{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:41:46Z","timestamp":1790628106790,"version":"4.1.0"},"reference-count":85,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2002,3,1]],"date-time":"2002-03-01T00:00:00Z","timestamp":1014940800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Best Practice &amp; Research Clinical Haematology"],"published-print":{"date-parts":[[2002,3]]},"DOI":"10.1053\/beha.2002.0187","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T07:24:48Z","timestamp":1027668288000},"page":"91-103","source":"Crossref","is-referenced-by-count":12,"title":["Molecular measurement of minimal residual disease in Philadelphia-positive acute lymphoblastic leukaemia"],"prefix":"10.1053","volume":"15","author":[{"given":"Jerald P.","family":"Radich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/beha.2002.0187_RF1","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1002\/(SICI)1097-0142(19981101)83:9<2030::AID-CNCR21>3.0.CO;2-Q","article-title":"Clinical significance of Philadelphia chromosome positive pediatric acute lymphoblastic leukemia in the context of contemporary intensive therapies: a report from the Children's Cancer Group","volume":"83","author":"Uckun","year":"1998","journal-title":"Cancer"},{"key":"10.1053\/beha.2002.0187_RF2","first-page":"196","article-title":"Philadelphia positive acute lymphoblastic leukemia in adults: age distribution, BCR breakpoint and prognostic significance","volume":"5","author":"Secker-Walker","year":"1991","journal-title":"Leukemia"},{"key":"10.1053\/beha.2002.0187_RF3","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1182\/blood.V73.5.1307.1307","article-title":"The bcr gene in Philadelphia chromosome positive acute lymphoblastic leukemia","volume":"73","author":"Heisterkamp","year":"1989","journal-title":"Blood"},{"key":"10.1053\/beha.2002.0187_RF4","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1182\/blood.V68.6.1369.1369","article-title":"bcr rearrangement and translocation of the c-abl oncogene in Philadelphia positive acute lymphoblastic leukemia","volume":"68","author":"De Klein","year":"1986","journal-title":"Blood"},{"key":"10.1053\/beha.2002.0187_RF5","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/325635a0","article-title":"A novel abl protein expressed in Philadelphia chromosome positive acute lymphoblastic leukaemia","volume":"325","author":"Chan","year":"1987","journal-title":"Nature"},{"key":"10.1053\/beha.2002.0187_RF6","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1126\/science.3541203","article-title":"Unique forms of the abl tyrosine kinase distinguish Ph1-positive CML from Ph1-positive ALL","volume":"235","author":"Clark","year":"1987","journal-title":"Science"},{"key":"10.1053\/beha.2002.0187_RF7","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/0092-8674(84)90438-0","article-title":"An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity","volume":"37","author":"Konopka","year":"1984","journal-title":"Cell"},{"key":"10.1053\/beha.2002.0187_RF8","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1182\/blood.V79.4.1029.bloodjournal7941029","article-title":"Clonal development and karyotype evolution during leukemogenesis of BCR\/ABL transgenic mice","volume":"79","author":"Voncken","year":"1992","journal-title":"Blood"},{"key":"10.1053\/beha.2002.0187_RF9","doi-asserted-by":"crossref","first-page":"4603","DOI":"10.1182\/blood.V86.12.4603.bloodjournal86124603","article-title":"BCR\/ABL P210 and P190 cause distinct leukemia in transgenic mice","volume":"86","author":"Voncken","year":"1995","journal-title":"Blood"},{"key":"10.1053\/beha.2002.0187_RF10","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.1073\/pnas.85.8.2795","article-title":"Heterogeneity of genomic fusion of BCR and ABL in Philadelphia chromosome-positive acute lymphoblastic leukemia","volume":"85","author":"Rubin","year":"1988","journal-title":"Proceedings of the National Academy of Sciences of the USA"},{"key":"10.1053\/beha.2002.0187_RF11","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1365-2141.1987.tb02296.x","article-title":"Molecular analysis of chromosome 22 breakpoints in adult Philadelphia-positive acute