{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:39:29Z","timestamp":1791117569931,"version":"4.1.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2000,9,1]],"date-time":"2000-09-01T00:00:00Z","timestamp":967766400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2000,9,1]],"date-time":"2000-09-01T00:00:00Z","timestamp":967766400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ajkd.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Kidney Diseases"],"published-print":{"date-parts":[[2000,9]]},"DOI":"10.1053\/ajkd.2000.9790","type":"journal-article","created":{"date-parts":[[2008,3,20]],"date-time":"2008-03-20T21:11:45Z","timestamp":1206047505000},"page":"498-506","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"title":["Tubular osteopontin expression in human glomerulonephritis and renal vasculitis"],"prefix":"10.1053","volume":"36","author":[{"given":"Hirokazu","family":"Okada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenshi","family":"Moriwaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kounosuke","family":"Konishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Souichi","family":"Sugahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidetomo","family":"Nakamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Saruta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromichi","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/ajkd.2000.9790_bib1","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0140-6736(68)90589-8","article-title":"Relationship between renal function and histologic changes found in renal biopsy specimens from patients with persistent glomerulonephritis","volume":"2","author":"Risdon","year":"1968","journal-title":"Lancet"},{"key":"10.1053\/ajkd.2000.9790_bib2","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1159\/000167514","article-title":"Significance of tubulointerstitial changes in the renal cortex for the excretory function and concentration ability of the kidney: A morphometric contribution","volume":"7","author":"Bohle","year":"1989","journal-title":"Am J Nephrol"},{"key":"10.1053\/ajkd.2000.9790_bib3","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1053\/ajkd.1998.v31.pm9631856","article-title":"Chemotactic factors and renal inflammation","volume":"6","author":"Rovin","year":"1998","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/ajkd.2000.9790_bib4","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1159\/000425088","article-title":"Possible mechanisms of renal fibrosis","volume":"118","author":"Okada","year":"1996","journal-title":"Contrib Nephrol"},{"key":"10.1053\/ajkd.2000.9790_bib5","first-page":"317","article-title":"The pathogenesis of tubulointerstitial disease associated with glomerulonephritis: The glomerular cytokine theory","volume":"21","author":"Pichler","year":"1995","journal-title":"Miner Electrolyte Metab"},{"key":"10.1053\/ajkd.2000.9790_bib6","doi-asserted-by":"crossref","first-page":"26232","DOI":"10.1074\/jbc.270.44.26232","article-title":"A biochemical characterization of the binding of osteopontin to integrins \u03b1v\u03b21 and \u03b1v\u03b25","volume":"270","author":"Hu","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1053\/ajkd.2000.9790_bib7","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1126\/science.271.5248.509","article-title":"Receptor-ligand interaction between CD44 and osteopontin (Eta-1)","volume":"271","author":"Weber","year":"1996","journal-title":"Science"},{"key":"10.1053\/ajkd.2000.9790_bib8","doi-asserted-by":"crossref","first-page":"15180","DOI":"10.1016\/S0021-9258(18)82453-X","article-title":"Structure and expression of the mRNA encoding urinary stone protein (osteopontin)","volume":"268","author":"Kohri","year":"1993","journal-title":"J Biol Chem"},{"key":"10.1053\/ajkd.2000.9790_bib9","first-page":"205","article-title":"Experimental insights into the tubulointerstitial disease accompanying primary glomerular lesions","volume":"23","author":"Eddy","year":"1994","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/ajkd.2000.9790_bib10","first-page":"915","article-title":"Tubulointerstitial disease in glomerulonephritis: Potential role of osteopontin (uropontin)","volume":"144","author":"Pichler","year":"1994","journal-title":"Am J Pathol"},{"key":"10.1053\/ajkd.2000.9790_bib11","first-page":"456","article-title":"Macrophages and progressive renal disease","volume":"71","author":"Van Goor","year":"1994","journal-title":"Lab Invest"},{"key":"10.1053\/ajkd.2000.9790_bib12","first-page":"50","article-title":"A functional role for osteopontin in experimental crescentic glomerulonephritis in the rat","volume":"110","author":"Yu","year":"1998","journal-title":"Proc Assoc Am Physician"},{"key":"10.1053\/ajkd.2000.9790_bib13","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1046\/j.1523-1755.1998.00748.x","article-title":"De novo glomerular osteopontin expression in rat crescentic glomerulonephritis","volume":"53","author":"Lan","year":"1998","journal-title":"Kidney Int"},{"key":"10.1053\/ajkd.2000.9790_bib14","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1046\/j.1523-1755.1999.00580.x","article-title":"Obstructive uropathy in the mouse: Role of osteopontin in interstitial fibrosis and apoptosis","volume":"56","author":"Ophascharoensuk","year":"1999","journal-title":"Kidney Int"},{"key":"10.1053\/ajkd.2000.9790_bib15","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1002\/art.1780251101","article-title":"The 1982 revised criteria for the classification of systemic lupus erythematosus","volume":"25","author":"Tan","year":"1982","journal-title":"Arthritis