{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T01:03:00Z","timestamp":1783645380521,"version":"3.55.0"},"reference-count":96,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2002,8,1]],"date-time":"2002-08-01T00:00:00Z","timestamp":1028160000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Best Practice &amp; Research Clinical Obstetrics &amp; Gynaecology"],"published-print":{"date-parts":[[2002,8]]},"DOI":"10.1053\/beog.2002.0296","type":"journal-article","created":{"date-parts":[[2002,11,5]],"date-time":"2002-11-05T13:40:05Z","timestamp":1036503605000},"page":"449-468","source":"Crossref","is-referenced-by-count":54,"title":["The genetics of ovarian cancer"],"prefix":"10.1053","volume":"16","author":[{"given":"Paul D.P","family":"Pharoah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce A.J","family":"Ponder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/beog.2002.0296_RF1","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1111\/j.1471-0528.1998.tb10148.x","article-title":"A systematic review and meta-analysis of family history and risk of ovarian cancer","volume":"105","author":"Stratton","year":"1998","journal-title":"British Journal of Obstetrics and Gynaecology"},{"key":"10.1053\/beog.2002.0296_RF2","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/bjc.1996.352","article-title":"Cancer incidence in the first-degree relatives of ovarian cancer patients","volume":"74","author":"Auranen","year":"1996","journal-title":"British Journal of Cancer"},{"key":"10.1053\/beog.2002.0296_RF3","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1002\/(SICI)1097-0215(19960126)65:3<284::AID-IJC2>3.0.CO;2-W","article-title":"Cancer mortality in relatives of women with ovarian cancer: the OPCS study","volume":"65","author":"Easton","year":"1996","journal-title":"International Journal of Cancer"},{"key":"10.1053\/beog.2002.0296_RF4","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1093\/oxfordjournals.aje.a114994","article-title":"Familial ovarian cancer: a population-based case-control study","volume":"128","author":"Schildkraut","year":"1988","journal-title":"American Journal of Epidemiology"},{"key":"10.1053\/beog.2002.0296_RF5","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/1097-0215(20000701)87:1<110::AID-IJC16>3.0.CO;2-6","article-title":"Ovarian and breast cancer risks to women in families with two or more cases of ovarian cancer","volume":"87","author":"Sutcliffe","year":"2000","journal-title":"International Journal of Cancer"},{"key":"10.1053\/beog.2002.0296_RF6","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1056\/NEJM200007133430201","article-title":"Environmental and heritable factors in the causation of cancer \u2013 analyses of cohorts of twins from Sweden, Denmark, and Finland","volume":"343","author":"Lichtenstein","year":"2000","journal-title":"New England Journal of Medicine"},{"key":"10.1053\/beog.2002.0296_RF7","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1126\/science.7545954","article-title":"A strong candidate for the 17 linked breast and ovarian cancer susceptibility gene BRCA1","volume":"266","author":"Miki","year":"1994","journal-title":"Science"},{"key":"10.1053\/beog.2002.0296_RF8","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/378789a0","article-title":"Identification of the breast cancer susceptibility gene BRCA2","volume":"378","author":"Wooster","year":"1995","journal-title":"Nature"},{"key":"10.1053\/beog.2002.0296_RF9","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/ng1095-198","article-title":"The carrier frequency of the BRCA1 185delAG mutation is approximately 1 percent in Ashkenazi Jewish individuals","volume":"11","author":"Struewing","year":"1995","journal-title":"Nature Genetics"},{"key":"10.1053\/beog.2002.0296_RF10","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1056\/NEJM199601183340302","article-title":"Germ-line BRCA1 mutations in Jewish and non-Jewish women with early-onset breast cancer","volume":"334","author":"Fitzgerald","year":"1996","journal-title":"New England Journal of Medicine"},{"key":"10.1053\/beog.2002.0296_RF11","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1016\/S0140-6736(96)91484-1","article-title":"Germline BRCA1 185delAG mutations in Jewish women with breast cancer","volume":"347","author":"Offit","year":"1996","journal-title":"Lancet"},{"key":"10.1053\/beog.2002.0296_RF12","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/ng0596-126","article-title":"Recurrent