{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T16:21:34Z","timestamp":1771863694488,"version":"3.50.1"},"reference-count":27,"publisher":"EDP Sciences","license":[{"start":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T00:00:00Z","timestamp":1541376000000},"content-version":"vor","delay-in-days":308,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["SICOT-J"],"accepted":{"date-parts":[[2018,9,5]]},"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>: Osteonecrosis is a rare event during or after pregnancy. Due to the low number of cases, there is no report of long-term results after conservative surgery in this population.<\/jats:p>\n<jats:p><jats:italic>Method<\/jats:italic>: From 1992 to 2010, 145 consecutive female patients with unilateral symptomatic (94 stage I and 51 stage II) left hip osteonecrosis (ON) related to pregnancy were treated between 4 and 16 months after delivery with percutaneous mesenchymal stem cell (MSC) injection obtained from bone marrow concentration. The average total number of MSCs (counted as number of colonies forming units-fibroblast) injected in the hip was 185 000\u2009\u00b1\u200965 000 cells (range 95 000\u2013240 000 cells).<\/jats:p>\n<jats:p><jats:italic>Results<\/jats:italic>: At the most recent follow-up (average 15 years after hip surgery, range 8\u201325 years), among the 145 hips included in the study, 4 hips (2.7%) had collapsed and were treated with total hip arthroplasty (THA). Thirty-two of the 94 stage I had progressed to stage II; and 4 of the 51 stage II had progressed to stage III and collapse. The other 141 hips (97.3%) were without collapse and pain free. On MRI, as percentage of the volume of the femoral head, the osteonecrosis had decreased from 34.5% pre-operatively to 6% at the most recent follow-up. For women who had other children after treatment, a subsequent pregnancy was not associated with osteonecrosis.<\/jats:p>\n<jats:p><jats:italic>Conclusion<\/jats:italic>: Patients with hip osteonecrosis following pregnancy had a low conversion rate to THA when treated early with cell therapy.<\/jats:p>","DOI":"10.1051\/sicotj\/2018044","type":"journal-article","created":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T08:52:53Z","timestamp":1541407973000},"page":"46","source":"Crossref","is-referenced-by-count":8,"title":["Unusual indication of Cell therapy for hip osteonecrosis after pregnancy"],"prefix":"10.1051","volume":"4","author":[{"given":"Philippe","family":"Hernigou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillaume","family":"Rigoulot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean Charles","family":"Auregan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Housset","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Bastard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnaud","family":"Dubory","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles Henri Flouzat","family":"Lachaniette","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"250","published-online":{"date-parts":[[2018,11,5]]},"reference":[{"issue":"6","key":"R1","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1007\/s00264-017-3736-3","volume":"42","author":"Hernigou","year":"2018","journal-title":"Int Orthop"},{"key":"R2","unstructured":"ameli.fr \u2212 l'Assurance Maladie en ligne [Internet]. 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