{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T08:19:50Z","timestamp":1783066790852,"version":"3.54.6"},"reference-count":21,"publisher":"EDP Sciences","license":[{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"vor","delay-in-days":183,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["SICOT-J"],"accepted":{"date-parts":[[2025,12,8]]},"published-print":{"date-parts":[[2026]]},"abstract":"<jats:p>\n                    <jats:italic>Introduction<\/jats:italic>\n                    : Severe Osteogenesis Imperfecta (OI) can cause distinct proximal femoral deformities, but specific femoral neck changes remain poorly defined. This study aimed to characterize dystrophic femoral neck morphology and determine a diagnostic threshold.\n                    <jats:italic>Methods<\/jats:italic>\n                    : We retrospectively reviewed anteroposterior pelvic radiographs from patients &gt;8\u00a0years old with severe OI (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a024 hips) and age-matched controls (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a024 hips). Measurements included femoral neck length, neck diameter, head diameter, neck-shaft angle, anterior lateral proximal femoral angle (aLPFA), and acetabular protrusion. Ratios of neck length-to-diameter and neck length-to-head diameter were calculated. Statistical comparisons used t-tests; ROC analysis identified the optimal threshold for distinguishing dystrophic necks.\n                    <jats:italic>Results<\/jats:italic>\n                    : OI patients had shorter femoral necks (52.7 \u00b1 9.9\u00a0mm vs. 64.8\u00a0\u00b1\u00a09.6\u00a0mm,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001), smaller diameters (19.4 \u00b1 4.7\u00a0mm vs. 32.8 \u00b1 4.8\u00a0mm,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.0001), and higher neck length-to-diameter ratios (2.82 \u00b1 0.63 vs. 1.98 \u00b1 0.19,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.000001). A threshold of \u22652.35 (AUC\u00a0=\u00a00.90) identified dystrophic necks, associated with greater acetabular protrusion (\u20132.91 \u00b1 12.33\u00a0mm vs. 4.42 \u00b1 8.67\u00a0mm,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.004).\n                    <jats:italic>Discussion<\/jats:italic>\n                    : A neck length-to-diameter ratio \u2265 2.35 reliably defines dystrophic femoral necks in OI and correlates with increased acetabular protrusion. Early recognition may guide surgical planning and help preserve hip function.\n                    <jats:italic>Level of Evidence<\/jats:italic>\n                    : Level IV \u2013 Retrospective comparative study.\n                  <\/jats:p>","DOI":"10.1051\/sicotj\/2026001","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T07:58:34Z","timestamp":1783065514000},"page":"42","source":"Crossref","is-referenced-by-count":0,"title":["Defining the dystrophic femoral neck in osteogenesis imperfecta: a radiographic and anatomical entity with diagnostic threshold"],"prefix":"10.1051","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3862-1262","authenticated-orcid":false,"given":"Samuel","family":"Georges","sequence":"first","affiliation":[{"name":"Service de Chirurgie orthop\u00e9dique et traumatologie p\u00e9diatrique, H\u00f4pital Necker Enfants malades - AP-HP","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jad","family":"Zalaket","sequence":"additional","affiliation":[{"name":"Service de Chirurgie orthop\u00e9dique et traumatologie p\u00e9diatrique, H\u00f4pital Necker Enfants malades - AP-HP","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina","family":"Badina","sequence":"additional","affiliation":[{"name":"Service de Chirurgie orthop\u00e9dique et traumatologie p\u00e9diatrique, H\u00f4pital Necker Enfants malades - AP-HP","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Pannier","sequence":"additional","affiliation":[{"name":"Service de Chirurgie orthop\u00e9dique et traumatologie p\u00e9diatrique, H\u00f4pital Necker Enfants malades - AP-HP","place":["France"]},{"name":"Genetics Department, Paris Cit\u00e9 University, INSERM UMR 1163, Imagine Institutee","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Saliba","sequence":"additional","affiliation":[{"name":"Service de Chirurgie orthop\u00e9dique et traumatologie p\u00e9diatrique, H\u00f4pital Necker Enfants malades - AP-HP","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zagorka","family":"Pejin","sequence":"additional","affiliation":[{"name":"Service de Chirurgie orthop\u00e9dique et traumatologie p\u00e9diatrique, H\u00f4pital Necker Enfants malades - AP-HP","place":["France"]},{"name":"Genetics Department, Paris Cit\u00e9 University, INSERM UMR 1163, Imagine Institutee","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"250","published-online":{"date-parts":[[2026,7,3]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1749-6632.1988.tb55328.x","volume":"543","author":"Cole","year":"1988","journal-title":"Ann N Y Acad Sci"},{"key":"R2","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1002\/ajmg.1320450225","volume":"45","author":"Cole","year":"1993","journal-title":"Am J Med Genet"},{"key":"R3","first-page":"259","volume":"76","author":"Cammarata-Scalisi","year":"2019","journal-title":"Bol Med Hosp Infant Mex"},{"key":"R4","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1302\/1863-2548.11.160212","volume":"11","author":"Papanna","year":"2017","journal-title":"J Child Orthop"},{"key":"R5","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1097\/01.bpo.0000189007.55174.7c","volume":"26","author":"Aarabi","year":"2006","journal-title":"J Pediatr Orthop"},{"key":"R6","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1055\/s-0041-1732476","volume":"12","author":"Ramos-Mej\u00eda","year":"2023","journal-title":"J Pediatr Genet"},{"key":"R7","first-page":"622","volume":"22","author":"Violas","year":"2002","journal-title":"J Pediatr Orthop"},{"key":"R8","doi-asserted-by":"crossref","first-page":"e114","DOI":"10.1097\/BPB.0000000000000887","volume":"31","author":"Hong","year":"2022","journal-title":"J Pediatr Orthop B"},{"key":"R9","doi-asserted-by":"crossref","first-page":"111390","DOI":"10.1016\/j.injury.2024.111390","volume":"55","author":"Vahabi","year":"2024","journal-title":"Injury"},{"key":"R10","first-page":"493","volume":"7","author":"Georgescu","year":"2014","journal-title":"J Med Life"},{"key":"R11","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1097\/BPO.0b013e31818e19b7","volume":"28","author":"Fassier","year":"2008","journal-title":"J Pediatric Orthop"},{"key":"R12","first-page":"82","volume":"11","author":"Logheswaren","year":"2017","journal-title":"Malays Orthop J"},{"key":"R13","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1097\/00003086-197805000-00005","volume":"132","author":"Sotelo-Garza","year":"1978","journal-title":"Clin Orthop Relat Res"},{"key":"R14","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jtbi.2006.06.029","volume":"244","author":"Skedros","year":"2007","journal-title":"J Theor Biol"},{"key":"R15","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s11845-014-1070-y","volume":"184","author":"Hammer","year":"2015","journal-title":"Ir J Med Sci"},{"key":"R16","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1097\/BPO.0000000000000343","volume":"35","author":"Trehan","year":"2015","journal-title":"J Pediatr Orthop"},{"key":"R17","doi-asserted-by":"crossref","first-page":"e750","DOI":"10.1097\/BPO.0000000000001051","volume":"39","author":"Ahn","year":"2019","journal-title":"J Pediatr Orthop"},{"key":"R18","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1097\/01241398-198507000-00014","volume":"5","author":"Shapiro","year":"1985","journal-title":"J Pediatr Orthop"},{"key":"R19","first-page":"248","volume":"114","author":"Rodr\u00edguez Celin","year":"2016","journal-title":"Arch Argent Pediatr"},{"key":"R20","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.apmr.2003.08.085","volume":"85","author":"Engelbert","year":"2004","journal-title":"Arch Phys Med Rehabil"},{"key":"R21","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.anpedi.2009.12.022","volume":"72","author":"Fano","year":"2010","journal-title":"Anales de Pediatr\u00eda"}],"container-title":["SICOT-J"],"original-title":[],"link":[{"URL":"https:\/\/www.sicot-j.org\/10.1051\/sicotj\/2026001\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T07:58:38Z","timestamp":1783065518000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.sicot-j.org\/10.1051\/sicotj\/2026001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":21,"alternative-id":["sicotj250110"],"URL":"https:\/\/doi.org\/10.1051\/sicotj\/2026001","relation":{},"ISSN":["2426-8887"],"issn-type":[{"value":"2426-8887","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}