BRCA2 6174delT mutations in Ashkenazi Jewish women affected by breast cancer","volume":"13","author":"Neuhausen","year":"1996","journal-title":"Nature Genetics"},{"key":"10.1053\/beog.2002.0296_RF13","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/ng0596-117","article-title":"A single BRCA2 mutation in male and female breast cancer families from Iceland with varied cancer phenotypes","volume":"13","author":"Thorlacius","year":"1996","journal-title":"Nature Genetics"},{"key":"10.1053\/beog.2002.0296_RF14","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1023\/A:1018779830743","article-title":"The genetics of inherited breast cancer","volume":"3","author":"Gayther","year":"1998","journal-title":"Journal of Mammary Gland Biology and Neoplasia"},{"key":"10.1053\/beog.2002.0296_RF15","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1086\/301749","article-title":"Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families","volume":"62","author":"Ford","year":"1998","journal-title":"American Journal of Human Genetics"},{"key":"10.1053\/beog.2002.0296_RF16","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1086\/302583","article-title":"The contribution of germline BRCA1 and BRCA2 mutations to familial ovarian cancer: no evidence for other ovarian cancer-susceptibility genes","volume":"65","author":"Gayther","year":"1999","journal-title":"American Journal of Human Genetics"},{"key":"10.1053\/beog.2002.0296_RF17","first-page":"2998","article-title":"Mutation analysis of the BRCA1 gene in ovarian cancers","volume":"55","author":"Takahashi","year":"1995","journal-title":"Cancer Research"},{"key":"10.1053\/beog.2002.0296_RF18","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1093\/hmg\/4.10.1953","article-title":"Mutation analysis of the BRCA1 gene in 76 Japanese ovarian cancer patients: four germline mutations, but no evidence of somatic mutation","volume":"4","author":"Matsushima","year":"1995","journal-title":"Human Molecular Genetics"},{"key":"10.1053\/beog.2002.0296_RF19","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1056\/NEJM199704173361602","article-title":"Contribution of BRCA1 mutations to ovarian cancer","volume":"336","author":"Stratton","year":"1997","journal-title":"New England Journal of Medicine"},{"key":"10.1053\/beog.2002.0296_RF20","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/S0002-9378(98)70476-4","article-title":"BRCA1, BRCA2, and hereditary nonpolyposis colorectal cancer gene mutations in an unselected ovarian cancer population: relationship to family history and implications for genetic testing","volume":"178","author":"Rubin","year":"1998","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"10.1053\/beog.2002.0296_RF21","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1093\/hmg\/8.5.889","article-title":"Germline BRCA1 alterations in a population-based series of ovarian cancer cases","volume":"8","author":"Janezic","year":"1999","journal-title":"Human Molecular Genetics"},{"key":"10.1053\/beog.2002.0296_RF22","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/1098-1004(200007)16:1<88::AID-HUMU16>3.0.CO;2-G","article-title":"Mutational analysis of BRCA1 and BRCA2 genes in Chinese ovarian cancer identifies 6 novel germline mutations","volume":"16","author":"Khoo","year":"2000","journal-title":"Human Mutation"},{"key":"10.1053\/beog.2002.0296_RF23","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1002\/(SICI)1097-0215(20000601)86:5<737::AID-IJC21>3.0.CO;2-1","article-title":"Prevalence of founder BRCA1 and BRCA2 mutations among breast and ovarian cancer patients in Hungary","volume":"86","author":"van der Looij","year":"2000","journal-title":"International Journal of Cancer"},{"key":"10.1053\/beog.2002.0296_RF24","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1086\/318787","article-title":"Prevalence and penetrance of germline BRCA1 and BRCA2 mutations in a population series of 649 women with ovarian cancer","volume":"68","author":"Risch","year":"2001","journal-title":"American Journal of Human Genetics"},{"key":"10.1053\/beog.2002.0296_RF25","first-page":"505","article-title":"The founder mutations 185delAG and 5382insC in BRCA1 and 6174delT in BRCA2 appear in 60% of ovarian cancer and 30% of early-onset breast cancer patients