{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T23:05:57Z","timestamp":1784675157438,"version":"3.55.0"},"reference-count":108,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2002,12,1]],"date-time":"2002-12-01T00:00:00Z","timestamp":1038700800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Best Practice & Research Clinical Gastroenterology"],"published-print":{"date-parts":[[2002,12]]},"DOI":"10.1053\/bega.2002.0356","type":"journal-article","created":{"date-parts":[[2002,12,11]],"date-time":"2002-12-11T01:48:30Z","timestamp":1039571310000},"page":"869-883","source":"Crossref","is-referenced-by-count":27,"title":["Evolving concepts in functional gastrointestinal disorders: promising directions for novel pharmaceutical treatments"],"prefix":"10.1053","volume":"16","author":[{"given":"Richard H.","family":"Hunt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gervais","family":"Tougas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/bega.2002.0356_RF1","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/236385a0","article-title":"Definition of antagonism of histamine H2-receptors","volume":"236","author":"Black","year":"1972","journal-title":"Nature"},{"key":"10.1053\/bega.2002.0356_RF2","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1097\/00004836-200207001-00002","article-title":"Evolving concepts in the pathophysiology of functional gastrointestinal disorders","volume":"35","author":"Hunt","year":"2002","journal-title":"Journal of Clinical Gastroenterology"},{"key":"10.1053\/bega.2002.0356_RF3","doi-asserted-by":"crossref","first-page":"782","DOI":"10.7326\/0003-4819-123-10-199511150-00007","article-title":"Sexual and physical abuse and gastrointestinal illness. Review and recommendations","volume":"123","author":"Drossman","year":"1995","journal-title":"Annals of Internal Medicine"},{"key":"10.1053\/bega.2002.0356_RF4","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0304-3959(01)00285-8","article-title":"Hypersensitivity to visceral and cutaneous pain in the irritable bowel syndrome","volume":"93","author":"Verne","year":"2001","journal-title":"Pain"},{"key":"10.1053\/bega.2002.0356_RF5","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/0016-5085(95)90267-8","article-title":"Altered rectal perception is a biological marker of patients with irritable bowel syndrome","volume":"109","author":"Mertz","year":"1995","journal-title":"Gastroenterology"},{"key":"10.1053\/bega.2002.0356_RF6","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/0016-5085(90)90332-U","article-title":"Tolerance for rectosigmoid distention in irritable bowel syndrome","volume":"98","author":"Whitehead","year":"1990","journal-title":"Gastroenterology"},{"key":"10.1053\/bega.2002.0356_RF7","doi-asserted-by":"crossref","first-page":"i20","DOI":"10.1136\/gut.51.suppl_1.i29","article-title":"Role of the brain and sensory pathways in gastrointestinal sensory disorders in humans","volume":"51","author":"Mertz","year":"2002","journal-title":"Gut"},{"key":"10.1053\/bega.2002.0356_RF8","doi-asserted-by":"crossref","first-page":"G519","DOI":"10.1152\/ajpgi.2001.280.4.G519","article-title":"Stress and irritable bowel syndrome","volume":"280","author":"Mayer","year":"2001","journal-title":"American Journal of Physiology\u2013Gastrointestinal Liver Physiology"},{"key":"10.1053\/bega.2002.0356_RF9","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1053\/gast.1997.v113.pm9322517","article-title":"Persistent intestinal neuromuscular dysfunction after acute nematode infection in mice","volume":"113","author":"Barbara","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1053\/bega.2002.0356_RF10","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1749-6632.1992.tb39780.x","article-title":"Effect of inflammation of enteric nerves. Cytokine-induced changes in neurotransmitter content and release","volume":"664","author":"Collins","year":"1992","journal-title":"Annals of the New York Academy of Sciences"},{"key":"10.1053\/bega.2002.0356_RF11","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0016-5085(91)90456-U","article-title":"T-lymphocyte modulation of intestinal muscle function in the Trichinella-infected rat","volume":"101","author":"Vermillion","year":"1991","journal-title":"Gastroenterology"},{"key":"10.1053\/bega.2002.0356_RF12","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/S0016-5085(97)70230-0","article-title":"The