lymphoblastic leukaemia","volume":"67","author":"Kurzrock","year":"1987","journal-title":"British Journal of Haematology"},{"key":"10.1053\/beha.2002.0187_RF12","doi-asserted-by":"crossref","first-page":"4259","DOI":"10.1073\/pnas.86.11.4259","article-title":"Unexpected heterogeneity of BCR-ABL fusion mRNA detected by polymerase chain reaction in Philadelphia chromosome-positive acute lymphoblastic leukemia","volume":"86","author":"Hooberman","year":"1989","journal-title":"Proceedings of the National Academy of Sciences of the USA"},{"key":"10.1053\/beha.2002.0187_RF13","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0092-8674(87)90007-9","article-title":"Unique fusion of bcr and c-abl genes in Philadelphia chromosome positive acute lymphoblastic leukemia","volume":"51","author":"Hermans","year":"1987","journal-title":"Cell"},{"key":"10.1053\/beha.2002.0187_RF14","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1182\/blood.V78.2.458.bloodjournal782458","article-title":"Chimeric BCR-ABL messenger RNA as a marker for minimal residual disease in patients transplanted for Philadelphia chromosome-positive acute lymphoblastic leukemia","volume":"78","author":"Gehly","year":"1991","journal-title":"Blood"},{"key":"10.1053\/beha.2002.0187_RF15","first-page":"211","article-title":"Molecular diagnosis of the Philadelphia chromosome in chronic myelogenous and acute lymphoblastic leukemias by PCR","volume":"8","author":"Maurer","year":"1990","journal-title":"Disease Markers"},{"key":"10.1053\/beha.2002.0187_RF16","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1046\/j.1365-2141.1997.d01-2066.x","article-title":"A novel acute lymphoid leukaemia type BCR\/ABL transcript in chronic myelogenous leukaemia","volume":"96","author":"Okamoto","year":"1997","journal-title":"British Journal of Haematology"},{"key":"10.1053\/beha.2002.0187_RF17","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1111\/j.1365-2141.1993.tb03234.x","article-title":"A novel 203kD aberrant BCR-ABL product in a girl with Philadelphia chromosome positive acute lymphoblastic leukaemia","volume":"85","author":"Inukai","year":"1993","journal-title":"British Journal of Haematology"},{"key":"10.1053\/beha.2002.0187_RF18","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1046\/j.1365-2141.1998.01033.x","article-title":"Expression of p210 and p190 BCR-ABL due to alternative splicing in chronic myelogenous leukaemia","volume":"103","author":"Lichty","year":"1998","journal-title":"British Journal of Haematology"},{"key":"10.1053\/beha.2002.0187_RF19","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1182\/blood.V87.3.1075.bloodjournal8731075","article-title":"Consistent amounts of acute leukemia-associated P190BCR\/ABL transcripts are expressed by chronic myelogenous leukemia patients at diagnosis","volume":"87","author":"Saglio","year":"1996","journal-title":"Blood"},{"key":"10.1053\/beha.2002.0187_RF20","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.1182\/blood.V89.7.2602","article-title":"Detection of bcr-abl transcripts in Philadelphia chromosome-positive acute lymphoblastic leukemia after marrow transplantation","volume":"89","author":"Radich","year":"1997","journal-title":"Blood"},{"key":"10.1053\/beha.2002.0187_RF21","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/sj.leu.2400986","article-title":"Multilineage involvement of Philadelphia chromosome positive acute lymphoblastic leukemia","volume":"12","author":"Schenk","year":"1998","journal-title":"Leukemia"},{"key":"10.1053\/beha.2002.0187_RF22","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1046\/j.1365-2141.1997.4203237.x","article-title":"New insights into the biology of Philadelphia-chromosome-positive acute lymphoblastic leukaemia using a combination of May-Grunwald-Giemsa staining and fluorescence in situ hybridization techniques at the single cell level","volume":"99","author":"Haferlach","year":"1997","journal-title":"British Journal of Haematology"},{"key":"10.1053\/beha.2002.0187_RF23","first-page":"795","article-title":"Lineage involvement by BCR\/ABL in Ph+ lymphoblastic leukemias: chronic myelogenous leukemia presenting in lymphoid blast vs Ph+ acute lymphoblastic