{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T10:53:56Z","timestamp":1772103236363,"version":"3.50.1"},"reference-count":57,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2002,4,1]],"date-time":"2002-04-01T00:00:00Z","timestamp":1017619200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Best Practice & Research Clinical Obstetrics & Gynaecology"],"published-print":{"date-parts":[[2002,4]]},"DOI":"10.1053\/beog.2001.0273","type":"journal-article","created":{"date-parts":[[2002,9,19]],"date-time":"2002-09-19T13:54:50Z","timestamp":1032443690000},"page":"237-246","source":"Crossref","is-referenced-by-count":11,"title":["Medical abortion in the second trimester"],"prefix":"10.1053","volume":"16","author":[{"given":"Oi Shan","family":"Tang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pak Chung","family":"Ho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1053\/beog.2001.0273_RF1","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1097\/00006254-197903000-00001","article-title":"Complications from legally-induced abortion: A review","volume":"34","author":"Grimes","year":"1979","journal-title":"Obstetrical and Gynecological Survey"},{"key":"10.1053\/beog.2001.0273_RF2","series-title":"The Care of Women Requesting Induced Abortion","year":"2000"},{"key":"10.1053\/beog.2001.0273_RF3","series-title":"Induced Abortion. Guideline no. 11","year":"1997"},{"key":"10.1053\/beog.2001.0273_RF4","first-page":"121","article-title":"Mode of action of medical methods of abortion","volume":"55","author":"Baird","year":"2000","journal-title":"Journal of the American Medical Women's Association"},{"key":"10.1053\/beog.2001.0273_RF5","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0950-3552(05)80226-3","article-title":"The physiology of cervical ripening and cervical dilatation and the effect of abortifacient drugs","volume":"4","author":"Uldbjerg","year":"1990","journal-title":"Bailli\u00e8re's Clinical Obstetrics and Gynaecology"},{"key":"10.1053\/beog.2001.0273_RF6","doi-asserted-by":"crossref","first-page":"381","DOI":"10.3109\/00016347109157343","article-title":"Induction of abortion by the intravenous administration of prostaglandin F2\u03b1","volume":"50","author":"Wiqvist","year":"1971","journal-title":"Acta Obstetriciaet Gynecologica Scandinavica"},{"key":"10.1053\/beog.2001.0273_RF7","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/0002-9378(72)90472-3","article-title":"Therapeutic abortion with the use of prostaglandin F2\u03b1","volume":"112","author":"Gillett","year":"1972","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"10.1053\/beog.2001.0273_RF8","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/0002-9378(75)90353-1","article-title":"Mid-trimester abortion induced by intravaginal administration of prostaglandin E2 suppositories","volume":"122","author":"Lauersen","year":"1975","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"10.1053\/beog.2001.0273_RF9","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/S0140-6736(70)91978-1","article-title":"Therapeutic abortion by local administration of prostaglandin","volume":"2","author":"Wiqvist","year":"1970","journal-title":"Lancet"},{"key":"10.1053\/beog.2001.0273_RF10","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0090-6980(72)90064-0","article-title":"Induction of abortion by extra-amniotic prostaglandin administration","volume":"1","author":"Wiqvist","year":"1972","journal-title":"Prostaglandins"},{"key":"10.1053\/beog.2001.0273_RF11","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0010-7824(71)90001-1","article-title":"Induction of abortion by intra-amniotic administration of prostaglandin F2\u03b1","volume":"4","author":"Topapozada","year":"1971","journal-title":"Contraception"},{"key":"10.1053\/beog.2001.0273_RF12","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0020-7292(88)90207-X","volume":"26","year":"1988","journal-title":"International Journal of Gynaecology and Obstetrics"},{"key":"10.1053\/beog.2001.0273_RF13","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/0002-9378(77)90637-8","volume":"129","year":"1977","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"10.1053\/beog.2001.0273_RF14","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0002-9378(16)33294-X","article-title":"Termination of mid-trimester pregnancy by serial intramuscular injection of 15(S)-15-methyl PG F2\u03b1","volume":"124","author":"Lauresen","year":"1976","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"10.1053\/beog.2001.0273_RF15","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0010-7824(77)90085-3","volume":"16","year":"1977","journal-title":"Contraception"},{"key":"10.1053\/beog.2001.0273_RF16","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0952-3278(88)90151-2","article-title":"Development