{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T02:47:33Z","timestamp":1787885253141,"version":"build-2784847793"},"reference-count":54,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2000,10,1]],"date-time":"2000-10-01T00:00:00Z","timestamp":970358400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Best Practice & Research Clinical Gastroenterology"],"published-print":{"date-parts":[[2000,10]]},"DOI":"10.1053\/bega.2000.0119","type":"journal-article","created":{"date-parts":[[2002,9,19]],"date-time":"2002-09-19T13:54:50Z","timestamp":1032443690000},"page":"701-717","source":"Crossref","is-referenced-by-count":50,"title":["Mechanisms of oesophageal mucosal defence"],"prefix":"10.1053","volume":"14","author":[{"given":"Jerzy","family":"Sarosiek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard W.","family":"McCallum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/bega.2000.0119_RF1","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1016\/0016-5085(91)90070-2","article-title":"Mechanisms of acid injury to rabbit esophageal epithelium. Role of basolateral cell membrane acidification","volume":"101","author":"Tobey","year":"1991","journal-title":"Gastroenterology"},{"key":"10.1053\/bega.2000.0119_RF2","series-title":"The esophagus","first-page":"463","article-title":"Pathophysiology of gastroesophageal reflux disease: esophageal epithelial resistance","author":"Orlando","year":"1992"},{"key":"10.1053\/bega.2000.0119_RF3","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/0016-5085(94)90756-0","article-title":"Human esophageal secretion: mucosal response to luminal acid and pepsin","volume":"106","author":"Namiot","year":"1994","journal-title":"Gastroenterology"},{"key":"10.1053\/bega.2000.0119_RF4","first-page":"20J","article-title":"The evolving appreciation of the role of esophageal mucosal protection in the pathophysiology of gastroesophageal reflux disease","volume":"18","author":"Sarosiek","year":"1994","journal-title":"Journal of Practical Gastroenterology"},{"key":"10.1053\/bega.2000.0119_RF5","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1053\/gast.1996.v110.pm8608875","article-title":"Enhancement of salivary esophagoprotection: the rationale for a physiologic approach to gastroesophageal reflux disease","volume":"110","author":"Sarosiek","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1053\/bega.2000.0119_RF6","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1159\/000201297","article-title":"What is the secretory potential of submucosal mucous glands within the human gullet in health and disease?","volume":"56","author":"Sarosiek","year":"1995","journal-title":"Digestion"},{"key":"10.1053\/bega.2000.0119_RF7","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1016\/0016-5085(87)90619-6","article-title":"pH of the microclimate lining human gastric and duodenal mucosa in vivo: studies in control subjects and in duodenal ulcer patients","volume":"92","author":"Quigley","year":"1987","journal-title":"Gastroenterology"},{"key":"10.1053\/bega.2000.0119_RF8","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/0016-5085(92)90177-Z","article-title":"Barriers to paracellular permeability in rabbit esophageal epithelium","volume":"102","author":"Orlando","year":"1992","journal-title":"Gastroenterology"},{"key":"10.1053\/bega.2000.0119_RF9","series-title":"Human saliva: clinical chemistry and microbiology","first-page":"26","article-title":"Salivary secretion rate, buffer capacity, and pH","author":"Birkhed","year":"1989"},{"key":"10.1053\/bega.2000.0119_RF10","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1113\/jphysiol.1959.sp006303","article-title":"Responses of the salivary glands to distension of the oesophagus and rumen","volume":"148","author":"Kay","year":"1959","journal-title":"Journal of Physiology"},{"key":"10.1053\/bega.2000.0119_RF11","series-title":"Disease of the salivary glands","first-page":"27","article-title":"Physiology and biochemistry","author":"Seifert","year":"1986"},{"key":"10.1053\/bega.2000.0119_RF12","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1023\/A:1018825618043","article-title":"Esophagoprotective potential of cisapride: an additional benefit for gastroesophageal reflux disease","volume":"42","author":"Goldin","year":"1997","journal-title":"Digestive Diseases and Sciences"},{"key":"10.1053\/bega.2000.0119_RF13","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1159\/000201298","article-title":"What