{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T17:49:30Z","timestamp":1757699370768},"reference-count":92,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2001,10,1]],"date-time":"2001-10-01T00:00:00Z","timestamp":1001894400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Best Practice & Research Clinical Gastroenterology"],"published-print":{"date-parts":[[2001,10]]},"DOI":"10.1053\/bega.2001.0233","type":"journal-article","created":{"date-parts":[[2002,9,19]],"date-time":"2002-09-19T13:54:50Z","timestamp":1032443690000},"page":"755-773","source":"Crossref","is-referenced-by-count":22,"title":["Prevention and treatment of gastrointestinal symptoms and complications due to NSAIDs"],"prefix":"10.1053","volume":"15","author":[{"given":"Denis M.","family":"McCarthy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1053\/bega.2001.0233_RF1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0049-0172(87)90005-9","article-title":"Anti-inflammatory drugs and gastric mucosal damage","volume":"16","author":"Semble","year":"1987","journal-title":"Seminars in Arthritis & Rheumatism"},{"key":"10.1053\/bega.2001.0233_RF2","first-page":"1153","article-title":"Gastroduodenal mucosa and dyspeptic symptoms in arthritic patients during chronic nonsteroidal anti-inflammatory drug use","volume":"82","author":"Larkai","year":"1987","journal-title":"American Journal of Gastroenterology"},{"key":"10.1053\/bega.2001.0233_RF3","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1097\/00004836-198704000-00007","article-title":"The effect of nonsteroidal anti-inflammatory drugs on upper gastrointestinal tract symptoms and mucosal integrity","volume":"9","author":"Katzka","year":"1987","journal-title":"Journal of Clinical Gastroenterology"},{"key":"10.1053\/bega.2001.0233_RF4","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0002-9343(88)90248-3","article-title":"Clinical spectrum of the upper gastrointestinal effects of nonsteroidal anti-inflammatory drugs","volume":"84","author":"Butt","year":"1988","journal-title":"American Journal of Medicine"},{"key":"10.1053\/bega.2001.0233_RF5","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1097\/00004836-198904000-00009","article-title":"Dyspepsia in NSAID users: the size of the problem","volume":"11","author":"Larkai","year":"1989","journal-title":"Journal of Clinical Gastroenterology"},{"key":"10.1053\/bega.2001.0233_RF6","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1365-2036.1988.tb00767.x","article-title":"Treatment of endoscopy-negative NSAID-induced upper gastrointestinal symptoms with cimetidine; an international multicenter collaborative study","volume":"2S","author":"Bjilsma","year":"1988","journal-title":"Alimentary Pharmacology and Therapy"},{"key":"10.1053\/bega.2001.0233_RF7","doi-asserted-by":"crossref","first-page":"48S","DOI":"10.1016\/S0002-9343(99)00367-8","article-title":"Gastrointestinal safety profile of meloxicam: a meta-analysis and systematic review of randomized controlled clinical trials","volume":"107","author":"Schoenfeld","year":"1999","journal-title":"American Journal of Medicine"},{"key":"10.1053\/bega.2001.0233_RF8","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1056\/NEJM200011233432103","article-title":"Comparison of upper gastrointestinal toxicity of Rofecoxib and Naproxen in patients with rheumatoid arthritis","volume":"343","author":"Bombardier","year":"2000","journal-title":"New England Journal of Medicine"},{"key":"10.1053\/bega.2001.0233_RF9","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1001\/jama.284.10.1247","article-title":"Gastrointestinal toxicity with Celecoxib vs Nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis","volume":"284","author":"Silverstein","year":"2000","journal-title":"Journal of the American Medical Association"},{"key":"10.1053\/bega.2001.0233_RF10","first-page":"A146","article-title":"Prevention of NSAID-induced ulcers with cimetidine: results of a double-blind, placebo-controlled trial","volume":"98","author":"Wallin","year":"1990","journal-title":"Gastroenterology"},{"key":"10.1053\/bega.2001.0233_RF11","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/rheumatology\/30.1.16","article-title":"Serological evidence of infection with Helicobacter pylori may produce intolerance to non-steroidal anti-inflammatory drug (NSAID) treatment in rheumatoid arthritis","volume":"30","author":"Jones","year":"1991","journal-title":"British