among Ashkenazi women","volume":"60","author":"Abeliovich","year":"1997","journal-title":"American Journal of Human Genetics"},{"key":"10.1053\/beog.2002.0296_RF26","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1006\/gyno.1997.4844","article-title":"High frequency of BRCA1 and BRCA2 germline mutations in Ashkenazi Jewish ovarian cancer patients, regardless of family history","volume":"67","author":"Beller","year":"1997","journal-title":"Gynecologic Oncology"},{"key":"10.1053\/beog.2002.0296_RF27","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1093\/jnci\/90.13.995","article-title":"Rates of Jewish ancestral mutations in BRCA1 and BRCA2 in borderline ovarian tumors","volume":"90","author":"Gotlieb","year":"1998","journal-title":"Journal of the National Cancer Institute"},{"key":"10.1053\/beog.2002.0296_RF28","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/S0029-7844(98)00362-7","article-title":"A population-based study of BRCA1 and BRCA2 mutations in Jewish women with epithelial ovarian cancer","volume":"93","author":"Lu","year":"1999","journal-title":"Obstetrics Gynecology"},{"key":"10.1053\/beog.2002.0296_RF29","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1001\/jama.283.17.2260","article-title":"Clinicopathologic features of BRCA-linked and sporadic ovarian cancer","volume":"283","author":"Boyd","year":"2000","journal-title":"Journal of the American Medical Association"},{"key":"10.1053\/beog.2002.0296_RF30","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1086\/302853","article-title":"BRCA1 and BRCA2 mutation analysis of 208 Ashkenazi jewish women with ovarian cancer","volume":"66","author":"Moslehi","year":"2000","journal-title":"American Journal of Human Genetics"},{"key":"10.1053\/beog.2002.0296_RF31","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1053\/ejso.2000.1097","article-title":"Ovarian cancer survival in Ashkenazi Jewish patients with BRCA1 and BRCA2 mutations","volume":"27","author":"Ramus","year":"2001","journal-title":"European Journal of Surgery and Oncology"},{"key":"10.1053\/beog.2002.0296_RF32","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1034\/j.1399-0004.1999.550504.x","article-title":"Founder BRCA1 and BRCA2 mutations in French Canadian ovarian cancer cases unselected for family history","volume":"55","author":"Tonin","year":"1999","journal-title":"Clinical Genetics"},{"key":"10.1053\/beog.2002.0296_RF33","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/S0959-8049(99)00050-7","article-title":"Three per cent of Norwegian ovarian cancers are caused by BRCA1 1675delA or 1135insA","volume":"35","author":"Dorum","year":"1999","journal-title":"European Journal of Cancer"},{"key":"10.1053\/beog.2002.0296_RF34","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/S0140-6736(94)91578-4","article-title":"Risks of Cancer in BRCA1 mutation carriers","volume":"343","author":"Ford","year":"1994","journal-title":"Lancet"},{"key":"10.1053\/beog.2002.0296_RF35","first-page":"265","article-title":"Breast Cancer Linkage Consortium. Breast and ovarian cancer incidence in BRCA1 -mutation carriers","volume":"56","author":"Easton","year":"1995","journal-title":"American Journal of Human Genetics"},{"key":"10.1053\/beog.2002.0296_RF36","first-page":"741","article-title":"Population-based estimate of the average age-specific cumulative risk of breast cancer for a defined set of protein-truncating mutations in BRCA1 and BRCA2","volume":"8","author":"Hopper","year":"1999","journal-title":"Cancer Epidemiology Biomarkers and Prevention"},{"key":"10.1053\/beog.2002.0296_RF37","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/(SICI)1098-2272(200002)18:2<173::AID-GEPI6>3.0.CO;2-R","article-title":"Risk models for familial breast and ovarian cancer","volume":"18","author":"Antoniou","year":"2000","journal-title":"Genetics and Epidemiology"},{"key":"10.1053\/beog.2002.0296_RF38","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1016\/S0140-6736(98)03300-5","article-title":"Population-based study of risk of breast cancer in carriers of BRCA2 mutation","volume":"352","author":"Thorlacius","year":"1998","journal-title":"Lancet"},{"key":"10.1053\/beog.2002.0296_RF39","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1054\/bjoc.2000.1407","volume":"83","year":"2000","journal-title":"British Journal of