{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T21:46:24Z","timestamp":1783633584992,"version":"3.55.0"},"reference-count":133,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2002,3,1]],"date-time":"2002-03-01T00:00:00Z","timestamp":1014940800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2002,3,1]],"date-time":"2002-03-01T00:00:00Z","timestamp":1014940800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Best Practice &amp; Research Clinical Endocrinology &amp; Metabolism"],"published-print":{"date-parts":[[2002,3]]},"DOI":"10.1053\/beem.2002.0188","type":"journal-article","created":{"date-parts":[[2002,12,10]],"date-time":"2002-12-10T20:48:30Z","timestamp":1039553310000},"page":"165-189","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"title":["Treatment of central precocious puberty"],"prefix":"10.1053","volume":"16","author":[{"given":"Carl-Joachim","family":"Partsch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang G.","family":"Sippell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/beem.2002.0188_RF1","series-title":"Williams Textbook of Endocrinology","first-page":"1509","article-title":"Puberty: Ontogeny, neuroendocrinology, physiology, and disorders","author":"Grumbach","year":"1998"},{"key":"10.1053\/beem.2002.0188_RF2","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1542\/peds.104.4.936","article-title":"Reexamination of the age limit for defining when puberty is precocious in girls in the United States: implications for evaluation and treatment. Drug and Therapeutics and Executive Committees of the Lawson Wilkins Pediatric Endocrine Society","volume":"104","author":"Kaplowitz","year":"1999","journal-title":"Pediatrics"},{"key":"10.1053\/beem.2002.0188_RF3","first-page":"229","article-title":"Pubertal development in Swiss girls","volume":"38","author":"Largo","year":"1983","journal-title":"Helvetica Paediatrica Acta"},{"key":"10.1053\/beem.2002.0188_RF4","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1136\/adc.44.235.291","article-title":"Variations in the pattern of pubertal changes in girls","volume":"44","author":"Marshall","year":"1969","journal-title":"Archives of Disease in Childhood"},{"key":"10.1053\/beem.2002.0188_RF5","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1111\/j.1651-2227.1995.tb13569.x","article-title":"Sexual maturation in East German girls","volume":"84","author":"Engelhardt","year":"1995","journal-title":"Acta Paediatrica"},{"key":"10.1053\/beem.2002.0188_RF6","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1203\/00006450-200003000-00006","article-title":"Continuing positive secular growth change in the Netherlands 1955-1997","volume":"47","author":"Fredriks","year":"2000","journal-title":"Pediatric Research"},{"key":"10.1053\/beem.2002.0188_RF7","first-page":"211","article-title":"Pubertal development in Swiss boys","volume":"38","author":"Largo","year":"1983","journal-title":"Helvetica Paediatrica Acta"},{"key":"10.1053\/beem.2002.0188_RF8","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1136\/adc.45.239.13","article-title":"Variations in the pattern of pubertal changes in boys","volume":"45","author":"Marshall","year":"1970","journal-title":"Archives of Disease in Childhood"},{"key":"10.1053\/beem.2002.0188_RF9","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1111\/j.1651-2227.1996.tb14152.x","article-title":"Sexual maturation in East German boys","volume":"85","author":"Willers","year":"1996","journal-title":"Acta Paediatrica"},{"key":"10.1053\/beem.2002.0188_RF10","series-title":"Medicine for the Practicing Physician","first-page":"526","article-title":"Precocious puberty","author":"Cutler","year":"1988"},{"key":"10.1053\/beem.2002.0188_RF11","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1001\/jama.1982.03330100003001","article-title":"For puberty that comes too soon, new treatment highly effective","volume":"248","author":"Gonzalez","year":"1982","journal-title":"Journal of the American Medical Association"},{"key":"10.1053\/beem.2002.0188_RF12","first-page":"223","article-title":"Advances in the treatment of precocious puberty","volume":"41","author":"Kappy","year":"1994","journal-title":"Advances in Pediatrics"},{"key":"10.1053\/beem.2002.0188_RF13","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1136\/adc.70.2.116","article-title":"Sexual precocity: sex incidence and aetiology","volume":"70","author":"Bridges","year":"1994","journal-title":"Archives of Disease in Childhood"},{"key":"10.1053\/beem.2002.0188_RF14","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1515\/JPEM.2000.13.S1.695","article-title":"Etiology and age incidence of precocious puberty in girls: a multicentric study","volume":"13","author":"Cisternino","year":"2000","journal-title":"Journal of Pediatric Endocrinology and Metabolism"},{"key":"10.1053\/beem.2002.0188_RF15","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1515\/JPEM.2000.13.S1.687","article-title":"Etiology of central precocious puberty in males: the results of the Italian Study Group for Physiopathology of Puberty","volume":"13","author":"De Sanctis","year":"2000","journal-title":"Journal of Pediatric Endocrinology and Metabolism"},{"key":"10.1053\/beem.2002.0188_RF16","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1111\/j.1651-2227.1985.tb10063.x","article-title":"Isosexual precocious puberty in girls","volume":"74","author":"Lyon","year":"1985","journal-title":"Acta Paediatrica