{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:52:40Z","timestamp":1760575960643,"version":"build-2065373602"},"reference-count":36,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2003,5,1]],"date-time":"2003-05-01T00:00:00Z","timestamp":1051747200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2003,5,1]],"date-time":"2003-05-01T00:00:00Z","timestamp":1051747200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicaloncologyonline.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oncology"],"published-print":{"date-parts":[[2003,5]]},"DOI":"10.1053\/clon.2003.0200","type":"journal-article","created":{"date-parts":[[2003,4,30]],"date-time":"2003-04-30T21:44:22Z","timestamp":1051739062000},"page":"109-114","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["A Phase I\/II Study of CHARTWEL with Concurrent Chemotherapy in Locally Advanced, Inoperable Carcinoma of the Oesophagus"],"prefix":"10.1053","volume":"15","author":[{"given":"J","family":"Harney","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Goodchild","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Glynne-Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.J","family":"Hoskin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.I","family":"Saunders","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1053\/clon.2003.0200_RF2","first-page":"404","article-title":"Cancer of the oesophagus and cardia: overview of radiotherapy","volume":"32","author":"Flores","year":"1989","journal-title":"Can J Surg"},{"key":"10.1053\/clon.2003.0200_RF3","series-title":"American Society of Clinical Oncology Educational Book","first-page":"164","article-title":"Nonsurgical treatment approaches for oesophageal cancer","author":"Minsky","year":"1997"},{"key":"10.1053\/clon.2003.0200_RF4","first-page":"8","article-title":"An MRC prospective randomised trial of radiotherapy versus surgery for inoperable squamous cell carcinoma of the oesophagus","volume":"73","author":"Earlam","year":"1995","journal-title":"Ann R Coll Surg Engl"},{"key":"10.1053\/clon.2003.0200_RF5","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/bjs.1800670702","article-title":"A critical view of radiotherapy","volume":"67","author":"Earlam","year":"1980","journal-title":"Br J Surg"},{"key":"10.1053\/clon.2003.0200_RF6","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1002\/bjs.1800670602","article-title":"A critical overview of surgery","volume":"67","author":"Earlam","year":"1980","journal-title":"Br J Surg"},{"key":"10.1053\/clon.2003.0200_RF7","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0360-3016(98)00232-6","article-title":"Combined chemoradiotherapy versus radiotherapy alone for early stage squamous cell carcinoma of the oesophagus: a study of the Eastern Co-operative Oncology Group","volume":"42","author":"Smith","year":"1998","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1053\/clon.2003.0200_RF8","first-page":"A583","article-title":"Results of the EORTC-GTCCG phase 111 trial of irradiation versus irradiation and CDDP in inoperable oesophageal cancer","volume":"13","author":"Roussel","year":"1994","journal-title":"Proc Ann Meet Soc Clin Oncol"},{"key":"10.1053\/clon.2003.0200_RF9","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1200\/JCO.1997.15.1.277","article-title":"Progress report of combined chemoradiotherapy versus radiotherapy alone in patients with oesophageal cancer: an Intergroup Study","volume":"15","author":"Al-Sarraf","year":"1997","journal-title":"J Clin Oncol"},{"key":"10.1053\/clon.2003.0200_RF10","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1001\/jama.281.17.1623","article-title":"Chemoradiotherapy of locally advanced oesophageal cancer. Long term follow-up of a prospective randomised trial (RTOG 85-01)","volume":"281","author":"Cooper","year":"1999","journal-title":"JAMA"},{"key":"10.1053\/clon.2003.0200_RF11","series-title":"The Cochrane Library","article-title":"Combined chemotherapy and radiotherapy (without surgery) compared radiotherapy alone in localised carcinoma of the oesophagus (Cochrane Review)","author":"Wong","year":"2002"},{"key":"10.1053\/clon.2003.0200_RF12","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0167-8140(99)00087-0","article-title":"Continuous, hyperfractionated, accelerated radiotherapy (CHART) versus conventional radiotherapy in non-small cell lung cancer: mature data from the randomised multi-center trial","volume":"52","author":"Saunders","year":"1999","journal-title":"Radiother