{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:04:36Z","timestamp":1790633076013,"version":"4.1.0"},"reference-count":38,"publisher":"EDP Sciences","license":[{"start":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T00:00:00Z","timestamp":1697673600000},"content-version":"vor","delay-in-days":291,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"ANR","award":["17-CE35-0004"],"award-info":[{"award-number":["17-CE35-0004"]}]},{"name":"Bio-M\u00e9rieux"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite"],"accepted":{"date-parts":[[2023,8,21]]},"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>Assessing the prevalence of toxoplasmosis in pregnant women and the associated risk factors is the first step in defining policy for the prevention of congenital toxoplasmosis in a given population. An epidemiological study was conducted during prenatal consultations at the CHU-MEL of Cotonou (Benin) between September 2018 and April 2021 and recruited 549 pregnant women to determine the seroprevalence and potential factors associated with <jats:italic>Toxoplasma gondii<\/jats:italic> infection. <jats:italic>Toxoplasma gondii<\/jats:italic> IgG\/IgM antibodies were detected using an enzyme-linked fluorescence assay (ELFA) technique, an IgG avidity test and an IgG\/IgM comparative Western blot to diagnose the maternal toxoplasmosis serological status, the possibility of an infection acquired during pregnancy and congenital infection, respectively. Concomitantly, the participants answered a questionnaire investigating potential risk factors. Toxoplasmosis seroprevalence was estimated at 44.4% (95% CI 40.3\u201348.6) and the factors significantly associated with <jats:italic>T. gondii<\/jats:italic> seropositivity were: age over 30\u00a0years, multigravid women and contact with cats. The possibility of an infection acquired during the periconceptional period or the first trimester of pregnancy concerned six women [1.1% (95% CI 0.5\u20132.0)]. However, due to the low rate of serological controls in seronegative women, a significant proportion of women first tested during the 3rd trimester of pregnancy, and an insufficient sample size, the incidence of primary infection during pregnancy could not be determined. No cases of congenital transmission occurred in the newborns from the suspected cases of primary infection.<\/jats:p>","DOI":"10.1051\/parasite\/2023040","type":"journal-article","created":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T08:24:20Z","timestamp":1697703860000},"page":"43","source":"Crossref","is-referenced-by-count":7,"title":["Seroepidemiology of toxoplasmosis in pregnant women and detection of infection acquired during pregnancy in Cotonou, Benin"],"prefix":"10.1051","volume":"30","author":[{"given":"Richard","family":"Amagb\u00e9gnon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8439-9976","authenticated-orcid":false,"given":"Celia","family":"Dechavanne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magalie","family":"Dambrun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urielle","family":"Yehou\u00e9nou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"No\u00e9","family":"Akond\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9982-594X","authenticated-orcid":false,"given":"Florence","family":"Migot-Nabias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aretas Babatound\u00e9","family":"Nounnagnon Tonouh\u00e9wa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azra","family":"Hamidovi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Fievet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang\u00e9line","family":"Tonato-Bagnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurore","family":"Ogouyemi-Hounto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maroufou Jules","family":"Alao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Laure","family":"Dard\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4332-5879","authenticated-orcid":false,"given":"Aur\u00e9lien","family":"Mercier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doroth\u00e9e","family":"Kind\u00e9-Gazard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"250","published-online":{"date-parts":[[2023,10,19]]},"reference":[{"key":"R1","first-page":"21","volume":"18","author":"Atchouta","year":"2016","journal-title":"Journal