Scandinavica"},{"key":"10.1053\/beem.2002.0188_RF17","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1007\/s001120050474","article-title":"Treatment of progressive central precocious puberty with leuprorelin depot","volume":"147","author":"Partsch","year":"1999","journal-title":"Monatsschrift Kinderheilkunde"},{"key":"10.1053\/beem.2002.0188_RF18","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1259\/0007-1285-68-805-34","article-title":"Idiopathic isosexual central precocious puberty: magnetic resonance findings in 30 patients","volume":"68","author":"Robben","year":"1995","journal-title":"British Journal of Radiology"},{"key":"10.1053\/beem.2002.0188_RF19","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1515\/JPEM.2000.13.S1.703","article-title":"Central precocious puberty: clinical and imaging aspects","volume":"13","author":"Cassio","year":"2000","journal-title":"Journal of Pediatric Endocrinology and Metabolism"},{"key":"10.1053\/beem.2002.0188_RF20","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1210\/jcem-59-5-888","article-title":"Luteinizing hormone-releasing hormone analog treatment of boys with hypothalamic hamartoma and true precocious puberty","volume":"59","author":"Comite","year":"1984","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1053\/beem.2002.0188_RF21","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1136\/adc.80.3.231","article-title":"Treatment of gonadotropin dependent precocious puberty due to hypothalamic hamartoma with gonadotropin-releasing hormone agonist depot","volume":"80","author":"De Brito","year":"1999","journal-title":"Archives of Disease in Childhood"},{"key":"10.1053\/beem.2002.0188_RF22","first-page":"118","article-title":"The luteinizing hormone-releasing hormone-secreting hypothalamic hamartoma is a congenital malformation: natural history","volume":"77","author":"Mahachoklertwattana","year":"1993","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1053\/beem.2002.0188_RF23","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1542\/peds.103.6.1257","article-title":"Growth, puberty, and endocrine functions in patients with sporadic or familial neurofibromatosis type 1: a longitudinal study","volume":"103","author":"Carmi","year":"1999","journal-title":"Pediatrics"},{"key":"10.1053\/beem.2002.0188_RF24","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1515\/JPEM.2000.13.S1.841","article-title":"Neurofibromatosis type 1 and precocious puberty","volume":"13","author":"Virdis","year":"2000","journal-title":"Journal of Pediatric Endocrinology and Metabolism"},{"key":"10.1053\/beem.2002.0188_RF25","first-page":"467","article-title":"True precocious puberty: a long-term complication in children with shunted non-tumoral hydrocephalus","volume":"40","author":"De Luca","year":"1985","journal-title":"Helvetica Paediatrica Acta"},{"key":"10.1053\/beem.2002.0188_RF26","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1136\/adc.74.6.490","article-title":"Accelerated pubertal development in patients with shunted hydrocephalus","volume":"74","author":"Lopponen","year":"1996","journal-title":"Archives of Disease in Childhood"},{"key":"10.1053\/beem.2002.0188_RF27","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1097\/01241398-198401000-00007","article-title":"Precocious puberty in myelomeningocele patients","volume":"4","author":"Meyer","year":"1984","journal-title":"Journal of Pediatric Orthopaedics"},{"key":"10.1053\/beem.2002.0188_RF28","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1651-2227.1996.tb13894.x","article-title":"Growth and pubertal development in patients with meningomyelocele: a retrospective analysis","volume":"85","author":"Trollmann","year":"1996","journal-title":"Acta Paediatrica"},{"key":"10.1053\/beem.2002.0188_RF29","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/0887-8994(90)90042-Y","article-title":"Neonatal encephalopathy: an indicator for early sexual maturation in girls","volume":"6","author":"Robertson","year":"1990","journal-title":"Pediatric Neurology"},{"key":"10.1053\/beem.2002.0188_RF30","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1056\/NEJM198410043111414","article-title":"Precocious puberty after hypothalamic and pituitary irradiation in young children","volume":"311","author":"Brauner","year":"1984","journal-title":"New England Journal of Medicine"},{"key":"10.1053\/beem.2002.0188_RF31","first-page":"1282","article-title":"Cranial irradiation and early puberty","volume":"78","author":"Ogilvy-Stuart","year":"1994","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1053\/beem.2002.0188_RF32","first-page":"117","article-title":"Early puberty in Williams syndrome","volume":"8","author":"Cherniske","year":"1999","journal-title":"Clinical Dysmorphology"},{"key":"10.1053\/beem.2002.0188_RF33","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S0022-3476(99)70376-8","article-title":"Longitudinal development of height, growth rate, bone maturation and puberty in girls and boys with Williams\u2013Beuren syndrome","volume":"134","author":"Partsch","year":"1999","journal-title":"Journal of Pediatrics"},{"key":"10.1053\/beem.2002.0188_RF34","series-title":"Pediatric Endocrinology. Physiology, Pathophysiology, and Clinical Aspects","first-page":"387","article-title":"Precocious puberty","author":"Brauner","year":"1993"},{"key":"10.1053\/beem.2002.0188_RF35","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0022-3476(86)80767-3","article-title":"The NIH experience