of a vaginal gel containing 9-deoxo-16, 16-dimethyl-9-methylene PGE2 for cervical dilatation and pregnancy termination","volume":"33","author":"Green","year":"1988","journal-title":"Prostaglandins, Leukotrienes and Essential Fatty Acids"},{"key":"10.1053\/beog.2001.0273_RF17","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/0020-7292(82)90198-9","volume":"20","year":"1982","journal-title":"International Journal of Gynaecology and Obstetrics"},{"key":"10.1053\/beog.2001.0273_RF18","doi-asserted-by":"crossref","first-page":"278","DOI":"10.3109\/00016349209021052","article-title":"Medical termination of early pregnancy with mifepristone (RU 486) followed by a prostaglandin analogue. Study in 16,369 women","volume":"71","author":"Ulmann","year":"1992","journal-title":"Acta Obstetriciaet Gynecologica Scandinavica"},{"key":"10.1053\/beog.2001.0273_RF19","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0090-6980(87)90268-1","article-title":"Prostaglandin-induced pregnancy termination: further studies using gemeprost (16, 16 dimethyl-trans-\u03942-PGE1 methyl ester) vaginal pessaries in the early second trimester","volume":"34","author":"Cameron","year":"1987","journal-title":"Prostaglandins"},{"key":"10.1053\/beog.2001.0273_RF20","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0010-7824(90)90091-9","article-title":"Late second trimester abortion with 16, 16 dimethyl-trans-\u25b52-PGE1 methyl ester (gemeprost)","volume":"42","author":"Querido","year":"1990","journal-title":"Contraception"},{"key":"10.1053\/beog.2001.0273_RF21","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0090-6980(92)90108-6","article-title":"A retrospective study of 932 second trimester terminations using gemeprost (16, 16 dimethyl-trans-\u25b52-PGE1 methyl ester)","volume":"44","author":"Thong","year":"1992","journal-title":"Prostaglandins"},{"key":"10.1053\/beog.2001.0273_RF22","doi-asserted-by":"crossref","first-page":"191","DOI":"10.3109\/00016349209009917","article-title":"An open study comparing two regimens of gemeprost for the termination of pregnancy in the second trimester","volume":"71","author":"Thong","year":"1992","journal-title":"Acta Obstetriciaet Gynecologica Scandinavica"},{"key":"10.1053\/beog.2001.0273_RF23","doi-asserted-by":"crossref","first-page":"316","DOI":"10.3109\/00016349409015770","article-title":"An open prospective randomized study of dinoproston and gemeprost in second trimester legal abortions","volume":"73","author":"Kj\u00f8lhede","year":"1994","journal-title":"Acta Obstetriciaet Gynecologica Scandinavica"},{"key":"10.1053\/beog.2001.0273_RF24","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0010-7824(96)00115-1","article-title":"Termination of second trimester pregnancy with gemeprost and misoprostol: a randomized double-blind placebo-controlled trial","volume":"54","author":"Wong","year":"1996","journal-title":"Contraception"},{"key":"10.1053\/beog.2001.0273_RF25","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0010-7824(98)00099-7","article-title":"Vaginal misoprostol compared with vaginal gemeprost in termination of second trimester pregnancy","volume":"58","author":"Wong","year":"1998","journal-title":"Contraception"},{"key":"10.1053\/beog.2001.0273_RF26","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0029-7844(97)00491-2","article-title":"A comparison between two doses of intravaginal misoprostol and gemeprost for induction of second-trimester abortion","volume":"90","author":"Nuutila","year":"1997","journal-title":"Obstetrics and Gynecology"},{"key":"10.1053\/beog.2001.0273_RF27","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/0140-6736(91)92106-C","volume":"338","year":"1991","journal-title":"Lancet"},{"key":"10.1053\/beog.2001.0273_RF28","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S0029-7844(97)00111-7","article-title":"Absorption kinetics of misoprostol with oral or vaginal administration","volume":"90","author":"Ziemam","year":"1997","journal-title":"Obstetrics and Gynecology"},{"key":"10.1053\/beog.2001.0273_RF29","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/S0029-7844(97)00419-5","article-title":"Vaginal misoprostol compared with oral misoprostol in termination of second-trimester pregnancy","volume":"90","author":"Ho","year":"1997","journal-title":"Obstetrics and Gynecology"},{"key":"10.1053\/beog.2001.0273_RF30","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1056\/NEJM199504133321502","article-title":"Induction of abortion with mifepristone (RU 486) and oral or vaginal misoprostol","volume":"332","author":"El-Rafaey","year":"1995","journal-title":"The New England Journal of Medicine"},{"key":"10.1053\/beog.2001.0273_RF31","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1056\/NEJM199408043310502","article-title":"A