{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T03:15:54Z","timestamp":1779333354031,"version":"3.51.4"},"reference-count":30,"publisher":"EDP Sciences","license":[{"start":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T00:00:00Z","timestamp":1741132800000},"content-version":"vor","delay-in-days":63,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Research Initiation Fund of Hainan University","award":["RZ2300002762"],"award-info":[{"award-number":["RZ2300002762"]}]},{"name":"Hainan Provincial Natural\u2002Science Foundation of China","award":["324QN200"],"award-info":[{"award-number":["324QN200"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite"],"accepted":{"date-parts":[[2025,2,13]]},"published-print":{"date-parts":[[2025]]},"abstract":"<jats:p>Toxocariasis is a zoonotic parasitic disease that is widely prevalent in the world. <jats:italic>Toxocara canis<\/jats:italic> adults are parasitic in the small intestinal tract of canids, and the larvae migrate to the liver and lungs before reaching the final destination. Our previous experiments have confirmed that <jats:italic>T. canis<\/jats:italic> infection could affect the composition of host intestinal microbial flora. In this experiment, we further analyze the potential effects of <jats:italic>T. canis<\/jats:italic> infection on host liver and lung microbial flora. Utilizing 16s rRNA high-throughput sequencing, coupled with various bioinformatics analysis techniques, our study revealed that <jats:italic>T. canis<\/jats:italic> infection significantly elevated the abundance of certain opportunistic pathogens in the host\u2019s liver and lungs. This marked elevation contributes to the establishment of infection. Through cluster analysis, we found that the changes in the microbiota of the liver and lungs were independent of the microbial flora carried by <jats:italic>T. canis<\/jats:italic> adults. However, whether the changes are due to the migration of larvae remains to be explored. In short, <jats:italic>T. canis<\/jats:italic> infections have a significant impact on the abundance and diversity of flora in the host tissues, and the changes in microbiota abundance and diversity could further influence tissue homeostasis and immune responses, thus regulating the establishment of infection.<\/jats:p>","DOI":"10.1051\/parasite\/2025011","type":"journal-article","created":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T08:52:50Z","timestamp":1741164770000},"page":"17","source":"Crossref","is-referenced-by-count":1,"title":["Effect of <i>Toxocara canis<\/i> infection on liver and lung microbial flora diversity and composition in 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