Rheum"},{"key":"10.1053\/ajkd.2000.9790_bib16","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1111\/j.1523-1755.1998.00893.x","article-title":"Accelerated fibrosis and collagen deposition develop in the renal interstitium of angiotensin type 2 receptor null mice during ureter obstruction","volume":"53","author":"Ma","year":"1998","journal-title":"Kidney Int"},{"key":"10.1053\/ajkd.2000.9790_bib17","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/0046-8177(94)90166-X","article-title":"Tubular atrophy in the end-stage kidney: A lectin and immunohistochemical study","volume":"25","author":"Nadasdy","year":"1994","journal-title":"Hum Pathol"},{"key":"10.1053\/ajkd.2000.9790_bib18","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1681\/ASN.V881324","article-title":"Immunoglobulin A nephropathy: A clinical perspective","volume":"8","author":"Donadio","year":"1997","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/ajkd.2000.9790_bib19","first-page":"108","article-title":"Morphological features in IgA nephropathy","volume":"150","author":"Ferrario","year":"1999","journal-title":"Ann Med Interne (Paris)"},{"key":"10.1053\/ajkd.2000.9790_bib20","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1007\/BF01711380","article-title":"The role of the tubulointerstitial changes in the prognosis of IgA glomerulonephritis","volume":"62","author":"Nagy","year":"1984","journal-title":"Klin Wochenschr"},{"key":"10.1053\/ajkd.2000.9790_bib21","first-page":"235","article-title":"Histological alterations in renal specimens as indicators of prognosis of IgA nephropathy","volume":"37","author":"Okada","year":"1992","journal-title":"Clin Nephrol"},{"key":"10.1053\/ajkd.2000.9790_bib22","doi-asserted-by":"crossref","first-page":"511","DOI":"10.3109\/08860229409045082","article-title":"Development of renal failure in IgA nephropathy: The importance of interstitial infiltration and deposition of fibrinogen","volume":"16","author":"Polenakowic","year":"1994","journal-title":"Ren Fail"},{"key":"10.1053\/ajkd.2000.9790_bib23","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1681\/ASN.V102413","article-title":"Lupus nephritis","volume":"10","author":"Cameron","year":"1999","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/ajkd.2000.9790_bib24","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/BF00749737","article-title":"Quantitative analysis of interstitial alterations in lupus nephritis","volume":"414","author":"Fujii","year":"1988","journal-title":"Virchows Arch A Pathol Anat Histopathol"},{"key":"10.1053\/ajkd.2000.9790_bib25","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/ki.1988.211","article-title":"Prognostic factors in diffuse proliferative lupus glomerulonephritis","volume":"34","author":"Magil","year":"1988","journal-title":"Kidney Int"},{"key":"10.1053\/ajkd.2000.9790_bib26","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1681\/ASN.V82314","article-title":"ANCA small-vessel vasculitis","volume":"8","author":"Falk","year":"1997","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/ajkd.2000.9790_bib27","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1681\/ASN.V7123","article-title":"Prognostic markers in patients with ANCA-associated microscopic polyangitis and glomerulonephritis","volume":"7","author":"Hogan","year":"1996","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/ajkd.2000.9790_bib28","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1681\/ASN.V103444","article-title":"Osteopontin expression in fetal and mature human kidney","volume":"10","author":"Hudkins","year":"1999","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/ajkd.2000.9790_bib29","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1681\/ASN.V971213","article-title":"In progressive nephropathies, overload of tubular cells with filtered proteins translates glomerular permeablity dysfunction into cellular signals of interstitial inflammation","volume":"9","author":"Abbate","year":"1998","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/ajkd.2000.9790_bib30","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1046\/j.1523-1755.1998.00137.x","article-title":"Regulation of proximal tubular osteopontin in experimental hydronephrosis in the rat","volume":"54","author":"Diamond","year":"1998","journal-title":"Kidney Int"},{"key":"10.1053\/ajkd.2000.9790_bib31","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1681\/ASN.V891383","article-title":"Osteopontin in chronic puromycin aminonucleoside nephrosis","volume":"8","author":"Magil","year":"1997","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/ajkd.2000.9790_bib32","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/ki.1994.67","article-title":"Osteopontin expression in angiotensin II-induced tubulointerstitial nephritis","volume":"45","author":"Giachelli","year":"1994","journal-title":"Kidney Int"},{"key":"10.1053\/ajkd.2000.9790_bib33","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/ki.1995.312","article-title":"Cellular proliferation and macrophage influx precede interstitial fibrosis in cyclosporine nephrotoxicity","volume":"48","author":"Young","year":"1995","journal-title":"Kidney Int"},{"key":"10.1053\/ajkd.2000.9790_bib34","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/ki.1994.67","article-title":"Osteopontin expression in angiotensin II-induced tubulointerstitial nephritis","volume":"45","author":"Giachelli","year":"1994","journal-title":"Kidney Int"},{"key":"10.1053\/ajkd.2000.9790_bib35","first-page":"915","article-title":"Tubulointerstitial disease in glomerulonephritis: Potential role of osteopontin (uropontin)","volume":"144","author":"Pichler","year":"1994","journal-title":"Am J Pathol"},{"key":"10.1053\/ajkd.2000.9790_bib36","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/ki.1995.312","article-title":"Cellular