leukemia","volume":"10","author":"Anastasi","year":"1996","journal-title":"Leukemia"},{"key":"10.1053\/beha.2002.0187_RF24","first-page":"3289","article-title":"Heterogeneity in lineage derivation of Philadelphia-positive acute lymphoblastic leukemia expressing p190BCR-ABL or p210BCR-ABL: determination by analysis of individual colonies with the polymerase chain reaction","volume":"53","author":"Estrov","year":"1993","journal-title":"Cancer Research"},{"key":"10.1053\/beha.2002.0187_RF25","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1182\/blood.V72.2.784.784","article-title":"Variable Philadelphia breakpoints and potential lineage restriction of bcr rearrangement in acute lymphoblastic leukemia","volume":"72","author":"Secker-Walker","year":"1988","journal-title":"Blood"},{"key":"10.1053\/beha.2002.0187_RF26","first-page":"147","article-title":"Prognostic implications of breakpoint and lineage heterogeneity in Philadelphia-positive acute lymphoblastic leukemia: a review","volume":"7","author":"Secker-Walker","year":"1993","journal-title":"Leukemia"},{"key":"10.1053\/beha.2002.0187_RF27","first-page":"678","article-title":"First intron and M-bcr breakpoints are restricted to the lymphoid lineage in Philadelphia positive acute lymphoblastic leukemia","volume":"4","author":"Craig","year":"1990","journal-title":"Leukemia"},{"key":"10.1053\/beha.2002.0187_RF28","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1182\/blood.V95.3.1007.003k35_1007_1013","article-title":"A primitive hematopoietic cell is the target for the leukemic transformation in human philadelphia-positive acute lymphoblastic leukemia","volume":"95","author":"Cobaleda","year":"2000","journal-title":"Blood"},{"key":"10.1053\/beha.2002.0187_RF29","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1056\/NEJM200004063421402","article-title":"Outcome of treatment in children with Philadelphia chromosome-positive acute lymphoblastic leukemia","volume":"342","author":"Arico","year":"2000","journal-title":"New England Journal of Medicine"},{"key":"10.1053\/beha.2002.0187_RF30","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1182\/blood.V76.3.489.489","article-title":"Philadelphia chromosome positive childhood acute lymphoblastic leukemia: clinical and cytogenetic characteristics and treatment outcome","volume":"76","author":"Crist","year":"1990","journal-title":"Blood"},{"key":"10.1053\/beha.2002.0187_RF31","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1038\/sj.leu.2400749","article-title":"Philadelphia chromosome-positive acute lymphoblastic leukemia in children: durable responses to chemotherapy associated with low initial white blood cell counts","volume":"11","author":"Ribeiro","year":"1997","journal-title":"Leukemia"},{"key":"10.1053\/beha.2002.0187_RF32","first-page":"957","article-title":"Incidence and clinical outcome of children with BCR\/ABL-positive acute lymphoblastic leukemia (ALL). A prospective RT-PCR study based on 673 patients enrolled in the German pediatric multicenter therapy trials ALL-BFM-90 and CoALL-05-92","volume":"10","author":"Schlieben","year":"1996","journal-title":"Leukemia"},{"key":"10.1053\/beha.2002.0187_RF33","first-page":"2730","article-title":"Philadelphia chromosome-positive (Ph+) childhood acute lymphoblastic leukemia: good initial steroid response allows early prediction of a favorable treatment outcome","volume":"92","author":"Schrappe","year":"1998","journal-title":"Blood"},{"key":"10.1053\/beha.2002.0187_RF34","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3109\/10428199909093730","article-title":"Poor treatment outcome of Philadelphia chromosome-positive pediatric acute lymphoblastic leukemia despite intensive chemotherapy","volume":"33","author":"Uckun","year":"1999","journal-title":"Leukemia and Lymphoma"},{"key":"10.1053\/beha.2002.0187_RF35","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1046\/j.1365-2141.1997.d01-2053.x","article-title":"Cytogenetics adds independent prognostic information in adults with acute lymphoblastic leukaemia on MRC trial UKALL XA","volume":"96","author":"Secker-Walker","year":"1997","journal-title":"British Journal of