella spiralis<\/i> excretory\/secretory products"],"prefix":"10.1051","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9892-1657","authenticated-orcid":false,"given":"Jing","family":"Ding","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shicun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7303-8534","authenticated-orcid":false,"given":"Xuelin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"250","published-online":{"date-parts":[[2020,7,21]]},"reference":[{"issue":"4","key":"R1","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/j.1365-3024.2012.01353.x","volume":"34","author":"Aranzamendi","year":"2012","journal-title":"Parasite Immunology"},{"issue":"1","key":"R2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1079\/JOH2003203","volume":"78","author":"Boonmars","year":"2004","journal-title":"Journal of Helminthology"},{"issue":"11","key":"R3","doi-asserted-by":"crossref","first-page":"4282","DOI":"10.1093\/cercor\/bhw216","volume":"26","author":"Bosch","year":"2016","journal-title":"Cerebral Cortex"},{"issue":"4","key":"R4","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1007\/s12026-017-8931-1","volume":"65","author":"Constantino","year":"2017","journal-title":"Journal of Immunology Research"},{"issue":"13\u201314","key":"R5","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.ijpara.2016.07.008","volume":"46","author":"Cvetkovic","year":"2016","journal-title":"International Journal for Parasitology"},{"issue":"3","key":"R6","doi-asserted-by":"crossref","first-page":"e12412","DOI":"10.1111\/pim.12412","volume":"39","author":"Della Bella","year":"2017","journal-title":"Parasite Immunology"},{"issue":"1","key":"R7","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.tracli.2017.08.002","volume":"25","author":"Deluce-Kakwata-Nkor","year":"2018","journal-title":"Transfusion Clinique et Biologique"},{"key":"R8","doi-asserted-by":"crossref","first-page":"438","DOI":"10.3389\/fimmu.2013.00438","volume":"4","author":"Dudek","year":"2013","journal-title":"Frontiers in Immunology"},{"issue":"1","key":"R9","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s10637-018-0609-6","volume":"37","author":"Eissa","year":"2019","journal-title":"Investigational New Drugs"},{"key":"R10","doi-asserted-by":"crossref","first-page":"5230219","DOI":"10.1155\/2016\/5230219","volume":"2016","author":"Eyileten","year":"2016","journal-title":"Mediators of Inflammation"},{"issue":"12","key":"R11","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.it.2016.09.006","volume":"37","author":"Gardner","year":"2016","journal-title":"Trends in Immunology"},{"issue":"9","key":"R12","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1111\/j.1365-3024.2008.01049.x","volume":"30","author":"Ilic","year":"2008","journal-title":"Parasite Immunology"},{"issue":"10","key":"R13","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1111\/j.1365-3024.2011.01322.x","volume":"33","author":"Ilic","year":"2011","journal-title":"Parasite Immunology"},{"issue":"4","key":"R14","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1083\/jcb.121.4.785","volume":"121","author":"Jasmer","year":"1993","journal-title":"Journal of Cell Biology"},{"issue":"1","key":"R15","doi-asserted-by":"crossref","first-page":"6547","DOI":"10.1038\/s41598-019-43057-1","volume":"9","author":"Kang","year":"2019","journal-title":"Scientific Reports"},{"issue":"1\u20132","key":"R16","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.vetpar.2013.02.021","volume":"196","author":"Kang","year":"2013","journal-title":"Veterinary Parasitology"},{"key":"R17","doi-asserted-by":"crossref","first-page":"570","DOI":"10.3389\/fimmu.2017.00570","volume":"8","author":"Keller","year":"2017","journal-title":"Frontiers in Immunology"},{"issue":"1","key":"R18","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s12038-017-9665-x","volume":"42","author":"Kumar","year":"2017","journal-title":"Journal of Biosciences"},{"issue":"12","key":"R19","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.ijpara.2017.08.001","volume":"47","author":"Laurent","year":"2017","journal-title":"International Journal for Parasitology"},{"issue":"1","key":"R20","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1186\/s13071-016-1662-7","volume":"9","author":"Lee","year":"2016","journal-title":"Parasites & Vectors"},{"key":"R21","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s13045-016-0254-5","volume":"9","author":"Li","year":"2016","journal-title":"Journal of Hematology & Oncology"},{"issue":"10","key":"R22","doi-asserted-by":"crossref","first-page":"e0138335","DOI":"10.1371\/journal.pone.0138335","volume":"10","author":"Lin","year":"2015","journal-title":"PLoS One"},{"key":"R23","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.biopha.2017.04.064","volume":"91","author":"Ling","year":"2017","journal-title":"Biomedicine & Pharmacotherapy"},{"issue":"6","key":"R24","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1017\/S0031182016002535","volume":"144","author":"Luo","year":"2017","journal-title":"Parasitology"},{"key":"R25","doi-asserted-by":"crossref","first-page":"327","DOI":"10.3389\/fimmu.2017.00327","volume":"8","author":"Mbongue","year":"2017","journal-title":"Frontiers