comparison of intravaginal misoprostol with prostaglandin E2 for termination of second-trimester pregnancy","volume":"5","author":"Jain","year":"1994","journal-title":"The New England Journal of Medicine"},{"key":"10.1053\/beog.2001.0273_RF32","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/S0002-9378(99)70081-5","article-title":"Second trimester uterine evacuation: A comparison of intra-amniotic (15S)-15-methyl-prostaglandin F2\u03b1 and intravaginal misoprostol","volume":"181","author":"Perry","year":"1999","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"10.1053\/beog.2001.0273_RF33","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0020-7292(97)00244-0","article-title":"Second trimester abortion using intravaginal misoprostol","volume":"60","author":"Herabutya","year":"1998","journal-title":"International Journal of Gynecology and Obstetrics"},{"key":"10.1053\/beog.2001.0273_RF34","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0029-7844(98)00485-2","article-title":"A comparison of two dosing regimens of intravaginal misoprostol for second-trimester pregnancy termination","volume":"93","author":"Jain","year":"1999","journal-title":"Obstetrics and Gynecology"},{"key":"10.1053\/beog.2001.0273_RF35","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1093\/humrep\/15.3.709","article-title":"A comparison of two regimens of intravaginal misoprostol for termination of second trimester pregnancy: a randomized comparative trial","volume":"15","author":"Wong","year":"2000","journal-title":"Human Reproduction"},{"key":"10.1053\/beog.2001.0273_RF36","first-page":"1","article-title":"Antiprogesterone steroids: A new dimension in human fertility regulation","volume":"11","author":"Van Look","year":"1989","journal-title":"Oxford Review in Reproductive Biology"},{"key":"10.1053\/beog.2001.0273_RF37","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0010-7824(92)90127-F","article-title":"A study of gemeprost alone, dilapan or mifepristone in combination with gemeprost for the termination of second trimester pregnancy","volume":"46","author":"Thong","year":"1992","journal-title":"Contraception"},{"key":"10.1053\/beog.2001.0273_RF38","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1111\/j.1471-0528.1993.tb14269.x","article-title":"Induction of second trimester abortion with mifepristone and gemeprost","volume":"100","author":"Thong","year":"1993","journal-title":"British Journal of Obstetrics and Gynaecology"},{"key":"10.1053\/beog.2001.0273_RF39","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1093\/oxfordjournals.humrep.a137927","article-title":"The abortifacient effect of misoprostol in the second trimester. A randomized comparison with gemeprost in patients pre-treated with mifepristone (RU486)","volume":"8","author":"El-Refaey","year":"1993","journal-title":"Human Reproduction"},{"key":"10.1053\/beog.2001.0273_RF40","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1111\/j.1471-0528.1995.tb11404.x","article-title":"Reducting the induction to abortion interval in termination of second trimester pregnancies: a comparison of mifepristone with laminaria tent","volume":"102","author":"Ho","year":"1995","journal-title":"British Journal of Obstetrics and Gynaecology"},{"key":"10.1053\/beog.2001.0273_RF41","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1093\/oxfordjournals.humrep.a135965","article-title":"Induction of abortion in the second trimester by a combination of misoprostol and mifepristone: a randomized comparison between two misoprostol regimens","volume":"10","author":"El-Refaey","year":"1995","journal-title":"Human Reproduction"},{"key":"10.1053\/beog.2001.0273_RF42","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1111\/j.1471-0528.1996.tb09842.x","article-title":"A comparison of 600mg and 200mg mifepristone prior to second trimester abortion with the prostaglandin misoprostol","volume":"103","author":"Webster","year":"1996","journal-title":"British Journal of Obstetrics and Gynaecology"},{"key":"10.1053\/beog.2001.0273_RF43","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0010-7824(96)00132-1","article-title":"A randomised study of two doses of gemeprost in combination with mifepristone for induction of abortion in the second trimester of pregnancy","volume":"54","author":"Thong","year":"1996","journal-title":"Contraception"},{"key":"10.1053\/beog.2001.0273_RF44","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0010-7824(96)00061-3","article-title":"Misoprostol is as effective as gemeprost in termination of second trimester pregnancy when combined with mifepristone: a randomised comparative trial","volume":"53","author":"Ho","year":"1996","journal-title":"Contraception"},{"key":"10.1053\/beog.2001.0273_RF45","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1093\/humrep\/15.10.2205","article-title":"Randomized