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The two studies were performed in the United States with the same <jats:italic>E. multilocularis<\/jats:italic> isolate sourced locally. In each study, 20 cats were inoculated intra-gastrically with ~30,000 <jats:italic>E. multilocularis<\/jats:italic> protoscoleces three weeks before treatment, then ten cats were randomly allocated to a placebo control group or to the novel formulation treated group. Inoculated cats were treated topically once at the minimum recommended dose of the novel formulation, or with an identical volume of placebo. One week after treatment, cats were humanely euthanized for parasite recovery and count. The efficacy calculation was based on comparison of number of scoleces found in the control group and the novel formulation group. In the two control groups, <jats:italic>E. multilocularis<\/jats:italic> scoleces were found in five (range: 30\u20131025) and eight (range 2\u2013345) cats, the geometric means inclusive of the ten cats per group were 8.9 and 28.8, respectively. In the two novel formulation-treated groups, none of the cats harbored any <jats:italic>E. multilocularis<\/jats:italic> scoleces, demonstrating 100% efficacy.<\/jats:p>","DOI":"10.1051\/parasite\/2021025","type":"journal-article","created":{"date-parts":[[2021,4,2]],"date-time":"2021-04-02T09:59:28Z","timestamp":1617357568000},"page":"29","source":"Crossref","is-referenced-by-count":6,"title":["Efficacy of a novel topical combination of esafoxolaner, eprinomectin and praziquantel against <i>Echinococcus multilocularis<\/i> infections in cats"],"prefix":"10.1051","volume":"28","author":[{"given":"Joe","family":"Prullage","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dwight","family":"Bowman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Ulrich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4798-3246","authenticated-orcid":false,"given":"Eric","family":"Tielemans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"250","published-online":{"date-parts":[[2021,4,2]]},"reference":[{"key":"R1","first-page":"1978","volume":"42","author":"Andersen","year":"1981","journal-title":"American Journal of Veterinary Research"},{"key":"R2","doi-asserted-by":"crossref","first-page":"002","DOI":"10.14411\/fp.2018.002","volume":"65","author":"Bastien","year":"2018","journal-title":"Folia Parasitologica"},{"key":"R3","unstructured":"Beugnet F, Halos L, Guillot J. 2018. 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