{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T08:38:37Z","timestamp":1792744717168,"version":"4.5.0"},"reference-count":36,"publisher":"EDP Sciences","license":[{"start":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:00:00Z","timestamp":1792713600000},"content-version":"vor","delay-in-days":295,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["SICOT-J"],"accepted":{"date-parts":[[2026,5,14]]},"published-print":{"date-parts":[[2026]]},"abstract":"<jats:p>\n                    <jats:italic>Introduction: Staphylococcus aureus<\/jats:italic>\n                    is the most frequently implicated pathogen in periprosthetic joint infections (PJIs) and surgical site infections (SSIs), with nasal colonization being a well-established risk factor for their onset. Despite this association, the role of routine preoperative screening and decolonization in reducing postoperative infection rates remains debated.\n                    <jats:italic>Methods<\/jats:italic>\n                    : This retrospective study analyzed 2,507 elective joint arthroplasty procedures performed between January 2022 and December 2024 at a single center in Italy. Starting in 2024, patients underwent nasal swab screening for methicillin-sensitive\n                    <jats:italic>S. aureus<\/jats:italic>\n                    (MSSA) and methicillin-resistant\n                    <jats:italic>S. aureus<\/jats:italic>\n                    (MRSA). Positive carriers received a decolonization protocol consisting of mupirocin nasal ointment and chlorhexidine showers in the days preceding surgery. The incidence of PJIs in this group was compared to that observed in a control cohort from 2022\u20132023, during which no screening or decolonization was implemented.\n                    <jats:italic>Results:<\/jats:italic>\n                    Among the 988 patients screened in 2024, 231 (25.2%) tested positive for MSSA and 18 (1.8%) for MRSA. Notably, no PJIs caused by MSSA or MRSA were reported that year, compared to three such cases recorded in the preceding 2 years. Overall, 11 PJIs (0.44%) were documented across the study period. All infections in 2024 occurred in patients who had tested negative for\n                    <jats:italic>S. aureus<\/jats:italic>\n                    colonization. However, the reduction in infection rates did not reach statistical significance (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a01.00).\n                    <jats:italic>Conclusions:<\/jats:italic>\n                    Although the observed decrease in\n                    <jats:italic>S. aureus<\/jats:italic>\n                    -related periprosthetic joint infections was not statistically significant, the trend suggests that preoperative screening and targeted decolonization may contribute to a lower incidence of these infections. These findings support further investigation into standardized preventive strategies to enhance outcomes in joint replacement surgery.\n                  <\/jats:p>","DOI":"10.1051\/sicotj\/2026040","type":"journal-article","created":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T07:53:02Z","timestamp":1792741982000},"page":"79","source":"Crossref","is-referenced-by-count":0,"title":["Preoperative\n                    <i>Staphylococcus aureus<\/i>\n                    nasal screening and decolonization for the prevention of periprosthetic joint infection in elective total joint arthroplasty: A single-center retrospective comparative study"],"prefix":"10.1051","volume":"12","author":[{"given":"Virginia","family":"Cinelli","sequence":"first","affiliation":[{"name":"Department of Orthopedics and Geriatric Sciences, Catholic University of the Sacred Heart","place":["Italy"]},{"name":"Department of Orthopedics, Ageing and Rheumatological Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS","place":["Italy"]},{"name":"Ortopedia e Traumatologia, Fondazione Poliambulanza Istituto Ospedaliero","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"El Motassime","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Geriatric Sciences, Catholic University of the Sacred Heart","place":["Italy"]},{"name":"Department of Orthopedics, Ageing and Rheumatological Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS","place":["Italy"]},{"name":"Ortopedia e Traumatologia, Fondazione Poliambulanza Istituto Ospedaliero","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Capece","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Geriatric