{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T16:43:44Z","timestamp":1770741824635,"version":"3.49.0"},"reference-count":12,"publisher":"EDP Sciences","license":[{"start":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T00:00:00Z","timestamp":1626048000000},"content-version":"vor","delay-in-days":192,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Regen Med Res"],"accepted":{"date-parts":[[2021,6,15]]},"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p><jats:italic>Objectives:<\/jats:italic> The purpose of this study is to assess the effectiveness of mineralized plasmatic matrix in the soft tissue closure of naso-alveolar fistula, to estimate the postoperative bone fill and volume of the graft placed in the alveolar cleft defect using cone-beam computed tomography (CBCT) at 3rd- month and 6th- month. <jats:italic>Material and methods:<\/jats:italic> 10 patients, in the age group of 15\u201130 years were included in this study. They were diagnosed with unilateral cleft lip and alveolus defects with or without a cleft palate requiring late secondary alveolar bone grafting. Alveolar cleft defects were closed with mineralized plasmatic matrix (MPM), a combination of autogenous iliac bone graft and platelet rich plasma (PRP) and platelet rich fibrin (PRF). <jats:italic>Results:<\/jats:italic> The mean defect volume pre-operatively is 0.75 cm<jats:sup>3<\/jats:sup> and at the end of 3rd-month postoperatively is 0.51 cm<jats:sup>3<\/jats:sup> and at 6th-month postoperatively is 0.27 cm<jats:sup>3<\/jats:sup>. The average percentage of bone fill between preoperative (A) &amp; 3th- month postoperatively (B) is 33.4% and between 3rd-month (B) and 6th-month post operatively (C) is 49.5%. <jats:italic>Conclusions:<\/jats:italic> Utilization of this new matrix (MPM), has shown to be effective in the closure of the cleft defect, oro-nasal fistula and also reduction in the volume of the residual cleft defect seen with sequential cone-beam computed tomography (CBCT) radiographs.<\/jats:p>","DOI":"10.1051\/rmr\/210004","type":"journal-article","created":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T08:08:52Z","timestamp":1626077332000},"page":"1","source":"Crossref","is-referenced-by-count":7,"title":["The effectiveness of mineralized plasmatic matrix in the closure of alveolar clefts with volumetric assessment"],"prefix":"10.1051","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1307-5987","authenticated-orcid":false,"given":"Padminii","family":"Ellapakurthi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gotike Siva Prasad","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"250","published-online":{"date-parts":[[2021,7,12]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"184","DOI":"10.4103\/0970-0358.73443","volume":"43","author":"Reddy","year":"2010","journal-title":"Indian J Plast Surg"},{"key":"R2","first-page":"87","volume":"30","author":"Boyne","year":"1972","journal-title":"J Oral Surg"},{"key":"R3","doi-asserted-by":"crossref","unstructured":"Giannoudis PV, Karadimas EJ, Kanakaris NK (2011) Anterior Iliac Crest Bone Graft Harvesting, In Giannoudis P. (eds) Practical Procedures in Orthopedic Surgery Springer, London. p. 51\u201355.","DOI":"10.1007\/978-0-85729-817-1_17"},{"key":"R4","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1097\/SCS.0000000000001951","volume":"26","author":"Nadon","year":"2015","journal-title":"J Craniofac Surg"},{"key":"R5","first-page":"27","volume":"1","author":"de Barros","year":"2018","journal-title":"Int J Growth Factors Stem Cells Dent"},{"key":"R6","doi-asserted-by":"crossref","first-page":"e37","DOI":"10.1016\/j.tripleo.2005.07.008","volume":"101","author":"Dohan","year":"2006","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"R7","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jobcr.2013.02.002","volume":"3","author":"Gupta","year":"2013","journal-title":"J Oral Biol Craniofac Res"},{"key":"R8","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.1834-7819.2012.01686.x","volume":"57","author":"Wu","year":"2012","journal-title":"Aust Dent J"},{"key":"R9","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.ijom.2008.11.019","volume":"38","author":"Lee","year":"2009","journal-title":"Int J Oral Maxillofac Surg"},{"key":"R10","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.jcms.2010.04.017","volume":"39","author":"Marukawa","year":"2011","journal-title":"J Craniomaxillofac Surg"},{"key":"R11","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1597\/08-171","volume":"47","author":"Oberoi","year":"2010","journal-title":"Cleft Palate Craniofac J"},{"key":"R12","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.joms.2003.08.023","volume":"62","author":"Oyama","year":"2004","journal-title":"J Oral Maxillofac Surg"}],"container-title":["Regenerative Medicine Research"],"original-title":[],"link":[{"URL":"https:\/\/www.regenmedres-journal.org\/10.1051\/rmr\/210004\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T08:09:12Z","timestamp":1626077352000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.regenmedres-journal.org\/10.1051\/rmr\/210004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":12,"alternative-id":["rmr210004"],"URL":"https:\/\/doi.org\/10.1051\/rmr\/210004","relation":{},"ISSN":["2050-490X"],"issn-type":[{"value":"2050-490X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}