{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T15:25:41Z","timestamp":1758122741705},"reference-count":50,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2000,10,1]],"date-time":"2000-10-01T00:00:00Z","timestamp":970358400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Best Practice & Research Clinical Gastroenterology"],"published-print":{"date-parts":[[2000,10]]},"DOI":"10.1053\/bega.2000.0127","type":"journal-article","created":{"date-parts":[[2002,9,19]],"date-time":"2002-09-19T13:54:50Z","timestamp":1032443690000},"page":"827-837","source":"Crossref","is-referenced-by-count":16,"title":["Endoscopy-negative reflux disease"],"prefix":"10.1053","volume":"14","author":[{"given":"Rolf","family":"Carlsson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard H","family":"Holloway","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1053\/bega.2000.0127_RF1","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1016\/S0016-5085(97)70025-8","article-title":"Prevalence and clinical spectrum of gastroesophageal reflux: a population-based study in Olmsted County, Minnesota","volume":"112","author":"Locke","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1053\/bega.2000.0127_RF2","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1136\/gut.44.2008.S1","article-title":"An evidenced-based appraisal of reflux disease management\u2014the Genval Workshop Report","volume":"44","author":"Dent","year":"1999","journal-title":"Gut"},{"key":"10.1053\/bega.2000.0127_RF3","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1001\/jama.1935.02760110034008","article-title":"Peptic esophagitis. A new clinical entity","volume":"104","author":"Winkelstein","year":"1935","journal-title":"Journal of the American Medical Association"},{"key":"10.1053\/bega.2000.0127_RF4","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1136\/gut.30.11.1523","article-title":"Heartburn\u2014the acid test","volume":"30","author":"Joelsson","year":"1989","journal-title":"Gut"},{"key":"10.1053\/bega.2000.0127_RF5","first-page":"33","article-title":"Epidemiology of oesophageal reflux disease","volume":"24","author":"Heading","year":"1989","journal-title":"Scandinavian Journal of Gastroenterology"},{"key":"10.1053\/bega.2000.0127_RF6","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0016-5085(76)80088-1","article-title":"Evaluation of esophageal tests in the diagnosis of reflux esophagitis","volume":"71","author":"Behar","year":"1976","journal-title":"Gastroenterology"},{"key":"10.1053\/bega.2000.0127_RF7","doi-asserted-by":"crossref","first-page":"837","DOI":"10.3109\/00365528609011128","article-title":"Oesophagitis, signs of reflux, and gastric acid secretion in patients with symptoms of gastro-oesophageal reflux disease","volume":"7","author":"Johansson","year":"1986","journal-title":"Scandinavian Journal of Gastroenterology"},{"key":"10.1053\/bega.2000.0127_RF8","doi-asserted-by":"crossref","first-page":"149","DOI":"10.3109\/13814789509161628","article-title":"Gastro-oesophageal reflux disease in primary care in Europe: clinical presentation and endoscopic findings","volume":"1","author":"Jones","year":"1995","journal-title":"European Journal of General Practice"},{"key":"10.1053\/bega.2000.0127_RF9","doi-asserted-by":"crossref","first-page":"965","DOI":"10.3109\/00365529709011211","article-title":"Omeprazole 10 milligrams once daily, omeprazole 20 milligrams once daily, or ranitidine 150 milligrams twice daily, evaluated as initial therapy for the relief of symptoms of gastro-oesophageal reflux disease in general practice","volume":"32","author":"Venables","year":"1997","journal-title":"Scandinavian Journal of Gastroenterology"},{"key":"10.1053\/bega.2000.0127_RF10","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1046\/j.1365-2036.1997.00185.x","article-title":"Treating the symptoms of gastro-oesophageal reflux disease: a double-blind comparison of omeprazole and cisapride","volume":"11","author":"Galmiche","year":"1997","journal-title":"Alimentary Pharmacology and Therapeutics"},{"key":"10.1053\/bega.2000.0127_RF11","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1097\/00042737-199802000-00004","article-title":"Gastro-oesophageal reflux disease in primary care: an international study of different treatment strategies with omeprazole. International GORD Study Group","volume":"10","author":"Carlsson","year":"1998","journal-title":"European Journal of