{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T02:23:29Z","timestamp":1789352609503,"version":"build-2803163510"},"reference-count":100,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2000,12,1]],"date-time":"2000-12-01T00:00:00Z","timestamp":975628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Best Practice &amp; Research Clinical Gastroenterology"],"published-print":{"date-parts":[[2000,12]]},"DOI":"10.1053\/bega.2000.0144","type":"journal-article","created":{"date-parts":[[2002,9,19]],"date-time":"2002-09-19T13:54:50Z","timestamp":1032443690000},"page":"1009-1031","source":"Crossref","is-referenced-by-count":108,"title":["Splenomegaly, hypersplenism and coagulation abnormalities in liver disease"],"prefix":"10.1053","volume":"14","author":[{"given":"P.Aiden","family":"McCormick","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen M.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/bega.2000.0144_RF1","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1056\/NEJM200004273421706","article-title":"Myelofibrosis with myeloid metaplasia","volume":"342","author":"Tefferi","year":"2000","journal-title":"New England Journal of Medicine"},{"key":"10.1053\/bega.2000.0144_RF2","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1007\/BF01308044","article-title":"Effect of portal hypertension on hypersplenism","volume":"25","author":"Mutchnick","year":"1980","journal-title":"Digestive Diseases and Sciences"},{"key":"10.1053\/bega.2000.0144_RF3","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1159\/000040975","article-title":"Splenomegaly at a university hospital compared to a nearby county hospital in 317 patients","volume":"102","author":"Swaroop","year":"1999","journal-title":"Acta Haematologica"},{"key":"10.1053\/bega.2000.0144_RF4","first-page":"1201","article-title":"Apropos de la communication de M Vaquez","volume":"24","author":"Chauffaud","year":"1907","journal-title":"Bulletins et Memoires de la Societe Medicale des Hopitaux de Paris"},{"key":"10.1053\/bega.2000.0144_RF5","first-page":"233","article-title":"Splenectomy is contraindicated for thrombocytopenia secondary to portal hypertension","volume":"160","author":"El-Khishen","year":"1985","journal-title":"Surgery, Gynecology Obstetrics"},{"key":"10.1053\/bega.2000.0144_RF6","first-page":"2580","article-title":"Measurement of spleen size and its relation to hypersplenism and portal haemodynamics in portal hypertension due to hepatic cirrhosis","volume":"91","author":"Shah","year":"1996","journal-title":"American Journal of Gastroenterology"},{"key":"10.1053\/bega.2000.0144_RF7","series-title":"Oxford Textbook of Clinical Hepatology","first-page":"1781","article-title":"Haematological abnormalities in liver disease","author":"Mehta","year":"1999"},{"key":"10.1053\/bega.2000.0144_RF8","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1182\/blood.V84.4.1283.1283","article-title":"Abnormal phospholipid metabolism in spur cell anaemia: decreased fatty acid incorporation into phosphatidylethanolamine and increased incorporation into acylcarnitine in spur cell anaemia erythrocytes","volume":"84","author":"Allen","year":"1994","journal-title":"Blood"},{"key":"10.1053\/bega.2000.0144_RF9","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1002\/hep.1840220418","article-title":"Reduced serum levels of immunoreactive erythropoietin in patients with cirrhosis and chronic anaemia","volume":"22","author":"Siciliano","year":"1995","journal-title":"Hepatology"},{"key":"10.1053\/bega.2000.0144_RF10","first-page":"727","article-title":"Autologous blood transfusion for hepatectomy in patients with cirrhosis and hepatocellular carcinoma: use of recombinant human erythropoietin","volume":"115","author":"Kajikawa","year":"1994","journal-title":"Surgery"},{"key":"10.1053\/bega.2000.0144_RF11","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1002\/hep.1840220611","article-title":"Changes in platelet kinetics after a partial splenic artery embolization in cirrhotic patients with hypersplenism","volume":"22","author":"Noguchi","year":"1995","journal-title":"Hepatology"},{"key":"10.1053\/bega.2000.0144_RF12","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/ajh.2830230307","article-title":"Organ distribution and fate of human platelets: studies of asplenic and splenomegalic patients","volume":"23","author":"Hill-Zobel","year":"1986","journal-title":"American Journal of Haematology"},{"key":"10.1053\/bega.2000.0144_RF13","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.1365-2257.1991.tb00261.x","article-title":"Inter-relationships