mechanism of altered neural function in a rat model of acute colitis","volume":"112","author":"Jacobson","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1053\/bega.2002.0356_RF13","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1053\/gast.2002.33579","article-title":"Activation of the mucosal immune system in irritable bowel syndrome","volume":"122","author":"Chadwick","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1053\/bega.2002.0356_RF14","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1053\/gast.2002.34097","article-title":"A case for an immunological basis for irritable bowel syndrome","volume":"122","author":"Collins","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1053\/bega.2002.0356_RF15","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/S0140-6736(96)90341-4","article-title":"Psychometric scores and persistence of irritable bowel after infectious diarrhoea","volume":"347","author":"Gwee","year":"1996","journal-title":"Lancet"},{"key":"10.1053\/bega.2002.0356_RF16","first-page":"R871","article-title":"On the suppression of food intake in experimental models of colitis in the rat","volume":"264","author":"McHugh","year":"1993","journal-title":"American Journal of Physiology"},{"key":"10.1053\/bega.2002.0356_RF17","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1016\/S0016-5085(96)70012-4","article-title":"Previous inflammation alters the response of the rat colon to stress","volume":"111","author":"Collins","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1053\/bega.2002.0356_RF18","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1053\/gast.2002.33584","article-title":"Evolving pathophysiologic models of functional gastrointestinal disorders","volume":"122","author":"Mayer","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1053\/bega.2002.0356_RF19","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/0016-5085(94)90753-6","article-title":"Predominant symptoms in irritable bowel syndrome correlate with specific autonomic nervous system abnormalities","volume":"106","author":"Aggarwal","year":"1994","journal-title":"Gastroenterology"},{"key":"10.1053\/bega.2002.0356_RF20","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1056\/NEJM199604253341707","article-title":"The enteric nervous system","volume":"334","author":"Goyal","year":"1996","journal-title":"New England Journal of Medicine"},{"key":"10.1053\/bega.2002.0356_RF21","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1016\/S0016-5085(96)70034-3","article-title":"The immunomodulation of enteric neuromuscular function: implications for motility and inflammatory disorders","volume":"111","author":"Collins","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1053\/bega.2002.0356_RF22","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0149-7634(05)80230-1","article-title":"The Flinders sensitive line rats: a genetic animal model of depression","volume":"17","author":"Overstreet","year":"1993","journal-title":"Neuroscience Biobehavioural Reviews"},{"key":"10.1053\/bega.2002.0356_RF23","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/0016-5085(91)90584-8","article-title":"Airway responsiveness to inhaled methacholine in patients with irritable bowel syndrome","volume":"100","author":"White","year":"1991","journal-title":"Gastroenterology"},{"key":"10.1053\/bega.2002.0356_RF24","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0168-5597(94)00297-R","article-title":"Topographic mapping of cortical potentials evoked by distension of the human proximal and distal oesophagus","volume":"96","author":"Aziz","year":"1995","journal-title":"Electroencephalography and Clinical Neurophysiology: Evoked Potentials"},{"key":"10.1053\/bega.2002.0356_RF25","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1007\/BF01299903","article-title":"Cerebral evoked potentials. A method of quantification of central nervous system response to esophageal pain","volume":"38","author":"DeVault","year":"1993","journal-title":"Digestive Diseases and Sciences"},{"key":"10.1053\/bega.2002.0356_RF26","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1007\/BF01536051","article-title":"Cerebral responses evoked by electrical stimulation of rectosigmoid in normal