with precocious puberty: diagnostic subgroups and response to short-term luteinizing hormone-releasing hormone analogue therapy","volume":"108","author":"Pescovitz","year":"1986","journal-title":"Journal of Pediatrics"},{"key":"10.1053\/beem.2002.0188_RF36","series-title":"Precocious Sexual Development, A Clinical Study of 100 Children","author":"Thamdrup","year":"1961"},{"key":"10.1053\/beem.2002.0188_RF37","series-title":"Sexual Precocity: Etiology, Diagnosis, and Management","first-page":"109","article-title":"Modifying the outcome of complete precocious puberty. To treat or not to treat","author":"Kreiter","year":"1993"},{"key":"10.1053\/beem.2002.0188_RF38","first-page":"70","article-title":"Spontaneously regressive central precocious puberty in girls. Impact on therapeutic indications in precocious puberty","volume":"34","author":"Brauner","year":"1987","journal-title":"Annales de P\u00e9diatrie"},{"key":"10.1053\/beem.2002.0188_RF39","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1067\/mpd.2000.109201","article-title":"Do all girls with apparent idiopathic precocious puberty require gonadotropin-releasing hormone agonist treatment?","volume":"137","author":"L\u00e9ger","year":"2000","journal-title":"Journal of Pediatrics"},{"key":"10.1053\/beem.2002.0188_RF40","first-page":"415","article-title":"Unsustained or slowly progressive puberty in young girls: initial presentation and long-term follow-up of 20 untreated patients","volume":"84","author":"Palmert","year":"1999","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1053\/beem.2002.0188_RF41","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1007\/s001120050310","article-title":"Self-remitting or transient precocious puberty","volume":"146","author":"Partsch","year":"1998","journal-title":"Monatsschrift Kinderheilkunde"},{"key":"10.1053\/beem.2002.0188_RF42","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1515\/JPEM.2000.13.S1.827","article-title":"Premature thelarche: clinical follow-up and indication for treatment","volume":"13","author":"Stanhope","year":"2000","journal-title":"Journal of Pediatric Endocrinology and Metabolism"},{"key":"10.1053\/beem.2002.0188_RF43","series-title":"The Neurobiology of Puberty","first-page":"199","article-title":"Pathophysiology of central precocious puberty","author":"Schroor","year":"1995"},{"key":"10.1053\/beem.2002.0188_RF44","first-page":"284","article-title":"The significance and characteristics of the LHRH test in diagnosing precocious puberty development in girls: the stimulated LH\/FSH ratio differentiates between central precocious puberty and premature thelarche","volume":"137","author":"Partsch","year":"1989","journal-title":"Monatsschrift Kinderheilkunde"},{"key":"10.1053\/beem.2002.0188_RF45","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1210\/jcem.84.2.5533","article-title":"Precocious puberty: who has it? who should be treated?","volume":"84","author":"Oerter Klein","year":"1999","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1053\/beem.2002.0188_RF46","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1159\/000183956","article-title":"Psychosocial aspects of precocious puberty","volume":"41","author":"Ehrhardt","year":"1994","journal-title":"Hormone Research"},{"key":"10.1053\/beem.2002.0188_RF47","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1159\/000181825","article-title":"Growth analysis up to final height and psychosocial adjustment of treated and untreated patients with precocious puberty","volume":"34","author":"Schoevaart","year":"1990","journal-title":"Hormone Research"},{"key":"10.1053\/beem.2002.0188_RF48","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1001\/archpedi.1988.02150040085025","article-title":"Sexual precocity in girls: an association with sexual abuse?","volume":"142","author":"Herman-Giddens","year":"1988","journal-title":"American Journal of Diseases in Childhood"},{"key":"10.1053\/beem.2002.0188_RF49","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/S0022-3476(05)83200-7","article-title":"Selection of children with precocious puberty for treatment with gonadotropin releasing hormone analogs","volume":"124","author":"Rosenfield","year":"1994","journal-title":"Journal of Pediatrics"},{"key":"10.1053\/beem.2002.0188_RF50","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1210\/jcem-71-4-785","article-title":"Clinical review 14: pathophysiology and treatment of sexual precocity","volume":"71","author":"Kaplan","year":"1990","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1053\/beem.2002.0188_RF51","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1007\/BF02171554","article-title":"Treatment of children with central precocious puberty by a slow-release GnRH agonist","volume":"149","author":"Oostdijk","year":"1990","journal-title":"European Journal of Pediatrics"},{"key":"10.1053\/beem.2002.0188_RF52","series-title":"The Neurobiology of Puberty","first-page":"319","article-title":"Hormonal evaluation during and after long-term treatment with a slow-release GnRH agonist of children with central precocious puberty; effect on final height","author":"Oostdijk","year":"1995"},{"key":"10.1053\/beem.2002.0188_RF53","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1007\/s001120050493","article-title":"Pubertal signs in a male infant","volume":"147","author":"Partsch","year":"1999","journal-title":"Monatsschrift Kinderheilkunde"},{"key":"10.1053\/beem.2002.0188_RF54","first-page":"44","article-title":"The