{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T23:13:19Z","timestamp":1789427599661,"version":"build-2803163510"},"reference-count":51,"publisher":"EDP Sciences","license":[{"start":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:00:00Z","timestamp":1758758400000},"content-version":"vor","delay-in-days":267,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32160264"],"award-info":[{"award-number":["32160264"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82372283"],"award-info":[{"award-number":["82372283"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NHC Key Laboratory of Echinococcosis Prevention and Control","award":["2024WZK1004"],"award-info":[{"award-number":["2024WZK1004"]}]},{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["20242BAB20266"],"award-info":[{"award-number":["20242BAB20266"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite"],"accepted":{"date-parts":[[2025,9,6]]},"published-print":{"date-parts":[[2025]]},"abstract":"<jats:p><jats:italic>Cryptosporidium<\/jats:italic> spp. are zoonotic protozoan parasites that cause diarrheal disease worldwide. Rodents can harbor diverse <jats:italic>Cryptosporidium<\/jats:italic> spp. and facilitate their transmission to the environment and other hosts, including humans. However, data on <jats:italic>Cryptosporidium<\/jats:italic> infection in wild rodents in the Poyang Lake region, China\u2019s largest freshwater lake, remain scarce. Here, we investigated <jats:italic>Cryptosporidium<\/jats:italic> spp. in 273 wild rodents collected from seven sites adjacent to villages around Poyang Lake between 2022 and 2024. The rodents were identified by cytochrome c oxidase subunit I (COI) gene sequencing as <jats:italic>Apodemus agrarius<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u00a0148) and <jats:italic>Rattus losea<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u00a0125). Nested PCR targeting the small subunit ribosomal RNA (SSU rRNA) gene revealed an overall <jats:italic>Cryptosporidium<\/jats:italic> spp. infection rate of 16.5% (45\/273, 95% CI: 12.3\u201321.9%), with 20.3% (30\/148, 95% CI: 14.2\u201327.8%) in <jats:italic>A. agrarius<\/jats:italic> and 12.0% (15\/125, 95% CI: 6.9\u201319.0%) in <jats:italic>R. losea<\/jats:italic>. Sequence and phylogenetic analyses identified seven <jats:italic>Cryptosporidium<\/jats:italic> species\/genotypes: <jats:italic>C. apodemi<\/jats:italic>, <jats:italic>C. canis<\/jats:italic>, <jats:italic>C. muris<\/jats:italic>, <jats:italic>C. suis<\/jats:italic>, <jats:italic>C. ubiquitum<\/jats:italic>, rat genotype II, and rat genotype III. Notably, the detection of four zoonotic species (<jats:italic>C. canis<\/jats:italic>, <jats:italic>C. muris<\/jats:italic>, <jats:italic>C. suis<\/jats:italic>, and <jats:italic>C. ubiquitum<\/jats:italic>) highlights the potential risk of zoonotic transmission of <jats:italic>Cryptosporidium<\/jats:italic> spp. from wild rodents to humans in this region. These findings underscore the need for systematic surveillance and control of <jats:italic>Cryptosporidium<\/jats:italic> spp. in wild rodent communities around Poyang Lake.<\/jats:p>","DOI":"10.1051\/parasite\/2025056","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T07:48:40Z","timestamp":1758786520000},"page":"63","source":"Crossref","is-referenced-by-count":1,"title":["<i>Cryptosporidium<\/i> spp. in wild rodents in the Poyang Lake region, China"],"prefix":"10.1051","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1344-6115","authenticated-orcid":false,"given":"Qingqiu","family":"Zuo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Weng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxiao","family":"Di","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaocheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuizhao","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxue","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujuan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"250","published-online":{"date-parts":[[2025,9,25]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"e00044","DOI":"10.1128\/CMR.00044-19","volume":"34","author":"Barbieri","year":"2020","journal-title":"Clinical 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Poyang Lake, Yangtze River Basin, China, in The wetland book: distribution, description and conservation, Finlayson MC, Davidson NC, Milton GR, Prentice C, Editors. 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