subjects","volume":"34","author":"Frieling","year":"1989","journal-title":"Digestive Diseases and Sciences"},{"key":"10.1053\/bega.2002.0356_RF27","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1023\/A:1026667123187","article-title":"Cortical evoked responses following esophageal balloon distension and electrical stimulation in healthy volunteers","volume":"43","author":"Hollerbach","year":"1998","journal-title":"Digestive Diseases and Sciences"},{"key":"10.1053\/bega.2002.0356_RF28","first-page":"G486","article-title":"Cerebral-evoked potential responses following direct vagal and esophageal electrical stimulation in humans","volume":"264","author":"Tougas","year":"1993","journal-title":"American Journal of Physiology"},{"key":"10.1053\/bega.2002.0356_RF29","first-page":"G955","article-title":"Cerebral potentials evoked by esophageal distension in human","volume":"259","author":"Smout","year":"1990","journal-title":"American Journal of Physiology"},{"key":"10.1053\/bega.2002.0356_RF30","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0079-6123(00)29020-1","article-title":"Concepts of pain mechanisms: the contribution of functional imaging of the human brain","volume":"129","author":"Casey","year":"2000","journal-title":"Progress in Brain Research"},{"key":"10.1053\/bega.2002.0356_RF31","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1152\/jn.2001.85.2.951","article-title":"Temporal and spatial dynamics of human forebrain activity during heat pain: analysis by positron emission tomography","volume":"85","author":"Casey","year":"2001","journal-title":"Journal of Neurophysiology"},{"key":"10.1053\/bega.2002.0356_RF32","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1097\/00006842-200105000-00006","article-title":"Cerebral activation in patients with irritable bowel syndrome and control subjects during rectosigmoid stimulation","volume":"63","author":"Naliboff","year":"2001","journal-title":"Psychosomatic Medicine"},{"key":"10.1053\/bega.2002.0356_RF33","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/S0016-5085(00)70170-3","article-title":"Regional cerebral activation in irritable bowel syndrome and control subjects with painful and nonpainful rectal distention","volume":"118","author":"Mertz","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1053\/bega.2002.0356_RF34","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/j.1572-0241.2002.05464.x","article-title":"Cortical mapping of visceral pain in patients with GI disorders using functional magnetic resonance imaging","volume":"97","author":"Bernstein","year":"2002","journal-title":"American Journal of Gastroenterology"},{"key":"10.1053\/bega.2002.0356_RF35","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1042\/cs0920167","article-title":"Modulation of neurocardiac function by oesophageal stimulation in humans","volume":"92","author":"Tougas","year":"1997","journal-title":"Clinical Science (London)"},{"key":"10.1053\/bega.2002.0356_RF36","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1615\/CritRevBiomedEng.v28.i12.150","article-title":"Effects of esophageal stimulation in patients with functional disorders of the gastrointestinal tract","volume":"28","author":"Kamath","year":"2000","journal-title":"Critical Review of Biomedicine Engineering"},{"key":"10.1053\/bega.2002.0356_RF37","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0304-3959(96)03062-X","article-title":"Rectal afferent function in patients with inflammatory and functional intestinal disorders","volume":"66","author":"Bernstein","year":"1996","journal-title":"Pain"},{"key":"10.1053\/bega.2002.0356_RF38","first-page":"245","article-title":"Power spectral analysis of heart rate variability: a noninvasive signature of cardiac autonomic function","volume":"21","author":"Kamath","year":"1993","journal-title":"Critical Review of Biomedicine Engineering"},{"key":"10.1053\/bega.2002.0356_RF39","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1097\/00006842-199405000-00001","article-title":"Low vagal activity as mediating mechanism for the relationship between personality factors and gastric symptoms in functional dyspepsia","volume":"56","author":"Haug","year":"1994","journal-title":"Psychosomatic Medicine"},{"key":"10.1053\/bega.2002.0356_RF40","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1097\/00006842-199301000-00004","article-title":"A