effects of cyproterone acetate on statural growth in children with precocious puberty","volume":"115","author":"Sorgo","year":"1987","journal-title":"Acta Endocrinologica"},{"key":"10.1053\/beem.2002.0188_RF55","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1056\/NEJM199101103240205","article-title":"Gonadotropin-releasing hormone and its analogues","volume":"324","author":"Conn","year":"1991","journal-title":"New England Journal of Medicine"},{"key":"10.1053\/beem.2002.0188_RF56","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1056\/NEJM198112243052602","article-title":"Short-term treatment of idiopathic precocious puberty with a long-acting analogue of luteinizing hormone-releasing hormone","volume":"305","author":"Comite","year":"1981","journal-title":"New England Journal of Medicine"},{"key":"10.1053\/beem.2002.0188_RF57","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1210\/jcem-52-2-370","article-title":"Therapeutic use of pituitary desensitization with a long-acting LHRH agonist: a potential new treatment for idiopathic precocious puberty","volume":"52","author":"Crowley","year":"1981","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1053\/beem.2002.0188_RF58","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/S0140-6736(81)91155-7","article-title":"D-Trp6-analogue of luteinising hormone releasing hormone in combination with cyproterone acetate to treat precocious puberty","volume":"ii","author":"Laron","year":"1981","journal-title":"Lancet"},{"key":"10.1053\/beem.2002.0188_RF59","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1210\/jcem.84.6.5647","article-title":"Final height after long-term treatment with triptorelin slow release for central precocious puberty: importance of statural growth after interruption of treatment","volume":"84","author":"Carel","year":"1999","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1053\/beem.2002.0188_RF60","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1210\/jcem-62-4-670","article-title":"Long term treatment of male and female precocious puberty by periodic administration of a long-acting preparation of D-Trp-6-LHRH microcapsules","volume":"62","author":"Roger","year":"1986","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1053\/beem.2002.0188_RF61","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1530\/eje.0.1320699","article-title":"Treatment of central precocious puberty with depot leuprorelin. French Leuprorelin Trial Group","volume":"132","author":"Carel","year":"1995","journal-title":"European Journal of Endocrinology"},{"key":"10.1053\/beem.2002.0188_RF62","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/S0022-3476(05)81162-X","article-title":"Two-year results of treatment with depot leuprolide acetate for central precocious puberty","volume":"121","author":"Neely","year":"1992","journal-title":"Journal of Pediatrics"},{"key":"10.1053\/beem.2002.0188_RF63","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1210\/jcem-69-3-689","article-title":"Depot leuprolide acetate for treatment of precocious puberty","volume":"69","author":"Parker","year":"1989","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1053\/beem.2002.0188_RF64","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1159\/000182709","article-title":"Comparison of complete and incomplete suppression of pituitary\u2013gonadal activity in girls with central precocious puberty: influence on growth and predicted final height. The German\u2013Dutch Precocious Puberty Study Group","volume":"39","author":"Partsch","year":"1993","journal-title":"Hormone Research"},{"key":"10.1053\/beem.2002.0188_RF65","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1111\/j.1651-2227.1994.tb12984.x","article-title":"Final height in girls with central precocious puberty: comparison of two different luteinizing hormone-releasing hormone agonist treatments","volume":"83","author":"Antoniazzi","year":"1994","journal-title":"Acta Paediatrica"},{"key":"10.1053\/beem.2002.0188_RF66","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1136\/adc.75.4.292","article-title":"Final height in central precocious puberty after long term treatment with a slow release GnRH agonist","volume":"75","author":"Oostdijk","year":"1996","journal-title":"Archives of Disease in Childhood"},{"key":"10.1053\/beem.2002.0188_RF67","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1210\/jcem-73-1-50","article-title":"Depot leuprolide acetate dosage for sexual precocity","volume":"73","author":"Parker","year":"1991","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1053\/beem.2002.0188_RF68","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1507\/endocrj1954.38.369","article-title":"A dose finding study of a super long-acting luteinizing hormone-releasing hormone analog (leuprolide acetate depot, TAP-144-SR) in the treatment of precocious puberty","volume":"38","author":"Tanaka","year":"1991","journal-title":"Endocrinologica Japonica"},{"key":"10.1053\/beem.2002.0188_RF69","series-title":"The Neurobiology of Puberty","first-page":"297","article-title":"Treatment of girls with central precocious puberty with depot GnRH analogue therapy","author":"Parker","year":"1995"},{"key":"10.1053\/beem.2002.0188_RF70","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1001\/archpedi.1994.02170040035006","article-title":"Laboratory monitoring of children with precocious puberty","volume":"148","author":"Lee","year":"1994","journal-title":"Archives