Oncol"},{"key":"10.1053\/clon.2003.0200_RF13","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0167-8140(97)00094-7","article-title":"A randomised multi-center trial of CHART versus conventional radiotherapy in head and neck cancer","volume":"44","author":"Dische","year":"1997","journal-title":"Radiother Oncol"},{"key":"10.1053\/clon.2003.0200_RF14","first-page":"163","article-title":"Cell kinetics of human solid tumours","volume":"24","author":"Laing","year":"1993","journal-title":"Br J Radiol"},{"key":"10.1053\/clon.2003.0200_RF15","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/0360-3016(94)90315-8","article-title":"Oesophageal cancer treated with radiotherapy. Impact of total treatment time and fractionation","volume":"30","author":"Nishimura","year":"1994","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1053\/clon.2003.0200_RF16","first-page":"61","article-title":"Multiple fraction per day radiation therapy for inoperable oesophageal cancer","volume":"19","author":"De Paoli","year":"1998","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1053\/clon.2003.0200_RF17","first-page":"537","article-title":"Study on clinical application of multiple fractions per day radiation therapy with concomitant boost technique for oesophageal cancer","volume":"68","author":"Kikuchi","year":"1993","journal-title":"Hokkaido Igaku Zasshi"},{"key":"10.1053\/clon.2003.0200_RF18","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0360-3016(96)00582-2","article-title":"Continuous, hyperfractionated, accelerated radiotherapy (CHART) in localised cancer of the oesophagus","volume":"38","author":"Powell","year":"1997","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1053\/clon.2003.0200_RF19","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/S0360-3016(97)00950-4","article-title":"Accelerated, hyperfractionated radiation therapy and concurrent 5-FU\/Cisplatin chemotherapy for loco-regional squamous cell carcinoma of the thoracic oesophagus","volume":"40","author":"Jeremic","year":"1998","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1053\/clon.2003.0200_RF20","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1148\/radiology.213.1.r99oc1767","article-title":"Resectable oesophageal carcinoma: local control with neoadjuvant chemotherapy and radiation therapy","volume":"213","author":"Chidel","year":"1999","journal-title":"Radiology"},{"key":"10.1053\/clon.2003.0200_RF21","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1002\/1097-0142(19940401)73:7<1779::AID-CNCR2820730702>3.0.CO;2-T","article-title":"A randomised study of chemotherapy, radiation therapy and surgery versus surgery alone for localised squamous cell carcinoma of the oesophagus","volume":"73","author":"LePrise","year":"1994","journal-title":"Cancer"},{"key":"10.1053\/clon.2003.0200_RF22","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1056\/NEJM199608153350702","article-title":"A Comparison of multimodal therapy and surgery for oesophageal cancer","volume":"335","author":"Walsh","year":"1996","journal-title":"N Engl J Med"},{"key":"10.1053\/clon.2003.0200_RF23","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1056\/NEJM199707173370304","article-title":"Chemoradiotherapy followed by surgery compared with surgery alone in squamous cell cancer of the oesophagus","volume":"337","author":"Bosset","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1053\/clon.2003.0200_RF24","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0360-3016(91)90134-P","article-title":"Long term infusional 5-FU, mitomycin-C and radiation as primary management of oesophageal carcinoma","volume":"20","author":"Coia","year":"1991","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1053\/clon.2003.0200_RF25","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0360-3016(02)02702-5","article-title":"Prospective randomised trial of HDR brachytherapy as a sole modality in palliation of advanced oesophageal carcinoma\u2013an International Atomic Energy Study","volume":"53","author":"Sur","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1053\/clon.2003.0200_RF26","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0167-8140(89)90026-1","article-title":"The recording of morbidity related to radiotherapy","volume":"16","author":"Dische","year":"1989","journal-title":"Radiother Oncol"},{"key":"10.1053\/clon.2003.0200_RF27","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","article-title":"Non-parametric estimations from incomplete