Haematology"},{"key":"10.1053\/beha.2002.0187_RF36","doi-asserted-by":"crossref","first-page":"2983","DOI":"10.1182\/blood.V80.12.2983.2983","article-title":"Clinical significance of the BCR-ABL fusion gene in adult acute lymphoblastic leukemia: a Cancer and Leukemia Group B Study (8762)","volume":"80","author":"Westbrook","year":"1992","journal-title":"Blood"},{"key":"10.1053\/beha.2002.0187_RF37","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1182\/blood.V85.8.2025.bloodjournal8582025","article-title":"A five-drug remission induction regimen with intensive consolidation for adults with acute lymphoblastic leukemia: cancer and leukemia group B study 8811","volume":"85","author":"Larson","year":"1995","journal-title":"Blood"},{"key":"10.1053\/beha.2002.0187_RF38","doi-asserted-by":"crossref","first-page":"263","DOI":"10.3109\/10428190009148847","article-title":"Outcome of Philadelphia chromosome-positive adult acute lymphoblastic leukemia","volume":"36","author":"Faderl","year":"2000","journal-title":"Leukemia and Lymphoma"},{"key":"10.1053\/beha.2002.0187_RF39","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0165-4608(89)90023-X","article-title":"Six-year follow-up of the clinical significance of karyotype in acute lymphoblastic leukemia","volume":"40","author":"Bloomfield","year":"1989","journal-title":"Cancer Genetics and Cytogenetics"},{"key":"10.1053\/beha.2002.0187_RF40","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1182\/blood.V67.2.415.415","article-title":"Chromosomal abnormalities identify high-risk and low-risk patients with acute lymphoblastic leukemia","volume":"67","author":"Bloomfield","year":"1986","journal-title":"Blood"},{"key":"10.1053\/beha.2002.0187_RF41","first-page":"664","article-title":"Adult Philadelphia-chromosome-positive acute lymphoblastic leukemia: experience of treatments during a ten-year period","volume":"8","author":"Annino","year":"1994","journal-title":"Leukemia"},{"key":"10.1053\/beha.2002.0187_RF42","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.1182\/blood.V87.8.3135.bloodjournal8783135","volume":"87","year":"1996","journal-title":"Blood"},{"key":"10.1053\/beha.2002.0187_RF43","first-page":"3983","article-title":"Prospective karyotype analysis in adult acute lymphoblastic leukemia: the cancer and leukemia Group B experience","volume":"93","author":"Wetzler","year":"1999","journal-title":"Blood"},{"key":"10.1053\/beha.2002.0187_RF44","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/0002-9343(94)90049-3","article-title":"Philadelphia-chromosome-positive adult acute lymphocytic leukemia: characteristics, treatment results, and prognosis in 41 patients","volume":"97","author":"Preti","year":"1994","journal-title":"American Journal of Medicine"},{"key":"10.1053\/beha.2002.0187_RF45","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1182\/blood.V79.11.3067.3067","article-title":"Bone marrow transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia","volume":"79","author":"Barrett","year":"1992","journal-title":"Blood"},{"key":"10.1053\/beha.2002.0187_RF46","first-page":"365","article-title":"Bone marrow transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia","volume":"17","author":"Dunlop","year":"1996","journal-title":"Bone Marrow Transplantation"},{"key":"10.1053\/beha.2002.0187_RF47","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1182\/blood.V90.4.1410","article-title":"Marrow transplants from unrelated donors for treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia","volume":"90","author":"Sierra","year":"1997","journal-title":"Blood"},{"key":"10.1053\/beha.2002.0187_RF48","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1038\/sj.leu.2401589","article-title":"Long-term follow-up of 23 patients with Philadelphia chromosome-positive acute lymphoblastic leukemia treated with allogeneic bone marrow transplant in first complete remission","volume":"13","author":"Snyder","year":"1999","journal-title":"Leukemia"},{"key":"10.1053\/beha.2002.0187_RF49","first-page":"663","article-title":"Bone marrow transplantation for Philadelphia-chromosome-positive acute lymphoblastic leukemia","volume":"16","author":"Stockschlader","year":"1995","journal-title":"Bone Marrow