Cancer"},{"key":"10.1053\/beog.2002.0296_RF40","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1093\/jnci\/91.14.1241","article-title":"Prevalence and penetrance of BRCA1 and BRCA2 gene mutations in unselected Ashkenazi Jewish women with breast cancer","volume":"91","author":"Warner","year":"1999","journal-title":"Journal of the National Cancer Institute"},{"key":"10.1053\/beog.2002.0296_RF41","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1056\/NEJM199705153362001","article-title":"The risk of cancer associated with specific mutations of BRCA1 and BRCA2 among Ashkenazi Jews","volume":"336","author":"Struewing","year":"1997","journal-title":"New England Journal of Medicine"},{"key":"10.1053\/beog.2002.0296_RF42","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1093\/jnci\/91.15.1310","volume":"91","year":"1999","journal-title":"Journal of the National Cancer Institute"},{"key":"10.1053\/beog.2002.0296_RF43","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/ng1295-428","article-title":"Germline mutations of the BRCA1 gene in breast and ovarian cancer families provide evidence for a genotype-phenotype correlation","volume":"11","author":"Gayther","year":"1995","journal-title":"Nature Genetics"},{"key":"10.1053\/beog.2002.0296_RF44","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/ng0197-103","article-title":"Variation of risks of breast and ovarian cancer associated with different germline mutations of the BRCA2 gene","volume":"15","author":"Gayther","year":"1997","journal-title":"Nature Genetics"},{"key":"10.1053\/beog.2002.0296_RF45","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1086\/318181","article-title":"Variation in cancer risks, by mutation position, in BRCA2 mutation carriers","volume":"68","author":"Thompson","year":"2001","journal-title":"American Journal of Human Genetics"},{"key":"10.1053\/beog.2002.0296_RF46","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1002\/ijc.2910640608","article-title":"Risk modifiers in carriers of BRCA1 mutations","volume":"64","author":"Narod","year":"1995","journal-title":"International Journal of Cancer"},{"key":"10.1053\/beog.2002.0296_RF47","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/S0140-6736(05)60750-7","article-title":"Pregnancy-associated breast cancer in BRCA1 and BRCA2 germline mutation carriers","volume":"352","author":"Johannsson","year":"1998","journal-title":"Lancet"},{"key":"10.1053\/beog.2002.0296_RF48","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1016\/S0140-6736(99)04336-6","article-title":"Pregnancy and risk of early breast cancer in carriers of BRCA1 and BRCA2","volume":"354","author":"Jernstrom","year":"1999","journal-title":"Lancet"},{"key":"10.1053\/beog.2002.0296_RF49","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1093\/jnci\/90.10.761","article-title":"Effect of smoking on breast cancer in carriers of mutant BRCA1 or BRCA2 genes","volume":"90","author":"Brunet","year":"1998","journal-title":"Journal of the National Cancer Institute"},{"key":"10.1053\/beog.2002.0296_RF50","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1056\/NEJM199808133390702","article-title":"Oral contraceptives and the risk of hereditary ovarian cancer","volume":"339","author":"Narod","year":"1998","journal-title":"New England Journal of Medicine"},{"key":"10.1053\/beog.2002.0296_RF51","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1056\/NEJM200107263450401","article-title":"Parity, oral contraceptives, and the risk of ovarian cancer among carriers and noncarriers of a BRCA1 or BRCA2 mutation","volume":"345","author":"Modan","year":"2001","journal-title":"New England Journal of Medicine"},{"key":"10.1053\/beog.2002.0296_RF52","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1016\/S0140-6736(00)04642-0","article-title":"Tubal ligation and risk of ovarian cancer in carriers of BRCA1 or BRCA2 mutations: a case-control study","volume":"357","author":"Narod","year":"2001","journal-title":"Lancet"},{"key":"10.1053\/beog.2002.0296_RF53","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1056\/NEJM199308193290801","article-title":"An association between the risk of cancer and mutations in the HRAS1 minisatellite locus","volume":"329","author":"Krontiris","year":"1993","journal-title":"New England Journal of Medicine"},{"key":"10.1053\/beog.2002.0296_RF54","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/ng0396-309","article-title":"Ovarian