{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:04:22Z","timestamp":1791320662892,"version":"4.3.1"},"reference-count":40,"publisher":"EDP Sciences","license":[{"start":{"date-parts":[[2021,9,10]],"date-time":"2021-09-10T00:00:00Z","timestamp":1631232000000},"content-version":"vor","delay-in-days":252,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["SICOT-J"],"accepted":{"date-parts":[[2021,8,11]]},"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>: Debate encompasses the use of Vitamin E Polyethylene or conventional Polyethylene liner in primary hip arthroplasty. Does the Inclusion of Vitamin E in PE give adequate protection from oxidation and maintains lower rates of wear? <jats:italic>Patients and methods<\/jats:italic>: We performed this study following the Preferred Reporting Items for Systematic Reviews and Meta-analyses Statement (PRISMA) and the Cochrane Handbook for systematic reviews and meta-analysis. Studies were included from any region, written in any language. We had only the randomised control trials comparing the femoral head penetration between Vitamin-E diffused highly cross-linked polyethylene (VEPE) liner and conventional liners in primary total hip arthroplasty. <jats:italic>Results<\/jats:italic>: We included 10 studies in this meta-analysis. We conducted them using Review Manager V.5.0. We computed the risk ratio to measure the treatment effect, considering the heterogeneity. We used Random-effect models. VEPE had insignificant marginal advantages for FHP within three months post-operative. Additionally, VEPE showed significantly less FHP after two and five years. After one year, it showed significantly less FHP with the VEPE group versus the UHMWPE cohort and a non-significant difference between the VEPE and XLPE group. <jats:italic>Conclusions<\/jats:italic>: In terms of FHP, this metanalysis shows less FHP for the VEPE than conventional PE. A longer follow-up period is required to evaluate whether the oxidation protection gained by Vitamin E results in lower wear rates, less osteolysis, and aseptic loosening compared to the conventional PE in the long term.<\/jats:p>","DOI":"10.1051\/sicotj\/2021045","type":"journal-article","created":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T08:10:18Z","timestamp":1631520618000},"page":"47","source":"Crossref","is-referenced-by-count":5,"title":["Femoral head penetration in Vitamin-E polyethylene liner versus conventional liners in total hip arthroplasty: systematic review and meta-analysis of randomised control trials"],"prefix":"10.1051","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8600-6339","authenticated-orcid":false,"given":"Hany","family":"Elbardesy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3403-460X","authenticated-orcid":false,"given":"Himanshu","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0075-0541","authenticated-orcid":false,"given":"Mohamed","family":"Rabea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shane","family":"Guerin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8437-4357","authenticated-orcid":false,"given":"James","family":"Harty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"250","published-online":{"date-parts":[[2021,9,10]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.arth.2005.03.015","volume":"20","author":"Jasty","year":"2005","journal-title":"J Arthroplasty"},{"key":"R2","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1097\/01.blo.0000238856.61862.7d","volume":"453","author":"Dumbleton","year":"2006","journal-title":"Clin Orthop Relat Res"},{"key":"R3","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/j.arth.2016.10.037","volume":"32","author":"Broomfield","year":"2017","journal-title":"J Arthroplasty"},{"key":"R4","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1007\/s00264-018-4237-8","volume":"43","author":"Lambert","year":"2019","journal-title":"Int Orthop"},{"key":"R5","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1016\/S0142-9612(99)00039-3","volume":"20","author":"Muratoglu","year":"1999","journal-title":"Biomaterials"},{"key":"R6","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/jor.1100170203","volume":"17","author":"McKellop","year":"1999","journal-title":"J Orthop Res"},{"key":"R7","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.arth.2005.07.019","volume":"21","author":"Wannomae","year":"2006","journal-title":"J Arthroplasty"},{"key":"R8","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1016\/j.biomaterials.2005.10.002","volume":"27","author":"Wannomae","year":"2006","journal-title":"Biomaterials"},{"key":"R9","doi-asserted-by":"crossref","first-page":"5580","DOI":"10.1016\/j.biomaterials.2006.07.017","volume":"27","author":"Oral","year":"2006","journal-title":"Biomaterials"},{"key":"R10","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.cca.2018.07.012","volume":"486","author":"Galliera","year":"2018","journal-title":"Clin Chim Acta"},{"key":"R11","doi-asserted-by":"crossref","first-page":"889","DOI":"10.3390\/jfb6030889","volume":"6","author":"Gigante","year":"2015","journal-title":"J Funct Biomater"},{"key":"R12","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.biomaterials.2017.07.028","volume":"143","author":"Chen","year":"2017","journal-title":"Biomaterials"},{"key":"R13","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.arth.2011.03.024","volume":"27","author":"Haider","year":"2012","journal-title":"J