role do salivary inorganic components play in health and disease of the esophageal mucosa?","volume":"56","author":"Sarosiek","year":"1995","journal-title":"Digestion"},{"key":"10.1053\/bega.2000.0119_RF14","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1159\/000201299","article-title":"Do salivary organic components play a protective role in health and disease of the esophageal mucosa?","volume":"56","author":"Sarosiek","year":"1995","journal-title":"Digestion"},{"key":"10.1053\/bega.2000.0119_RF15","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1097\/00000441-199407000-00006","article-title":"The effect of esophageal mechanical and chemical stimuli on salivary mucin secretion in healthy individuals","volume":"308","author":"Sarosiek","year":"1994","journal-title":"American Journal of the Medical Sciences"},{"key":"10.1053\/bega.2000.0119_RF16","first-page":"581","article-title":"Interrelationship between esophageal challenge with mechanical and chemical stimuli and salivary protective mechanisms","volume":"89","author":"Namiot","year":"1994","journal-title":"American Journal of Gastroenterology"},{"key":"10.1053\/bega.2000.0119_RF17","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/S0006-291X(88)80471-6","article-title":"Role of associated and covalently bound lipids in salivary mucin hydrophobicity: effect of proteolysis and disulphide bridge reduction","volume":"151","author":"Slomiany","year":"1988","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1053\/bega.2000.0119_RF18","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.3109\/00365528608996423","article-title":"Lysolecithin affects the viscosity, permeability and peptic susceptibility of gastric mucin","volume":"21","author":"Slomiany","year":"1986","journal-title":"Scandinavian Journal of Gastroenterology"},{"key":"10.1053\/bega.2000.0119_RF19","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/0006-291X(84)91334-2","article-title":"Hydrogen ion diffusion in dog gastric mucus glycoprotein: effect of associated lipids and covalently bound fatty acids","volume":"118","author":"Sarosiek","year":"1984","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1053\/bega.2000.0119_RF20","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/0006-291X(84)90213-4","article-title":"Effect of lipids and proteins on the viscosity of gastric mucus glycoprotein","volume":"121","author":"Murty","year":"1984","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1053\/bega.2000.0119_RF21","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1097\/00000441-199702000-00004","article-title":"Modulatory effect of esophageal intraluminal mechanical and chemical stressors on salivary prostaglandin E2 in humans","volume":"313","author":"Namiot","year":"1997","journal-title":"American Journal of Medical Science"},{"key":"10.1053\/bega.2000.0119_RF22","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0016-5085(82)80286-2","article-title":"Acid neutralizing capacity of human saliva","volume":"83","author":"Helm","year":"1982","journal-title":"Gastroenterology"},{"key":"10.1053\/bega.2000.0119_RF23","first-page":"1749","article-title":"Effect of esophageal intraluminal mechanical and chemical stressors on salivary epidermal growth factor in humans","volume":"88","author":"Li","year":"1993","journal-title":"American Journal of Gastroenterology"},{"key":"10.1053\/bega.2000.0119_RF24","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/0090-6980(86)90186-3","article-title":"Prostaglandin effect on the physical properties of gastric mucin and its susceptibility to pepsin","volume":"32","author":"Sarosiek","year":"1986","journal-title":"Prostaglandins"},{"key":"10.1053\/bega.2000.0119_RF25","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/j.1749-6632.1984.tb13888.x","article-title":"Rheological properties of gastric mucus glycoproteins: contribution of associated lipids","volume":"435","author":"Sarosiek","year":"1984","journal-title":"Annals of the New York Academy of Science"},{"key":"10.1053\/bega.2000.0119_RF26","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1136\/gut.34.5.584","article-title":"Mucosal polyamine metabolism in the columnar lined oesophagus","volume":"34","author":"Gray","year":"1993","journal-title":"Gut"},{"key":"10.1053\/bega.2000.0119_RF27","first-page":"237","article-title":"Impairment of salivary epidermal growth factor secretory response to esophageal