Transplantation"},{"key":"10.1053\/beha.2002.0187_RF50","first-page":"1504","article-title":"Detection and significance of bcr-abl mRNA transcripts and fusion proteins in Philadelphia-positive adult acute lymphoblastic leukemia","volume":"7","author":"Tuszynski","year":"1993","journal-title":"Leukemia"},{"key":"10.1053\/beha.2002.0187_RF51","first-page":"1688","article-title":"Detection of BCR-ABL fusion genes in adult acute lymphoblastic leukemia by the polymerase chain reaction","volume":"8","author":"Radich","year":"1994","journal-title":"Leukemia"},{"key":"10.1053\/beha.2002.0187_RF52","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1093\/ajcp\/109.1.24","article-title":"A comparative analysis of FISH, RT-PCR, and cytogenetics for the diagnosis of bcr-abl-positive leukemias","volume":"109","author":"Cox","year":"1998","journal-title":"American Journal of Clinical Pathology"},{"key":"10.1053\/beha.2002.0187_RF53","doi-asserted-by":"crossref","first-page":"5698","DOI":"10.1073\/pnas.85.15.5698","article-title":"Diagnosis of chronic myeloid and acute lymphocytic leukemias by detection of leukemia-specific mRNA sequences amplified in vitro","volume":"85","author":"Kawasaki","year":"1988","journal-title":"Proceedings of the National Academy of Sciences of the USA"},{"key":"10.1053\/beha.2002.0187_RF54","doi-asserted-by":"crossref","first-page":"4072","DOI":"10.1182\/blood.V92.11.4072","article-title":"Minimal residual disease status before allogeneic bone marrow transplantation is an important determinant of successful outcome for children and adolescents with acute lymphoblastic leukemia","volume":"92","author":"Knechtli","year":"1998","journal-title":"Blood"},{"key":"10.1053\/beha.2002.0187_RF55","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1046\/j.1365-2141.1998.00873.x","article-title":"Minimal residual disease status as a predictor of relapse after allogeneic bone marrow transplantation for children with acute lymphoblastic leukaemia","volume":"102","author":"Knechtli","year":"1998","journal-title":"British Journal of Haematology"},{"key":"10.1053\/beha.2002.0187_RF56","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1056\/NEJM199808273390904","article-title":"Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia","volume":"339","author":"Cave","year":"1998","journal-title":"New England Journal of Medicine"},{"key":"10.1053\/beha.2002.0187_RF57","first-page":"24","article-title":"Polymerase chain reaction-based detection of minimal residual disease in acute lymphoblastic leukemia predicts relapse after allogeneic BMT","volume":"1","author":"Radich","year":"1995","journal-title":"Biology of Blood Marrow Transplantation"},{"key":"10.1053\/beha.2002.0187_RF58","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1056\/NEJM199701303360501","article-title":"Measurement of residual leukemia during remission in childhood acute lymphoblastic leukemia","volume":"336","author":"Roberts","year":"1997","journal-title":"New England Journal of Medicine"},{"key":"10.1053\/beha.2002.0187_RF59","first-page":"495","article-title":"Monitoring of residual disease in chronic myelogenous leukemia by quantitative polymerase chain reaction","volume":"6","author":"Lion","year":"1992","journal-title":"Leukemia"},{"key":"10.1053\/beha.2002.0187_RF60","doi-asserted-by":"crossref","first-page":"4473","DOI":"10.1182\/blood.V87.10.4473.bloodjournal87104473","article-title":"Kinetics of increasing BCR-ABL transcript numbers in chronic myeloid leukemia patients who relapse after bone marrow transplantation","volume":"87","author":"Lin","year":"1996","journal-title":"Blood"},{"key":"10.1053\/beha.2002.0187_RF61","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1182\/blood.V97.6.1560","article-title":"Early detection of BCR-ABL transcripts by quantitative reverse transcriptase-polymerase chain reaction predicts outcome after allogeneic stem cell transplantation for chronic myeloid leukemia","volume":"97","author":"Olavarria","year":"2001","journal-title":"Blood"},{"key":"10.1053\/beha.2002.0187_RF62","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1046\/j.1365-2141.1998.00823.x","article-title":"Quantitation of minimal