Low vagal tone and antral dysmotility in patients with functional dyspepsia","volume":"55","author":"Hausken","year":"1993","journal-title":"Psychosomatic Medicine"},{"key":"10.1053\/bega.2002.0356_RF41","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1136\/gut.49.5.706","article-title":"Cardiac autonomic function and oesophageal acid sensitivity in patients with non-cardiac chest pain","volume":"49","author":"Tougas","year":"2001","journal-title":"Gut"},{"key":"10.1053\/bega.2002.0356_RF42","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0016-5085(94)90086-8","article-title":"Basic and clinical aspects of visceral hyperalgesia","volume":"107","author":"Mayer","year":"1994","journal-title":"Gastroenterology"},{"key":"10.1053\/bega.2002.0356_RF43","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1016\/S0016-5085(97)70056-8","article-title":"Mediators and pharmacology of visceral sensitivity: From basic to clinical investigations","volume":"112","author":"Bueno","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1053\/bega.2002.0356_RF44","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1016\/S0140-6736(99)01306-9","article-title":"Visceral pain","volume":"353","author":"Cervero","year":"1999","journal-title":"Lancet"},{"key":"10.1053\/bega.2002.0356_RF45","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0014-2999(01)01319-X","article-title":"Gastrointestinal afferents as targets of novel drugs for the treatment of functional bowel disorders and visceral pain","volume":"429","author":"Holzer","year":"2001","journal-title":"European Journal of Pharmacology"},{"key":"10.1053\/bega.2002.0356_RF46","doi-asserted-by":"crossref","first-page":"S58","DOI":"10.1097\/00004836-200207001-00011","article-title":"Irritable Bowel Syndrome Neuropharmacology. A review of approved and investigational compounds","volume":"35","author":"Callahan","year":"2002","journal-title":"Journal of Clinical Gastroenterology"},{"key":"10.1053\/bega.2002.0356_RF47","doi-asserted-by":"crossref","first-page":"G787","DOI":"10.1152\/ajpgi.2001.280.5.G787","article-title":"Receptors and transmission in the brain-gut axis: potential for novel therapies. I. Receptors on visceral afferents","volume":"280","author":"Kirkup","year":"2001","journal-title":"American Journal of Physiology - Gastrointestinal & Liver Physiology"},{"key":"10.1053\/bega.2002.0356_RF48","first-page":"101","article-title":"Domperidone improves myogenically transmitted antroduodenal coordination by blocking dopaminergic receptor sites","volume":"96","author":"Schuurkes","year":"1984","journal-title":"Scandinavian Journal of Gastroenterology"},{"key":"10.1053\/bega.2002.0356_RF49","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/316126a0","article-title":"Identification of serotonin M-receptor subtypes and their specific blockade by a new class of drugs","volume":"316","author":"Richardson","year":"1985","journal-title":"Nature"},{"key":"10.1053\/bega.2002.0356_RF50","first-page":"A648","article-title":"A selective 5-HT4 agonist induces CAMP mediated CI-flux from rat colonocytes","volume":"116","author":"Stoner","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1053\/bega.2002.0356_RF51","first-page":"A643","article-title":"Dose dependent modulation of rectal afferent sensitivity by a 5-HT4 agonist [abstract]","volume":"117","author":"Schikowski","year":"1999","journal-title":"Gastroenterology"},{"key":"10.1053\/bega.2002.0356_RF52","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1046\/j.1365-2036.2001.01094.x","article-title":"Tegaserod, a 5-HT4 receptor partial agonist, relieves symptoms in irritable bowel syndrome patients with abdominal pain, bloating and constipation","volume":"15","author":"Muller-Lissner","year":"2001","journal-title":"Alimentary Pharmacology Therapeutics"},{"key":"10.1053\/bega.2002.0356_RF53","first-page":"735","article-title":"Validation of global relief measure in two clinical trials of irritable bowel syndrome with Tegaserod [abstract]","volume":"59","author":"Lefkowitz","year":"1998","journal-title":"Digestion"},{"key":"10.1053\/bega.2002.0356_RF54","doi-asserted-by":"crossref","first-page":"A1204","DOI":"10.1016\/S0016-5085(00)80649-6","article-title":"Tegaserod has a favorable safety and tolerability profile in patients with constipation