Sciences, Catholic University of the Sacred Heart","place":["Italy"]},{"name":"Department of Orthopedics, Ageing and Rheumatological Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS","place":["Italy"]},{"name":"U.O.C. Orthopedics and Traumatology, Ospedale dei Pellegrini","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Vitiello","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Geriatric Sciences, Catholic University of the Sacred Heart","place":["Italy"]},{"name":"Department of Orthopedics, Ageing and Rheumatological Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Maccauro","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Geriatric Sciences, Catholic University of the Sacred Heart","place":["Italy"]},{"name":"Department of Orthopedics, Ageing and Rheumatological Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1586-2542","authenticated-orcid":false,"given":"Luca","family":"Andriollo","sequence":"additional","affiliation":[{"name":"Ortopedia e Traumatologia, Fondazione Poliambulanza Istituto Ospedaliero","place":["Italy"]},{"name":"Artificial Intelligence Center, Alma Mater Europaea University","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Lustig","sequence":"additional","affiliation":[{"name":"Univ Lyon, Claude Bernard Lyon 1 University, IFSTTAR, LBMC UMR_T9406","place":["France"]},{"name":"Orthopaedics Surgery and Sports Medicine Department, FIFA Medical Center of Excellence, Croix-Rousse Hospital, Hospices Civils de Lyon, Lyon North University Hospital","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Benazzo","sequence":"additional","affiliation":[{"name":"Ortopedia e Traumatologia, Fondazione Poliambulanza Istituto Ospedaliero","place":["Italy"]},{"name":"IUSS Istituto Universitario Di Studi Superiori","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudy","family":"Sangaletti","sequence":"additional","affiliation":[{"name":"Ortopedia e Traumatologia, Fondazione Poliambulanza Istituto Ospedaliero","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"250","published-online":{"date-parts":[[2026,10,23]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"1179544121994092","DOI":"10.1177\/1179544121994092","volume":"14","author":"Concoff","year":"2021","journal-title":"Clin Med Insights Arthr Musculoskel Disord"},{"key":"R2","doi-asserted-by":"crossref","first-page":"3092","DOI":"10.3390\/jcm13113092","volume":"13","author":"Andriollo","year":"2024","journal-title":"J Clin Med"},{"key":"R3","doi-asserted-by":"crossref","first-page":"334","DOI":"10.5397\/cise.2025.00150","volume":"28","author":"Niccoli","year":"2025","journal-title":"Clin Shoulder Elb"},{"key":"R4","doi-asserted-by":"crossref","first-page":"5131","DOI":"10.1007\/s00402-024-05301-w","volume":"144","author":"Egerci","year":"2024","journal-title":"Arch Orthop Trauma Surg"},{"key":"R5","doi-asserted-by":"crossref","unstructured":"Vicenti G, Pesare E, Colasuonno G, et al. (2024) Debridement, antibiotic pearls, and retention of the implant (DAPRI) in the treatment of early periprosthetic knee joint infections: a literature review. In: Healthcare. MDPI, p 843.","DOI":"10.3390\/healthcare12080843"},{"key":"R6","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1302\/0301-620X.104B11.BJJ-2022-0944","volume":"104","author":"Rajput","year":"2022","journal-title":"Bone Joint J"},{"key":"R7","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s00264-021-05291-z","volume":"46","author":"Akkaya","year":"2022","journal-title":"Int Orthop"},{"key":"R8","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1556\/1886.2024.00010","volume":"14","author":"Eiselt","year":"2024","journal-title":"Eur J Microbiol Immunol"},{"key":"R9","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.2106\/JBJS.N.01114","volume":"97","author":"Weiser","year":"2015","journal-title":"JBJS"},{"key":"R10","first-page":"2082","volume":"12","author":"Sangaletti","year":"2024","journal-title":"Biomedicine"},{"key":"R11","doi-asserted-by":"crossref","first-page":"S326","DOI":"10.1016\/j.arth.2023.02.025","volume":"38","author":"Hays","year":"2023","journal-title":"J Arthroplasty"},{"key":"R12","doi-asserted-by":"crossref","first-page":"765","DOI":"10.3390\/jcm14030765","volume":"14","author":"Areti","year":"2025","journal-title":"J Clin Med"},{"key":"R13","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.1016\/j.arth.2018.09.053","volume":"34","author":"\u00c5kesson","year":"2019","journal-title":"J