between platelet count, platelet IgG, serum IgG, immune complexes and severity of liver disease","volume":"13","author":"de Noronha","year":"1991","journal-title":"Clinical Laboratory and Haematology"},{"key":"10.1053\/bega.2000.0144_RF14","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/S0168-8278(98)80348-6","article-title":"Translocation of platelets into Disse spaces and their entry into hepatocytes in response to lipopolysaccharides, interleukin-i and tumour necrosis factor: the role of kupffer cells","volume":"28","author":"Nakamura","year":"1998","journal-title":"Journal of Hepatology"},{"key":"10.1053\/bega.2000.0144_RF15","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S0168-8278(00)80668-6","article-title":"Platelets accumulation in the liver after partial hepatectomy: the role of platelets in liver regeneration","volume":"32","author":"Abe","year":"2000","journal-title":"Journal of Hepatology"},{"key":"10.1053\/bega.2000.0144_RF16","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1034\/j.1399-0012.1999.130503.x","article-title":"Functional, life-threatening disorders and splenectomy following liver transplantation","volume":"13","author":"Troisi","year":"1999","journal-title":"Clinical Transplantation"},{"key":"10.1053\/bega.2000.0144_RF17","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/bjs.1800760230","article-title":"Surgical anatomy of the human spleen","volume":"76","author":"Redmond","year":"1989","journal-title":"British Journal of Surgery"},{"key":"10.1053\/bega.2000.0144_RF18","first-page":"735","article-title":"Late postoperative follow-up of patients submitted to subtotal splenectomy","volume":"63","author":"Petroianu","year":"1997","journal-title":"American Journal of Surgery"},{"key":"10.1053\/bega.2000.0144_RF19","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1097\/00007890-199702150-00029","article-title":"Partial splenic embolization in the treatment of thrombocytopenia after liver transplantation","volume":"63","author":"Herrero","year":"1997","journal-title":"Transplantation"},{"key":"10.1053\/bega.2000.0144_RF20","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1148\/radiology.209.3.9844678","article-title":"Partial splenic embolization in five children with hypersplenism: effects of reduced-volume embolization on efficacy and morbidity","volume":"209","author":"Harned","year":"1998","journal-title":"Radiology"},{"key":"10.1053\/bega.2000.0144_RF21","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0002-9610(97)00006-8","article-title":"Effect of transjugular intrahepatic portosystemic shunt on secondary hypersplenism","volume":"173","author":"Pursnani","year":"1997","journal-title":"American Journal of Surgery"},{"key":"10.1053\/bega.2000.0144_RF22","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/hep.510230105","article-title":"The haematologic consequences of transjugular intrahepatic portosystemic shunts","volume":"23","author":"Sanyal","year":"1996","journal-title":"Hepatology"},{"key":"10.1053\/bega.2000.0144_RF23","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1097\/00007890-200001150-00014","article-title":"Thrombocytopenia in liver transplant recipients","volume":"69","author":"Chang","year":"2000","journal-title":"Transplantation"},{"key":"10.1053\/bega.2000.0144_RF24","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/0016-5085(91)90293-T","article-title":"Does auxiliary heterotropic liver transplantation reverse hypersplenism and portal hypertension?","volume":"100","author":"Rinkes","year":"1991","journal-title":"Gastroenterology"},{"key":"10.1053\/bega.2000.0144_RF25","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/S0168-8278(00)80525-5","article-title":"Short and long-term changes in splanchnic haemodynamics after liver transplantation (OLT)","volume":"32","author":"Bolognesi","year":"2000","journal-title":"Journal of Hepatology"},{"key":"10.1053\/bega.2000.0144_RF26","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1046\/j.1365-2141.1998.00998.x","article-title":"Splenic irradiation for symptomatic splenomegaly associated with myelofibrosis with myeloid metaplasia","volume":"103","author":"Elliot","year":"1998","journal-title":"British Journal of Haematology"},{"key":"10.1053\/bega.2000.0144_RF27","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1148\/radiology.195.1.7892465","article-title":"Congestive hypersplenism: treatment by means of radioembolization of the spleen with