predominant and alternating forms of irritable bowel syndrome [abstract]","volume":"118","author":"Whorwell","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1053\/bega.2002.0356_RF55","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/00004836-199102000-00012","article-title":"\u201cProkinetic\u201d treatment of constipation predominant irritable bowel syndrome: a placebo-controlled study of cisapride","volume":"13","author":"Van Outryve","year":"1991","journal-title":"Journal of Clinical Gastroenterology"},{"key":"10.1053\/bega.2002.0356_RF56","first-page":"1312","article-title":"Effect of cisapride and renzapride on gastrointestinal motility and plasma motilin concentration in dogs","volume":"281","author":"Song","year":"1997","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1053\/bega.2002.0356_RF57","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.2042-7158.1998.tb06196.x","article-title":"5-Hydroxytyptamine-induced secretion by rat jejunum in-vitro involves several 5-hydroxytryptamine receptor subtypes","volume":"50","author":"Hardcastle","year":"1998","journal-title":"Journal of Pharmacy and Pharmacology"},{"key":"10.1053\/bega.2002.0356_RF58","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0304-3959(89)90045-6","article-title":"The role of CCK, caerulein, and CCK antagonists in nociception","volume":"39","author":"Baber","year":"1989","journal-title":"Pain"},{"key":"10.1053\/bega.2002.0356_RF59","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/j.1472-8206.1995.tb00517.x","article-title":"Opioid and anti-opioid peptides","volume":"9","author":"Cesselin","year":"1995","journal-title":"Fundamentals of Clinical Pharmacology"},{"key":"10.1053\/bega.2002.0356_RF60","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1016\/0016-5085(90)90475-G","article-title":"Role of visceral afferent mechanisms in functional bowel disorders","volume":"99","author":"Mayer","year":"1990","journal-title":"Gastroenterology"},{"key":"10.1053\/bega.2002.0356_RF61","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/j.1440-1746.1992.tb00983.x","article-title":"Responses to cholecystokinin octapeptide in patients with functional abdominal pain syndromes","volume":"7","author":"Roberts-Thomson","year":"1992","journal-title":"Journal of Gastroenterology and Hepatology"},{"key":"10.1053\/bega.2002.0356_RF62","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1136\/gut.29.9.1236","article-title":"Dysmotility of the small intestine in irritable bowel syndrome","volume":"29","author":"Kellow","year":"1988","journal-title":"Gut"},{"key":"10.1053\/bega.2002.0356_RF63","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1517\/13543784.9.1.129","article-title":"Therapeutic and chemical developments of cholecystokinin receptor ligands","volume":"9","author":"De Tullio","year":"2000","journal-title":"Expert Opinion Investigational Drugs"},{"key":"10.1053\/bega.2002.0356_RF64","series-title":"Methods in Neurosciences","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/B978-0-12-185271-9.50014-9","article-title":"Role of cholecystokinin type B receptor in nociception studied with peptide agonists and antagonists","author":"Wiesenfeld-Hallin","year":"1993"},{"key":"10.1053\/bega.2002.0356_RF65","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1213\/00000539-199301000-00031","article-title":"Peripheral mechanism of opioid analgesia","volume":"76","author":"Stein","year":"1993","journal-title":"Anesthesia and Analgesia"},{"key":"10.1053\/bega.2002.0356_RF66","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1016\/0024-3205(92)90150-N","article-title":"Role of opioids in peripheral analgesia","volume":"51","author":"Junien","year":"1992","journal-title":"Life Sciences"},{"key":"10.1053\/bega.2002.0356_RF67","doi-asserted-by":"crossref","first-page":"I91","DOI":"10.1136\/gut.51.suppl_1.i91","article-title":"Centrally acting agents and visceral sensitivity","volume":"51","author":"Fioramonti","year":"2002","journal-title":"Gut"},{"key":"10.1053\/bega.2002.0356_RF68","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0306-4522(93)90465-R","article-title":"Inflammation of the rat paw enhances neuronal transport of opioid receptors in the sciatic nerve and increases their density in the inflamed