Journal of Rheumatology"},{"key":"10.1053\/bega.2001.0233_RF12","first-page":"735","article-title":"Effect of Helicobacter pylori infection on the severity of gastroduodenal mucosal injury after the acute administration of naproxen or aspirin to normal volunteers","volume":"86","author":"Lanza","year":"1991","journal-title":"American Journal of Gastroenterology"},{"key":"10.1053\/bega.2001.0233_RF13","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1016\/0016-5085(91)90665-8","article-title":"Long-term nonsteroidal anti-inflammatory drug use and Helicobacter pylori infection","volume":"100","author":"Graham","year":"1991","journal-title":"Gastroenterology"},{"key":"10.1053\/bega.2001.0233_RF14","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1016\/0016-5085(92)90311-L","article-title":"Long-term Nonsteroidal anti-inflammatory drug use and gastroduodenal injury: the role of Helicobacter pylori","volume":"102","author":"Leob","year":"1992","journal-title":"Gastroenterology"},{"key":"10.1053\/bega.2001.0233_RF15","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1007\/BF02087562","article-title":"Inter-relationships between Helicobacter pylori infection, nonsteroidal anti-inflammatory drugs and gastroduodenal disease","volume":"39","author":"Thillainayagan","year":"1994","journal-title":"Digestive Diseases and Sciences"},{"key":"10.1053\/bega.2001.0233_RF16","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1093\/rheumatology\/27.2.110","article-title":"Nonsteroidal anti-inflammatory drug-induced dyspepsia\u2013is campylobacter pyloridis implicated","volume":"27","author":"Doube","year":"1998","journal-title":"British Journal of Rheumatology"},{"key":"10.1053\/bega.2001.0233_RF17","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1093\/rheumatology\/27.2.113","article-title":"Campylobacter pylori -associated gastritis in patients with rheumatoid arthritis taking nonsteroidal anti-inflammatory drugs","volume":"27","author":"Upadhyay","year":"1988","journal-title":"British Journal of Rheumatology"},{"key":"10.1053\/bega.2001.0233_RF18","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1136\/jcp.45.2.135","article-title":"Chemical gastritis and Helicobacter pylori related gastritis in patients receiving nonsteroidal anti-inflammatory drugs: comparison and correlation with peptic ulceration","volume":"45","author":"Taha","year":"1992","journal-title":"Journal of Clinical Pathology"},{"key":"10.1053\/bega.2001.0233_RF19","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1136\/gut.34.6.748","article-title":"Effect of Helicobacter pylori colonisation on gastric mucosal eicosanoid synthesis in patients taking NSAIDs","volume":"34","author":"Hudson","year":"1993","journal-title":"Gut"},{"key":"10.1053\/bega.2001.0233_RF20","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1136\/gut.34.12.1677","article-title":"Helicobacter pylori infection and its effect on symptoms and nonsteroidal drug-induced gastrointestinal damage in patients with rheumatoid athritis","volume":"34","author":"Goggin","year":"1993","journal-title":"Gut"},{"key":"10.1053\/bega.2001.0233_RF21","first-page":"A66","article-title":"Dyspepsia with nonsteroidal anti-inflammatory drugs: role of prostaglandins and enteric neurones","volume":"106","author":"Cullen","year":"1994","journal-title":"Gastroenterology"},{"key":"10.1053\/bega.2001.0233_RF22","first-page":"276","article-title":"Nonsteroidal anti-inflammatory drugs cause gastrointestinal ulcers mainly in Helicobacter pylori carriers","volume":"106","author":"Publig","year":"1994","journal-title":"Wien Klin Wochenschr"},{"key":"10.1053\/bega.2001.0233_RF23","first-page":"A318","article-title":"New or worsening dyspepsia as a predictor of ulcer bleeding with reference to H. pylori status and NSAID use","volume":"116","author":"Stack","year":"1999","journal-title":"Gastroenterology"},{"key":"10.1053\/bega.2001.0233_RF24","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.1365-2036.1995.tb00361.x","article-title":"Interaction of NSAIDs and Helicobacter pylori on gastrointestinal injury and prostaglandin: a controlled double-blind trial","volume":"9","author":"Laine","year":"1995","journal-title":"Alimentary Pharmacology and Therapy"},{"key":"10.1053\/bega.2001.0233_RF25","doi-asserted-by":"crossref","DOI":"10.1080\/110241501317076272","article-title":"Helicobacter pylori and NSAIDs\u2013What