de la Recherche Scientifique de l\u2019Universit\u00e9 de Lom\u00e9"},{"key":"R2","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.3923\/pjbs.2014.1074.1078","volume":"17","author":"Bamba","year":"2014","journal-title":"Pakistan Journal of Biological Sciences"},{"key":"R3","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1186\/s12879-017-2583-6","volume":"17","author":"Bamba","year":"2017","journal-title":"BMC Infectious Diseases"},{"key":"R4","first-page":"43","volume":"12","author":"Bamba","year":"2012","journal-title":"Pan African Medical Journal"},{"issue":"4","key":"R5","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.respe.2009.03.006","volume":"57","author":"Berger","year":"2009","journal-title":"Revue d\u2019\u00c9pid\u00e9miologie et de Sant\u00e9 Publique"},{"issue":"9","key":"R6","doi-asserted-by":"crossref","first-page":"e0221709","DOI":"10.1371\/journal.pone.0221709","volume":"14","author":"Binquet","year":"2019","journal-title":"PLoS One"},{"key":"R7","unstructured":"Dakpahossou T, Mousse B. 2008. D\u00e9terminants de l\u2019irr\u00e9gularit\u00e9 aux soins pr\u00e9natals en milieu rural au B\u00e9nin. \u00c9cole Nationale d\u2019\u00c9conomie Appliqu\u00e9e et de Management & Institut National de la Statistique et de l\u2019Analyse \u00c9conomique. M\u00e9moire Online, 66. https:\/\/www.memoireonline.com\/11\/13\/7827\/Determinants-de-l-irregularite-aux-soins-prenatals-en-milieu-rural-au-Benin.html."},{"issue":"1","key":"R8","doi-asserted-by":"crossref","first-page":"e0262018","DOI":"10.1371\/journal.pone.0262018","volume":"17","author":"Dambrun","year":"2022","journal-title":"PLoS One"},{"issue":"6","key":"R9","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1111\/tmi.12296","volume":"19","author":"De Paschale","year":"2014","journal-title":"Tropical Medicine & International Health"},{"issue":"1","key":"R10","doi-asserted-by":"crossref","first-page":"479","DOI":"10.4314\/ijbcs.v12i1.37","volume":"12","author":"Degbe","year":"2018","journal-title":"International Journal of Biological and Chemical Sciences"},{"key":"R11","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0168-6445(03)00071-8","volume":"27","author":"Dum\u00e8tre","year":"2003","journal-title":"FEMS Microbiology Reviews"},{"key":"R12","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s41426-018-0164-4","volume":"7","author":"El Bissati","year":"2018","journal-title":"Emerging Microbes & Infections"},{"issue":"9","key":"R13","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/j.cmi.2020.04.014","volume":"26","author":"Garnaud","year":"2020","journal-title":"Clinical Microbiology and Infection"},{"key":"R14","unstructured":"Giezendanner FD. 2012. Taille d\u2019un \u00e9chantillon al\u00e9atoire et Marge d\u2019erreur. Gen\u00e8ve: Instruction publique, culture et sport Service \u00c9coles-M\u00e9dias. p. 22."},{"issue":"2","key":"R15","doi-asserted-by":"crossref","first-page":"e0008980","DOI":"10.1371\/journal.pntd.0008980","volume":"15","author":"Hamidovi\u0107","year":"2021","journal-title":"PLoS Neglected Tropical Diseases"},{"key":"R16","unstructured":"Haute Autorit\u00e9 de Sant\u00e9. 2009. Surveillance s\u00e9rologique et pr\u00e9vention de la toxoplasmose et de la rub\u00e9ole au cours de la grossesse. Available at https:\/\/www.has-sante.fr\/upload\/docs\/application\/pdf\/2009-12\/depistages_prenatals_obligatoires_synthese_vf.pdf."},{"key":"R17","unstructured":"Institut National de la Statistique et de l\u2019Analyse \u00c9conomique (INSAE) et ICF. 2019. Enqu\u00eate D\u00e9mographique et de Sant\u00e9 au B\u00e9nin, 2017\u20132018. Cotonou, B\u00e9nin et Rockville, Maryland, USA: INSAE et ICF."},{"key":"R18","unstructured":"Institut National de la Statistique et de l\u2019Analyse \u00c9conomique (INSAE). 2016. Cahier des villages et quartiers de ville du d\u00e9partement du Littoral (RGPH-4, 2013). B\u00e9nin: INSAE."