{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T23:12:21Z","timestamp":1793661141652,"version":"4.5.1"},"reference-count":44,"publisher":"EDP Sciences","license":[{"start":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T00:00:00Z","timestamp":1652227200000},"content-version":"vor","delay-in-days":130,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"EDCTP2 Programme supported by the European Union","award":["Project DRIA-2014-306-DiTECT-HAT"],"award-info":[{"award-number":["Project DRIA-2014-306-DiTECT-HAT"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite"],"accepted":{"date-parts":[[2022,4,19]]},"published-print":{"date-parts":[[2022]]},"abstract":"<jats:p>The World Health Organisation has targeted the elimination of human African trypanosomiasis (HAT) as zero transmission by 2030. Continued surveillance needs to be in place for early detection of re-emergent cases. In this context, the performance of diagnostic tests and testing algorithms for detection of the re-emergence of <jats:italic>Trypanosoma brucei gambiense<\/jats:italic> HAT remains to be assessed. We carried out a door-to-door active medical survey for HAT in the historical focus of Bati\u00e9, South\u2013West Burkina Faso. Screening was done using three rapid diagnostic tests (RDTs). Two laboratory tests (ELISA\/<jats:italic>T. b. gambiense<\/jats:italic> and immune trypanolysis) and parasitological examination were performed on RDT positives only. In total, 5883 participants were screened, among which 842 (14%) tested positive in at least one RDT. Blood from 519 RDT positives was examined microscopically but no trypanosomes were observed. The HAT Sero-<jats:italic>K<\/jats:italic>-Set test showed the lowest specificity of 89%, while the specificities of SD Bioline HAT and rHAT Sero-Strip were 92% and 99%, respectively. The specificity of ELISA\/<jats:italic>T. b. gambiense<\/jats:italic> and trypanolysis was 99% (98\u201399%) and 100% (99\u2013100%), respectively. Our results suggest that <jats:italic>T. b. gambiense<\/jats:italic> is no longer circulating in the study area and that zero transmission has probably been attained. While a least cost analysis is still required, our study showed that RDT preselection followed by trypanolysis may be a useful strategy for post-elimination surveillance in Burkina Faso.<\/jats:p>","DOI":"10.1051\/parasite\/2022024","type":"journal-article","created":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T07:53:57Z","timestamp":1652255637000},"page":"25","source":"Crossref","is-referenced-by-count":19,"title":["Monitoring the elimination of <i>gambiense<\/i> human African trypanosomiasis in the historical focus of Bati\u00e9, South\u2013West Burkina Faso"],"prefix":"10.1051","volume":"29","author":[{"given":"Charlie Franck 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