of Pediatric and Adolescent Medicine"},{"key":"10.1053\/beem.2002.0188_RF71","first-page":"4536","article-title":"A single sample subcutaneous luteinizing hormone (LH)-releasing hormone (LHRH) stimulation test for monitoring LH suppression in children with central precocious puberty receiving LHRH agonists","volume":"84","author":"Lawson","year":"1999","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1053\/beem.2002.0188_RF72","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1159\/000023275","article-title":"Central precocious puberty: a single blood sample after gonadotropin-releasing hormone agonist administration in monitoring treatment","volume":"50","author":"Salerno","year":"1998","journal-title":"Hormone Research"},{"key":"10.1053\/beem.2002.0188_RF73","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1159\/000023413","article-title":"Auxological and biochemical evaluation of pubertal suppression with the GnRH agonist leuprolide acetate in early and precocious puberty","volume":"51","author":"Mul","year":"1999","journal-title":"Hormone Research"},{"key":"10.1053\/beem.2002.0188_RF74","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1203\/00006450-199010000-00021","article-title":"Monthly urinary LH and FSH secretory patterns in normal children and patients with sexual disorders","volume":"28","author":"Maesaka","year":"1990","journal-title":"Pediatric Research"},{"key":"10.1053\/beem.2002.0188_RF75","first-page":"1353","article-title":"Treatment of central precocious puberty: comparison of urinary gonadotropin excretion and gonadotropin-releasing hormone (GnRH) stimulation tests in monitoring GnRH analog therapy","volume":"81","author":"Witchel","year":"1996","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1053\/beem.2002.0188_RF76","doi-asserted-by":"crossref","first-page":"501","DOI":"10.7863\/jum.1994.13.7.501","article-title":"Monitoring of girls undergoing medical therapy for isosexual precocious puberty","volume":"13","author":"Ambrosino","year":"1994","journal-title":"Journal of Ultrasound Medicine"},{"key":"10.1053\/beem.2002.0188_RF77","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1111\/j.1651-2227.1995.tb13691.x","article-title":"Pelvic ultrasound findings in different forms of sexual precocity","volume":"84","author":"Griffin","year":"1995","journal-title":"Acta Paediatrica"},{"key":"10.1053\/beem.2002.0188_RF78","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1007\/BF01954267","article-title":"Pelvic ultrasonography: early differentiation between isolated premature thelarche and central precocious puberty","volume":"154","author":"Haber","year":"1995","journal-title":"European Journal of Pediatrics"},{"key":"10.1053\/beem.2002.0188_RF79","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/S0022-3476(88)80208-7","article-title":"Pelvic ultrasonography in girls with precocious puberty, congenital adrenal hyperplasia, obesity, or hirsutism","volume":"112","author":"Salardi","year":"1988","journal-title":"Journal of Pediatrics"},{"key":"10.1053\/beem.2002.0188_RF80","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1136\/adc.75.4.330","article-title":"Growth of the uterus","volume":"75","author":"Bridges","year":"1996","journal-title":"Archives of Disease in Childhood"},{"key":"10.1053\/beem.2002.0188_RF81","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1111\/j.1651-2227.1998.tb00921.x","article-title":"Pelvic ultrasonography in normal girls and in girls with pubertal precocity","volume":"87","author":"Buzi","year":"1998","journal-title":"Acta Paediatrica"},{"key":"10.1053\/beem.2002.0188_RF82","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/j.1651-2227.1999.tb01090.x","article-title":"Pelvic ultrasonography cannot alone be used to diagnose pubertal anomalies","volume":"88","author":"Andolf","year":"1999","journal-title":"Acta Paediatrica"},{"key":"10.1053\/beem.2002.0188_RF83","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0022-3476(98)70493-7","article-title":"Central precocious puberty in girls: internal genitalia before, during, and after treatment with long-acting gonadotropin-releasing hormone analogues","volume":"132","author":"Jensen","year":"1998","journal-title":"Journal of Pediatrics"},{"key":"10.1053\/beem.2002.0188_RF84","doi-asserted-by":"crossref","first-page":"3575","DOI":"10.1210\/jcem.84.10.6032","article-title":"Lack of effect of GnRH agonists on final height in girls with advanced puberty: a randomized long-term pilot study","volume":"84","author":"Bouvattier","year":"1999","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1053\/beem.2002.0188_RF85","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1136\/adc.81.4.329","article-title":"Randomised trial of LHRH analogue treatment on final height in girls with onset of puberty aged 7\u00b75\u20138\u00b75 years","volume":"81","author":"Cassio","year":"1999","journal-title":"Archives of Disease in Childhood"},{"key":"10.1053\/beem.2002.0188_RF86","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1046\/j.1365-2265.2001.01315.x","article-title":"Gonadotrophin releasing hormone agonist treatment with or without recombinant human GH in adopted children with early puberty","volume":"55","author":"Mul","year":"2001","journal-title":"Clinical Endocrinology"},{"key":"10.1053\/beem.2002.0188_RF87","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1159\/000184674","article-title":"Use of combined