in Immunology"},{"issue":"1","key":"R26","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s13045-019-0742-5","volume":"12","author":"Mizukoshi","year":"2019","journal-title":"Journal of Hematology & Oncology"},{"issue":"1\u20136","key":"R27","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1159\/000231956","volume":"55","author":"Molinari","year":"1977","journal-title":"International Archives of Allergy and Immunology"},{"issue":"4","key":"R28","doi-asserted-by":"crossref","first-page":"14448","DOI":"10.4238\/2015.November.18.7","volume":"14","author":"Niu","year":"2015","journal-title":"Genetics and Molecular Research"},{"key":"R29","doi-asserted-by":"crossref","first-page":"356","DOI":"10.3389\/fphar.2016.00356","volume":"7","author":"Nocera","year":"2016","journal-title":"Frontiers in Pharmacology"},{"key":"R30","doi-asserted-by":"crossref","first-page":"5740373","DOI":"10.1155\/2016\/5740373","volume":"2016","author":"Oth","year":"2016","journal-title":"Mediators of Inflammation"},{"issue":"2","key":"R31","doi-asserted-by":"crossref","first-page":"87","DOI":"10.4103\/0976-500X.72350","volume":"1","author":"Parasuraman","year":"2010","journal-title":"Journal of Pharmacology & Pharmacotherapeutics"},{"key":"R32","doi-asserted-by":"crossref","first-page":"743169","DOI":"10.1155\/2015\/743169","volume":"2015","author":"Said","year":"2015","journal-title":"Journal of Immunology Research"},{"key":"R33","doi-asserted-by":"crossref","first-page":"455","DOI":"10.3389\/fimmu.2018.00455","volume":"9","author":"Sch\u00fclke","year":"2018","journal-title":"Frontiers in Immunology"},{"key":"R34","doi-asserted-by":"crossref","first-page":"523875","DOI":"10.1155\/2015\/523875","volume":"2015","author":"Sofronic-Milosavljevic","year":"2015","journal-title":"Journal of Immunology Research"},{"key":"R35","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1051\/parasite\/2019074","volume":"26","author":"Song","year":"2019","journal-title":"Parasite"},{"issue":"3","key":"R36","first-page":"197","volume":"3","author":"Sun","year":"2006","journal-title":"Cellular & Molecular Immunology"},{"issue":"6","key":"R37","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1042\/BST20180136","volume":"46","author":"Taher","year":"2018","journal-title":"Biochemical Society Transactions"},{"issue":"5","key":"R38","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1007\/s00018-016-2317-8","volume":"74","author":"Tang","year":"2017","journal-title":"Cellular and Molecular Life Sciences"},{"issue":"3","key":"R39","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.3892\/ol.2017.5568","volume":"13","author":"Tomizawa","year":"2017","journal-title":"Oncology Letters"},{"issue":"1","key":"R40","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1186\/s40425-018-0446-3","volume":"6","author":"Truxova","year":"2018","journal-title":"Journal for ImmunoTherapy of Cancer"},{"key":"R41","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.cytogfr.2016.04.002","volume":"32","author":"Ul-Haq","year":"2016","journal-title":"Cytokine & Growth Factor Reviews"},{"issue":"5","key":"R42","doi-asserted-by":"crossref","first-page":"579","DOI":"10.3390\/jcm8050579","volume":"8","author":"Van Acker","year":"2019","journal-title":"Journal of Clinical Medicine"},{"issue":"1","key":"R43","doi-asserted-by":"crossref","first-page":"42","DOI":"10.5114\/ceji.2015.50832","volume":"40","author":"Vasilev","year":"2015","journal-title":"Central-European Journal of Immunology"},{"issue":"3\u20134","key":"R44","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.vetpar.2008.10.052","volume":"159","author":"Wang","year":"2009","journal-title":"Veterinary Parasitology"},{"issue":"2\u20134","key":"R45","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.vetpar.2013.01.052","volume":"194","author":"Wang","year":"2013","journal-title":"Veterinary Parasitology"},{"issue":"4","key":"R46","doi-asserted-by":"crossref","first-page":"521","DOI":"10.3390\/cancers11040521","volume":"11","author":"Wylie","year":"2019","journal-title":"Cancers (Basel)"},{"issue":"Pt 6","key":"R47","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1242\/jcs.02821","volume":"119","author":"Zhang","year":"2006","journal-title":"Journal of Cell Science"},{"key":"R48","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.vetpar.2016.02.003","volume":"219","author":"Zhang","year":"2016","journal-title":"Veterinary Parasitology"}],"container-title":["Parasite"],"original-title":[],"link":[{"URL":"https:\/\/www.parasite-journal.org\/10.1051\/parasite\/2020045\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T11:15:09Z","timestamp":1595330109000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.parasite-journal.org\/10.1051\/parasite\/2020045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":48,"alternative-id":["parasite200003"],"URL":"https:\/\/doi.org\/10.1051\/parasite\/2020045","relation":{},"ISSN":["1776-1042"],"issn-type":[{"value":"1776-1042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]}}}