Gastroenterology and Hepatology"},{"key":"10.1053\/bega.2000.0127_RF12","doi-asserted-by":"crossref","first-page":"974","DOI":"10.3109\/00365529709011212","article-title":"Heartburn without oesophagitis: efficacy of omeprazole therapy and features determining therapeutic response","volume":"32","author":"Lind","year":"1997","journal-title":"Scandinavian Journal of Gastroenterology"},{"key":"10.1053\/bega.2000.0127_RF13","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1365-2036.1997.tb00798.x","article-title":"Endoscopy-negative acid reflux disease","volume":"11","author":"Smout","year":"1997","journal-title":"Alimentary Pharmacology and Therapeutics"},{"key":"10.1053\/bega.2000.0127_RF14","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1365-2982.1990.tb00030.x","article-title":"Relationship between gastroesophageal reflux and symptoms in patients referred for ambulatory pH monitoring","volume":"2","author":"Howard","year":"1990","journal-title":"Journal of Gastrointestinal Motility"},{"key":"10.1053\/bega.2000.0127_RF15","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1002\/bjs.1800791022","article-title":"Symptom index as a marker of gastro-oesophageal reflux disease","volume":"79","author":"Johnston","year":"1992","journal-title":"British Journal of Surgery"},{"key":"10.1053\/bega.2000.0127_RF16","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1007\/BF01308595","article-title":"The symptom index. Differential usefulness in suspected acid-related complaints of heartburn and chest pain","volume":"38","author":"Singh","year":"1993","journal-title":"Digestive Diseases and Sciences"},{"key":"10.1053\/bega.2000.0127_RF17","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1136\/gut.37.4.457","article-title":"Reflux related symptoms in patients with normal oesophageal exposure to acid","volume":"37","author":"Shi","year":"1995","journal-title":"Gut"},{"key":"10.1053\/bega.2000.0127_RF18","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1136\/gut.37.1.7","article-title":"Lowered oesophageal sensory thresholds in patients with symptomatic but not excess gastro-oesophageal reflux: evidence for a spectrum of visceral sensitivity in GORD","volume":"37","author":"Trimble","year":"1995","journal-title":"Gut"},{"key":"10.1053\/bega.2000.0127_RF19","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1111\/j.1572-0241.1999.00925.x","article-title":"Esophageal hypersensitivity may be a major cause of heartburn","volume":"94","author":"Rodriguez-Stanley","year":"1999","journal-title":"American Journal of Gastroenterology"},{"key":"10.1053\/bega.2000.0127_RF20","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3109\/00365529609095544","article-title":"Relevance of normal values as part of the documentation of quality of life instruments for use in upper gastrointestinal disease","volume":"31","author":"Dimenas","year":"1996","journal-title":"Scandinavian Journal of Gastroenterology"},{"key":"10.1053\/bega.2000.0127_RF21","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/BF00191963","article-title":"Quality-of-life assessments in evaluation of laparoscopic Rosetti fundoplication","volume":"9","author":"Glise","year":"1995","journal-title":"Surgical Endoscopy"},{"key":"10.1053\/bega.2000.0127_RF22","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/S0002-9343(97)00354-9","article-title":"The impact of gastroesophageal reflux disease on health-related quality of life","volume":"104","author":"Revicki","year":"1998","journal-title":"American Journal of Medicine"},{"key":"10.1053\/bega.2000.0127_RF23","first-page":"19","article-title":"Quality of life during acute and intermittent treatment of gastro-oesophageal reflux disease with omeprazole compared with ranitidine. Results from a multicentre clinical trial. The European Study Group","volume":"30","author":"Wiklund","year":"1998","journal-title":"Italian Journal of Gastroenterology and Hepatology"},{"key":"10.1053\/bega.2000.0127_RF24","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1111\/j.1572-0241.1999.01206.x","article-title":"Quality of life in patients with heartburn but without oesophagitis: effects of treatment with omeprazole","volume":"94","author":"Havelund","year":"1999","journal-title":"American Journal of Gastroenterology"},{"key":"10.1053\/bega.2000.0127_RF25","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1136\/gut.32.8.845","article-title":"Natural history of