Gn-RH agonist and hGH therapy for better attaining the goals in precocious puberty treatment","volume":"44","author":"Tato","year":"1995","journal-title":"Hormone Research"},{"key":"10.1053\/beem.2002.0188_RF88","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1111\/j.1651-2227.1999.tb00183.x","article-title":"Growth hormone treatment during suppression of early puberty in adopted girls. Swedish Growth Hormone Advisory Group","volume":"88","author":"Tuvemo","year":"1999","journal-title":"Acta Paediatrica"},{"key":"10.1053\/beem.2002.0188_RF89","series-title":"Sexual Precocity: Etiology, Diagnosis, and Management","first-page":"139","article-title":"Treatment of central precocious puberty with Depot Lupron","author":"Lee","year":"1993"},{"key":"10.1053\/beem.2002.0188_RF90","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1159\/000023241","article-title":"Three-month sustained-release form of triptorelin in patients with advanced prostatic adenocarcinoma: results of an open pharmacodynamic and pharmacokinetic multicenter study","volume":"50","author":"Bouchot","year":"1998","journal-title":"Hormone Research"},{"key":"10.1053\/beem.2002.0188_RF91","first-page":"327","article-title":"Prolonged vaginal bleeding during central precocious puberty therapy with a long-acting gonadotropin-releasing hormone agonist","volume":"77","author":"Yeshaya","year":"1998","journal-title":"Acta Obstetrica and Gynecologica Scandinavica"},{"key":"10.1053\/beem.2002.0188_RF92","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/S0022-3476(05)81720-2","article-title":"Local reactions to depot leuprolide therapy for central precocious puberty","volume":"123","author":"Manasco","year":"1993","journal-title":"Journal of Pediatrics"},{"key":"10.1053\/beem.2002.0188_RF93","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0022-3476(95)70534-1","article-title":"Local reactions to luteinizing hormone releasing hormone analog therapy","volume":"126","author":"Tonini","year":"1995","journal-title":"Journal of Pediatrics"},{"key":"10.1053\/beem.2002.0188_RF94","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/(SICI)1520-6394(1998)7:4<171::AID-DA5>3.0.CO;2-D","article-title":"Depressive symptoms associated with gonadotropin-releasing hormone agonists","volume":"7","author":"Warnock","year":"1998","journal-title":"Depression and Anxiety"},{"key":"10.1053\/beem.2002.0188_RF95","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1210\/jcem.84.1.5409","article-title":"Reproductive axis after discontinuation of gonadotropin-releasing hormone analog treatment of girls with precocious puberty: long term follow-up comparing girls with hypothalamic hamartoma to those with idiopathic precocious puberty","volume":"84","author":"Feuillan","year":"1999","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1053\/beem.2002.0188_RF96","first-page":"4480","article-title":"Is obesity an outcome of gonadotropin-releasing hormone agonist administration? Analysis of growth and body composition in 110 patients with central precocious puberty","volume":"84","author":"Palmert","year":"1999","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1053\/beem.2002.0188_RF97","first-page":"S143","article-title":"Adipositas bei M\u00e4dchen mit Pubertas praecox unter oder nach Therapie mit GnRH-Agonisten?","volume":"147","author":"Partsch","year":"1999","journal-title":"Monatsschrift Kinderheilkunde"},{"key":"10.1053\/beem.2002.0188_RF98","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1210\/jcem-61-1-142","article-title":"Treatment of true precocious puberty with a potent luteinizing hormone-releasing factor agonist: effect on growth, sexual maturation, pelvic sonography, and the hypothalamic\u2013pituitary\u2013gonadal axis","volume":"61","author":"Styne","year":"1985","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1053\/beem.2002.0188_RF99","first-page":"4583","article-title":"Long-term outcome after depot gonadotropin-releasing hormone agonist treatment of central precocious puberty: final height, body proportions, body composition, bone mineral density, and reproductive function","volume":"84","author":"Heger","year":"1999","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1053\/beem.2002.0188_RF100","first-page":"890","article-title":"Ovulation and menstrual function of adolescent girls with central precocious puberty after therapy with gonadotropin-releasing hormone agonists","volume":"75","author":"Jay","year":"1992","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1053\/beem.2002.0188_RF101","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1365-2265.1995.tb01853.x","article-title":"Ovaries in sexual precocity","volume":"42","author":"Bridges","year":"1995","journal-title":"Clinical Endocrinology"},{"key":"10.1053\/beem.2002.0188_RF102","series-title":"The Neurobiology of Puberty","first-page":"327","article-title":"Completion of growth and puberty in girls with central precocious puberty following long-term GnRH agonist-induced pituitary-gonadal suppression","author":"Boepple","year":"1995"},{"key":"10.1053\/beem.2002.0188_RF103","first-page":"157","article-title":"GnRH agonist and GnRH antagonist for the suppression of puberty in a non-human primate (Macaca fascicularis)","volume":"155","author":"Partsch","year":"1996","journal-title":"European Journal of Pediatrics"},{"key":"10.1053\/beem.2002.0188_RF104","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/j.1939-4640.1987.tb00970.x","article-title":"Reversibility