interaction?","volume":"167","author":"McCarthy","year":"2001","journal-title":"European Journal of Surgery"},{"key":"10.1053\/bega.2001.0233_RF26","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/S0140-6736(98)04206-8","article-title":"Randomized controlled trial of Helicobacter pylori eradication in patients on non-steroidal anti-inflammatory drugs: Help NSAIDs Study","volume":"352","author":"Hawkey","year":"1998","journal-title":"Lancet"},{"key":"10.1053\/bega.2001.0233_RF27","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1111\/j.1572-0241.1999.00863.x","article-title":"Gastric emptying of solids in NSAID-users: correlation with endoscopic findings and H. pylori status","volume":"94","author":"Kulkarni","year":"1999","journal-title":"American Journal of Gastroenterology"},{"key":"10.1053\/bega.2001.0233_RF28","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1016\/S0016-5085(19)30504-9","article-title":"Effect of prostacyclin on gastric emptying and secretion in Rhesus monkeys","volume":"78","author":"Shea-Donohue","year":"1980","journal-title":"Gastroenterology"},{"key":"10.1053\/bega.2001.0233_RF29","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/0016-5085(90)90816-J","article-title":"Aspirin-induced changes in gastric function\u2013 role of endogenous prostaglandins and mucosal damage","volume":"98","author":"Shea-Donohue","year":"1990","journal-title":"Gastroenterology"},{"key":"10.1053\/bega.2001.0233_RF30","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/S0016-5085(89)80063-0","article-title":"Nonsteroidal anti-inflammatory drug-induced ulcers: management by traditional therapies","volume":"96","author":"McCarthy","year":"1989","journal-title":"Gastroenterology"},{"key":"10.1053\/bega.2001.0233_RF31","doi-asserted-by":"crossref","first-page":"307","DOI":"10.7326\/0003-4819-114-4-307","article-title":"Nonsteroidal anti-inflammatory drugs and peptic ulcer disease","volume":"114","author":"Soll","year":"1991","journal-title":"Annals of Internal Medicine"},{"key":"10.1053\/bega.2001.0233_RF32","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1136\/bmj.300.6720.278","article-title":"Nonsteroidal anti-inflammatory drugs and peptic ulcer","volume":"300","author":"Hawkey","year":"1990","journal-title":"British Medical Journal"},{"key":"10.1053\/bega.2001.0233_RF33","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0016-5107(80)73248-0","article-title":"The prevalence of duodenal lesions in patients with rheumatic disease on chronic aspirins therapy","volume":"26","author":"Lockard","year":"1980","journal-title":"Gastrointestinal Endoscopy"},{"key":"10.1053\/bega.2001.0233_RF34","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1093\/rheumatology\/32.suppl_4.35","article-title":"Nonsteroidal anti-inflammatory drugs","volume":"32","author":"Blower","year":"1993","journal-title":"British Journal of Rheumatology"},{"key":"10.1053\/bega.2001.0233_RF35","series-title":"Digestive diseases in the United States: Epidemiology and Impact\u2013NIH: 94\u20131447","first-page":"359","article-title":"Peptic ulcer","author":"Sonnenberg","year":"1994"},{"key":"10.1053\/bega.2001.0233_RF36","doi-asserted-by":"crossref","first-page":"37S","DOI":"10.1016\/S0002-9343(99)00366-6","article-title":"Comparative toxicity of nonsteroidal and anti-inflammatory drugs","volume":"107","author":"McCarthy","year":"1999","journal-title":"American Journal of Medicine"},{"key":"10.1053\/bega.2001.0233_RF37","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/S0016-5085(89)80060-5","article-title":"Epidemiologic evidence on the association between peptic ulceration anti-inflammatory drug use","volume":"96","author":"Langman","year":"1989","journal-title":"Gastronterology"},{"key":"10.1053\/bega.2001.0233_RF38","doi-asserted-by":"crossref","first-page":"438","DOI":"10.3109\/00365529509093304","article-title":"Nonsteroidal anti-inflammatory drugs and upper gastrointestinal bleeding, identifying high-risk groups by excess risk estimates","volume":"30","author":"Hallas","year":"1995","journal-title":"Scandinavian Journal of Gastroenterology"},{"key":"10.1053\/bega.2001.0233_RF39","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1001\/archinte.160.14.2093","article-title":"Association between nonsteroidal anti-inflammatory drugs and upper gastrointestinal tract-bleeding\/perforation","volume":"160","author":"Hernandez-Diaz","year":"2000","journal-title":"Archives of