Y-90","volume":"195","author":"Becker","year":"1995","journal-title":"Radiology"},{"key":"10.1053\/bega.2000.0144_RF28","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/(SICI)1096-8652(199810)59:2<105::AID-AJH1>3.0.CO;2-1","article-title":"Effect of recombinant human erythropoietin treatment on circulating reticulated platelets in uraemic patient: association with early improvement in platelet function","volume":"59","author":"Tassies","year":"1998","journal-title":"American Journal of Haematology"},{"key":"10.1053\/bega.2000.0144_RF29","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/S0168-8278(05)80316-2","article-title":"Thrombocytopenia of chronic liver disease corrected by erythropoietin treatment","volume":"21","author":"Pirisi","year":"1994","journal-title":"Journal of Hepatology"},{"key":"10.1053\/bega.2000.0144_RF30","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1056\/NEJM199809103391107","article-title":"Thrombopoietin","volume":"339","author":"Kaushansky","year":"1998","journal-title":"New England Journal of Medicine"},{"key":"10.1053\/bega.2000.0144_RF31","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1159\/000040888","article-title":"Changes in serum thrombopoietin levels after splenectomy","volume":"100","author":"Ichikawa","year":"1998","journal-title":"Acta Haematologica"},{"key":"10.1053\/bega.2000.0144_RF32","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1136\/gut.44.5.754","article-title":"Thrombopoietin concentrations are low in patients with cirrhosis and thrombocytopenia and are restored after orthotopic liver transplantation","volume":"44","author":"Goulis","year":"1999","journal-title":"Gut"},{"key":"10.1053\/bega.2000.0144_RF33","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1002\/hep.510280535","article-title":"Blunted thrombopoietin response to interferon alfa-induced thrombocytopenia during treatment for hepatitis C","volume":"28","author":"Peck-Radosavljevic","year":"1998","journal-title":"Hepatology"},{"key":"10.1053\/bega.2000.0144_RF34","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1055\/s-0037-1614848","article-title":"Haematological abnormalities in early abstinent alcoholics are closely associated with alterations in thrombopoietin and erythropoietin profiles","volume":"82","author":"Schmitt","year":"1999","journal-title":"Thrombosis and Haemostasis"},{"key":"10.1053\/bega.2000.0144_RF35","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S0272-2712(18)30355-X","article-title":"Coagulopathies of liver disease","volume":"14","author":"Mammen","year":"1994","journal-title":"Clinical Laboratory Medicine"},{"key":"10.1053\/bega.2000.0144_RF36","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1136\/gut.27.3.339","article-title":"Haemostatic problems in liver disease","volume":"27","author":"Kelly","year":"1986","journal-title":"Gut"},{"key":"10.1053\/bega.2000.0144_RF37","first-page":"119","article-title":"Platelet abnormalities in hepatobiliary disease","volume":"20","author":"Gassman","year":"1990","journal-title":"Annals of Clinical and Laboratory Science"},{"key":"10.1053\/bega.2000.0144_RF38","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0950-3536(05)80192-1","article-title":"The control of production and release of haemostatic factors in the endothelial cell","volume":"6","author":"Pearson","year":"1993","journal-title":"Bailli\u00e8re's Clinical Haematology"},{"key":"10.1053\/bega.2000.0144_RF39","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1365-2141.1984.tb02892.x","article-title":"Production and availability of thromboplastin in endothelial cells: the effect of thrombin, endotoxin and platelets","volume":"57","author":"Brox","year":"1984","journal-title":"British Journal of Haematology"},{"key":"10.1053\/bega.2000.0144_RF40","doi-asserted-by":"crossref","unstructured":"Rapaport, S, I, Rao, L, V, The tissue factor pathway: how it has become a \u2018prima ballerina\u2019 Thrombosis and Haemostasis, 74, 7, 17","DOI":"10.1055\/s-0038-1642646"},{"key":"10.1053\/bega.2000.0144_RF41","series-title":"Haemostasis and Thrombosis","author":"Harper","year":"1994"},{"key":"10.1053\/bega.2000.0144_RF42","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1055\/s-2007-1004413","article-title":"Structure and function of protein C","volume":"10","author":"Stenflo","year":"1984","journal-title":"Seminars in Thrombosis and Hemostasis"},{"key":"10.1053\/bega.2000.0144_RF43","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1055\/s-2007-994930","article-title":"Protein C and S