cancer risk in BRCA1 carriers is modified by the HRAS1 variable number of tandem repeat (VNTR) locus","volume":"12","author":"Phelan","year":"1996","journal-title":"Nature Genetics"},{"key":"10.1053\/beog.2002.0296_RF55","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1086\/302366","article-title":"Modification of BRCA1 -associated breast cancer risk by the polymorphic androgen-receptor CAG repeat","volume":"64","author":"Rebbeck","year":"1999","journal-title":"American Journal of Human Genetics"},{"key":"10.1053\/beog.2002.0296_RF56","first-page":"908","article-title":"The androgen receptor and genetic susceptibility to ovarian cancer: results from a case series","volume":"61","author":"Levine","year":"2001","journal-title":"Cancer Research"},{"key":"10.1053\/beog.2002.0296_RF57","unstructured":"Rebbeck, T, R, Kantoff, P, W, Krithivas, K, Modification of breast cancer risk in BRCA1 mutation carriers by the AIB1 gene, p 194"},{"key":"10.1053\/beog.2002.0296_RF58","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1006\/gyno.1993.1265","article-title":"Familial ovarian cancer","volume":"51","author":"Buller","year":"1993","journal-title":"Gynecologic Oncology"},{"key":"10.1053\/beog.2002.0296_RF59","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1093\/oxfordjournals.annonc.a059053","article-title":"A matched control study of familial epithelial ovarian cancer: patient characteristics, response to chemotherapy and outcome","volume":"6","author":"Chang","year":"1995","journal-title":"Annals of Oncology"},{"key":"10.1053\/beog.2002.0296_RF60","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/S0959-8049(97)89007-7","article-title":"Tumour biological features of BRCA1-induced breast and ovarian cancer","volume":"33","author":"Johannsson","year":"1997","journal-title":"European Journal of Cancer"},{"key":"10.1053\/beog.2002.0296_RF61","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1056\/NEJM199611073351901","article-title":"Clinical and pathological features of ovarian cancer in women with germ-line mutations of BRCA1","volume":"335","author":"Rubin","year":"1996","journal-title":"New England Journal of Medicine"},{"key":"10.1053\/beog.2002.0296_RF62","first-page":"868","article-title":"Survival in familial, BRCA1 and BRCA2 associated epithelial ovarian cancer","volume":"59","author":"Pharoah","year":"1999","journal-title":"Cancer Research"},{"key":"10.1053\/beog.2002.0296_RF63","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1016\/S0046-8177(00)80014-3","article-title":"Histopathology of familial ovarian tumors in women from families with and without germline BRCA1 mutations","volume":"31","author":"Werness","year":"2000","journal-title":"Human Pathology"},{"key":"10.1053\/beog.2002.0296_RF64","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1200\/JCO.1998.16.2.397","article-title":"Survival of BRCA1 breast and ovarian cancer patients: a population-based study from southern Sweden","volume":"16","author":"Johannsson","year":"1998","journal-title":"Journal of Clinical Oncology"},{"key":"10.1053\/beog.2002.0296_RF65","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1093\/jnci\/91.3.259","article-title":"Survival after breast cancer in Ashkenazi Jewish BRCA1 and BRCA2 mutation carriers","volume":"91","author":"Lee","year":"1999","journal-title":"Journal of the National Cancer Institute"},{"key":"10.1053\/beog.2002.0296_RF66","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1001\/archinte.1966.03870080050009","article-title":"Hereditary factors in cancer. Study of two large midwestern kindreds","volume":"117","author":"Lynch","year":"1966","journal-title":"Archives of Internal Medicine"},{"key":"10.1053\/beog.2002.0296_RF67","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1136\/gut.47.1.148","article-title":"DNA mismatch repair genes and colorectal cancer","volume":"47","author":"Wheeler","year":"2000","journal-title":"Gut"},{"key":"10.1053\/beog.2002.0296_RF68","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1002\/(SICI)1097-0215(19990412)81:2<214::AID-IJC8>3.0.CO;2-L","article-title":"Cancer risk in mutation carriers of DNA-mismatch-repair genes","volume":"81","author":"Aarnio","year":"1999","journal-title":"International Journal of Cancer"},{"key":"10.1053\/beog.2002.0296_RF69","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1086\/302671","article-title":"The