Internal Medicine"},{"key":"10.1053\/bega.2001.0233_RF40","doi-asserted-by":"crossref","first-page":"241","DOI":"10.7326\/0003-4819-123-4-199508150-00001","article-title":"Misoprostol reduces serious gastrointestinal complications in patients with rheumatoid arthritis receiving nonsteroidal anti-inflammatory drugs","volume":"123","author":"Silverstein","year":"1995","journal-title":"Annals of Internal Medicine"},{"key":"10.1053\/bega.2001.0233_RF41","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0016-5085(82)90029-4","article-title":"Editorial\u2013inadequacy of the literature on the relationship between drugs, ulcers, and gastrointestinal bleeding","volume":"82","author":"Kurata","year":"1982","journal-title":"Gastroenterology"},{"key":"10.1053\/bega.2001.0233_RF42","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1042\/cs0810565","article-title":"Separation of the impairment of homeostasis by aspirin from mucosal injury in the human stomach","volume":"81","author":"Hawkey","year":"1991","journal-title":"Clinical Science"},{"key":"10.1053\/bega.2001.0233_RF43","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3109\/00365529209095974","article-title":"Nonsteroidal anti-inflammatory drugs: the clinical dilemmas","volume":"27","author":"McCarthy","year":"1992","journal-title":"Scandinavian Journal of Gastroenterology"},{"key":"10.1053\/bega.2001.0233_RF44","doi-asserted-by":"crossref","first-page":"3S","DOI":"10.1016\/S0002-9343(98)00274-5","article-title":"Nonsteroidal anti-inflammatory drug-related gastrointestinal toxicity: definitions and epidemiology","volume":"105","author":"McCarthy","year":"1998","journal-title":"American Journal of Medicine"},{"key":"10.1053\/bega.2001.0233_RF45","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1097\/00004836-199006000-00005","article-title":"The effect of chronic aspirin use on duodenal and gastric ulcer hospitalizations","volume":"12","author":"Kurata","year":"1990","journal-title":"Journal of Clinical Gastroenterology"},{"key":"10.1053\/bega.2001.0233_RF46","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/0016-5085(92)90018-T","article-title":"Objective evidence of aspirin use in both ulcer and non-ulcer upper and lower gastrointestinal bleeding","volume":"103","author":"Lanas","year":"1992","journal-title":"Gastroenterology"},{"key":"10.1053\/bega.2001.0233_RF47","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1136\/bmj.2.5707.450","article-title":"Influence of achlorhyhydria on aspirin-induced occult gastrointestinal blood loss: Studies in Addisonian pernicious anemia","volume":"2","author":"St John","year":"1970","journal-title":"British Medical Journal"},{"key":"10.1053\/bega.2001.0233_RF48","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/j.1552-4604.1995.tb04050.x","article-title":"Effects of nonsteroidal anti-inflammatory drugs on platelet function and systemic hemostasis","volume":"35","author":"Schafer","year":"1995","journal-title":"Journal of Clinical Pharmacology"},{"key":"10.1053\/bega.2001.0233_RF49","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S0140-6736(94)91843-0","article-title":"Risk of upper gastrointestinal bleeding and perforation associated with individual nonsteroidal anti-inflammatory drugs","volume":"343","author":"Garcia-Rodriguez","year":"1994","journal-title":"Lancet"},{"key":"10.1053\/bega.2001.0233_RF50","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/0016-5085(93)90952-9","article-title":"Variability in the risk of major gastrointestinal complications from non-aspirin nonsteroidal anti-inflammatory drugs","volume":"105","author":"Henry","year":"1993","journal-title":"Gastroenterology"},{"key":"10.1053\/bega.2001.0233_RF51","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1046\/j.1365-2125.1997.00631.x","article-title":"Consumption of nonsteroidal anti-inflammatory drugs and the development of functional renal impairment in elderly subjects: results of a case control study","volume":"44","author":"Henry","year":"1997","journal-title":"British Journal of Clinical Pharmacology"},{"key":"10.1053\/bega.2001.0233_RF52","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1053\/gast.1997.v112.pm9041228","article-title":"Evidence of aspirin use in both upper and lower gastrointestinal perforation","volume":"112","author":"Lanas","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1053\/bega.2001.0233_RF53","first-page":"631","article-title":"Nonsteroidal