mechanical and chemical stimulation in patients with reflux esophagitis","volume":"89","author":"Rourk","year":"1994","journal-title":"American Journal of Gastroenterology"},{"key":"10.1053\/bega.2000.0119_RF28","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/S0039-6060(95)80015-8","article-title":"Synergism of acid and duodenogastroesophageal reflux in complicated Barrett's esophagus","volume":"117","author":"Vaezi","year":"1995","journal-title":"Surgery"},{"key":"10.1053\/bega.2000.0119_RF29","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/0016-5085(94)90123-6","article-title":"Duodenogastroesophageal reflux: relationship to pH and importance in Barrett's esophagus","volume":"107","author":"Champion","year":"1994","journal-title":"Gastroenterology"},{"key":"10.1053\/bega.2000.0119_RF30","article-title":"Bile acids accompanied by acid and pepsin stimulate salivary secretion both in controls and patients with gastroesophageal reflux disease","author":"Poplawski","year":"2000","journal-title":"American Journal of Gastroenterology"},{"key":"10.1053\/bega.2000.0119_RF31","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/S1079-2104(96)80410-0","article-title":"Relationship of medical status, medications, and salivary flow rates in adults of different ages","volume":"81","author":"Navazesh","year":"1996","journal-title":"Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology"},{"key":"10.1053\/bega.2000.0119_RF32","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1111\/j.1440-1827.1981.tb02013.x","article-title":"Dysplasia and reserve cell hyperplasia-like change in human esophagus","volume":"31","author":"Takubo","year":"1981","journal-title":"Acta Pathologica Japonica"},{"key":"10.1053\/bega.2000.0119_RF33","first-page":"431","article-title":"Developmental changes in the oesophageal epithelium in man","volume":"86","author":"Johns","year":"1952","journal-title":"Journal of Anatomy"},{"key":"10.1053\/bega.2000.0119_RF34","first-page":"588","article-title":"Impact of acid and pepsin on human esophageal prostaglandins","volume":"89","author":"Sarosiek","year":"1994","journal-title":"American Journal of Gastroenterology"},{"key":"10.1053\/bega.2000.0119_RF35","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/0016-5085(92)91501-T","article-title":"In vivo bicarbonate secretion by human esophagus","volume":"103","author":"Meyers","year":"1992","journal-title":"Gastroenterology"},{"key":"10.1053\/bega.2000.0119_RF36","first-page":"1177","article-title":"Diminished content of esophageal epidermal growth factor in patients with reflux esophagitis","volume":"89","author":"Rourk","year":"1994","journal-title":"American Journal of Gastroenterology"},{"key":"10.1053\/bega.2000.0119_RF37","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1007\/BF02087685","article-title":"Declined human esophageal mucin secretion in patients with severe reflux esophagitis","volume":"39","author":"Namiot","year":"1994","journal-title":"Digestive Diseases and Sciences"},{"key":"10.1053\/bega.2000.0119_RF38","first-page":"1081","article-title":"Evidence on secretion of EGF by the esophageal mucosa in humans","volume":"88","author":"Sarosiek","year":"1993","journal-title":"American Journal of Gastroenterology"},{"key":"10.1053\/bega.2000.0119_RF39","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1097\/00004836-199512000-00003","article-title":"Monophasic luminal release of prostaglandin E2in patients with reflux esophagitis under the impact of acid and acid\/pepsin solutions: its potential pathogenetic significance","volume":"21","author":"Marcinkiewicz","year":"1995","journal-title":"Journal of Clinical Gastroenterology"},{"key":"10.1053\/bega.2000.0119_RF40","article-title":"The beneficial effect of cisapride administration on the esophageal pre-epithelial barrier in controls and patients with gastroesophageal reflux disease during mucosal exposure to components of duodenogastroesophageal reflux","author":"Poplawski","year":"2000","journal-title":"American Journal of Gastroenterology"},{"key":"10.1053\/bega.2000.0119_RF41","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1097\/00004836-199112002-00002","article-title":"Esophageal epithelial defense against acid injury","volume":"13","author":"Orlando","year":"1991","journal-title":"Journal of Clinical Gastroenterology"},{"key":"10.1053\/bega.2000.0119_RF42","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1016\/0016-5085(89)90514-3","article-title":"Serosal