{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T05:07:12Z","timestamp":1768453632606,"version":"3.49.0"},"reference-count":14,"publisher":"EDP Sciences","license":[{"start":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T00:00:00Z","timestamp":1712102400000},"content-version":"vor","delay-in-days":93,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["SICOT-J"],"accepted":{"date-parts":[[2024,3,20]]},"published-print":{"date-parts":[[2024]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>: Scheuermann\u2019s disease is a diagnosis of hyperkyphosis commonly encountered in pediatric patients. Studies in animal models suggest an association with vitamin D deficiency, however, extensive studies have not been performed in humans. This study analyzes the role of vitamin D deficiency on unfavorable results in patients with Scheuermann\u2019s disease. <jats:italic>Methods<\/jats:italic>: The TriNetX database was utilized to perform a retrospective analysis. Patients in the United States aged 0\u201318\u00a0years with Scheuermann\u2019s disease were identified using International Classification of Diseases, Tenth Revision (ICD-10) codes and categorized into those with and without a diagnosis of vitamin D deficiency. Comparison of patient groups depending on age, sex, ethnic origin, prior diagnosis of fibromyalgia, anxiety disorder, myositis, and major depressive disorder. Statistical analysis was conducted to identify the association between vitamin D levels and unfavorable results including pain, depression, suicide attempt, emergency department (ED) consult, hospitalization, and procedures on the spine or spinal cord. <jats:italic>Results<\/jats:italic>: In total, 11,277 patients were identified, 39% of whom had a concurrent diagnosis of scoliosis. A total of 1,024 (9.08%) were deficient in vitamin D. Patients with vitamin D deficiency had greater odds of pain (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001), depression (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001), suicide attempt (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0021), ED visits (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0246), and hospital admission (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0015). Conversely, patients with vitamin D deficiency had decreased odds of surgery on the spine or spinal cord (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0009). <jats:italic>Conclusion<\/jats:italic>: Vitamin D deficiency is associated with an elevated risk of pain, depression, suicide attempts, ED visits, and hospitalization. Our analysis highlights the need for more research to study the effect of vitamin D on Scheuermann\u2019s disease.<\/jats:p>\n<jats:p><jats:italic>Level of evidence<\/jats:italic>: Level III, Prognostic<\/jats:p>","DOI":"10.1051\/sicotj\/2024010","type":"journal-article","created":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T08:10:45Z","timestamp":1712131845000},"page":"13","source":"Crossref","is-referenced-by-count":4,"title":["Vitamin D deficiency in Scheuermann\u2019s disease is associated with increased adverse outcomes"],"prefix":"10.1051","volume":"10","author":[{"given":"Shivan N.","family":"Chokshi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9585-2569","authenticated-orcid":false,"given":"Srikanth","family":"Mudiganty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"Rutledge Carter","family":"Clement","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Accousti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"250","published-online":{"date-parts":[[2024,4,3]]},"reference":[{"issue":"3","key":"R1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.jbspin.2013.11.012","volume":"81","author":"Palazzo","year":"2014","journal-title":"Jt Bone Spine"},{"issue":"4","key":"R2","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s00132-022-04239-4","volume":"51","author":"Diaremes","year":"2022","journal-title":"Orthopade"},{"issue":"2","key":"R3","doi-asserted-by":"crossref","first-page":"113","DOI":"10.5435\/00124635-201202000-00007","volume":"20","author":"Wood","year":"2012","journal-title":"J Am Acad Orthop Surg"},{"issue":"10","key":"R4","doi-asserted-by":"crossref","first-page":"e462","DOI":"10.5435\/JAAOS-D-17-00748","volume":"27","author":"Sardar","year":"2019","journal-title":"J Am Acad Orthop Surg"},{"issue":"4","key":"R5","doi-asserted-by":"crossref","first-page":"383","DOI":"10.3233\/BMR-140483","volume":"27","author":"Bezalel","year":"2014","journal-title":"J Back Musculoskelet Rehabil"},{"key":"R6","doi-asserted-by":"crossref","first-page":"396541","DOI":"10.1155\/2013\/396541","volume":"2013","author":"Christodoulou","year":"2013","journal-title":"Biomed Res Int"},{"issue":"5","key":"R7","doi-asserted-by":"crossref","first-page":"406","DOI":"10.2106\/JBJS.17.00182","volume":"100","author":"Halanski","year":"2018","journal-title":"J Bone Joint Surg Am"},{"issue":"2","key":"R8","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.ecl.2010.02.008","volume":"39","author":"Binkley","year":"2010","journal-title":"Endocrinol Metab Clin North Am"},{"issue":"4","key":"R9","doi-asserted-by":"crossref","first-page":"1159S","DOI":"10.1093\/jn\/126.suppl_4.1159S","volume":"126","author":"Holick","year":"1996","journal-title":"J Nutr"},{"issue":"5","key":"R10","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3390\/nu5010111","volume":"10","author":"Wacker","year":"2013","journal-title":"Nutrients"},{"issue":"1","key":"R11","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1310\/sci2001-13","volume":"20","author":"Klaas","year":"2014","journal-title":"Top Spinal Cord Inj Rehabil"},{"issue":"4","key":"R12","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1097\/CORR.0000000000000569","volume":"477","author":"Wong","year":"2019","journal-title":"Clin Orthop Relat Res"},{"key":"R13","doi-asserted-by":"crossref","first-page":"e27","DOI":"10.1016\/j.wneu.2019.01.095","volume":"126","author":"Lin","year":"2019","journal-title":"World Neurosurg"},{"issue":"3","key":"R14","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1097\/BRS.0000000000001187","volume":"41","author":"Chang","year":"2016","journal-title":"Spine"}],"container-title":["SICOT-J"],"original-title":[],"link":[{"URL":"https:\/\/www.sicot-j.org\/10.1051\/sicotj\/2024010\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T08:10:55Z","timestamp":1712131855000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.sicot-j.org\/10.1051\/sicotj\/2024010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":14,"alternative-id":["sicotj240019"],"URL":"https:\/\/doi.org\/10.1051\/sicotj\/2024010","relation":{},"ISSN":["2426-8887"],"issn-type":[{"value":"2426-8887","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}