tissue","volume":"55","author":"Hassan","year":"1993","journal-title":"Neuroscience"},{"key":"10.1053\/bega.2002.0356_RF69","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1046\/j.1365-2982.2000.00188.x","article-title":"Fedotozine, a kappa-opioid agonist, prevents spinal and supra-spinal Fos expression induced by a noxious visceral stimulus in the rat","volume":"12","author":"Bonaz","year":"2000","journal-title":"Neurogastroenterology and Motility"},{"key":"10.1053\/bega.2002.0356_RF70","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0014-2999(94)90710-2","article-title":"Peripheral kappa-opioid receptors mediate the antinociceptive effect of fedotozine on the duodenal pain reflex in rat","volume":"257","author":"Diop","year":"1994","journal-title":"European Journal of Pharmacology"},{"key":"10.1053\/bega.2002.0356_RF71","series-title":"Sensitive Gastrointestinal Disorders","first-page":"73","article-title":"Effect of fedotozine, a kappa opioid agonist, on gastric visceral nociception in healthy subjects","author":"Coffin","year":"1995"},{"key":"10.1053\/bega.2002.0356_RF72","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1517\/13543784.10.1.97","article-title":"Pharmacology and clinical experience with fedotozine","volume":"10","author":"Delvaux","year":"2001","journal-title":"Expert Opinion Investigational Drugs"},{"key":"10.1053\/bega.2002.0356_RF73","doi-asserted-by":"crossref","first-page":"A576","DOI":"10.1016\/0016-5085(95)26617-8","article-title":"Effect of fedotizine on gastric nociception assessed by a reflexologic technique","volume":"108","author":"Bouhassira","year":"1995","journal-title":"Gastroenterology"},{"key":"10.1053\/bega.2002.0356_RF74","doi-asserted-by":"crossref","first-page":"A676","DOI":"10.1016\/0016-5085(95)27015-9","article-title":"Fedotozine in functional dyspepsia: results of a six week placebo controlled multicentre therapeutic trial","volume":"108","author":"Read","year":"1995","journal-title":"Gastroenterology"},{"key":"10.1053\/bega.2002.0356_RF75","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/S0016-5085(99)70226-X","article-title":"The kappa agonist fedotozine relieves hypersensitivity to colonic distention in patients with irritable bowel syndrome","volume":"116","author":"Delvaux","year":"1999","journal-title":"Gastroenterology"},{"key":"10.1053\/bega.2002.0356_RF76","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/0024-3205(94)00021-J","article-title":"Pre-clinical and clinical pharmacology of selective muscarinic M3 receptor antagonists","volume":"56","author":"Wallis","year":"1995","journal-title":"Life Science"},{"key":"10.1053\/bega.2002.0356_RF77","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1254\/jjp.86.281","article-title":"Effects of YM-905, a novel muscarinic M3 receptor antagonist one experimental model of bowel dysfunction in vivo","volume":"86","author":"Kobayashi","year":"2001","journal-title":"Japanese Journal of Pharmacology"},{"key":"10.1053\/bega.2002.0356_RF78","first-page":"85","article-title":"Substance P","volume":"35","author":"Pernow","year":"1983","journal-title":"Pharmacology Reviews"},{"key":"10.1053\/bega.2002.0356_RF79","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1146\/annurev.me.40.020189.002013","article-title":"Neuropeptides and inflammation: the role of substance P","volume":"40","author":"Payan","year":"1989","journal-title":"Annual Review of Medicine"},{"key":"10.1053\/bega.2002.0356_RF80","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1139\/y95-117","article-title":"Alterations in neurokinin 1 receptor gene expression in models of pain and inflammation","volume":"73","author":"Krause","year":"1995","journal-title":"Canadian Journal of Physiology and Pharmacology"},{"key":"10.1053\/bega.2002.0356_RF81","series-title":"Helicobacter pylori: Basic Mechanisms to Clinical Cure","first-page":"195","article-title":"The impact of Helicobacter pylori infection on gastric neuromuscular function in the rat: basic observations and clinical implications for our understanding of functional dyspepsia","author":"Collins","year":"1998"},{"key":"10.1053\/bega.2002.0356_RF82","doi-asserted-by":"crossref","first-page":"3235","DOI":"10.1073\/pnas.85.9.3235","article-title":"Receptor binding sites for substance P, but not substance K or neuromedin K, are expressed in high concentrations by arterioles venules and lymph