deficiency","volume":"25","author":"Nizzi","year":"1999","journal-title":"Seminars in Thrombosis and Hemostasis"},{"key":"10.1053\/bega.2000.0144_RF44","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0014-4827(72)90260-1","article-title":"Synthesis of coagulation factors by a clonal strain of rat hepatoma cells","volume":"71","author":"Rugstad","year":"1972","journal-title":"Experimental Cell Research"},{"key":"10.1053\/bega.2000.0144_RF45","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/317726a0","article-title":"Distribution of factor VIII mRNA and antigen in human liver and other tissues","volume":"317","author":"Wion","year":"1985","journal-title":"Nature"},{"key":"10.1053\/bega.2000.0144_RF46","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1080\/00365521.1976.12097123","article-title":"Observations of increased levels of blood coagulation factors and plasma proteins in cholestatic liver disease","volume":"11","author":"Cederblad","year":"1976","journal-title":"Scandinavian Journal of Gastroenterology"},{"key":"10.1053\/bega.2000.0144_RF47","first-page":"213","article-title":"Vitamin K: biochemistry, function and deficiency","volume":"39","author":"Mijares","year":"1998","journal-title":"Investigacion Clinica"},{"key":"10.1053\/bega.2000.0144_RF48","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/0268-960X(92)90011-E","article-title":"Vitamin K metabolism and nutrition","volume":"6","author":"Sheraer","year":"1992","journal-title":"Blood Reviews"},{"key":"10.1053\/bega.2000.0144_RF49","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1056\/NEJM198107303050502","article-title":"Acquired vitamin K dependent carboxylation in liver disease","volume":"305","author":"Blanchard","year":"1981","journal-title":"New England Journal of Medicine"},{"key":"10.1053\/bega.2000.0144_RF50","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1136\/jcp.35.6.667","article-title":"Acquired dysfibrinogenaemia in liver disease","volume":"35","author":"Francis","year":"1982","journal-title":"Journal of Clinical Pathology"},{"key":"10.1053\/bega.2000.0144_RF51","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/bja\/69.3.307","article-title":"Thromboelastography","volume":"69","author":"Mallett","year":"1992","journal-title":"British Journal of Anaesthesia"},{"key":"10.1053\/bega.2000.0144_RF52","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/0016-5085(89)90090-5","article-title":"Haemostasis in liver transplantation","volume":"97","author":"Porte","year":"1989","journal-title":"Gastroenterology"},{"key":"10.1053\/bega.2000.0144_RF53","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1213\/00000539-198509000-00008","article-title":"Intra-operative changes in blood coagulation and thromboelastographic monitoring in liver transplantation","volume":"64","author":"Kang","year":"1985","journal-title":"Anaesthesia and Analgesia"},{"key":"10.1053\/bega.2000.0144_RF54","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/ajh.2830110206","article-title":"The aggregation of human platelets by ascitic fluid: a possible mechanism for disseminated intravascular coagulation complicating LeVeen shunts","volume":"11","author":"Salem","year":"1981","journal-title":"American Journal of Haematology"},{"key":"10.1053\/bega.2000.0144_RF55","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1111\/j.1572-0241.1999.01446.x","article-title":"Disseminated intravascular coagulation in liver cirrhosis: fact or fiction?","volume":"94","author":"Ben-ari","year":"1999","journal-title":"American Journal of Gastroenterology"},{"key":"10.1053\/bega.2000.0144_RF56","first-page":"83","article-title":"Fibrinopeptide a in liver cirrhosis: evidence against a major contribution of disseminated intravascular coagulation to coagulopathy of chronic liver disease","volume":"121","author":"Mombelli","year":"1993","journal-title":"Journal of Laboratory and Clinical Medicine"},{"key":"10.1053\/bega.2000.0144_RF57","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1182\/blood.V67.5.1468.1468","article-title":"Analysis of elevated fibrin(ogen) degradation product levels in patients with liver disease","volume":"67","author":"van de Water","year":"1986","journal-title":"Blood"},{"key":"10.1053\/bega.2000.0144_RF58","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1111\/j.1572-0241.1999.02801.x","article-title":"AICF and DIC in liver cirrhosis: expressions of a hypercoagulable state","volume":"94","author":"Joist","year":"1999","journal-title":"American Journal of Gastroenterology"},{"key":"10.1053\/bega.2000.0144_RF59","first-page":"230","article-title":"High