observations","volume":"53","author":"Kaplan","year":"1958","journal-title":"Am Stat Assoc J"},{"key":"10.1053\/clon.2003.0200_RF28","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.1200\/JCO.1999.17.9.2915","article-title":"Definitive chemoradiotherapy for T4 and\/or M1 lymph node squamous cell carcinoma of the oesophagus","volume":"17","author":"Ohtsu","year":"1999","journal-title":"J Clin Oncol"},{"key":"10.1053\/clon.2003.0200_RF29","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/S0959-8049(00)00399-3","article-title":"Prospective randomised study of split course radiotherapy versus cisplatin plus split course radiotherapy in inoperable squamous cell carcinoma of the oesophagus","volume":"37","author":"Wobbes","year":"2001","journal-title":"Eur J Cancer"},{"key":"10.1053\/clon.2003.0200_RF30","doi-asserted-by":"crossref","first-page":"3156","DOI":"10.1200\/JCO.1996.14.12.3156","article-title":"Treatment of cancer with radiation and drugs","volume":"14","author":"Tannock","year":"1996","journal-title":"J Clin Oncol"},{"key":"10.1053\/clon.2003.0200_RF31","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1200\/JCO.1989.7.4.425","article-title":"A prospective randomised comparison of continuous infusion fluorouracil with a conventional bolus schedule in metastatic colo-rectal carcinoma: a Mid-Atlantic Oncology Program Study","volume":"7","author":"Locich","year":"1989","journal-title":"J Clin Oncol"},{"key":"10.1053\/clon.2003.0200_RF32","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1056\/NEJM199904153401509","article-title":"Improved treatment for cervical cancer\u2013concurrent chemotherapy and radiotherapy","volume":"340","author":"Thomas","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1053\/clon.2003.0200_RF33","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1056\/NEJM199904153401502","article-title":"Concurrent cisplatin based radiotherapy and chemotherapy for locally advanced cervical cancer","volume":"340","author":"Rose","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1053\/clon.2003.0200_RF34","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1056\/NEJM199202203260805","article-title":"Effects of concomitant cisplatin and radiotherapy on inoperable non-small-cell lung cancer","volume":"326","author":"Schaake-Koning","year":"1992","journal-title":"N Engl J Med"},{"key":"10.1053\/clon.2003.0200_RF35","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S0360-3016(01)02813-9","article-title":"Prospective trial of concurrent chemoradiotherapy with protracted infusion of 5-Fluorouracil and cisplatin for T4 oesophageal cancer with or without fistula","volume":"53","author":"Nishimura","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1053\/clon.2003.0200_RF36","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1002\/1097-0142(197906)43:6<2254::AID-CNCR2820430616>3.0.CO;2-A","article-title":"Carcinoma of the oesophagus: Pre-treatment assessment, correlation of radiation treatment parameters with survival and identification and management of radiation treatment failure","volume":"43","author":"Beatty","year":"1979","journal-title":"Cancer"},{"key":"10.1053\/clon.2003.0200_RF37","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0936-6555(05)80741-1","article-title":"Hyperfractionated accelerated radiotherapy for carcinoma of he oesophagus","volume":"3","author":"Sule-Suso","year":"1991","journal-title":"Clin Oncol"}],"container-title":["Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0936655503902007?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0936655503902007?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T15:22:48Z","timestamp":1760541768000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0936655503902007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,5]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2003,5]]}},"alternative-id":["S0936655503902007"],"URL":"https:\/\/doi.org\/10.1053\/clon.2003.0200","relation":{},"ISSN":["0936-6555"],"issn-type":[{"type":"print","value":"0936-6555"}],"subject":[],"published":{"date-parts":[[2003,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Phase I\/II Study of CHARTWEL with Concurrent Chemotherapy in Locally Advanced, Inoperable Carcinoma of the Oesophagus","name":"articletitle","label":"Article Title"},{"value":"Clinical Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/clon.2003.0200","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2003 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}