{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T19:52:40Z","timestamp":1773949960427,"version":"3.50.1"},"reference-count":29,"publisher":"EDP Sciences","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":21,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100020968","name":"Boehringer Ingelheim Animal Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite"],"accepted":{"date-parts":[[2025,1,5]]},"published-print":{"date-parts":[[2026]]},"abstract":"<jats:p>\n                    Canine sarcoptic mange, caused by\n                    <jats:italic>Sarcoptes scabiei<\/jats:italic>\n                    , is a highly contagious and intensely pruritic skin disease in dogs. It is prevalent worldwide and has zoonotic potential. Therefore, effective treatment is important to safeguard animal welfare and public health. The present clinical field study aimed to confirm the efficacy of NexGard\n                    <jats:sup>\u00ae<\/jats:sup>\n                    Plus, an oral combination of afoxolaner, moxidectin and pyrantel pamoate, in treating dogs naturally infested with\n                    <jats:italic>S. scabiei<\/jats:italic>\n                    . It was a blinded, randomised, single-centre, negative-controlled efficacy study. Twenty naturally infested dogs were allocated into two groups: a group treated on Day 0 and Day 26\/28 at the label dose, and an untreated control group. Skin scrapings were conducted similarly, once between Day \u22126 to 0, then on Days 26\/28 and 56 for mite counts. Assessments of clinical signs were conducted at the same time intervals. In the treated group, mite infestations were reduced by 97% after the first treatment and were eliminated (100%) after the second treatment (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.0005), while all dogs in the untreated control group remained infested for the whole study. Treated dogs had no pruritus, papules or crusts and clear evidence of hair regrowth by Day 56, unlike the dogs in the control group. This study demonstrated the elimination of\n                    <jats:italic>S. scabiei<\/jats:italic>\n                    mites and significant improvement of sarcoptic mange clinical signs in naturally infested dogs treated with the oral combination of afoxolaner, moxidectin and pyrantel.\n                  <\/jats:p>","DOI":"10.1051\/parasite\/2026001","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T08:56:38Z","timestamp":1769072198000},"page":"2","source":"Crossref","is-referenced-by-count":1,"title":["Field efficacy assessment of a combination of afoxolaner, moxidectin and pyrantel pamoate to treat dogs naturally infested with\n                    <i>Sarcoptes scabiei<\/i>"],"prefix":"10.1051","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5708-0571","authenticated-orcid":false,"given":"Lo\u00efc","family":"Antoine","sequence":"first","affiliation":[{"name":"Boehringer Ingelheim Animal Health","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elias","family":"Papadopoulos","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitology and Parasitic Diseases, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki","place":["Greece"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgios","family":"Sioutas","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitology and Parasitic Diseases, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki","place":["Greece"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Do Yew","family":"Tan","sequence":"additional","affiliation":[{"name":"Boehringer Ingelheim Animal Health","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maxime","family":"Madder","sequence":"additional","affiliation":[{"name":"Clinglobal Limited","place":["Mauritius"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Tielemans","sequence":"additional","affiliation":[{"name":"Boehringer Ingelheim Animal Health","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"250","published-online":{"date-parts":[[2026,1,22]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.vetpar.2016.02.017","volume":"222","author":"Becskei","year":"2016","journal-title":"Veterinary Parasitology"},{"key":"R2","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1186\/s13071-023-06049-9","volume":"16","author":"Becskei","year":"2023","journal-title":"Parasites & Vectors"},{"key":"R3","doi-asserted-by":"crossref","first-page":"e02334-17","DOI":"10.1128\/AAC.02334-17","volume":"62","author":"Bernigaud","year":"2018","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"R4","unstructured":"Beugnet F, Halos L, Guillot J. 2018. Textbook of clinical parasitology in dogs and cats. Zaragoza, Spain: Grupo Asis Biomedia."},{"key":"R5","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1051\/parasite\/2016026","volume":"23","author":"Beugnet","year":"2016","journal-title":"Parasite"},{"key":"R6","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1186\/s13071-020-04395-6","volume":"13","author":"Chiummo","year":"2020","journal-title":"Parasites & Vectors"},{"key":"R7","doi-asserted-by":"crossref","first-page":"62","DOI":"10.3390\/pathogens12010062","volume":"12","author":"Colombo","year":"2022","journal-title":"Pathogens"},{"key":"R8","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/j.2044-3862.2012.00222.x","volume":"17","author":"Curtis","year":"2012","journal-title":"Companion Animal"},{"key":"R9","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s00436-010-1860-8","volume":"107","author":"Feather","year":"2010","journal-title":"Parasitology Research"},{"key":"R10","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1751-0813.2006.tb13117.x","volume":"84","author":"Fourie","year":"2006","journal-title":"Australian Veterinary Journal"},{"key":"R11","unstructured":"Guagu\u00e8re E, Beugnet F. 2008. Parasitic skin conditions, in A Practical Guide to Canine Dermatology, Guagu\u00e8re E, Pr\u00e9laud P, Craig M, Editors. Kalianxis: Paris. pp. 179\u2013226."},{"key":"R12","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1051\/parasite\/2018064","volume":"25","author":"Hampel","year":"2018","journal-title":"Parasite"},{"key":"R13","doi-asserted-by":"crossref","first-page":"267-e81","DOI":"10.1111\/vde.12741","volume":"30","author":"Hyun","year":"2019","journal-title":"Veterinary Dermatology"},{"key":"R14","unstructured":"Jacobs D, Fox M, Gibbons L, Hermosilla C. 2015. Principles of Veterinary Parasitology. NY: Wiley-Blackwell. p. 320."},{"key":"R15","doi-asserted-by":"crossref","first-page":"S81","DOI":"10.1007\/s00436-005-1449-9","volume":"97","author":"Krieger","year":"2005","journal-title":"Parasitology Research"},{"key":"R16","unstructured":"Miller W, Griffin C, Campbell K, Muller G. 2013. Muller and Kirk\u2019s Small animal Dermatology (7th ed.). St Louis, Missouri: Elsevier, Mosby. p. 952."},{"key":"R17","doi-asserted-by":"crossref","first-page":"6639017","DOI":"10.1155\/2021\/6639017","volume":"2021","author":"Moog","year":"2021","journal-title":"Case Reports in Veterinary Medicine"},{"key":"R18","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3390\/pathogens11020213","volume":"11","author":"Moroni","year":"2022","journal-title":"Pathogens"},{"key":"R19","doi-asserted-by":"crossref","unstructured":"Mounsey KE, Walton SF. 2011. Scabies and other mite infections, in Oxford Textbook of Zoonoses, 2nd Ed., Palmer SR, Torgerson P, Brown DWG, Editors. 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