anti-inflammatory drugs and peptic ulcer perforation","volume":"13","author":"Collier","year":"1972","journal-title":"Gut"},{"key":"10.1053\/bega.2001.0233_RF54","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1136\/gut.13.8.631","article-title":"Aspirin ingestion and perforated peptic ulcer","volume":"13","author":"Duggan","year":"1972","journal-title":"Gut"},{"key":"10.1053\/bega.2001.0233_RF55","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1136\/gut.41.2.177","article-title":"Smoking and ulcer perforation","volume":"41","author":"Svanes","year":"1997","journal-title":"Gut"},{"key":"10.1053\/bega.2001.0233_RF56","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/bjs.1800640406","article-title":"Drug consumption before perforation of peptic ulcer","volume":"64","author":"Jorgensen","year":"1977","journal-title":"British Journal of Surgery"},{"key":"10.1053\/bega.2001.0233_RF57","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1097\/00004836-199504000-00006","article-title":"Nonsteroidal anti-inflammatory drugs are associated with gastric outlet obstruction","volume":"20","author":"Weaver","year":"1995","journal-title":"Journal of Clinical Gastroenterology"},{"key":"10.1053\/bega.2001.0233_RF58","first-page":"219","article-title":"Nonsteroidal anti-inflammatory drugs: reducing the risk to the gastrointestinal tract","volume":"2","author":"McCarthy","year":"1999","journal-title":"Clinical Perspectives in Gastroenterology"},{"key":"10.1053\/bega.2001.0233_RF59","first-page":"497","article-title":"Gastrointestinal events in patients prescribed nonsteroidal anti-inflammatory drugs: a controlled study using record linkage in Tayside","volume":"NS 71","author":"Beardon","year":"1989","journal-title":"Quarterly Journal of Medicine"},{"key":"10.1053\/bega.2001.0233_RF60","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0895-4356(96)00361-7","article-title":"A cohort study (with resampled comparator groups) to measure the association between new NSAID prescribing and upper gastrointestinal hemorrhage and perforation","volume":"50","author":"McMahon","year":"1997","journal-title":"Journal of Clinical Epidemiology"},{"key":"10.1053\/bega.2001.0233_RF61","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1001\/archinte.1992.00400180139023","article-title":"The impact of research quality and study design on epidemiologic estimates of the effect of nonsteroidal anti-inflammatory drugs on upper gastrointestinal tract disease","volume":"152","author":"Bollini","year":"1992","journal-title":"Archives of Internal Medicine"},{"key":"10.1053\/bega.2001.0233_RF62","first-page":"171","article-title":"Gastrointestinal bleeding and nonsteroidal anti-inflammatory drugs","volume":"3","author":"Henry","year":"1994","journal-title":"Current Medicine"},{"key":"10.1053\/bega.2001.0233_RF63","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/0895-4356(94)90170-8","article-title":"Evidence of the \u201cdepletion of susceptibles\u201d effect in non-experimental pharmaco-epidemiologic research","volume":"47","author":"Moride","year":"1994","journal-title":"Journal of Clinical Epidemiology"},{"key":"10.1053\/bega.2001.0233_RF64","doi-asserted-by":"crossref","first-page":"257","DOI":"10.7326\/0003-4819-114-4-257","article-title":"Nonsteroidal anti-inflammatory drug use and increased risk for peptic ulcer disease in elderly persons","volume":"114","author":"Griffin","year":"1991","journal-title":"Annals of Internal Medicine"},{"key":"10.1053\/bega.2001.0233_RF65","doi-asserted-by":"crossref","unstructured":"Somerville, K, Faulkner, G, Langman, M, Nonsteroidal anti-inflammatory drugs and bleeding peptic ulcer, Lancet, 1, (8479), 462, 464","DOI":"10.1016\/S0140-6736(86)92927-2"},{"key":"10.1053\/bega.2001.0233_RF66","first-page":"A143","article-title":"Peptic ulcer (PU) deaths: how many occurs at home or after nonsteroidal anti-inflammatory drug (NSAID) prescribing?","volume":"29","author":"Quader","year":"1988","journal-title":"Gut"},{"key":"10.1053\/bega.2001.0233_RF67","doi-asserted-by":"crossref","first-page":"359","DOI":"10.7326\/0003-4819-109-5-359","article-title":"Nonsteroidal anti-inflammatory drug use and death from peptic ulcer in elderly persons","volume":"109","author":"Griffin","year":"1998","journal-title":"Annals of Internal Medicine"},{"key":"10.1053\/bega.2001.0233_RF68","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1136\/bmj.295.6608.1227","article-title":"Fatal