D-dimer levels: a possible index of risk of overt bleeding and\/or digestive bleeding in advanced liver cirrhosis","volume":"85","author":"Cioni","year":"1994","journal-title":"Recenti Progressi in Medicine"},{"key":"10.1053\/bega.2000.0144_RF60","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1007\/s001340050472","article-title":"The influence of antithrombin III (ATIII) substitution to supernormal activities on systemic procoagulant turnover in patients with end stage chronic liver disease","volume":"23","author":"Scherer","year":"1997","journal-title":"Intensive Care Medicine"},{"key":"10.1053\/bega.2000.0144_RF61","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1423-0410.1987.tb05065.x","article-title":"Clinical use of antithrombin concentrates","volume":"53","author":"Vinazzer","year":"1987","journal-title":"Vox Sanguinis"},{"key":"10.1053\/bega.2000.0144_RF62","first-page":"s147","article-title":"Recombinant activated factor VII as a universal haemostatic agent","volume":"9","author":"Hedner","year":"1998","journal-title":"Blood Coagulation and Fibrinolysis"},{"key":"10.1053\/bega.2000.0144_RF63","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S0168-8278(99)80357-2","article-title":"Correction of both prothrombin time and primary haemostasis by recombinant factor VII during therapeutic alcohol injection of hepatocellular cancer in liver cirrhosis","volume":"31","author":"Papatheodoridis","year":"1999","journal-title":"Journal of Hepatology"},{"key":"10.1053\/bega.2000.0144_RF64","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/S0041-1345(98)01669-8","article-title":"Quick correction of haemostasis in two patients with fulminant liver failure undergoing liver transplantation by recombinant activated factor VII","volume":"31","author":"Kalicinski","year":"1999","journal-title":"Transplant Proceedings"},{"key":"10.1053\/bega.2000.0144_RF65","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1002\/hep.1840180514","article-title":"Randomized controlled trial of desmopressin plus terlipressin vs terlipressin alone for the treatment of acute variceal hemorrhage in cirrhotic patients: a multicenter, double-blind study","volume":"18","author":"De Franchis","year":"1993","journal-title":"Hepatology"},{"key":"10.1053\/bega.2000.0144_RF66","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1056\/NEJM199807233390407","article-title":"Hemostatic drugs","volume":"339","author":"Mannucci","year":"1998","journal-title":"New England Journal of Medicine"},{"key":"10.1053\/bega.2000.0144_RF67","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1002\/hep.510260509","article-title":"The prophylactic effect of aprotinin on intraoperative bleeding in liver transplantation: a randomized clinical study","volume":"26","author":"Garcia-Huete","year":"1997","journal-title":"Hepatology"},{"key":"10.1053\/bega.2000.0144_RF68","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/S0140-6736(00)02111-5","article-title":"Aprotinin and transfusion requirements in orthotopic liver transplantation: a multicentre randomised double-blind study","volume":"355","author":"Porte","year":"2000","journal-title":"Lancet"},{"key":"10.1053\/bega.2000.0144_RF69","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/S0140-6736(98)10266-0","article-title":"Venous thrombosis: a multicausal disease","volume":"353","author":"Rosendall","year":"1993","journal-title":"Lancet"},{"key":"10.1053\/bega.2000.0144_RF70","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1097\/00000658-198603000-00012","article-title":"Portal thrombosis in cirrhotics, a retrospective analysis","volume":"203","author":"Belli","year":"1986","journal-title":"Annals of Surgery"},{"key":"10.1053\/bega.2000.0144_RF71","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/hep.510310213","article-title":"Inherited coagulation disorders in cirrhotic patients with portal vein thrombosis","volume":"31","author":"Amitrano","year":"2000","journal-title":"Hepatology"},{"key":"10.1053\/bega.2000.0144_RF72","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1002\/hep.510310307","article-title":"Cause of portal or hepatic venous thrombosis in adults: the role of multiple concurrent factors","volume":"31","author":"Denninger","year":"2000","journal-title":"Hepatology"},{"key":"10.1053\/bega.2000.0144_RF73","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/0016-5085(88)90567-7","article-title":"Etiology of portal vein thrombosis in adults. A prospective evaluation of primary