nodules in surgical specimens obtained from patients with ulcerative colitis and Crohn's disease","volume":"85","author":"Mantyh","year":"1988","journal-title":"Proceedings of the National Academy of Sciences of the USA"},{"key":"10.1053\/bega.2002.0356_RF83","first-page":"133","article-title":"High concentrations of substance P as a possible transmission of abdominal pain in rats with chemically induced ulcerative colitis","volume":"15","author":"Kishimoto","year":"1994","journal-title":"Biomedical Research"},{"key":"10.1053\/bega.2002.0356_RF84","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1007\/BF02093789","article-title":"Viscerosensitivity to colorectal distension is altered during experimental inflammation of rectum in awake rats","volume":"39","author":"Morteau","year":"1994","journal-title":"Digestive Diseases and Sciences"},{"key":"10.1053\/bega.2002.0356_RF85","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1126\/science.281.5383.1640","article-title":"Distinct mechanism for antidepressant activity by blockade of central substance P receptors","volume":"281","author":"Kramer","year":"1988","journal-title":"Science"},{"key":"10.1053\/bega.2002.0356_RF86","doi-asserted-by":"crossref","first-page":"533","DOI":"10.2165\/00003495-200060030-00002","article-title":"Potential of substance P antagonists as anti-emetics","volume":"60","author":"Diemunsch","year":"2000","journal-title":"Drugs"},{"key":"10.1053\/bega.2002.0356_RF87","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0163-7258(96)00195-7","article-title":"Tachykinins in the gut: Part I. Expression release and motor function","volume":"73","author":"Holzer","year":"1997","journal-title":"Pharmacology and Therapeutics"},{"key":"10.1053\/bega.2002.0356_RF88","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0163-7258(96)00196-9","article-title":"Tachykinins in the gut: Part II. Roles in neural excitation, secretion and inflammation","volume":"73","author":"Holzer","year":"1997","journal-title":"Pharmacology and Therapeutics"},{"key":"10.1053\/bega.2002.0356_RF89","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1159\/000007504","article-title":"Implications of tachykinins and calcitonin gene related peptide in inflammatory bowel disease","volume":"59","author":"Holzer","year":"1998","journal-title":"Digestion"},{"key":"10.1053\/bega.2002.0356_RF90","first-page":"G191","article-title":"Calcitonin gene-related peptide in viscerosensitive response to colorectal distension in rats","volume":"273","author":"Plourde","year":"1997","journal-title":"American Journal of Physiology"},{"key":"10.1053\/bega.2002.0356_RF91","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/S0016-5085(98)70597-9","article-title":"Neural emergency system in the stomach","volume":"114","author":"Holzer","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1053\/bega.2002.0356_RF92","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0167-0115(97)02141-1","article-title":"Involvement of prostaglandins and CGRP-dependent sensory afferents in peritoneal irritation-induced visceral pain","volume":"7","author":"Friese","year":"1997","journal-title":"Regulatory Peptides"},{"key":"10.1053\/bega.2002.0356_RF93","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/sj.bjp.0700909","article-title":"Functional GABAA receptors on rat vagal afferent neurons","volume":"120","author":"Ashworth-Preece","year":"1997","journal-title":"British Journal of Pharmacology"},{"key":"10.1053\/bega.2002.0356_RF94","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1046\/j.1460-9568.1999.00445.x","article-title":"Substance P release in the dorsal horn assessed by receptor internalization: NMDA receptors counteract a tonic inhibition by GABAB receptors","volume":"11","author":"Marvizon","year":"1999","journal-title":"European Journal of Neuroscience"},{"key":"10.1053\/bega.2002.0356_RF95","first-page":"219","article-title":"Intrathecal baclofen and muscimol but not midazolam are antinociceptive using the rat formalin model","volume":"275","author":"Dirig","year":"1995","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1053\/bega.2002.0356_RF96","first-page":"736","article-title":"GABergic effects on nucleus tractus solitarius neurons receiving gastric vagal