{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T04:12:22Z","timestamp":1777349542104,"version":"3.51.4"},"reference-count":46,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2001,12,1]],"date-time":"2001-12-01T00:00:00Z","timestamp":1007164800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Kidney Diseases"],"published-print":{"date-parts":[[2001,12]]},"DOI":"10.1053\/ajkd.2001.29283","type":"journal-article","created":{"date-parts":[[2008,3,21]],"date-time":"2008-03-21T01:11:45Z","timestamp":1206061905000},"page":"1430-1436","source":"Crossref","is-referenced-by-count":27,"title":["Strategies to minimize bone disease in renal failure"],"prefix":"10.1053","volume":"38","author":[{"given":"Kevin J.","family":"Martin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther A.","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1053\/ajkd.2001.29283_bib1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/ki.1990.187","article-title":"Renal bone disease 1990: An unmet challenge for the nephrologist","volume":"38","author":"Malluche","year":"1990","journal-title":"Kidney Int"},{"key":"10.1053\/ajkd.2001.29283_bib2","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/ki.1993.64","article-title":"The spectrum of bone disease in end-stage renal failure\u2014an evolving disorder","volume":"43","author":"Sherrard","year":"1993","journal-title":"Kidney Int"},{"key":"10.1053\/ajkd.2001.29283_bib3","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1172\/JCI106517","article-title":"On the pathogenesis of hyperparathyroidism in chronic experimental renal insufficiency in the dog","volume":"50","author":"Slatopolsky","year":"1971","journal-title":"J Clin Invest"},{"key":"10.1053\/ajkd.2001.29283_bib4","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/ki.1973.92","article-title":"The role of phosphorus restriction in the prevention of secondary hyperparathyroidism in chronic renal disease","volume":"4","author":"Slatopolsky","year":"1973","journal-title":"Kidney Int"},{"key":"10.1053\/ajkd.2001.29283_bib5","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1172\/JCI108781","article-title":"Phosphate control and 25-hydroxycholecalciferol administration in preventing experimental renal osteodystrophy in the dog","volume":"60","author":"Rutherford","year":"1977","journal-title":"J Clin Invest"},{"key":"10.1053\/ajkd.2001.29283_bib6","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1172\/JCI118701","article-title":"Phosphorus restriction prevents parathyroid gland growth. High phosphorus directly stimulates PTH secretion in vitro","volume":"97","author":"Slatopolsky","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1053\/ajkd.2001.29283_bib7","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1002\/jbmr.5650110714","article-title":"Direct effect of phosphorus on PTH secretion from whole rat parathyroid glands in vitro","volume":"11","author":"Almaden","year":"1996","journal-title":"J Bone Miner Res"},{"key":"10.1053\/ajkd.2001.29283_bib8","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1681\/ASN.V9101845","article-title":"High phosphate level directly stimulates parathyroid hormone secretion and synthesis by human parathyroid tissue in vitro","volume":"9","author":"Almaden","year":"1998","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/ajkd.2001.29283_bib9","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1172\/JCI118224","article-title":"Parathyroid cell proliferation in normal and chronic renal failure rats. The effects of calcium, phosphate, and vitamin D","volume":"96","author":"Naveh-Many","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1053\/ajkd.2001.29283_bib10","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/S0272-6386(96)90473-4","article-title":"Phosphorus accelerates the development of parathyroid hyperplasia and secondary hyperparathyroidism in rats with renal failure","volume":"28","author":"Denda","year":"1996","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/ajkd.2001.29283_bib11","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/S0272-6386(00)70064-3","article-title":"Re-evaluation of risks associated with hyperphosphatemia and hyperparathyroidism in dialysis patients: Recommendations for a change in management","volume":"35","author":"Block","year":"2000","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/ajkd.2001.29283_bib12","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1053\/ajkd.1998.v31.pm9531176","article-title":"Association of serum phosphorus and calcium x phosphate product with mortality risk in chronic hemodialysis patients: A national study","volume":"31","author":"Block","year":"1998","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/ajkd.2001.29283_bib13","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1093\/ndt\/9.8.1121","article-title":"Calcium acetate versus calcium carbonate as phosphate-binding agents in chronic haemodialysis","volume":"9","author":"Pflanz","year":"1994","journal-title":"Nephrol Dial Transplant"},{"key":"10.1053\/ajkd.2001.29283_bib14","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1159\/000168713","article-title":"Calcium acetate versus calcium carbonate for the control of serum phosphorus in hemodialysis patients","volume":"14","author":"Almirall","year":"1994","journal-title":"Am J Nephrol"},{"key":"10.1053\/ajkd.2001.29283_bib15","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1681\/ASN.V3196","article-title":"Calcium