comparison of vaginal (200\u03bcg every 3h) and oral (400\u03bcg every 3h) misoprostol when combined with mifepristone in termination of second trimester pregnancy","volume":"15","author":"Ngai","year":"2000","journal-title":"Human Reproduction"},{"key":"10.1053\/beog.2001.0273_RF46","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0010-7824(97)00184-4","volume":"56","year":"1997","journal-title":"Contraception"},{"key":"10.1053\/beog.2001.0273_RF47","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1111\/j.1471-0528.1999.tb08371.x","article-title":"Nonsurgical mid-trimester termination of pregnancy: a review of 500 consecutive cases","volume":"106","author":"Ashok","year":"1999","journal-title":"British Journal of Obstetrics and Gynaecology"},{"key":"10.1053\/beog.2001.0273_RF48","first-page":"702","article-title":"Termination of second trimester pregnancy with mifepristone and gemeprost. The clinical experience of 197 consecutive cases","volume":"79","author":"Gemzell-Danielsson","year":"2000","journal-title":"Acta Obstetricia et Gynecologica Scandinavica"},{"key":"10.1053\/beog.2001.0273_RF49","unstructured":"Tang, O, S, Thong, K, J, Baird, D, T, Second trimester medical abortion with mifepristone and gemeprost: a review of 956 cases, Contraception"},{"key":"10.1053\/beog.2001.0273_RF50","doi-asserted-by":"crossref","first-page":"535","DOI":"10.3109\/00016348309154232","article-title":"Termination of second trimester pregnancy by laminaria and intramuscular injections of 15-methyl PGF2\u03b1 or 16-phenoxy-\u03c9-17,18,19,20-tetranor PGE2 methyl sulphonylamide. A randomized study","volume":"62","author":"Bygdeman","year":"1983","journal-title":"Acta Obstetricia et Gynecologica Scandinavica"},{"key":"10.1053\/beog.2001.0273_RF51","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0090-6980(82)90053-3","article-title":"Termination of second trimester pregnancy with laminaria and intramuscular 16-phenoxy-\u03c9-17,18,19,20-tetranor PGE2 methyl sulphonylamide (sulprostone): a randomized study","volume":"23","author":"Karim","year":"1982","journal-title":"Prostaglandins"},{"key":"10.1053\/beog.2001.0273_RF52","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0002-9378(96)70270-3","article-title":"A comparison of misoprostol with and without laminaria tents for induction of second-trimester abortion","volume":"175","author":"Jain","year":"1996","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"10.1053\/beog.2001.0273_RF53","unstructured":"WHO Scientific Group on Medical Methods for Termination of Pregnancy, Method of abortion after 14 weeks of gestation, 42, 54"},{"key":"10.1053\/beog.2001.0273_RF54","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0301-2115(95)02365-8","article-title":"Uterine rupture during second trimester of pregnancy using mifepristone and a prostaglandin","volume":"65","author":"Phillips","year":"1996","journal-title":"European Journal of Obstetrics and Gynaecology"},{"key":"10.1053\/beog.2001.0273_RF55","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/S0029-7844(99)00335-X","article-title":"Separation of cesarean scar during second-trimester intravaginal misoprostol abortion","volume":"94","author":"Chen","year":"1999","journal-title":"Obstetrics and Gynecology"},{"key":"10.1053\/beog.2001.0273_RF56","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/j.1471-0528.1995.tb09142.x","article-title":"Uterine rupture during therapeutic abortion in the second trimester using mifepristone and prostaglandin","volume":"102","author":"Norman","year":"1995","journal-title":"British Journal of Obstetrics and Gynaecology"},{"key":"10.1053\/beog.2001.0273_RF57","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1111\/j.1471-0528.1990.tb02484.x","article-title":"Uterine rupture in midtrimester abortion. A complication of gemeprost vaginal pessaries and oxytocin, case report","volume":"97","author":"Wiener","year":"1990","journal-title":"British Journal of Obstetrics and Gynaecology"}],"container-title":["Best Practice & Research Clinical Obstetrics & Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521693401902731?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521693401902731?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T22:52:23Z","timestamp":1555023143000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521693401902731"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,4]]},"references-count":57,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002,4]]}},"alternative-id":["S1521693401902731"],"URL":"https:\/\/doi.org\/10.1053\/beog.2001.0273","relation":{},"ISSN":["1521-6934"],"issn-type":[{"value":"1521-6934","type":"print"}],"subject":[],"published":{"date-parts":[[2002,4]]}}}