bicarbonate protects against acid injury to rabbit esophagus","volume":"96","author":"Tobey","year":"1989","journal-title":"Gastroenterology"},{"key":"10.1053\/bega.2000.0119_RF43","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1097\/00004836-198606001-00004","article-title":"Esophageal epithelial resistance","volume":"8","author":"Orlando","year":"1986","journal-title":"Journal of Clinical Gastroenterology"},{"key":"10.1053\/bega.2000.0119_RF44","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1111\/j.1365-2036.1995.tb00436.x","article-title":"A comparative study of cisapride and ranitidine at controlling oesophageal acid exposure in erosive oesophagitis","volume":"9","author":"Pouderoux","year":"1995","journal-title":"Alimentary Pharmacology and Therapeutics"},{"key":"10.1053\/bega.2000.0119_RF45","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1097\/00005176-199604000-00007","article-title":"Cisapride therapy for gastrointestinal disease","volume":"22","author":"Cucchiara","year":"1996","journal-title":"Journal of Pediatric Gastroenterology and Nutrition"},{"key":"10.1053\/bega.2000.0119_RF46","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1365-2036.1993.tb00088.x","article-title":"Cisapride in the treatment of gastro-esophageal reflux disease","volume":"7","author":"Robertson","year":"1993","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/bega.2000.0119_RF47","first-page":"423","article-title":"Cisapride for gastresophageal reflux disease: a placebo-controlled, double-blind study","volume":"90","author":"Richter","year":"1995","journal-title":"American Journal of Gastroenterology"},{"key":"10.1053\/bega.2000.0119_RF48","first-page":"775","article-title":"Motor-stimulating properties of cisapride on isolated gastrointestinal preparations of the guinea pig","volume":"234","author":"Schuurkes","year":"1985","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1053\/bega.2000.0119_RF49","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0014-2999(91)90821-7","article-title":"Prokinetic benzamides stimulate peristaltic activity in the isolated guinea pig ileum by activation of 5-HT4 receptors","volume":"205","author":"Buchheit","year":"1991","journal-title":"European Journal of Pharmacology"},{"key":"10.1053\/bega.2000.0119_RF50","series-title":"Esophagus","first-page":"1","article-title":"Functional anatomy and physiology of the esophagus","author":"Kahrilas","year":"1992"},{"key":"10.1053\/bega.2000.0119_RF51","series-title":"The physiological basis of medical practice","first-page":"1061","article-title":"Salivary secretion","author":"Hightower","year":"1966"},{"key":"10.1053\/bega.2000.0119_RF52","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1007\/BF02282322","article-title":"Effect of cisapride on salivary production in normal subjects","volume":"41","author":"Patel","year":"1996","journal-title":"Digestive Diseases and Sciences"},{"key":"10.1053\/bega.2000.0119_RF53","article-title":"The potential clinical benefit of cisapride administration in patients with gastroesophageal reflux disease accompanied by the duodenogastroesophageal reflux","author":"Poplawski","year":"2000","journal-title":"Digestive Diseases and Sciences"},{"key":"10.1053\/bega.2000.0119_RF54","doi-asserted-by":"crossref","first-page":"A276","DOI":"10.1016\/S0016-5085(98)81126-8","article-title":"Enhanced salivary bicarbonate, transforming growth factor alpha, protein, and prostaglandin E2 as potential factors preventing the development of reflux esophagitis in patients with gastroesophageal reflux disease","volume":"114","author":"Poplawski","year":"1998","journal-title":"Gastroenterology"}],"container-title":["Best Practice & Research Clinical Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521691800901197?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521691800901197?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,7]],"date-time":"2024-12-07T18:58:32Z","timestamp":1733597912000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521691800901197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,10]]},"references-count":54,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2000,10]]}},"alternative-id":["S1521691800901197"],"URL":"https:\/\/doi.org\/10.1053\/bega.2000.0119","relation":{},"ISSN":["1521-6918"],"issn-type":[{"value":"1521-6918","type":"print"}],"subject":[],"published":{"date-parts":[[2000,10]]}}}