myeloproliferative disorders","volume":"94","author":"Valla","year":"1988","journal-title":"Gastroenterology"},{"key":"10.1053\/bega.2000.0144_RF74","first-page":"981","article-title":"In vitro colony culture and chromosomal studies in hepatic and portal vein thrombosis\u2014possible evidence of an occult myeloproliferative disorder","volume":"76","author":"Pagliuca","year":"1990","journal-title":"Quarterly Journal of Medicine"},{"key":"10.1053\/bega.2000.0144_RF75","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1136\/bmj.302.6770.192","article-title":"Hepatic and portal vein thrombosis associated with chronic myeloproliferative disorders","volume":"302","author":"Boughton","year":"1991","journal-title":"British Medical Journal"},{"key":"10.1053\/bega.2000.0144_RF76","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1055\/s-2007-996117","article-title":"Spontaneous erythroid colony formation as the clue to an underlying myeloproliferative disorder in patients with Budd\u2013Chiari syndrome or portal vein thrombosis","volume":"23","author":"De Stefano","year":"1997","journal-title":"Seminars in Thrombosis and Hemostasis"},{"key":"10.1053\/bega.2000.0144_RF77","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1056\/NEJM199511093331904","article-title":"Natural history of paroxysmal nocturnal haemoglobinuria","volume":"333","author":"Hillmen","year":"1995","journal-title":"New England Journal of Medicine"},{"key":"10.1053\/bega.2000.0144_RF78","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1136\/gut.40.6.798","article-title":"Prevalence of the factor V leiden mutation in hepatic and portal vein thrombosis","volume":"40","author":"Mahmoud","year":"1997","journal-title":"Gut"},{"key":"10.1053\/bega.2000.0144_RF79","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1001\/archinte.1984.00350150102029","article-title":"Thromboembolism in patients with the \u2018lupus-like\u2019 circulating anticoagulant","volume":"144","author":"Elias","year":"1984","journal-title":"Archives of Internal Medicine"},{"key":"10.1053\/bega.2000.0144_RF80","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1097\/00004836-200001000-00013","article-title":"The role of natural anticoagulant deficiencies and factor V Leiden in the development of idiopathic portal vein thrombosis","volume":"30","author":"Egesel","year":"2000","journal-title":"Journal of Clinical Gastroenterology"},{"key":"10.1053\/bega.2000.0144_RF81","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1097\/00007890-199910150-00026","article-title":"Inhibitor against factor V after liver transplantation","volume":"68","author":"Leroy-Matheron","year":"1999","journal-title":"Transplantation"},{"key":"10.1053\/bega.2000.0144_RF82","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1111\/j.1365-2141.1994.tb04941.x","article-title":"Acquired factor VIII inhibitor associated with chronic interferon-alpha therapy in a patient with haemophilia A","volume":"87","author":"Castenskiold","year":"1994","journal-title":"British Journal of Haematology"},{"key":"10.1053\/bega.2000.0144_RF83","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1111\/j.1572-0241.1999.01317.x","article-title":"Acquired inhibitors to the coagulation factor XII associated with liver disease","volume":"94","author":"Chalkiadakis","year":"1999","journal-title":"American Journal of Gastroenterology"},{"key":"10.1053\/bega.2000.0144_RF84","first-page":"395","article-title":"Acquired thrombin inhibitor in a patient with liver cirrhosis","volume":"15","author":"Barthels","year":"1985","journal-title":"Haemostasis"},{"key":"10.1053\/bega.2000.0144_RF85","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0039-6060(96)80009-2","article-title":"Current management of visceral artery aneurysms","volume":"120","author":"Carr","year":"1996","journal-title":"Surgery"},{"key":"10.1053\/bega.2000.0144_RF86","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S1072-7515(99)00168-4","article-title":"Management of splenic artery aneurysms: the significance of portal and essential hypertension","volume":"189","author":"Lee","year":"1999","journal-title":"Journal of the American College of Surgeons"},{"key":"10.1053\/bega.2000.0144_RF87","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/S0168-8278(97)80327-3","article-title":"Splenic artery aneurysms in liver transplant patients","volume":"27","author":"Kobori","year":"1997","journal-title":"Journal of Hepatology"},{"key":"10.1053\/bega.2000.0144_RF88","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/S0002-9610(99)80225-6","article-title":"The