inputs","volume":"286","author":"Yuan","year":"1998","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1053\/bega.2002.0356_RF97","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0016-5085(00)70408-2","article-title":"Control of transient lower esophageal sphincter relaxations and reflux by the GABAB agonist baclofen in normal subjects","volume":"118","author":"Lidums","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1053\/bega.2002.0356_RF98","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s004410000261","article-title":"Localization of CB1-cannabinoid receptor immunoreactivity in the porcine enteric nervous system","volume":"302","author":"Kulkarni-Narla","year":"2000","journal-title":"Cell Tissue Research"},{"key":"10.1053\/bega.2002.0356_RF99","doi-asserted-by":"crossref","first-page":"635","DOI":"10.2174\/0929867306666220401124036","article-title":"Pharmacology of cannabinoid receptor ligands","volume":"6","author":"Pertwee","year":"1999","journal-title":"Current Medical Chemistry"},{"key":"10.1053\/bega.2002.0356_RF100","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/S0028-3908(99)00056-8","article-title":"Cannabinoid inhibition of guinea-pig intestinal peristalsis via inhibition of excitatory and activation of inhibitory neural pathways","volume":"38","author":"Heinmann","year":"1999","journal-title":"Neuropharmacology"},{"key":"10.1053\/bega.2002.0356_RF101","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0014-2999(99)00673-1","article-title":"The role of cannabinoid receptors in intestinal motility, defecation and diarrhea in rats","volume":"384","author":"Izzo","year":"1999","journal-title":"European Journal of Pharmacology"},{"key":"10.1053\/bega.2002.0356_RF102","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/28393","article-title":"Control of pain initiation by endogenous cannabinoids","volume":"394","author":"Calignano","year":"1998","journal-title":"Nature"},{"key":"10.1053\/bega.2002.0356_RF103","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1016\/S0140-6736(87)92676-6","article-title":"Somatostatin and irritable bowel syndrome","volume":"2","author":"Binimelis","year":"1987","journal-title":"Lancet"},{"key":"10.1053\/bega.2002.0356_RF104","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/S0140-6736(87)91564-9","article-title":"Somatostatin and symptomatic relief of irritable bowel syndrome","volume":"2","author":"Talley","year":"1987","journal-title":"Lancet"},{"key":"10.1053\/bega.2002.0356_RF105","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1111\/j.1365-2036.1991.tb00534.x","article-title":"Plasma somatostatin concentration in the irritable bowel syndrome","volume":"5","author":"O'Donnell","year":"1991","journal-title":"Alimentary Pharmacology and Therapeutics"},{"key":"10.1053\/bega.2002.0356_RF106","first-page":"976","article-title":"Effects of somatostatin analogue on sensory perception to balloon distension","volume":"37","author":"Plourde","year":"1992","journal-title":"Digestive Diseases and Sciences"},{"key":"10.1053\/bega.2002.0356_RF107","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1016\/0016-5085(93)90347-F","article-title":"A somatostatin analog inhibits afferent pathways mediating perception of rectal distension","volume":"104","author":"Hasler","year":"1993","journal-title":"Gastroenterology"},{"key":"10.1053\/bega.2002.0356_RF108","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1007\/BF02093780","article-title":"Octreotide increases thresholds of colonic visceral perception in IBS patients without modifying muscle tone","volume":"39","author":"Bradette","year":"1994","journal-title":"Digestive Diseases and Science"}],"container-title":["Best Practice & Research Clinical Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521691802903562?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521691802903562?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T07:16:53Z","timestamp":1704698213000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521691802903562"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,12]]},"references-count":108,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2002,12]]}},"alternative-id":["S1521691802903562"],"URL":"https:\/\/doi.org\/10.1053\/bega.2002.0356","relation":{},"ISSN":["1521-6918"],"issn-type":[{"value":"1521-6918","type":"print"}],"subject":[],"published":{"date-parts":[[2002,12]]}}}