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This approach is not sustainable and not always effective. The<jats:italic>Vitis<\/jats:italic>genus comprise different species that exhibit varying levels of resistance to pathogens, thus the understanding of the innate resistance\/susceptibility mechanisms of these different<jats:italic>Vitis<\/jats:italic>species is crucial to cope with these threats. In this work, an untargeted metabolomics approach was followed, using Fourier transform-ion cyclotron resonance mass spectrometry (FT-ICR-MS), to analyse the metabolic chemical diversity of two<jats:italic>Vitis<\/jats:italic>species:<jats:italic>Vitis rotundifolia<\/jats:italic>(resistant to pathogens) and<jats:italic>V. vinifera<\/jats:italic>cv. \u2018Cabernet Sauvignon\u2019 (susceptible to pathogens). Chemical formulas from both<jats:italic>Vitis<\/jats:italic>were used to build Van Krevelen diagrams and compositional space plots, which do not require full metabolite identification and provide an easy comparison method. Based only on these visualization tools, it was shown that the<jats:italic>V. rotundifolia<\/jats:italic>metabolome is more complex than the metabolome of<jats:italic>V. vinifera<\/jats:italic>cv. \u2018Cabernet Sauvignon\u2019. Moreover, the regions that present a higher density are associated to lipids, polyketides and carbohydrates. Also,<jats:italic>V. rotundifolia<\/jats:italic>metabolome presented a higher ratio O\/C compounds.<\/jats:p>","DOI":"10.1051\/ctv\/20213601001","type":"journal-article","created":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T09:41:56Z","timestamp":1610530916000},"page":"1-8","source":"Crossref","is-referenced-by-count":3,"title":["Comparison of the chemical diversity of<i>Vitis rotundifolia<\/i>and<i>Vitis vinifera<\/i>cv. \u2018Cabernet Sauvignon\u2019"],"prefix":"10.1051","volume":"36","author":[{"given":"Marisa","family":"Maia","sequence":"first","affiliation":[]},{"given":"Ant\u00f3nio E.N.","family":"Ferreira","sequence":"additional","affiliation":[]},{"given":"Jorge","family":"Cunha","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9","family":"Eiras-Dias","sequence":"additional","affiliation":[]},{"given":"Carlos","family":"Cordeiro","sequence":"additional","affiliation":[]},{"given":"Andreia","family":"Figueiredo","sequence":"additional","affiliation":[]},{"given":"Marta Sousa","family":"Silva","sequence":"additional","affiliation":[]}],"member":"250","published-online":{"date-parts":[[2021,1,13]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3389\/fpls.2017.00101","volume":"8","author":"Adrian","year":"2017","journal-title":"Front Plant Sci"},{"key":"R2","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.aca.2013.07.068","volume":"795","author":"Becker","year":"2013","journal-title":"Anal. 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