management of splenic artery aneurysms: experience with 23 cases","volume":"169","author":"Mattar","year":"1995","journal-title":"American Journal of Surgery"},{"key":"10.1053\/bega.2000.0144_RF89","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1053\/gast.1997.v113.pm9322535","article-title":"The arterioportal fistula syndrome: clinicopathologic features, diagnosis and therapy","volume":"113","author":"Vauthey","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1053\/bega.2000.0144_RF90","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/S0016-5085(76)80247-8","article-title":"Symptomatic hepatic disease in cystic fibrosis: incidence, course, and outcome of portal systemic shunt","volume":"70","author":"Stern","year":"1976","journal-title":"Gastroenterology"},{"key":"10.1053\/bega.2000.0144_RF91","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1002\/hep.510300527","article-title":"Natural history of liver disease in cystic fibrosis","volume":"30","author":"Lindblad","year":"1999","journal-title":"Hepatology"},{"key":"10.1053\/bega.2000.0144_RF92","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1006\/bcmd.1998.0198","article-title":"Splenic \u2018regereration\u2019 after partial splenectomy for Gauchers disease: histological features","volume":"24","author":"Freud","year":"1998","journal-title":"Blood Cells Molecules and Diseases"},{"key":"10.1053\/bega.2000.0144_RF93","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0002-9343(97)00134-4","article-title":"Differential effects of enzyme supplementation therapy on manifestations of type 1 Gaucher disease","volume":"103","author":"Hollak","year":"1997","journal-title":"American Journal of Medicine"},{"key":"10.1053\/bega.2000.0144_RF94","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/BF00201528","article-title":"Niemann-Pick disease type C; nodular splenomegaly","volume":"20","author":"Omarini","year":"1995","journal-title":"Abdominal Imaging"},{"key":"10.1053\/bega.2000.0144_RF95","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1136\/jcp.41.6.619","article-title":"Late Niemann\u2013Pick disease with neurovisceral storage: a classification problem","volume":"41","author":"McFarlane","year":"1988","journal-title":"Journal of Clinical Pathology"},{"key":"10.1053\/bega.2000.0144_RF96","series-title":"Portal Hypertension","first-page":"271","article-title":"Idiopathic portal hypertension (hepatoportal sclerosis)","author":"Okuda","year":"1991"},{"key":"10.1053\/bega.2000.0144_RF97","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1002\/hep.510270621","article-title":"Changes in lymph vessels and portal veins in the portal tract of patients with idiopathic portal hypertension: a morphometric study","volume":"27","author":"Oikawa","year":"1998","journal-title":"Hepatology"},{"key":"10.1053\/bega.2000.0144_RF98","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1111\/j.1440-1827.1995.tb03516.x","article-title":"Structural characteristic of splenic sinuses in idiopathic portal hypertension","volume":"45","author":"Maesawa","year":"1995","journal-title":"Pathology International"},{"key":"10.1053\/bega.2000.0144_RF99","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1001\/archsurg.1991.01410300098015","article-title":"High rate of portal thrombosis after splenectomy in patients with esophageal varices and idiopathic portal hypertension","volume":"126","author":"Eguchi","year":"1991","journal-title":"Archives of Surgery"},{"key":"10.1053\/bega.2000.0144_RF100","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1053\/he.2000.5636","article-title":"Hepatocyte transplantation in rats with decompensated cirrhosis","volume":"31","author":"Kabayshi","year":"2000","journal-title":"Hepatology"}],"container-title":["Best Practice &amp; Research Clinical Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521691800901446?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521691800901446?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,16]],"date-time":"2021-05-16T05:50:45Z","timestamp":1621144245000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521691800901446"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,12]]},"references-count":100,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2000,12]]}},"alternative-id":["S1521691800901446"],"URL":"https:\/\/doi.org\/10.1053\/bega.2000.0144","relation":{},"ISSN":["1521-6918"],"issn-type":[{"value":"1521-6918","type":"print"}],"subject":[],"published":{"date-parts":[[2000,12]]}}}