genetic epidemiology of early-onset epithelial ovarian cancer: a population-based study","volume":"65","author":"Stratton","year":"1999","journal-title":"American Journal of Human Genetics"},{"key":"10.1053\/beog.2002.0296_RF70","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1093\/jnci\/91.11.943","article-title":"Prevalence of BRCA1 and BRCA2 gene mutations in patients with early-onset breast cancer","volume":"91","author":"Peto","year":"1999","journal-title":"Journal of the National Cancer Institute"},{"key":"10.1053\/beog.2002.0296_RF71","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1038\/35057149","volume":"409","year":"2001","journal-title":"Natue"},{"key":"10.1053\/beog.2002.0296_RF72","series-title":"Modern epidemiology","article-title":"Genetic Epidemiology","author":"Khoury","year":"1997"},{"key":"10.1053\/beog.2002.0296_RF73","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1126\/science.273.5281.1516","article-title":"The future of genetic studies of complex diseases","author":"Risch","year":"1996","journal-title":"Science"},{"key":"10.1053\/beog.2002.0296_RF74","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1002\/1097-0215(20000915)87:6<798::AID-IJC6>3.0.CO;2-X","article-title":"Refinement of an ovarian cancer tumour suppressor gene locus on chromosome arm 22q and mutation analysis of CYP2D6, SREBP2 and NAGA","volume":"87","author":"Bryan","year":"2000","journal-title":"International Journal of Cancer"},{"key":"10.1053\/beog.2002.0296_RF75","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/S0140-6736(95)90745-9","article-title":"p53-based blood test for p53PIN3 and risk for sporadic ovarian cancer","volume":"345","author":"Runnebaum","year":"1995","journal-title":"Lancet"},{"key":"10.1053\/beog.2002.0296_RF76","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S0140-6736(95)91239-8","article-title":"p53 polymorphism in ovarian and bladder cancer","volume":"346","author":"Lancaster","year":"1995","journal-title":"Lancet"},{"key":"10.1053\/beog.2002.0296_RF77","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0140-6736(96)90569-3","article-title":"p53 polymorphism in ovarian and breast cancer","volume":"347","author":"Campbell","year":"1996","journal-title":"Lancet"},{"key":"10.1053\/beog.2002.0296_RF78","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/sj.bjc.6690669","article-title":"Intron variants of the p53 gene are associated with increased risk for ovarian cancer but not in carriers of BRCA1 or BRCA2 germline mutations","volume":"81","author":"Wang Gohrke","year":"1999","journal-title":"British Journal of Cancer"},{"key":"10.1053\/beog.2002.0296_RF79","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/bjc.1998.108","article-title":"TP53 intron 6 polymorphism and the risk of ovarian and breast cancer","volume":"77","author":"Mavridou","year":"1998","journal-title":"British Journal of Cancer"},{"key":"10.1053\/beog.2002.0296_RF80","first-page":"239","article-title":"The influence of the p53 codon 72 polymorphism on ovarian carcinogenesis and prognosis","volume":"4","author":"Buller","year":"1997","journal-title":"Cancer Gene Therapy"},{"key":"10.1053\/beog.2002.0296_RF81","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0304-3835(98)00123-2","article-title":"Glutathione S-transferase T1 and M1 gene defects in ovarian carcinoma","volume":"130","author":"Hengstler","year":"1998","journal-title":"Cancer Letters"},{"key":"10.1053\/beog.2002.0296_RF82","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/carcin\/22.1.67","article-title":"Polymorphisms at the glutathione S-transferase GSTM1, GSTT1 and GSTP1 loci: risk of ovarian cancer by histological subtype","volume":"22","author":"Spurdle","year":"2001","journal-title":"Carcinogenesis"},{"key":"10.1053\/beog.2002.0296_RF83","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1002\/1097-0215(20000901)87:5<637::AID-IJC3>3.0.CO;2-R","article-title":"Androgen receptor exon 1 CAG repeat length and risk of ovarian cancer","volume":"87","author":"Spurdle","year":"2000","journal-title":"International Journal of Cancer"},{"key":"10.1053\/beog.2002.0296_RF84","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1002\/(SICI)1097-0215(20000501)86:3<436::AID-IJC21>3.0.CO;2-A","article-title":"CYP17 promotor polymorphism and ovarian cancer risk","volume":"86","author":"Spurdle","year":"2000","journal-title":"International