{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T23:27:27Z","timestamp":1791070047588,"version":"4.1.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2000,10,1]],"date-time":"2000-10-01T00:00:00Z","timestamp":970358400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Kidney Diseases"],"published-print":{"date-parts":[[2000,10]]},"DOI":"10.1053\/ajkd.2000.17690","type":"journal-article","created":{"date-parts":[[2013,9,29]],"date-time":"2013-09-29T15:17:18Z","timestamp":1380467838000},"page":"844-850","source":"Crossref","is-referenced-by-count":88,"title":["Cyclosporine and tacrolimus\u2013associated thrombotic microangiopathy"],"prefix":"10.1053","volume":"36","author":[{"given":"Phuong-Thu T.","family":"Pham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan H.","family":"Wilkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.Albin","family":"Gritsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Lassman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phuong-Chi T.","family":"Pham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel M.","family":"Danovitch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/ajkd.2000.17690_bib1","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1056\/NEJM198112033052306","article-title":"Nephrotoxicity of cyclosporine A after allogeneic marrow transplantation","volume":"305","author":"Shulman","year":"1981","journal-title":"N Engl J Med"},{"key":"10.1053\/ajkd.2000.17690_bib2","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1365-2141.1983.tb02067.x","article-title":"Cyclosporine A associated nephrotoxicity in the first 100 days after allogeneic bone marrow transplantation: Three distinct syndrome","volume":"54","author":"Atkinson","year":"1983","journal-title":"Br J Haematol"},{"key":"10.1053\/ajkd.2000.17690_bib3","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1016\/S0140-6736(84)90842-0","article-title":"Cyclosporine-induced haemolytic uremic syndrome in liver allograft recipient","volume":"2","author":"Bronser","year":"1984","journal-title":"Lancet"},{"key":"10.1053\/ajkd.2000.17690_bib4","first-page":"54","article-title":"De novo hemolytic uremic syndrome in renal transplant recipients immunosuppressed with cyclosporine","volume":"98","author":"Van Buren","year":"1985","journal-title":"Surgery"},{"key":"10.1053\/ajkd.2000.17690_bib5","first-page":"440","article-title":"Cyclosporine-induced hemolytic uremic syndrome in a heart transplant recipient","volume":"12","author":"Galli","year":"1993","journal-title":"J Heart Lung Transplant"},{"key":"10.1053\/ajkd.2000.17690_bib6","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/S0272-6386(12)81010-9","article-title":"Transplant-associated thrombotic microangiopathy: The role of IgG administration as initial therapy","volume":"23","author":"Hochstetler","year":"1994","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/ajkd.2000.17690_bib7","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1097\/00007890-199902270-00009","article-title":"FK506-associated thrombotic microangiopathy: Report of two cases and review of the literature","volume":"67","author":"Trimarchi","year":"1999","journal-title":"Transplantation"},{"key":"10.1053\/ajkd.2000.17690_bib8","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1016\/S0140-6736(89)92951-6","article-title":"Treatment of cyclosporine-induced haemolytic uremic syndrome with FK506","volume":"30","author":"McCauley","year":"1989","journal-title":"Lancet"},{"key":"10.1053\/ajkd.2000.17690_bib9","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1034\/j.1399-0012.1999.130614.x","article-title":"Cyclosporine-induced hemolytic uremic syndrome and hemorrhagic colitis following renal transplantation","volume":"13","author":"Lapointe","year":"1999","journal-title":"Clin Transplant"},{"key":"10.1053\/ajkd.2000.17690_bib10","first-page":"3156","article-title":"Hemolytic uremic syndrome in a renal transplant recipient on FK506 immunosuppression","volume":"23","author":"Schmidt","year":"1991","journal-title":"Transplant Proc"},{"key":"10.1053\/ajkd.2000.17690_bib11","first-page":"205","article-title":"FK506-associated thrombotic thrombocytopenic purpura","volume":"55","author":"Holman","year":"1992","journal-title":"Transplantation"},{"key":"10.1053\/ajkd.2000.17690_bib12","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1097\/00007890-199911150-00020","article-title":"Microangiopathy in kidney and simultaneous pancreas\/kidney recipients treated with tacrolimus: Evidence of endothelin and cytokine involvement","volume":"68","author":"Burke","year":"1999","journal-title":"Transplantation"},{"key":"10.1053\/ajkd.2000.17690_bib13","first-page":"2608","article-title":"Cyclosporine-induced hemolytic uremic syndrome: Factors that obscure its diagnosis","volume":"26","author":"Katznelson","year":"1994","journal-title":"Transplant Proc"},{"key":"10.1053\/ajkd.2000.17690_bib14","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/sj.bmt.1700875","article-title":"Microangiopathy without hemolysis in a patient following allogeneic bone marrow transplantation","volume":"20","author":"Akiyama","year":"1997","journal-title":"Bone Marrow Transplant"},{"key":"10.1053\/ajkd.2000.17690_bib15","first-page":"322","article-title":"Microangiopathic hemolytic anemia secondary to cyclosporine therapy in a heart and liver transplant recipient","volume":"15","author":"Oteo","year":"1996","journal-title":"J Heart Lung Transplant"},{"key":"10.1053\/ajkd.2000.17690_bib16","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1681\/ASN.V101146","article-title":"Renal thrombotic microangiopathy associated with anti-cardiolipin antibodies in hepatitis C-positive renal allograft