{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T21:10:42Z","timestamp":1785186642111,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,1,9]],"date-time":"2012-01-09T00:00:00Z","timestamp":1326067200000},"content-version":"vor","delay-in-days":4056,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2000,12]]},"abstract":"<jats:p>Several reports indicate that pregnancy and parturition are associated with elevated maternal pain thresholds to noxious stimuli. The objective of this study was to examine whether the human placental extract, a clinically used preparation, can inhibit experimental nociception. Nociception was assessed in mice using acetic acid\u2010induced writhing and hot\u2010plate tests. The human placental extract (200 and 400 mg\/kg, i.p.) elicited dose\u2010related antinociception in the acetic acid\u2010induced writhing test. Furthermore, it (200 mg\/kg, i.p.) potentiated the morphine\u2010induced antinociception (1.25 mg\/kg, s.c.). In the hot\u2010plate test, the human placental extract (100, 200 and 400 mg\/kg, i.p.) <jats:italic>per se<\/jats:italic>, displayed no significant antinociception but potentiated the duration of morphine (10 mg\/kg, s.c.) analgesia. The potentiation by the extract of the morphine\u2010induced antinociception in both acetic acid and hot\u2010plate tests was, however, found to be naloxone sensitive. Mice treated with the extract (400 mg\/kg, i.p.) neither manifested any overt behavioural change in the open\u2010field test nor demonstrated significant influence on pentobarbital sleeping time, suggesting that it has no central depressant or sedative activity. The data provide evidence to show that the human placental extract has a peripheral analgesic property possibly mediated by an opioid mechanism.<\/jats:p>","DOI":"10.1053\/eujp.2000.0202","type":"journal-article","created":{"date-parts":[[2002,9,19]],"date-time":"2002-09-19T13:56:27Z","timestamp":1032443787000},"page":"403-408","source":"Crossref","is-referenced-by-count":12,"title":["Effects of human placental extract on chemical and thermal nociception in mice"],"prefix":"10.1002","volume":"4","author":[{"given":"Luilma A.","family":"Gurgel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00e1via A.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vietla S.N.","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,1,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(92)90290-6"},{"key":"e_1_2_1_3_1","first-page":"120","article-title":"Oral submucous fibrosis in a 12\u2010year\u2010old girl: case report","volume":"15","author":"Anil S.","year":"1993","journal-title":"Pediatr Dent"},{"key":"e_1_2_1_4_1","first-page":"361","article-title":"Anti\u2010inflammatory effect of human placental extract: a biochemical mechanism approach","volume":"14","author":"Banerjie K.K.","year":"1992","journal-title":"Riv Eur Sci Med Farmacol"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-66-2-283"},{"key":"e_1_2_1_6_1","first-page":"19","article-title":"Effects of human placental extract on hepatic drug metabolizing enzyme","volume":"17","author":"Bisheyee A.","year":"1995","journal-title":"Riv Eur Sci Med Farmacol"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.12.5391"},{"key":"e_1_2_1_8_1","first-page":"85","article-title":"Treatment with placental extract in periodontal disease","volume":"57","author":"Calvarano G.","year":"1989","journal-title":"Dent Cadmos"},{"key":"e_1_2_1_9_1","first-page":"228","article-title":"The open\u2010field: a simple method to show ethanol withdrawal symptoms","volume":"251","author":"Capaz F.R.","year":"1981","journal-title":"Arch Int Pharmacodyn"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(86)90223-X"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(95)00092-5"},{"key":"e_1_2_1_12_1","first-page":"567","article-title":"International Union of Pharmacology: XII. 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