Journal of Cancer"},{"key":"10.1053\/beog.2002.0296_RF85","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1093\/carcin\/22.5.717","article-title":"No significant association between progesterone receptor exon 4 Val660Leu G\/T polymorphism and risk of ovarian cancer","volume":"22","author":"Spurdle","year":"2001","journal-title":"Carcinogenesis"},{"key":"10.1053\/beog.2002.0296_RF86","first-page":"259","article-title":"The HRAS1 minisatellite locus and risk of ovarian cancer","volume":"60","author":"Weitzel","year":"2000","journal-title":"Cancer Research"},{"key":"10.1053\/beog.2002.0296_RF87","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1002\/cncr.2820710214","article-title":"Familial ovarian cancer. A report of 658 families from the Gilda Radner Familial Ovarian Cancer Registry 1981\u20131991","volume":"71","author":"Piver","year":"1993","journal-title":"Cancer"},{"key":"10.1053\/beog.2002.0296_RF88","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1016\/S0140-6736(96)90806-5","volume":"347","year":"1996","journal-title":"Lancet"},{"key":"10.1053\/beog.2002.0296_RF89","first-page":"33","article-title":"Prophylactic oophorectomy in inherited breast\/ovarian cancer families","volume":"17","author":"Struewing","year":"1995","journal-title":"Journal of the National Cancer Institute Monographs"},{"key":"10.1053\/beog.2002.0296_RF90","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.1002\/1097-0142(19930501)71:9<2751::AID-CNCR2820710911>3.0.CO;2-J","article-title":"Primary peritoneal carcinoma after prophylactic oophorectomy in women with a family history of ovarian cancer. A report of the Gilda Radner Familial Ovarian Cancer Registry","volume":"71","author":"Piver","year":"1993","journal-title":"Cancer"},{"key":"10.1053\/beog.2002.0296_RF91","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1001\/jama.1995.03520300065039","volume":"273","year":"1995","journal-title":"Journal of the American Medical Association"},{"key":"10.1053\/beog.2002.0296_RF92","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1001\/jama.1997.03540360065034","article-title":"Recommendations for follow-up care of individuals with an inherited predisposition to cancer. II. BRCA1 and BRCA2","volume":"277","author":"Burke","year":"1997","journal-title":"Journal of the American Medical Association"},{"key":"10.1053\/beog.2002.0296_RF93","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1093\/jnci\/91.17.1475","article-title":"Breast cancer risk after bilateral prophylactic oophorectomy in BRCA1 mutation carriers","volume":"91","author":"Rebbeck","year":"1999","journal-title":"Journal of the National Cancer Institute"},{"key":"10.1053\/beog.2002.0296_RF94","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1136\/bmj.306.6884.1025","article-title":"Screening for early familial ovarian cancer with transvaginal ultrasonography and colour blood flow imaging","volume":"306","author":"Bourne","year":"1993","journal-title":"British Medical Journal"},{"key":"10.1053\/beog.2002.0296_RF95","first-page":"14","article-title":"Prospective evaluation of serum CA 125 levels for early detection of ovarian cancer","volume":"80","author":"Einhorn","year":"1992","journal-title":"Obstetrics and Gynecology"},{"key":"10.1053\/beog.2002.0296_RF96","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/S0002-9378(99)70663-0","article-title":"Peritoneal serous papillary carcinoma, a phenotypic variant of familial ovarian cancer: implications for ovarian cancer screening","volume":"180","author":"Karlan","year":"1999","journal-title":"American Journal of Obstetrics and Gynecology"}],"container-title":["Best Practice &amp; Research Clinical Obstetrics &amp; Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521693402902968?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521693402902968?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T09:53:12Z","timestamp":1554371592000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521693402902968"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,8]]},"references-count":96,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002,8]]}},"alternative-id":["S1521693402902968"],"URL":"https:\/\/doi.org\/10.1053\/beog.2002.0296","relation":{},"ISSN":["1521-6934"],"issn-type":[{"value":"1521-6934","type":"print"}],"subject":[],"published":{"date-parts":[[2002,8]]}}}