of long-term effects of GnRH agonist administration on testicular histology and sperm production in the nonhuman primate","volume":"8","author":"Weinbauer","year":"1987","journal-title":"Journal of Andrology"},{"key":"10.1053\/beem.2002.0188_RF105","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0022-3476(52)80205-7","article-title":"Tables for predicting adult height from skeletal age: revised use with the Greulich\u2013Pyle hand standards","volume":"40","author":"Bayley","year":"1952","journal-title":"Journal of Pediatrics"},{"key":"10.1053\/beem.2002.0188_RF106","series-title":"Radiographic Atlas of Skeletal Development of the Hand and Wrist","author":"Greulich","year":"1990"},{"key":"10.1053\/beem.2002.0188_RF107","series-title":"Assessment of Skeletal Maturity and Prediction of Adult Height (TW2 Method)","author":"Tanner","year":"1983"},{"key":"10.1053\/beem.2002.0188_RF108","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/S0022-3476(95)70221-0","article-title":"Bayley\u2013Pinneau method of height prediction in girls with central precocious puberty: correlation with adult height","volume":"126","author":"Bar","year":"1995","journal-title":"Journal of Pediatrics"},{"key":"10.1053\/beem.2002.0188_RF109","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1159\/000185432","article-title":"Final height of girls with central precocious puberty, untreated versus treated with cyproterone acetate or GnRH analogue. A comparative study with re-evaluation of predictions by the Bayley\u2013Pinneau method","volume":"47","author":"Kauli","year":"1997","journal-title":"Hormone Research"},{"key":"10.1053\/beem.2002.0188_RF110","doi-asserted-by":"crossref","first-page":"4127","DOI":"10.1210\/jcem.86.9.7852","article-title":"Sexual precocity in boys: accelerated versus slowly progressive puberty gonadotropin-suppressive therapy and final height","volume":"86","author":"Lazar","year":"2001","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1053\/beem.2002.0188_RF111","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1210\/jcem-73-6-1235","article-title":"Adult height in precocious puberty after long-term treatment with deslorelin","volume":"73","author":"Oerter","year":"1991","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1053\/beem.2002.0188_RF112","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1515\/JPEM.2000.13.S1.773","article-title":"End results in central precocious puberty with GnRH analog treatment: the data of the Italian Study Group for Physiopathology of Puberty","volume":"13","author":"Antoniazzi","year":"2000","journal-title":"Journal of Pediatric Endocrinology and Metabolism"},{"key":"10.1053\/beem.2002.0188_RF113","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1530\/eje.0.1410140","article-title":"Analysis of the factors affecting auxological response to GnRH agonist treatment and final height outcome in girls with idiopathic central precocious puberty","volume":"141","author":"Arrigo","year":"1999","journal-title":"European Journal of Endocrinology"},{"key":"10.1053\/beem.2002.0188_RF114","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1515\/JPEM.2000.13.S1.747","article-title":"Treatment of central precocious puberty: lessons from a 15 years, prospective trial","volume":"13","author":"Partsch","year":"2000","journal-title":"Journal of Pediatric Endocrinology and Metabolism"},{"key":"10.1053\/beem.2002.0188_RF115","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1530\/eje.0.1330412","article-title":"Bone mineral metabolism in girls with precocious puberty during gonadotrophin-releasing hormone agonist treatment","volume":"133","author":"Antoniazzi","year":"1995","journal-title":"European Journal of Endocrinology"},{"key":"10.1053\/beem.2002.0188_RF116","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3109\/09513599509160459","article-title":"Bone mineral content in girls with precocious puberty treated with gonadotropin-releasing hormone analog","volume":"9","author":"Verrotti","year":"1995","journal-title":"Gynecological Endocrinology"},{"key":"10.1053\/beem.2002.0188_RF117","first-page":"370","article-title":"Bone mineral density and body composition before and during treatment with gonadotropin-releasing hormone agonist in children with central precocious and early puberty","volume":"83","author":"Boot","year":"1998","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1053\/beem.2002.0188_RF118","first-page":"49","article-title":"Reference ranges of lutropin and follitropin in the luliberin test in prepubertal and pubertal children using a monoclonal immunoradiometric assay","volume":"28","author":"Partsch","year":"1990","journal-title":"Journal of Clinical Chemistry and Clinical Biochemistry"},{"key":"10.1053\/beem.2002.0188_RF119","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1001\/archpedi.1968.02100010311003","article-title":"Precocious puberty. A report of 96 cases","volume":"115","author":"Sigurjonsdottir","year":"1968","journal-title":"American Journal of Diseases in Children"},{"key":"10.1053\/beem.2002.0188_RF120","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1203\/00006450-197404000-00006","article-title":"Treatment of precocious puberty with cyproterone acetate","volume":"8","author":"Werder","year":"1974","journal-title":"Pediatric Research"},{"key":"10.1053\/beem.2002.0188_RF121","first-page":"443","article-title":"Medroxyprogesterone therapy for