gastro-oesophageal reflux disease without oesophagitis","volume":"32","author":"Pace","year":"1991","journal-title":"Gut"},{"key":"10.1053\/bega.2000.0127_RF26","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1136\/gut.38.4.481","article-title":"Natural history of reflux oesophagitis: a 10 year follow up of its effect on patient symptomatology and quality of life","volume":"38","author":"McDougall","year":"1996","journal-title":"Gut"},{"key":"10.1053\/bega.2000.0127_RF27","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1007\/BF02064206","article-title":"Clinical characteristics and natural history of symptomatic but not excess gastroesophageal reflux","volume":"40","author":"Trimble","year":"1995","journal-title":"Digestive Diseases and Sciences"},{"key":"10.1053\/bega.2000.0127_RF28","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1136\/gut.33.8.1016","article-title":"Three year follow-up of patients with gastro-oesophageal reflux disease","volume":"33","author":"Schindlbeck","year":"1992","journal-title":"Gut"},{"key":"10.1053\/bega.2000.0127_RF29","series-title":"Mechanisms of Mucosal Protection in the Upper Gastrointestinal Tract","first-page":"75","article-title":"Studies of oesophageal epithelial electrolyte transport and potential difference in man","author":"Orlando","year":"1984"},{"key":"10.1053\/bega.2000.0127_RF30","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/S0016-5085(82)80069-3","article-title":"Esophageal potential difference measurements in esophageal disease","volume":"83","author":"Orlando","year":"1982","journal-title":"Gastroenterology"},{"key":"10.1053\/bega.2000.0127_RF31","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/S0016-5085(84)80012-8","article-title":"Barrett's esophagus: clinical, endoscopic, histologic, manometric and electrical potential difference characteristics","volume":"86","author":"Herlihy","year":"1984","journal-title":"Gastroenterology"},{"key":"10.1053\/bega.2000.0127_RF32","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1080\/003655299750026155","article-title":"Is the esophageal squamous epithelial barrier function impaired in patients with gastroesophageal reflux disease?","volume":"34","author":"Carlsson","year":"1999","journal-title":"Scandinavian Journal of Gastroenterology"},{"key":"10.1053\/bega.2000.0127_RF33","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1136\/gut.19.5.396","article-title":"Transmucosal potential difference; diagnostic value in gastro-oesophageal reflux","volume":"19","author":"Khamis","year":"1978","journal-title":"Gut"},{"key":"10.1053\/bega.2000.0127_RF34","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1136\/gut.25.10.1103","article-title":"Endoscopic measurement of oesophageal transmucosal potential difference in reflux oesophagitis","volume":"25","author":"Collins","year":"1984","journal-title":"Gut"},{"key":"10.1053\/bega.2000.0127_RF35","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/BF01476571","article-title":"Esophageal transmucosal potential difference in patients with symptomatic gastroesophageal reflux","volume":"58","author":"Eckhardt","year":"1980","journal-title":"Klinische Wochenschrift"},{"key":"10.1053\/bega.2000.0127_RF36","first-page":"G718","article-title":"Mechanisms of H+injury in rabbit esophageal epithelium","volume":"246","author":"Orlando","year":"1984","journal-title":"American Journal of Physiology"},{"key":"10.1053\/bega.2000.0127_RF37","doi-asserted-by":"crossref","first-page":"714","DOI":"10.3109\/00365528709011148","article-title":"Symptoms and endoscopic findings in the diagnosis of gastroesophageal reflux disease","volume":"22","author":"Johnsson","year":"1987","journal-title":"Scandinavian Journal of Gastroenterology"},{"key":"10.1053\/bega.2000.0127_RF38","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0140-6736(90)90287-F","article-title":"Symptoms in gastro-oesophageal reflux disease","volume":"335","author":"Klauser","year":"1990","journal-title":"Lancet"},{"key":"10.1053\/bega.2000.0127_RF39","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1136\/gut.31.4.401","article-title":"Dyspepsia in England and Scotland","volume":"31","author":"Jones","year":"1990","journal-title":"Gut"},{"key":"10.1053\/bega.2000.0127_RF40","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1365-2036.1993.tb00073.x","article-title":"Cimetidine improves GERD symptoms in patients selected by a validated