{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T21:44:37Z","timestamp":1789595077604,"version":"build-2803163510"},"reference-count":33,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2002,9,1]],"date-time":"2002-09-01T00:00:00Z","timestamp":1030838400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Best Practice & Research Clinical Endocrinology & Metabolism"],"published-print":{"date-parts":[[2002,9]]},"DOI":"10.1053\/beem.2002.0218","type":"journal-article","created":{"date-parts":[[2002,12,3]],"date-time":"2002-12-03T12:40:22Z","timestamp":1038919222000},"page":"421-431","source":"Crossref","is-referenced-by-count":49,"title":["The spectrum of hypopituitarism caused by PROP1 mutations"],"prefix":"10.1053","volume":"16","author":[{"given":"Sushil","family":"Mody","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milton R","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John S","family":"Parks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/beem.2002.0218_RF1","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/384327a0","article-title":"Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism","volume":"384","author":"Sornson","year":"1996","journal-title":"Nature"},{"key":"10.1053\/beem.2002.0218_RF2","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/ng0298-147","article-title":"Mutations in PROP1 cause familial pituitary combined hormone deficiency","volume":"18","author":"Wu","year":"1998","journal-title":"Nature Genetics"},{"key":"10.1053\/beem.2002.0218_RF3","doi-asserted-by":"crossref","first-page":"4362","DOI":"10.1210\/jc.84.12.4362","article-title":"Heritable disorders of pituitary development","volume":"84","author":"Parks","year":"1999","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1053\/beem.2002.0218_RF4","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1210\/jc.84.5.1645","article-title":"\u2018Hot spot\u2019 in the PROP1 gene responsible for combined pituitary hormone deficiency","volume":"84","author":"Deladoey","year":"1999","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1053\/beem.2002.0218_RF5","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1210\/jc.83.7.2601","article-title":"Compound heterozygous deletion of the PROP-1 gene in children with combined pituitary hormone deficiency","volume":"83","author":"Fofanova","year":"1998","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1053\/beem.2002.0218_RF6","doi-asserted-by":"crossref","first-page":"4529","DOI":"10.1210\/jc.86.9.4529","article-title":"PROP1 gene screening in patients with multiple pituitary hormone deficiency reveals two sites of hypermutability and a high incidence of corticotroph deficiency","volume":"86","author":"Vallette-Kasic","year":"2001","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1053\/beem.2002.0218_RF7","first-page":"50","article-title":"Combined pituitary hormone deficiency caused by a novel mutation of a highly conserved residue (F88S) in the homeodomain of PROP1","volume":"84","author":"Osorio","year":"2000","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1053\/beem.2002.0218_RF8","doi-asserted-by":"crossref","first-page":"3727","DOI":"10.1210\/jc.83.10.3727","article-title":"Phenotypic variability in familial combined pituitary hormone deficiency caused by a PROP1 gene mutation resulting in the substitution of Arg-->Cys at codon 120 (R120C)","volume":"83","author":"Fluck","year":"1998","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1053\/beem.2002.0218_RF9","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1210\/jc.85.1.390","article-title":"Impaired adrenocorticotropin-adrenal axis in combined pituitary hormone deficiency caused by a two-base pair deletion (301-302delAG) in the prophet of Pit-1 gene","volume":"85","author":"Pernasetti","year":"2000","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1053\/beem.2002.0218_RF10","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1136\/adc.67.7.920","article-title":"Growth of infants with neonatal growth hormone deficiency","volume":"67","author":"Wit","year":"1992","journal-title":"Archives of Disease in Childhood"},{"key":"10.1053\/beem.2002.0218_RF11","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/sim.4780060210","article-title":"On the modeling of human growth","volume":"6","author":"Karlberg","year":"1987","journal-title":"Statistics in Medicine"},{"key":"10.1053\/beem.2002.0218_RF12","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1126\/science.257.5073.1118","article-title":"Mutation of the POU-specific domain of Pit-1 and hypopituitarism without pituitary hypoplasia","volume":"257","author":"Pfaffle","year":"1992","journal-title":"Science"},{"key":"10.1053\/beem.2002.0218_RF13","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1136\/adc.68.6.768","article-title":"Growth curves for Laron syndrome","volume":"68","author":"Laron","year":"1993","journal-title":"Archives of Disease in Childhood"},{"key":"10.1053\/beem.2002.0218_RF14","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0031-3955(05)70484-3","article-title":"Growth hormone insensitivity","volume":"44","author":"Rosenbloom","year":"1997","journal-title":"Pediatric Clinics of North America"},{"key":"10.1053\/beem.2002.0218_RF15","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1210\/jc.84.3.942","article-title":"Longitudinal hormonal and pituitary imaging changes in two females with combined pituitary hormone deficiency due to deletion of A301,G302 in the PROP1 gene","volume":"84","author":"Mendonca","year":"1999","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1053\/beem.2002.0218_RF16","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1056\/NEJM197803302981302","article-title":"Familial hypopituitarism with large sella turcica","volume":"298","author":"Parks","year":"1978","journal-title":"New England Journal of