peptic ulcer complications and the use of non-steroidal anti-inflammatory drugs, aspirin and corticosteroids","volume":"295","author":"Henry","year":"1987","journal-title":"British Medical Journal"},{"key":"10.1053\/bega.2001.0233_RF69","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1007\/BF02087411","article-title":"Prognostic factors in upper gastrointestinal bleeding","volume":"39","author":"Katschinski","year":"1994","journal-title":"Digestive Diseases and Sciences"},{"key":"10.1053\/bega.2001.0233_RF70","first-page":"A17","article-title":"Pattern and prevalence of nonsteroidal anti-inflammatory drug (NSAID) use in complicated peptic ulcer disease","volume":"100","author":"Saleeby","year":"1991","journal-title":"Gastroenterology"},{"key":"10.1053\/bega.2001.0233_RF71","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S0002-9343(96)00380-4","article-title":"Toxicity of nonsteroidal anti-inflammatory drugs in the elderly: is advanced age a risk factor?","volume":"102","author":"Solomon","year":"1997","journal-title":"American Journal of Medicine"},{"key":"10.1053\/bega.2001.0233_RF72","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3109\/03009749409103057","article-title":"Effect of cimetidine on gastrointestinal symptoms in patients taking nonsteroidal anti-inflammatory drugs","volume":"23","author":"Rugstad","year":"1994","journal-title":"Scandinavian Journal of Rheumatology"},{"key":"10.1053\/bega.2001.0233_RF73","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/0895-4356(92)90127-9","article-title":"Trends in the utilization of nonsteroidal anti-inflammatory drugs in the United States, 1986\u20131990","volume":"45","author":"Gabriel","year":"1992","journal-title":"Journal of Clinical Epidemiology"},{"key":"10.1053\/bega.2001.0233_RF74","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S0889-8553(05)70253-3","article-title":"The risks and costs of upper gastrointestinal disease attributable to NSAIDs","volume":"25","author":"Smalley","year":"1996","journal-title":"Gastroenterology Clinics of North America"},{"key":"10.1053\/bega.2001.0233_RF75","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/0002-9343(87)90832-1","article-title":"Sucralfate treatment of nonsteroidal anti-inflammatory drug-induced gastrointestinal symptoms and mucosal damage","volume":"83","author":"Caldwell","year":"1987","journal-title":"American Journal of Medicine"},{"key":"10.1053\/bega.2001.0233_RF76","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/0002-9343(89)90160-5","article-title":"Lack of gastric mucosal protection by sucralfate during long-term aspirin ingestion in human subjects","volume":"86","author":"Stern","year":"1989","journal-title":"American Journal of Medicine"},{"key":"10.1053\/bega.2001.0233_RF77","doi-asserted-by":"crossref","first-page":"195","DOI":"10.7326\/0003-4819-115-3-195","article-title":"Misoprostol compared with sucralfate in the prevention of nonsteroidal anti-inflammatory drug-induced gastric ulcer","volume":"115","author":"Agrawal","year":"1991","journal-title":"Annals of Internal Medicine"},{"key":"10.1053\/bega.2001.0233_RF78","first-page":"333","article-title":"Efficacy of sucralfate in the prevention of stomach disease induced by nonsteroidal anti-inflammatory drugs","volume":"130","author":"Fioravanti","year":"1989","journal-title":"Clinical Therapy"},{"key":"10.1053\/bega.2001.0233_RF79","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/S0140-6736(88)92892-9","article-title":"Prevention of NSAID-induced gastric ulcer with misoprostol, multi-center, double-blind, placebo-controlled trial","volume":"ii","author":"Graham","year":"1988","journal-title":"Lancet"},{"key":"10.1053\/bega.2001.0233_RF80","first-page":"358","article-title":"Patient preferences for nonsteroidal anti-inflammatory drug-related gastrointestinal complications and their prophylaxis","volume":"20","author":"Gabriel","year":"1993","journal-title":"Journal of Rheumatology"},{"key":"10.1053\/bega.2001.0233_RF81","doi-asserted-by":"crossref","first-page":"753","DOI":"10.3109\/00365529609010347","article-title":"Prevention of peptic ulcer and dyspeptic symptoms with omeprazole in patients receiving continuous nonsteroidal anti-inflammatory drug therapy","volume":"31","author":"Ekstrom","year":"1996","journal-title":"Scandinavian Journal of