acetate as a phosphorus binder in hemodialysis patients","volume":"3","author":"Delmez","year":"1992","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/ajkd.2001.29283_bib16","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1056\/NEJM198607173150304","article-title":"Calcium carbonate as a phosphate binder in patients with chronic renal failure undergoing dialysis","volume":"315","author":"Slatopolsky","year":"1986","journal-title":"N Engl J Med"},{"key":"10.1053\/ajkd.2001.29283_bib17","first-page":"314","article-title":"Use of calcium carbonate as a phosphate binder in dialysis patients","volume":"12","author":"Hercz","year":"1986","journal-title":"Miner Electrolyte Metab"},{"key":"10.1053\/ajkd.2001.29283_bib18","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1056\/NEJM198908033210502","article-title":"Intravenous calcitriol in the treatment of refractory osteitis fibrosa of chronic renal failure","volume":"321","author":"Andress","year":"1989","journal-title":"N Engl J Med"},{"key":"10.1053\/ajkd.2001.29283_bib19","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1038\/ki.1994.375","article-title":"Evidence of healing of secondary hyperparathyroidism in chronically hemodialyzed uremic patients treated with long-term intravenous calcitriol","volume":"46","author":"Cannella","year":"1994","journal-title":"Kidney Int"},{"key":"10.1053\/ajkd.2001.29283_bib20","first-page":"S41","article-title":"The parathyroid-calcitriol axis in health and chronic renal failure","volume":"29","author":"Slatopolsky","year":"1990","journal-title":"Kidney Int Suppl"},{"key":"10.1053\/ajkd.2001.29283_bib21","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1172\/JCI112714","article-title":"Regulation by vitamin D metabolites of parathyroid hormone gene transcription in vivo in the rat","volume":"78","author":"Silver","year":"1986","journal-title":"J Clin Invest"},{"key":"10.1053\/ajkd.2001.29283_bib22","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1172\/JCI114931","article-title":"Regulation of 1,25-dihydroxyvitamin D3 receptor gene expression by 1,25-dihydroxyvitamin D3 in the parathyroid in vivo","volume":"86","author":"Naveh-Many","year":"1990","journal-title":"J Clin Invest"},{"key":"10.1053\/ajkd.2001.29283_bib23","first-page":"F454","article-title":"Rat calcium-sensing receptor is regulated by vitamin D but not by calcium","volume":"270","author":"Brown","year":"1996","journal-title":"Am J Physiol"},{"key":"10.1053\/ajkd.2001.29283_bib24","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/ki.1976.60","article-title":"Skeletal resistance to the calcemic action of parathyroid hormone in uremia: Role of 1,25 (OH)2 D3","volume":"9","author":"Massry","year":"1976","journal-title":"Kidney Int"},{"key":"10.1053\/ajkd.2001.29283_bib25","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/ki.1986.252","article-title":"The absorption of dietary phosphorus and calcium in hemodialysis patients","volume":"30","author":"Ramirez","year":"1986","journal-title":"Kidney Int"},{"key":"10.1053\/ajkd.2001.29283_bib26","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1681\/ASN.V981427","article-title":"19-Nor-1-\u03b1-25-dihydroxyvitamin D2 (Paricalcitol) safely and effectively reduces the levels of intact PTH in patients on hemodialysis","volume":"10","author":"Martin","year":"1998","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/ajkd.2001.29283_bib27","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1053\/ajkd.2000.16193","article-title":"Intermittent doxercalciferol (1-alpha-hydroxyvitamin D(2)) therapy for secondary hyperparathyroidism","volume":"36","author":"Frazao","year":"2000","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/ajkd.2001.29283_bib28","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1053\/ajkd.1998.v32.pm9708607","article-title":"Controlled trial of falecalcitriol versus alfacalcidol in suppression of parathyroid hormone in hemodialysis patients with secondary hyperparathyroidism","volume":"32","author":"Akiba","year":"1998","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/ajkd.2001.29283_bib29","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1093\/ndt\/11.supp3.121","article-title":"Effect of 22-oxacalcitriol on hyperparathyroidism of dialysis patients: Results of a preliminary study","volume":"11","author":"Kurokawa","year":"1996","journal-title":"Nephrol Dial Transplant"},{"key":"10.1053\/ajkd.2001.29283_bib30","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1159\/000184946","article-title":"Suppression of serum parathyroid hormone levels by intravenous alphacalcidol in uremic patients on maintenance hemodialysis. A pilot study","volume":"48","author":"Lind","year":"1988","journal-title":"Nephron"},{"key":"10.1053\/ajkd.2001.29283_bib31","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1046\/j.1365-2796.1998.00323.x","article-title":"Long-term effects of intermittent oral alphacalcidol, calcium carbonate and low-calcium dialysis (1.25 mmol L-1) on secondary hyperparathyroidism in patients on continuous ambulatory peritoneal dialysis","volume":"244","author":"Brandi","year":"1998","journal-title":"J Intern Med"},{"key":"10.1053\/ajkd.2001.29283_bib32","first-page":"573A","article-title":"Differential effects of 19-nor-1,25-(OH)2D2 on calcium and phosphate resorption in