Medicine"},{"key":"10.1053\/beem.2002.0218_RF17","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1006\/mgme.1999.2841","article-title":"Combined pituitary hormone deficiency in an inbred Brazilian kindred associated with a mutation in the PROP-1 gene","volume":"67","author":"Nogueira","year":"1999","journal-title":"Molecular Genetics and Metabolism"},{"key":"10.1053\/beem.2002.0218_RF18","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1056\/NEJM196801112780201","article-title":"Growth and growth hormone","volume":"278","author":"Goodman","year":"1968","journal-title":"New England Journal of Medicine"},{"key":"10.1053\/beem.2002.0218_RF19","doi-asserted-by":"crossref","first-page":"3346","DOI":"10.1210\/jc.83.9.3346","article-title":"The PROP1 2-base pair deletion is a common cause of combined pituitary hormone deficiency","volume":"83","author":"Cogan","year":"1998","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1053\/beem.2002.0218_RF20","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1210\/jc.84.1.50","article-title":"Clinical and biochemical phenotype of familial anterior hypopituitarism from mutation of the PROP1 gene","volume":"84","author":"Rosenbloom","year":"1999","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1053\/beem.2002.0218_RF21","first-page":"9","article-title":"The \u2018Little People\u2019 of the Island of Krk \u2013 revisited etiology of hypopituitarism revealed","volume":"1","author":"Krzisnik","year":"1999","journal-title":"Journal Endocrine Genetics"},{"key":"10.1053\/beem.2002.0218_RF22","doi-asserted-by":"crossref","first-page":"4556","DOI":"10.1210\/jc.85.12.4556","article-title":"Adrenocorticotropn deficiency in combined pituitary hormone deficiency patients homozygous for a novel PROP1 deletion","volume":"85","author":"Agarwal","year":"2000","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1053\/beem.2002.0218_RF23","doi-asserted-by":"crossref","first-page":"4353","DOI":"10.1210\/jc.86.9.4353","article-title":"Longitudinal imaging reveals pituitary enlargement preceding hypoplasia in two brothers with combined pituitary hormone deficiency attributable to PROP1 mutation","author":"Riepe","year":"2001","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1053\/beem.2002.0218_RF24","doi-asserted-by":"crossref","first-page":"555","DOI":"10.2214\/ajr.174.2.1740555","article-title":"MR imaging of the pituitary gland in children and young adults with congenital combined pituitary hormone deficiency associated with PROP1 mutations","volume":"174","author":"Fofanova","year":"2000","journal-title":"American Journal of Roentgenology"},{"key":"10.1053\/beem.2002.0218_RF25","unstructured":"Osorio, M, GF, Mendonca, B, B, Latronico, A, C, Proceedings of the 80th Annual Meeting of the Endocrine Society, 1998 P1\u201329 (abstract)"},{"key":"10.1053\/beem.2002.0218_RF26","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1210\/jcem-73-1-79","article-title":"Hypothalamic-pituitary dysfunction in growth hormone-deficient patients with pituitary abnormalities","volume":"73","author":"Maghnie","year":"1991","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1053\/beem.2002.0218_RF27","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1136\/pgmj.51.599.676","article-title":"Familial dwarfism: case report","volume":"51","author":"Nader","year":"1975","journal-title":"Postgraduate Medical Journal"},{"key":"10.1053\/beem.2002.0218_RF28","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/j.1365-2265.1986.tb03255.x","article-title":"Familial hypopituitarism associated with an enlarged pituitary fossa and an empty sella","volume":"24","author":"White","year":"1986","journal-title":"Clinical Endocrinology (Oxford)"},{"key":"10.1053\/beem.2002.0218_RF29","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/BF01258498","article-title":"Immunohistological study of the anterior pituitary gland-pars distalis and pars intermedia-in dwarf mice","volume":"223","author":"Roux","year":"1982","journal-title":"Cell and Tissue Research"},{"key":"10.1053\/beem.2002.0218_RF30","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/76041","article-title":"Mutations in LHX3 result in a new syndrome revealed by combined pituitary hormone deficiency","volume":"25","author":"Netchine","year":"2000","journal-title":"Nature Genetics"},{"key":"10.1053\/beem.2002.0218_RF31","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/ar.1091490206","article-title":"Histology of the anterior hypophysis, thyroid and gonads of two types of dwarf mice","volume":"149","author":"Bartke","year":"1964","journal-title":"Anatomical Record"},{"key":"10.1053\/beem.2002.0218_RF32","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.1210\/jc.84.7.2581","article-title":"Prop-1 gene expression in human pituitary tumours","volume":"84","author":"Nakamura","year":"1999","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1053\/beem.2002.0218_RF33","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1093\/hmg\/10.11.1141","article-title":"Persistent Prop1 expression delays gonadotrope differentiation and enhances pituitary tumour susceptibility","volume":"10","author":"Cushman","year":"2001","journal-title":"Human Molecular Genetics"}],"container-title":["Best Practice & Research Clinical Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521690X02902186?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521690X02902186?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T10:21:50Z","timestamp":1554200510000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521690X02902186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,9]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2002,9]]}},"alternative-id":["S1521690X02902186"],"URL":"https:\/\/doi.org\/10.1053\/beem.2002.0218","relation":{},"ISSN":["1521-690X"],"issn-type":[{"value":"1521-690X","type":"print"}],"subject":[],"published":{"date-parts":[[2002,9]]}}}