residual disease in Philadelphia chromosome positive chronic myeloid leukaemia patients using real-time quantitative RT-PCR","volume":"102","author":"Mensink","year":"1998","journal-title":"British Journal of Haematology"},{"key":"10.1053\/beha.2002.0187_RF63","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1038\/sj.leu.2401393","article-title":"Detection of BCR-ABL transcripts in chronic myeloid leukemia (CML) using an in situ RT-PCR assay","volume":"13","author":"Preudhomme","year":"1999","journal-title":"Leukemia"},{"key":"10.1053\/beha.2002.0187_RF64","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1046\/j.1365-2141.1999.01749.x","article-title":"Monitoring chronic myeloid leukaemia therapy by real-time quantitative PCR in blood is a reliable alternative to bone marrow cytogenetics","volume":"107","author":"Branford","year":"1999","journal-title":"British Journal of Haematology"},{"key":"10.1053\/beha.2002.0187_RF65","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1182\/blood.V79.5.1366.1366","article-title":"Detection of Philadelphia chromosome-positive acute lymphoblastic leukemia by polymerase chain reaction: possible eradication of minimal residual disease by marrow transplantation","volume":"79","author":"Miyamura","year":"1992","journal-title":"Blood"},{"key":"10.1053\/beha.2002.0187_RF66","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1111\/j.1365-2141.1995.tb08444.x","article-title":"PCR-monitoring of minimal residual leukaemia after conventional chemotherapy and bone marrow transplantation in BCR-ABL-positive acute lymphoblastic leukaemia","volume":"89","author":"Mitterbauer","year":"1995","journal-title":"British Journal of Haematology"},{"key":"10.1053\/beha.2002.0187_RF67","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1046\/j.1365-2141.1999.01605.x","article-title":"Quantification of minimal residual disease in patients with BCR-ABL-positive acute lymphoplastic leukaemia using quantitative competitive polymerase chain reaction","volume":"106","author":"Mitterbauer","year":"1999","journal-title":"British Journal of Haematology"},{"key":"10.1053\/beha.2002.0187_RF68","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1038\/sj.leu.2400567","article-title":"Good correlation between RT-PCR analysis and relapse in Philadelphia (Ph1)-positive acute lymphoblastic leukemia (ALL)","volume":"11","author":"Preudhomme","year":"1997","journal-title":"Leukemia"},{"key":"10.1053\/beha.2002.0187_RF69","first-page":"541","article-title":"Expression of bcr-abl fusion transcripts following bone marrow transplantation for Philadelphia chromosome-positive leukemia","volume":"4","author":"Kohler","year":"1990","journal-title":"Leukemia"},{"key":"10.1053\/beha.2002.0187_RF70","first-page":"329","article-title":"Quantification of residual disease in Philadelphia-positive acute lymphoblastic leukemia: comparison of blood and bone marrow","volume":"9","author":"van Rhee","year":"1995","journal-title":"Leukemia"},{"key":"10.1053\/beha.2002.0187_RF71","first-page":"265","article-title":"The use of PCR technology for detecting minimal residual disease in patients with leukemia","volume":"1","author":"Radich","year":"1999","journal-title":"Reviews in Immunogenetics"},{"key":"10.1053\/beha.2002.0187_RF72","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1126\/science.2408149","article-title":"Tyrosine kinase activity and transformation potency of bcr-abl oncogene products","volume":"247","author":"Lugo","year":"1990","journal-title":"Science"},{"key":"10.1053\/beha.2002.0187_RF73","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1128\/MCB.9.5.1866","article-title":"Alternative forms of the BCR-ABL oncogene have quantitatively different potencies for stimulation of immature lymphoid cells","volume":"9","author":"McLaughlin","year":"1989","journal-title":"Molecular and Cell Biology"},{"key":"10.1053\/beha.2002.0187_RF74","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1182\/blood.V78.9.2411.2411","article-title":"Significance of the P210 versus P190 molecular abnormalities in adults with Philadelphia chromosome-positive acute