bone","volume":"8","author":"Finch","year":"1997","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/ajkd.2001.29283_bib33","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/0272-6386(95)90455-7","article-title":"A new analog of calcitriol, 19-nor-1,25-(OH)2D2, suppresses parathyroid hormone secretion in uremic rats in the absence of hypercalcemia","volume":"26","author":"Slatopolsky","year":"1995","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/ajkd.2001.29283_bib34","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0272-6386(97)90571-0","article-title":"A new analog of 1,25-(OH)2D3, 19-NOR-1,25-(OH)2D2, suppresses serum PTH and parathyroid gland growth in uremic rats without elevation of intestinal vitamin D receptor content","volume":"30","author":"Takahashi","year":"1997","journal-title":"Am J Kidney Dis"},{"issue":"suppl 2","key":"10.1053\/ajkd.2001.29283_bib35","doi-asserted-by":"crossref","first-page":"S61","DOI":"10.1053\/ajkd.1998.v32.pm9808145","article-title":"Therapy of secondary hyperparathyroidism with 19-nor-1\u03b1,25-dihydroxyvitamin D2","volume":"32","author":"Martin","year":"1998","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/ajkd.2001.29283_bib36","first-page":"574A","article-title":"Differential potencies of 1,25(OH)2D3 and 19-nor-1,25(OH)2D2 on bone resorption in hemodialysis patients","volume":"11","author":"Coyne","year":"2000","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/ajkd.2001.29283_bib37","first-page":"578A","article-title":"A comparative study between 19-nor-1-alpha-25-dihydroxyvitamin D2 and intravenous calcitriol on PTH suppression in hemodialysis patients","volume":"11","author":"Lerma","year":"2000","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/ajkd.2001.29283_bib38","doi-asserted-by":"crossref","first-page":"432","DOI":"10.3181\/00379727-178-42028","article-title":"1-alpha-hydroxyvitamin D2 is less toxic than 1 alpha-hydroxyvitamin D3 in the rat","volume":"178","author":"Sjoden","year":"1985","journal-title":"Proc Soc Exp Biol Med"},{"key":"10.1053\/ajkd.2001.29283_bib39","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s002239900261","article-title":"1-alpha-hydroxyvitamin D2 partially dissociates between preservation of cancellous bone mass and effects on calcium homeostasis in ovariectomized rats","volume":"60","author":"Erben","year":"1997","journal-title":"Calcif Tissue Int"},{"key":"10.1053\/ajkd.2001.29283_bib40","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1359\/jbmr.2001.16.4.639","article-title":"1alpha-hydroxyvitamin D2 is less toxic but not bone selective relative to 1-alpha-hydroxyvitamin D3 in ovariectomized rats","volume":"16","author":"Weber","year":"2001","journal-title":"J Bone Miner Res"},{"key":"10.1053\/ajkd.2001.29283_bib41","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1053\/ajkd.2001.22077","article-title":"Efficacy and side effects of intermittent intravenous and oral doxercalciferol (1alpha-hydroxyvitamin D(2)) in dialysis patients with secondary hyperparathyroidism: A sequential comparison","volume":"37","author":"Maung","year":"2001","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/ajkd.2001.29283_bib42","doi-asserted-by":"crossref","first-page":"S70","DOI":"10.1046\/j.1523-1755.1999.07308.x","article-title":"Low bone turnover in patients with renal failure","volume":"73","author":"Couttenye","year":"1999","journal-title":"Kidney Int Suppl"},{"key":"10.1053\/ajkd.2001.29283_bib43","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/0272-6386(95)90453-0","article-title":"Relationship between intact 1-84 parathyroid hormone and bone histomorphometric parameters in dialysis patients without aluminum toxicity","volume":"26","author":"Wang","year":"1995","journal-title":"Am J Kidney Dis"},{"key":"10.1053\/ajkd.2001.29283_bib44","first-page":"145","article-title":"Intact parathyroid hormone overestimates the presence and severity of parathyroid-mediated osseous abnormalities in uremia","volume":"75","author":"Quarles","year":"1992","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1053\/ajkd.2001.29283_bib45","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1093\/oxfordjournals.ndt.a027950","article-title":"Long-term effects of sevelamer hydrochloride on the calcium x phosphate product and lipid profile of haemodialysis patients","volume":"15","author":"Chertow","year":"2000","journal-title":"Nephrol Dial Transplant"},{"key":"10.1053\/ajkd.2001.29283_bib46","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1046\/j.1523-1755.2000.00183.x","article-title":"A calcimimetic agent lowers plasma parathyroid hormone levels in patients with secondary hyperparathyroidism","volume":"58","author":"Goodman","year":"2000","journal-title":"Kidney Int"}],"container-title":["American Journal of Kidney Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272638601282869?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272638601282869?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T07:02:26Z","timestamp":1630911746000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0272638601282869"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,12]]},"references-count":46,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2001,12]]}},"alternative-id":["S0272638601282869"],"URL":"https:\/\/doi.org\/10.1053\/ajkd.2001.29283","relation":{},"ISSN":["0272-6386"],"issn-type":[{"value":"0272-6386","type":"print"}],"subject":[],"published":{"date-parts":[[2001,12]]}}}