{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T12:42:16Z","timestamp":1773924136963,"version":"3.50.1"},"reference-count":28,"publisher":"EDP Sciences","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":77,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite"],"accepted":{"date-parts":[[2026,2,12]]},"published-print":{"date-parts":[[2026]]},"abstract":"<jats:p>\n                    <jats:italic>Otodectes cynotis<\/jats:italic>\n                    is the agent of otodectic mange, a disease affecting wild and domestic felines, canines and mustelids. It is a highly contagious and pruritic condition and a major cause of otitis externa in dogs. This study was designed to verify the efficacy of NexGard\n                    <jats:sup>\u00ae<\/jats:sup>\n                    PLUS, a combination of afoxolaner, moxidectin and pyrantel pamoate, against natural\n                    <jats:italic>O. cynotis<\/jats:italic>\n                    infestations in dogs. It was a blinded, randomised, single-centre, negative controlled clinical efficacy study. Twenty-four naturally infested dogs were allocated to three groups of eight dogs: an untreated control group, a group treated on Day 0 and a group treated on Days 0 and 29 (both groups were treated per label recommendations). Otoscopic examinations were performed on Days -3, 14, 29, 42 and 55 for clinical otodectic mange evaluation. Ear canal flushings were performed on Day 56 for\n                    <jats:italic>O. cynotis<\/jats:italic>\n                    counts, the primary variable of efficacy, calculated per comparison of live mites in the treated groups, with the untreated control group. The otoscopic examinations revealed treatment effect by Day 14 and a highly significant effect by Day 29, while the conditions remained unchanged or worsened in the untreated control group. The\n                    <jats:italic>O. cynotis<\/jats:italic>\n                    counts revealed reductions of 100% in the group treated once on Day 0 (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.0004) and 99.7% (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.0006) in the group treated on Days 0 and 29, while 48.8 (geometric mean) live mites were collected in the untreated control group. NexGard\n                    <jats:sup>\u00ae<\/jats:sup>\n                    PLUS was demonstrated to be highly efficacious in dogs naturally infested with\n                    <jats:italic>O. cynotis<\/jats:italic>\n                    following one or two treatments.\n                  <\/jats:p>","DOI":"10.1051\/parasite\/2026015","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T08:54:06Z","timestamp":1773910446000},"page":"12","source":"Crossref","is-referenced-by-count":0,"title":["Field efficacy of a combination of afoxolaner, moxidectin and pyrantel pamoate against natural infestation with\n                    <i>Otodectes cynotis<\/i>\n                    in dogs"],"prefix":"10.1051","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4798-3246","authenticated-orcid":false,"given":"Eric","family":"Tielemans","sequence":"first","affiliation":[{"name":"Boehringer Ingelheim Animal Health","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgios","family":"Sioutas","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitology and Parasitic Diseases, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki","place":["Greece"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elias","family":"Papadopoulos","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitology and Parasitic Diseases, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki","place":["Greece"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"250","published-online":{"date-parts":[[2026,3,19]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1051\/parasite\/2026001","volume":"33","author":"Antoine","year":"2026","journal-title":"Parasite"},{"key":"R2","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1051\/parasite\/2014045","volume":"21","author":"Beugnet","year":"2014","journal-title":"Parasite"},{"key":"R3","unstructured":"Beugnet F, Halos L, Guillot J. 2018. Textbook of clinical parasitology in dogs and cats. Zaragoza, Spain: Grupo Asis Biomedia."},{"key":"R4","unstructured":"Bowman A. 2014. Otodectes cynotis. https:\/\/www.aavp.org."},{"issue":"5","key":"R5","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1177\/1098612X211007072","volume":"23","author":"Brame","year":"2021","journal-title":"J Feline Med Surg"},{"issue":"1","key":"R6","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1186\/s13071-016-1924-4","volume":"9","author":"Carithers","year":"2016","journal-title":"Parasites & Vectors"},{"key":"R7","doi-asserted-by":"crossref","unstructured":"Deplazes P, Eckert J, Mathis A, von Samson-Himmelstjerna G, Zahner H. 2016. Parasitology in Veterinary Medicine. Wageningen: Wageningen Academic Publishers.","DOI":"10.3920\/978-90-8686-274-0"},{"key":"R8","unstructured":"Griffin CE, Kwochka KW, MacDonald JM. 1993. Editors. Current Veterinary Dermatology: The Science and Art of Therapy, St. Louis, Missouri: Mosby Year Book. pp. 245\u2013262."},{"key":"R9","unstructured":"Guagu\u00e8re E, Beugnet F. 2008. Parasitic skin, in Parasitic Skin Conditions. Guagu\u00e8re E, Pr\u00e9laud P, Craig M, Editors. Kalianxis: Paris. pp. 179\u2013226."},{"key":"R10","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1051\/parasite\/2018064","volume":"25","author":"Hampel","year":"2018","journal-title":"Parasite"},{"key":"R11","unstructured":"Jacobs D, Fox M, Gibbons L, Hermosilla C. 2015. Principle of veterinary parasitology. Wiley-Blackwell. p. 320."},{"key":"R12","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1080\/01647954.2021.1900911","volume":"47","author":"Lefkaditis","year":"2021","journal-title":"International Journal of Acarology"},{"key":"R13","doi-asserted-by":"crossref","unstructured":"Medleau L, Hnilica K. 2006. 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