recipients","volume":"10","author":"Baid","year":"1999","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/ajkd.2000.17690_bib17","first-page":"1474","article-title":"Thrombotic thrombocytopenic purpura in systemic lupus erythematosus and antiphospholipid antibodies: Effective treatment with plasma exchange and immunosuppression","volume":"19","author":"Hess","year":"1992","journal-title":"J Rheumatol"},{"key":"10.1053\/ajkd.2000.17690_bib18","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1097\/00007890-199806270-00018","article-title":"Thrombotic microangiopathy in association with cytomegalovirus infection in a renal transplant patient: A new treatment strategy","volume":"65","author":"Jecjeebhoy","year":"1998","journal-title":"Transplantation"},{"key":"10.1053\/ajkd.2000.17690_bib19","first-page":"1256","article-title":"Reversal of cyclosporine-associated hemolytic-uremic syndrome by plasma exchange with fresh frozen plasma replacement in renal transplant recipients","volume":"23","author":"Venkat","year":"1991","journal-title":"Transplant Proc"},{"key":"10.1053\/ajkd.2000.17690_bib20","first-page":"329","article-title":"Identification and treatment of cyclosporine-associated allograft thrombosis","volume":"100","author":"Schlanger","year":"1986","journal-title":"Surgery"},{"key":"10.1053\/ajkd.2000.17690_bib21","first-page":"455","article-title":"Cyclosporine-induced endothelial cell injury","volume":"55","author":"Zoja","year":"1986","journal-title":"Lab Invest"},{"key":"10.1053\/ajkd.2000.17690_bib22","first-page":"2398","article-title":"Effect of cyclosporine on prostacyclin synthesis by vascular tissue in rabbits","volume":"15","author":"Neild","year":"1983","journal-title":"Transplant Proc"},{"key":"10.1053\/ajkd.2000.17690_bib23","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0272-6386(89)80032-0","article-title":"Renal vascular and thrombotic effects of cyclosporine","volume":"13","author":"Remuzzi","year":"1989","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/ajkd.2000.17690_bib24","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1097\/00007890-199103000-00030","article-title":"Decrease in endothelial cell-dependent C activation induced by thrombomodulin by treatment with cyclosporine","volume":"51","author":"Garcia-Maldonado","year":"1991","journal-title":"Transplantation"},{"key":"10.1053\/ajkd.2000.17690_bib25","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1097\/00007890-198810000-00022","article-title":"Cytokine-induced procoagulant activity in monocytes and endothelial cells: Further enhancement by cyclosporine","volume":"46","author":"Carlsen","year":"1988","journal-title":"Transplantation"},{"key":"10.1053\/ajkd.2000.17690_bib26","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1097\/00007890-199311000-00032","article-title":"Cyclosporine and cremophor modulate von Willebrand factor release from cultured human endothelial cells","volume":"56","author":"Collins","year":"1993","journal-title":"Transplantation"},{"key":"10.1053\/ajkd.2000.17690_bib27","first-page":"3141","article-title":"The effects of cyclosporine A, cyclosporine G, and FK506 upon prostaglandin production in renal mesangial cells in culture","volume":"23","author":"McCauley","year":"1991","journal-title":"Transplant Proc"},{"key":"10.1053\/ajkd.2000.17690_bib28","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/0009-9120(93)90118-P","article-title":"Comparison of the effect of rapamycin and FK506 on release of prostacyclin and endothelin in vitro","volume":"26","author":"Yatscoff","year":"1993","journal-title":"Clin Biochem"},{"key":"10.1053\/ajkd.2000.17690_bib29","first-page":"3119","article-title":"FK506 is a direct glomeruloconstrictor, as determined by electrical resistance pulse sizing (ERPS)","volume":"23","author":"Lieberman","year":"1991","journal-title":"Transplant Proc"},{"key":"10.1053\/ajkd.2000.17690_bib30","first-page":"3133","article-title":"FK506 mechanism of nephrotoxicity: Stimulatory effect on endothelin secretion by cultured kidney cells and tubular cell toxicity in vitro","volume":"23","author":"Moutabarik","year":"1991","journal-title":"Transplant Proc"},{"key":"10.1053\/ajkd.2000.17690_bib31","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1056\/NEJM199811263392203","article-title":"Antibodies to von Willebrand factor-cleaving protease in acute thrombotic thrombocytopenic purpura","volume":"26","author":"Tsai","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1053\/ajkd.2000.17690_bib32","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1056\/NEJM199811263392202","article-title":"VonWillebrand factor-cleaving protease in thrombotic thrombocytopenic purpura and the hemolytic-uremic syndrome","volume":"26","author":"Furlan","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1053\/ajkd.2000.17690_bib33","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1097\/00007890-199108000-00001","article-title":"Preclinical evaluation of a new potent immunosuppressive agent, rapamycin","volume":"52","author":"Kahan","year":"1991","journal-title":"Transplantation"}],"container-title":["American Journal of Kidney Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272638600701119?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272638600701119?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T04:13:16Z","timestamp":1646626396000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0272638600701119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,10]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2000,10]]}},"alternative-id":["S0272638600701119"],"URL":"https:\/\/doi.org\/10.1053\/ajkd.2000.17690","relation":{},"ISSN":["0272-6386"],"issn-type":[{"value":"0272-6386","type":"print"}],"subject":[],"published":{"date-parts":[[2000,10]]}}}