Arthroplasty"},{"key":"R14","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/j.arth.2018.02.078","volume":"33","author":"Parvizi","year":"2018","journal-title":"J Arthroplasty"},{"key":"R15","doi-asserted-by":"crossref","first-page":"8","DOI":"10.2340\/17453674.2023.5670","volume":"94","author":"Sousa","year":"2023","journal-title":"Acta Orthop"},{"key":"R16","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1086\/501763","volume":"21","author":"Kalmeijer","year":"2000","journal-title":"Infect Control Hosp Epidemiol"},{"key":"R17","doi-asserted-by":"crossref","first-page":"186","DOI":"10.3390\/tropicalmed5040186","volume":"5","author":"Iannotti","year":"2020","journal-title":"Trop Med Infect Dis"},{"key":"R18","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1001\/archinte.1994.00420130101013","volume":"154","author":"Doebbeling","year":"1994","journal-title":"Arch Intern Med"},{"key":"R19","first-page":"57","volume":"11","author":"Grady","year":"2003","journal-title":"Surg Technol Int"},{"key":"R20","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1001\/jamasurg.2017.0904","volume":"152","author":"Berr\u00edos-Torres","year":"2017","journal-title":"JAMA Surg"},{"key":"R21","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.arth.2015.08.003","volume":"31","author":"Sousa","year":"2016","journal-title":"J Arthroplasty"},{"key":"R22","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.2106\/JBJS.I.01050","volume":"92","author":"Kim","year":"2010","journal-title":"JBJS"},{"key":"R23","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1007\/s11999-015-4191-3","volume":"473","author":"Baratz","year":"2015","journal-title":"Clin Orthop Relat Res"},{"key":"R24","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.arth.2013.03.036","volume":"28","author":"Chen","year":"2013","journal-title":"J Arthroplasty"},{"key":"R25","doi-asserted-by":"crossref","first-page":"2842","DOI":"10.1007\/s11999-008-0337-x","volume":"466","author":"Price","year":"2008","journal-title":"Clin Orthop Relat Res"},{"key":"R26","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.arth.2014.10.017","volume":"30","author":"Moroski","year":"2015","journal-title":"J Arthroplasty"},{"key":"R27","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1016\/j.injury.2017.04.012","volume":"48","author":"Iqbal","year":"2017","journal-title":"Injury"},{"key":"R28","doi-asserted-by":"crossref","first-page":"2309499019847068","DOI":"10.1177\/2309499019847068","volume":"27","author":"Ahmad","year":"2019","journal-title":"J Orthopaed Surg"},{"key":"R29","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1093\/jac\/dkm480","volume":"61","author":"Van Rijen","year":"2008","journal-title":"J Antimicrob Chemother"},{"key":"R30","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1086\/341025","volume":"35","author":"Kalmeijer","year":"2002","journal-title":"Clin Infect Dis"},{"key":"R31","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1128\/AAC.00682-20","volume":"64","author":"Lepelletier","year":"2020","journal-title":"Antimicrob Agents Chemother"},{"key":"R32","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/s43465-024-01109-3","volume":"58","author":"Mihara","year":"2024","journal-title":"Ind J Orthopaed"},{"key":"R33","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1056\/NEJMoa003069","volume":"346","author":"Perl","year":"2002","journal-title":"N Engl J Med"},{"key":"R34","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.arth.2016.05.019","volume":"31","author":"Sporer","year":"2016","journal-title":"J Arthroplasty"},{"key":"R35","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.jinf.2018.05.012","volume":"77","author":"Jeans","year":"2018","journal-title":"J Infect"},{"key":"R36","doi-asserted-by":"crossref","first-page":"5157","DOI":"10.1007\/s00402-024-05315-4","volume":"144","author":"Von Rehlingen-Prinz","year":"2024","journal-title":"Arch Orthop Trauma Surg"}],"container-title":["SICOT-J"],"original-title":[],"link":[{"URL":"https:\/\/www.sicot-j.org\/10.1051\/sicotj\/2026040\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T07:53:08Z","timestamp":1792741988000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.sicot-j.org\/10.1051\/sicotj\/2026040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":36,"alternative-id":["sicotj260010"],"URL":"https:\/\/doi.org\/10.1051\/sicotj\/2026040","relation":{},"ISSN":["2426-8887"],"issn-type":[{"value":"2426-8887","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}