Arthroplasty"},{"key":"R14","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/j.arth.2015.12.023","volume":"31","author":"Nebergall","year":"2016","journal-title":"J Arthroplasty"},{"key":"R15","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1302\/0301-620X.99B5.37521","volume":"99-B","author":"Nebergall","year":"2017","journal-title":"Bone Joint J"},{"key":"R16","doi-asserted-by":"crossref","unstructured":"Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA (2019) Cochrane handbook for systematic reviews of interventions.","DOI":"10.1002\/9781119536604"},{"key":"R17","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1302\/0301-620X.101B10.BJJ-2019-0456.R2","volume":"101-B","author":"Sk\u00f6ldenberg","year":"2019","journal-title":"Bone Jt J"},{"key":"R18","doi-asserted-by":"crossref","first-page":"107","DOI":"10.2106\/JBJS.16.01379","volume":"100","author":"Rochcongar","year":"2018","journal-title":"J Bone Jt Surg Am"},{"key":"R19","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1007\/s00264-015-2680-3","volume":"39","author":"Salemyr","year":"2015","journal-title":"Int Orthop"},{"key":"R20","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1007\/s00264-016-3320-2","volume":"41","author":"Scemama","year":"2017","journal-title":"Int Orthop"},{"key":"R21","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.2106\/JBJS.N.00595","volume":"97","author":"Shareghi","year":"2015","journal-title":"J Bone Jt Surg Am"},{"key":"R22","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.2106\/JBJS.16.00691","volume":"99","author":"Shareghi","year":"2017","journal-title":"J Bone Jt Surg Am"},{"key":"R23","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1302\/0301-620X.100B12.BJJ-2018-0371.R1","volume":"100B","author":"Galea","year":"2018","journal-title":"Bone Jt J"},{"key":"R24","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1302\/0301-620X.101B7.BJJ-2019-0268.R1","volume":"101 B","author":"Galea","year":"2019","journal-title":"Bone Jt J"},{"key":"R25","unstructured":"RM (RevMan) (2014) Computer P, Centre V 5. 3. CTNC, Collaboration. TC Review Manager V.5.0."},{"key":"R26","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1177\/1120700019858335","volume":"30","author":"Wyatt","year":"2020","journal-title":"HIP Int"},{"key":"R27","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.jmbbm.2011.03.012","volume":"4","author":"Atwood","year":"2011","journal-title":"J Mech Behav Biomed Mater"},{"key":"R28","doi-asserted-by":"crossref","first-page":"159","DOI":"10.3109\/17453674.2014.972890","volume":"86","author":"Callary","year":"2015","journal-title":"Acta Orthop"},{"key":"R29","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.otsr.2010.04.007","volume":"96","author":"Pineau","year":"2010","journal-title":"Orthop Traumatol Surg Res"},{"key":"R30","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.2106\/00004623-200008000-00006","volume":"82","author":"Dowd","year":"2000","journal-title":"J Bone Jt Surg Am"},{"key":"R31","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1080\/17453674.2020.1730073","volume":"91","author":"van Erp","year":"2020","journal-title":"Acta Orthop"},{"key":"R32","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.arth.2014.11.017","volume":"30","author":"Halma","year":"2015","journal-title":"J Arthroplasty"},{"key":"R33","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1080\/17453674.2017.1317515","volume":"88","author":"Zijlstra","year":"2017","journal-title":"Acta Orthop"},{"key":"R34","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.jos.2017.01.012","volume":"22","author":"Yamamoto","year":"2017","journal-title":"J Orthop Sci"},{"key":"R35","doi-asserted-by":"crossref","first-page":"3290","DOI":"10.1007\/s11999-009-1038-9","volume":"467","author":"Lachiewicz","year":"2009","journal-title":"Clin Orthop Relat Res"},{"key":"R36","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s11999-015-4319-5","volume":"474","author":"Lachiewicz","year":"2016","journal-title":"Clin Orthop Relat Res"},{"key":"R37","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/os.12337","volume":"9","author":"Tian","year":"2017","journal-title":"Orthop Surg"},{"key":"R38","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jcot.2017.03.007","volume":"9","author":"Tian","year":"2018","journal-title":"J Clin Orthop Trauma"},{"key":"R39","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00264-009-0731-3","volume":"34","author":"Gallo","year":"2010","journal-title":"International Orthopaedics (SICOT)"},{"key":"R40","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1302\/0301-620X.90B5.20545","volume":"90","author":"Glyn-Jones","year":"2008","journal-title":"J Bone Jt Surg \u2013 Ser B"}],"container-title":["SICOT-J"],"original-title":[],"link":[{"URL":"https:\/\/www.sicot-j.org\/10.1051\/sicotj\/2021045\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T08:11:03Z","timestamp":1631520663000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.sicot-j.org\/10.1051\/sicotj\/2021045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":40,"alternative-id":["sicotj210004"],"URL":"https:\/\/doi.org\/10.1051\/sicotj\/2021045","relation":{},"ISSN":["2426-8887"],"issn-type":[{"value":"2426-8887","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}