proliferation and macrophage influx precede interstitial fibrosis in cyclosporine nephrotoxicity","volume":"48","author":"Young","year":"1995","journal-title":"Kidney Int"},{"key":"10.1053\/ajkd.2000.9790_bib37","first-page":"F110","article-title":"Osteopontin expressed by renal tubular epithelium mediates interstitial monocyte infiltration in rats","volume":"278","author":"Okada","year":"2000","journal-title":"Am J Physiol"},{"key":"10.1053\/ajkd.2000.9790_bib38","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1681\/ASN.V76906","article-title":"Monocyte chemotactic peptide-1 expression in acute and chronic human nephritids: A pathogenetic role in interstitial monocytes recruitment","volume":"7","author":"Grandaliano","year":"1996","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/ajkd.2000.9790_bib39","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1093\/ndt\/14.2.304","article-title":"Nephrotoxicity of increased glomerular proteinuria traffic","volume":"14","author":"Abbate","year":"1999","journal-title":"Nephrol Dial Transplant"},{"key":"10.1053\/ajkd.2000.9790_bib40","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1046\/j.1523-1755.1998.00874.x","article-title":"Urinary protein excretion rate is the best independent predictor of ESRF in non-diabetic proteinuric chronic nephropathies","volume":"53","author":"Ruggenenti","year":"1998","journal-title":"Kidney Int"},{"key":"10.1053\/ajkd.2000.9790_bib41","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/S0002-9440(10)65330-8","article-title":"IL-1 up-regulates osteopontin expression in experimental crescentic glomerulonephritis in the rat","volume":"154","author":"Yu","year":"1999","journal-title":"Am J Pathol"},{"key":"10.1053\/ajkd.2000.9790_bib42","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1038\/ki.1997.243","article-title":"Osteopontin regulation in cultured rat renal epithelial cells","volume":"51","author":"Malyankar","year":"1997","journal-title":"Kidney Int"},{"key":"10.1053\/ajkd.2000.9790_bib43","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/ki.1996.65","article-title":"Expression of transforming growth factor-beta isoforms in human glomerular diseases","volume":"49","author":"Yamamoto","year":"1996","journal-title":"Kidney Int"},{"key":"10.1053\/ajkd.2000.9790_bib44","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/ki.1997.24","article-title":"Altered expression of fibrogenic growth factors in IgA nephropathy and focal and segmental glomerulosclerosis","volume":"51","author":"Stein-Oakley","year":"1997","journal-title":"Kidney Int"},{"key":"10.1053\/ajkd.2000.9790_bib45","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1046\/j.1365-2249.1996.d01-715.x","article-title":"Transforming growth factor-beta expression and interaction with proteinase 3 in anti-neutrophil cytoplasmic antibody-associated vasculitis","volume":"105","author":"Csernok","year":"1996","journal-title":"Clin Exp Immunol"},{"key":"10.1053\/ajkd.2000.9790_bib46","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1093\/ndt\/14.7.1627","article-title":"Necrotizing crescentic glomerulonephritis in ANCA-associated vasculitis: The role of monocytes","volume":"14","author":"Ferrario","year":"1999","journal-title":"Nephrol Dial Transplant"},{"key":"10.1053\/ajkd.2000.9790_bib47","first-page":"1455","article-title":"Early and persistent up-regulated expression of renal cortical osteopontin in experimental hydronephrosis","volume":"146","author":"Diamond","year":"1995","journal-title":"Am J Pathol"},{"key":"10.1053\/ajkd.2000.9790_bib48","first-page":"F563","article-title":"Early role of Fsp1 in epithelial-mesenchymal transformation","volume":"273","author":"Okada","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1053\/ajkd.2000.9790_bib49","first-page":"1","article-title":"Coexpression of keratin and vimentin in damaged and regenerating tubular epithelia of the kidney","volume":"129","author":"Grone","year":"1987","journal-title":"Am J Pathol"},{"key":"10.1053\/ajkd.2000.9790_bib50","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1681\/ASN.V871043","article-title":"Ultrastructural localization of osteopontin in the kidney: Induction by lipopolysaccharide","volume":"8","author":"Madsen","year":"1997","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/ajkd.2000.9790_bib51","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1096\/fasebj.7.15.8262332","article-title":"Osteopontin: A protein with diverse functions","volume":"7","author":"Denhardt","year":"1993","journal-title":"FASEB J"}],"container-title":["American Journal of Kidney Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272638600744088?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272638600744088?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T01:18:05Z","timestamp":1759454285000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0272638600744088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,9]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2000,9]]}},"alternative-id":["S0272638600744088"],"URL":"https:\/\/doi.org\/10.1053\/ajkd.2000.9790","relation":{},"ISSN":["0272-6386"],"issn-type":[{"value":"0272-6386","type":"print"}],"subject":[],"published":{"date-parts":[[2000,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tubular osteopontin expression in human glomerulonephritis and renal vasculitis","name":"articletitle","label":"Article Title"},{"value":"American Journal of Kidney Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/ajkd.2000.9790","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2000 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}