{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:40:41Z","timestamp":1791913241934,"version":"4.3.4"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,1,9]],"date-time":"2012-01-09T00:00:00Z","timestamp":1326067200000},"content-version":"vor","delay-in-days":3874,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2001,6]]},"abstract":"<jats:p>The response of skin to ultraviolet (UV) irradiation is an inflammation with pronounced vasodilation and hyperalgesia. Volunteers underwent UV irradiation of patches of forearm skin 3 cm in diameter. The intensity of the UV irradiation (290\u2013320 nm) ranged between 133 mJ\/cm<jats:sup>2<\/jats:sup>and 400 mJ\/cm<jats:sup>2<\/jats:sup>. Changes in skin blood flow were measured with laser Doppler technique at 3, 6, 9, 12, 24, 30, 36, 48, 60, 72, 96 and 216 h post UV irradiation. The alteration in pain threshold was measured for heat with a Peltier thermode and for pressure with a metal stylus. The effect of repeated topical pre\u2010treatment 4 days prior to UV irradiation with 1.5 g of 0.04% capsaicin containing ointment was also investigated.<\/jats:p><jats:p>UV irradiation resulted in a dose\u2010dependent increase of skin blood flow for more than 96 h post\u2010irradiation. There were two peaks of blood flow at 12 h and 36 h. Topical application of capsaicin prior to UV irradiation attenuated blood flow from 30 h to 45 h post UV irradiation. Enhanced blood flow was also present 5 mm outside the irradiated area (flare reaction). The control level of heat pain threshold was 44.5\u00b10.7 C in normal skin. Heat pain thresholds were lowered by up to 7.761.2C in UV\u2010irradiated areas in a dose\u2010dependent fashion. The control level of pressure pain threshold was 15.260.3N. Pressure pain thresholds were lowered by up to 6 N in irradiated areas. Maximal hyperalgesia coincided with the second peak of skin blood flow between 30 h and 60 h post UV irradiation. The effects of topical application of capsaicin suggests an involvement of neuropeptide mechanisms in the late phase of the human sunburn reaction.<\/jats:p>","DOI":"10.1053\/eujp.2001.0229","type":"journal-article","created":{"date-parts":[[2002,9,19]],"date-time":"2002-09-19T13:56:27Z","timestamp":1032443787000},"page":"155-169","source":"Crossref","is-referenced-by-count":40,"title":["Differential time courses of skin blood flow and hyperalgesia in the human sunburn reaction following ultraviolet irradiation of the 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