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Rats displaying allodynia\u2010like behaviours to brushing, von Frey hairs and cold stimulation 1\u20132 days after photochemically induced SCI were studied. In a cumulative dose regime, morphine (0.1\u201310 <jats:italic>\u03bc<\/jats:italic> g), baclofen (0.1\u20131 <jats:italic>\u03bc<\/jats:italic> g), clonidine (0.1\u201310 <jats:italic>\u03bc<\/jats:italic> g) and R\u2010PIA (0.01\u201310 nmol) were administered i.t. through an implanted catheter at the lumbar spinal cord. All tested drugs dose\u2010dependently reduced the brushing, von Frey hairs and cold stimulation\u2010induced allodynia\u2010like behaviour. No increase in adverse effects such as motor deficits was found for morphine, clonidine and R\u2010PIA. There was a slight increase in motor impairments at the highest dose of baclofen. For the mechanical allodynia, morphine appeared to be most effective, whereas baclofen, clonidine and R\u2010PIA only provided a partial alleviation. For the cold allodynia, morphine and baclofen were more effective than clonidine and R\u2010PIA. In relieving acute mechanical and cold allodynia\u2010like behaviours in rats 1\u20132 days after SCI, i.t. morphine and baclofen were superior to clonidine and R\u2010PIA.<\/jats:p>","DOI":"10.1053\/eujp.2000.0212","type":"journal-article","created":{"date-parts":[[2002,9,10]],"date-time":"2002-09-10T15:03:34Z","timestamp":1031670214000},"page":"1-10","source":"Crossref","is-referenced-by-count":26,"title":["Effects of intrathecal morphine, baclofen, clonidine and R\u2010PIA on the acute allodynia\u2010like behaviours after spinal cord ischaemia in rats"],"prefix":"10.1002","volume":"5","author":[{"given":"Margareta","family":"Von Heijne","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing\u2010Xia","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alf","family":"Sollevi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Jun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,1,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(88)90198-4"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-199907000-00023"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-199510000-00010"},{"key":"e_1_2_1_5_1","first-page":"871","volume-title":"Textbook of Pain","author":"Boivie J","year":"1994"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(93)90167-L"},{"key":"e_1_2_1_7_1","first-page":"757","article-title":"Adenosine A1 and A2 receptors of the substantia gelatinosa are located predominantly on intrinsic neurons: an autoradiography study","volume":"247","author":"Choca J.I.","year":"1988","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(91)90015-L"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(97)13435-8"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(94)00209-W"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiologyonline.1995.10.3.122"},{"key":"e_1_2_1_12_1","first-page":"511","article-title":"Differences in the antinociceptive effects of alpha\u20102 adrenoceptor agonists in two substrains of Sprague\u2010Dawley rats","volume":"283","author":"Graham B.A.","year":"1997","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-6576.1999.431010.x"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0304-3959(96)03019-9","article-title":"Treatment of a chronic allodynia\u2010like response in spinally injured rats: effects of systemically administered excitatory amino acid receptor antagonists","volume":"66","author":"Hao J.X.","year":"1996","journal-title":"Pain"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(91)90186-2"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(91)90174-B"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(92)90035-O"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(94)90821-4"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1152\/jn.1992.68.2.392","article-title":"Baclofen reverses the hypersensitivity of dorsal horn wide dynamic range neurons to mechanical stimulation after transient spinal cord ischemia; 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