sexual precocity in girls","volume":"135","author":"Lee","year":"1981","journal-title":"American Journal of Diseases in Children"},{"key":"10.1053\/beem.2002.0188_RF122","first-page":"415","article-title":"Adult height in girls with idiopathic true precocious puberty","volume":"79","author":"Brauner","year":"1994","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1053\/beem.2002.0188_RF123","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1159\/000184152","article-title":"Final height in sexually precocious girls after therapy with an intranasal analogue of gonadotrophin-releasing hormone (buserelin)","volume":"42","author":"Stasiowska","year":"1994","journal-title":"Hormone Research"},{"key":"10.1053\/beem.2002.0188_RF124","first-page":"546","article-title":"Long-term effect of gonadotropin-releasing hormone agonist therapy on final and near-final height in 26 children with true precocious puberty treated at a median age of less than 5 years","volume":"80","author":"Paul","year":"1995","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1053\/beem.2002.0188_RF125","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1159\/000185521","article-title":"Long-term outcome of male-limited gonadotropin-independent precocious puberty","volume":"48","author":"Bertelloni","year":"1997","journal-title":"Hormone Research"},{"key":"10.1053\/beem.2002.0188_RF126","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/BF01956737","article-title":"The long-term effect of cyproterone acetate on growth in girls with idiopathic precocious puberty. Androcur Study Group in Japan","volume":"152","author":"Kato","year":"1993","journal-title":"European Journal of Pediatrics"},{"key":"10.1053\/beem.2002.0188_RF127","first-page":"69","article-title":"Final height of girls with central precocious puberty \u2013 untreated as compared to treated with GnRH analog (GnRH-A) or with cyproterone acetate","volume":"44","author":"Kauli","year":"1995","journal-title":"Hormone Research"},{"key":"10.1053\/beem.2002.0188_RF128","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1651-2227.1991.tb17966.x","article-title":"Gonadotrophin-releasing hormone analogues as therapeutic probes in human growth and development: evidence from children with central precocious puberty","volume":"372","author":"Boepple","year":"1991","journal-title":"Acta Paediatrica Scandinavica"},{"key":"10.1053\/beem.2002.0188_RF129","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1001\/archpedi.1994.02170110080014","article-title":"Long-term follow-up and final height in girls with central precocious puberty treated with luteinizing hormone-releasing hormone analogue nasal spray","volume":"148","author":"Cacciari","year":"1994","journal-title":"Archives of Pediatric and Adolescent Medicine"},{"key":"10.1053\/beem.2002.0188_RF130","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1159\/000181437","article-title":"Pubertal development, growth and final height in girls with sexual precocity after therapy with the GnRH analogue D-TRP-6-LHRH. A report on 15 girls, followed after cessation of gonadotrophin suppressive therapy","volume":"33","author":"Kauli","year":"1990","journal-title":"Hormone Research"},{"key":"10.1053\/beem.2002.0188_RF131","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/j.1651-2227.1998.tb01497.x","article-title":"Adult height comparison between boys and girls with precocious puberty after long-term gonadotrophin-releasing hormone analogue therapy","volume":"87","author":"Galluzzi","year":"1998","journal-title":"Acta Paediatrica"},{"key":"10.1053\/beem.2002.0188_RF132","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1515\/JPEM.2000.13.S1.765","article-title":"Final height after gonadotropin-releasing hormone agonist treatment for central precocious puberty","volume":"13","author":"Mul","year":"2000","journal-title":"Journal of Pediatric Endocrinology and Metabolism"},{"key":"10.1053\/beem.2002.0188_RF133","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1515\/JPEM.2000.13.S1.781","article-title":"Factors influencing final\/near-final height in 12 boys with central precocious puberty treated with gonadotrophin-releasing hormone agonists. Italian Study Group of Physiopathology of Puberty","volume":"13","author":"Rizzo","year":"2000","journal-title":"Journal of Pediatric Endocrinology and Metabolism"}],"container-title":["Best Practice &amp; Research Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521690X02901880?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521690X02901880?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T16:34:37Z","timestamp":1761496477000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521690X02901880"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,3]]},"references-count":133,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,3]]}},"alternative-id":["S1521690X02901880"],"URL":"https:\/\/doi.org\/10.1053\/beem.2002.0188","relation":{},"ISSN":["1521-690X"],"issn-type":[{"value":"1521-690X","type":"print"}],"subject":[],"published":{"date-parts":[[2002,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Treatment of central precocious puberty","name":"articletitle","label":"Article Title"},{"value":"Best Practice & Research Clinical Endocrinology & Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/beem.2002.0188","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2002 Elsevier Science Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}