Gastroenterology"},{"key":"10.1053\/bega.2001.0233_RF82","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1046\/j.1365-2036.1998.00288.x","article-title":"Primary gastroduodenal prophylaxis with omeprazole for NSAID users","volume":"12","author":"Cullen","year":"1998","journal-title":"Alimentary Pharmacology and Therapy"},{"key":"10.1053\/bega.2001.0233_RF83","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1056\/NEJM199803123381104","article-title":"A comparison of omeprazole with ranitidine for ulcers associated with nonsteroidal anti-inflammatory drugs","volume":"338","author":"Yeomans","year":"1998","journal-title":"New England Journal of Medicine"},{"key":"10.1053\/bega.2001.0233_RF84","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1056\/NEJM199803123381105","article-title":"Omeprazole compared with misoprostol for ulcers associated with nonsteroidal anti-inflammatory drug use","volume":"338","author":"Hawkey","year":"1998","journal-title":"New England Journal of Medicine"},{"key":"10.1053\/bega.2001.0233_RF85","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1056\/NEJM199807303390516","article-title":"Therapies for ulcers associated with nonsteroidal anti-inflammatory drugs","volume":"339","author":"Guslandi","year":"1998","journal-title":"New England Journal of Medicine"},{"key":"10.1053\/bega.2001.0233_RF86","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1046\/j.1365-2036.2001.00874.x","article-title":"Helicobacter pylori screening for individuals requiring chronic NSAID therapy: a decision analysis","volume":"15","author":"Scheiman","year":"2001","journal-title":"Alimentary Pharmacology and Therapy"},{"key":"10.1053\/bega.2001.0233_RF87","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1097\/00004836-199000000-00004","article-title":"NSAID-induced gastrointestinal damage: a critical review of prophylaxis and therapy","volume":"12","author":"McCarthy","year":"1990","journal-title":"Journal of Clinical Gastroenterology"},{"key":"10.1053\/bega.2001.0233_RF88","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1136\/gut.32.3.252","article-title":"Ranitidine in the treatment of nonsteroidal anti-inflammatory drug associated gastric and duodenal ulcers","volume":"32","author":"Lancaster-Smith","year":"1991","journal-title":"Gut"},{"key":"10.1053\/bega.2001.0233_RF89","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1056\/NEJM198901123200201","article-title":"Effect of omeprazole and ranitidine on ulcer healing and relapse rates in patients with benign gastric ulcer","volume":"320","author":"Walan","year":"1989","journal-title":"New England Journal of Medicine"},{"key":"10.1053\/bega.2001.0233_RF90","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1001\/archinte.160.10.1455","article-title":"Superiority of lansoprazole vs ranitidine in healing nonsteroidal drug-associated gastric ulcers","volume":"160","author":"Agrawal","year":"2000","journal-title":"Archives of Internal Medicine"},{"key":"10.1053\/bega.2001.0233_RF91","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1056\/NEJM200103293441304","article-title":"Preventing recurrent upper gastrointestinal bleeding in patients with Helicobacter pylori infection who are taking low-dose aspirin or naproxen","volume":"344","author":"Chan","year":"2001","journal-title":"New England Journal of Medicine"},{"key":"10.1053\/bega.2001.0233_RF92","doi-asserted-by":"crossref","first-page":"58S","DOI":"10.1016\/S0002-9343(00)00644-6","article-title":"Helicobacter pylori and nonsteroidal anti-inflammatory drugs: interaction with PPI therapy for prevention of NSAID ulcers and ulcer complications\u2013future research needs","volume":"110","author":"Graham","year":"2001","journal-title":"American Journal of Medicine"}],"container-title":["Best Practice & Research Clinical Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521691801902331?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521691801902331?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T22:04:06Z","timestamp":1704319446000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521691801902331"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,10]]},"references-count":92,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2001,10]]}},"alternative-id":["S1521691801902331"],"URL":"https:\/\/doi.org\/10.1053\/bega.2001.0233","relation":{},"ISSN":["1521-6918"],"issn-type":[{"value":"1521-6918","type":"print"}],"subject":[],"published":{"date-parts":[[2001,10]]}}}