},{"issue":"5","key":"R19","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.jfo.2010.03.002","volume":"33","author":"Kodjikian","year":"2010","journal-title":"Journal Fran\u00e7ais d\u2019Ophtalmologie"},{"key":"R20","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1093\/cid\/ciw356","volume":"63","author":"Lykins","year":"2016","journal-title":"Clinical Infectious Diseases"},{"key":"R21","first-page":"6","volume":"19","author":"Nguefack","year":"2018","journal-title":"Journal de la SAGO (Gyn\u00e9cologie \u2013 Obst\u00e9trique et Sant\u00e9 de la Reproduction)"},{"key":"R22","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s13149-014-0355-8","volume":"107","author":"Ogouy\u00e8mi-Hounto","year":"2014","journal-title":"Bulletin de la Soci\u00e9t\u00e9 de Pathologie Exotique"},{"issue":"1","key":"R23","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1080\/20477724.2021.1949193","volume":"116","author":"Olarinde","year":"2022","journal-title":"Nigeria. Pathogens and Global Health"},{"key":"R24","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3390\/pathogens8010024","volume":"8","author":"Peyron","year":"2019","journal-title":"Pathogens"},{"issue":"1\u20132","key":"R25","first-page":"57","volume":"67","author":"Pfister","year":"2001","journal-title":"Archives de l\u2019Institut Pasteur de Madagascar"},{"key":"R26","doi-asserted-by":"crossref","first-page":"e0005648","DOI":"10.1371\/journal.pntd.0005648","volume":"11","author":"Prusa","year":"2017","journal-title":"PLoS Neglected Tropical Diseases"},{"key":"R27","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1128\/CMR.05013-11","volume":"25","author":"Robert-Gangneux","year":"2012","journal-title":"Clinical Microbiology Reviews"},{"key":"R28","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0001-706X(95)00087-U","volume":"59","author":"Rodier","year":"1995","journal-title":"Acta Tropica"},{"key":"R29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1678-9199-21-1","volume":"21","author":"Rodrigues","year":"2015","journal-title":"Journal of Venomous Animals and Toxins Including Tropical Diseases"},{"key":"R30","doi-asserted-by":"crossref","first-page":"e0007807","DOI":"10.1371\/journal.pntd.0007807","volume":"13","author":"Rostami","year":"2019","journal-title":"PLoS Neglected Tropical Diseases"},{"key":"R31","first-page":"112","volume":"29","author":"Savi","year":"2018","journal-title":"Pan African Medical Journal"},{"key":"R32","doi-asserted-by":"crossref","first-page":"e2979","DOI":"10.1097\/MD.0000000000002979","volume":"95","author":"Stajner","year":"2016","journal-title":"Medicine"},{"key":"R33","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3166\/bspe-2019-0078","volume":"112","author":"Tonouhewa","year":"2019","journal-title":"Bulletin de la Soci\u00e9t\u00e9 de Pathologie Exotique"},{"key":"R34","doi-asserted-by":"crossref","first-page":"194","DOI":"10.14202\/vetworld.2017.194-208","volume":"10","author":"Tonouhewa","year":"2017","journal-title":"Veterinary World"},{"key":"R35","doi-asserted-by":"crossref","first-page":"501","DOI":"10.2471\/BLT.12.111732","volume":"91","author":"Torgerson","year":"2013","journal-title":"Bulletin of the World Health Organization"},{"key":"R36","doi-asserted-by":"crossref","first-page":"2325958219867315","DOI":"10.1177\/2325958219867315","volume":"18","author":"Vidal","year":"2019","journal-title":"Journal of the International Association of Providers of AIDS Care"},{"key":"R37","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3390\/pathogens7010025","volume":"7","author":"Wallon","year":"2018","journal-title":"Pathogens"},{"key":"R38","doi-asserted-by":"crossref","first-page":"102300","DOI":"10.1016\/j.jogoh.2021.102300","volume":"51","author":"Wehbe","year":"2022","journal-title":"Journal of Gynecology Obstetrics and Human Reproduction"}],"container-title":["Parasite"],"original-title":[],"link":[{"URL":"https:\/\/www.parasite-journal.org\/10.1051\/parasite\/2023040\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T20:01:33Z","timestamp":1699992093000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.parasite-journal.org\/10.1051\/parasite\/2023040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":38,"alternative-id":["parasite220079"],"URL":"https:\/\/doi.org\/10.1051\/parasite\/2023040","relation":{},"ISSN":["1776-1042"],"issn-type":[{"value":"1776-1042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]}}}