leukemia","volume":"78","author":"Kantarjian","year":"1991","journal-title":"Blood"},{"key":"10.1053\/beha.2002.0187_RF75","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1006\/jmbi.1996.0345","article-title":"Kinetic selectivity of complementary nucleic acids: bcr-abl-directed antisense RNA and ribozymes","volume":"259","author":"Kronenwett","year":"1996","journal-title":"Journal of Molecular Biology"},{"key":"10.1053\/beha.2002.0187_RF76","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1172\/JCI116549","article-title":"Highly efficient elimination of Philadelphia leukemic cells by exposure to bcr\/abl antisense oligodeoxynucleotides combined with mafosfamide","volume":"92","author":"Skorski","year":"1993","journal-title":"Journal of Clinical Investigation"},{"key":"10.1053\/beha.2002.0187_RF77","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1093\/jnci\/89.2.124","article-title":"Treatment of Philadelphia leukemia in severe combined immunodeficient mice by combination of cyclophosphamide and bcr\/abl antisense oligodeoxynucleotides","volume":"89","author":"Skorski","year":"1997","journal-title":"Journal of the National Cancer Institute"},{"key":"10.1053\/beha.2002.0187_RF78","first-page":"179","article-title":"Ribozyme-mediated inhibition of a Philadelphia chromosome-positive acute lymphoblastic leukemia cell line expressing the p190 bcr-abl oncogene","volume":"3","author":"Snyder","year":"1997","journal-title":"Biology of Blood Marrow Transplantation"},{"key":"10.1053\/beha.2002.0187_RF79","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1182\/blood.V86.10.3891.bloodjournal86103891","article-title":"BCR-ABL antisense oligodeoxyribonucleotides suppress the growth of leukemic and normal hematopoietic cells by a sequence-specific but nonantisense mechanism","volume":"86","author":"Vaerman","year":"1995","journal-title":"Blood"},{"key":"10.1053\/beha.2002.0187_RF80","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/nm0596-561","article-title":"Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells","volume":"2","author":"Drucker","year":"1996","journal-title":"Nature Medicine"},{"key":"10.1053\/beha.2002.0187_RF81","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1182\/blood.V80.5.1330.1330","volume":"80","author":"Okabe","year":"1992","journal-title":"Blood"},{"key":"10.1053\/beha.2002.0187_RF82","first-page":"1661","article-title":"Selective inhibition of cell proliferation and BCR-ABL phosphorylation in acute lymphoblastic leukemia cells expressingMr 190 000 BCR-ABL protein by a tyrosine kinase inhibitor (CGP-57148)","volume":"4","author":"Beran","year":"1998","journal-title":"Clinical Cancer Research"},{"key":"10.1053\/beha.2002.0187_RF83","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1056\/NEJM200104053441401","article-title":"Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia","volume":"344","author":"Druker","year":"2001","journal-title":"New England Journal of Medicine"},{"key":"10.1053\/beha.2002.0187_RF84","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1056\/NEJM200104053441402","article-title":"Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome","volume":"344","author":"Druker","year":"2001","journal-title":"New England Journal of Medicine"},{"key":"10.1053\/beha.2002.0187_RF85","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1126\/science.1062538","article-title":"Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification","volume":"293","author":"Gorre","year":"2001","journal-title":"Science"}],"container-title":["Best Practice &amp; Research Clinical Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521692602901878?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521692602901878?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T16:30:39Z","timestamp":1581006639000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521692602901878"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,3]]},"references-count":85,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,3]]}},"alternative-id":["S1521692602901878"],"URL":"https:\/\/doi.org\/10.1053\/beha.2002.0187","relation":{},"ISSN":["1521-6926"],"issn-type":[{"value":"1521-6926","type":"print"}],"subject":[],"published":{"date-parts":[[2002,3]]}}}