GERD questionnaire","volume":"7","author":"Johnsson","year":"1993","journal-title":"Alimentary Pharmacology and Therapeutics"},{"key":"10.1053\/bega.2000.0127_RF41","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S0025-6196(12)62245-9","article-title":"A new questionnaire for gastroesophageal reflux disease","volume":"69","author":"Locke","year":"1994","journal-title":"Mayo Clinic Proceedings"},{"key":"10.1053\/bega.2000.0127_RF42","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1080\/003655298750026697","article-title":"The usefulness of a structured questionnaire in the assessment of symptomatic gastroesophageal reflux disease","volume":"33","author":"Carlsson","year":"1998","journal-title":"Scandinavian Journal of Gastroenterology"},{"key":"10.1053\/bega.2000.0127_RF43","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1046\/j.1365-2036.1997.00198.x","article-title":"Omeprazole is more effective than cimetidine for the relief of all grades of gastro-oesophageal reflux disease-associated heartburn, irrespective of the presence or absence of endoscopic oesophagitis","volume":"11","author":"Bate","year":"1997","journal-title":"Alimentary Pharmacology and Therapeutics"},{"key":"10.1053\/bega.2000.0127_RF44","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1136\/gut.40.5.587","article-title":"Double blind cross-over placebo controlled study of omeprazole in the treatment of patients with reflux symptoms and physiological levels of acid reflux\u2014the \u2018sensitive oesophagus\u2019","volume":"40","author":"Watson","year":"1997","journal-title":"Gut"},{"key":"10.1053\/bega.2000.0127_RF45","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1136\/bmj.319.7209.550","article-title":"Heartburn treatment in primary care: randomised, double blind study for 8 weeks","volume":"819","author":"Hatlebakk","year":"1999","journal-title":"British Medical Journal"},{"key":"10.1053\/bega.2000.0127_RF46","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1046\/j.1365-2036.1999.00558.x","article-title":"Lansoprazole in the treatment of heartburn in patients without erosive oesophagitis","volume":"13","author":"Richter","year":"1999","journal-title":"Alimentary Pharmacology and Therapeutics"},{"key":"10.1053\/bega.2000.0127_RF47","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1365-2036.1997.tb00799.x","article-title":"Management of endoscopy-negative reflux disease: progress with short-term treatment","volume":"11","author":"Lauritsen","year":"1997","journal-title":"Alimentary Pharmacology and Therapeutics"},{"key":"10.1053\/bega.2000.0127_RF48","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1046\/j.1365-2036.1999.00564.x","article-title":"On demand therapy with omeprazole for the long-term management of patients with heartburn without oesophagitis\u2014a placebo-controlled randomized trial","volume":"13","author":"Lind","year":"1999","journal-title":"Alimentary Pharmacology and Therapeutics"},{"key":"10.1053\/bega.2000.0127_RF49","doi-asserted-by":"crossref","first-page":"627","DOI":"10.3109\/00365529708996509","article-title":"Maintenance treatment for gastro-oesophageal reflux disease. A placebo-controlled evaluation of 10 milligrams omeprazole once daily in general practice","volume":"32","author":"Venables","year":"1997","journal-title":"Scandinavian Journal of Gastroenterology"},{"key":"10.1053\/bega.2000.0127_RF50","first-page":"G0466","article-title":"Quality of life as a predictor of treatment response? A meta-analysis of clinical trials in patients with heartburn with and without esophagitis [abstract]","volume":"116","author":"Wiklund","year":"1999","journal-title":"Gastroenterology"}],"container-title":["Best Practice & Research Clinical Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521691800901276?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521691800901276?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,16]],"date-time":"2021-05-16T05:35:38Z","timestamp":1621143338000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521691800901276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,10]]},"references-count":50,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2000,10]]}},"alternative-id":["S1521691800901276"],"URL":"https:\/\/doi.org\/10.1053\/bega.2000.0127","relation":{},"ISSN":["1521-6918"],"issn-type":[{"value":"1521-6918","type":"print"}],"subject":[],"published":{"date-parts":[[2000,10]]}}}