{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T20:47:45Z","timestamp":1761511665165},"reference-count":17,"publisher":"Wiley","issue":"SA","license":[{"start":{"date-parts":[[2012,1,9]],"date-time":"2012-01-09T00:00:00Z","timestamp":1326067200000},"content-version":"vor","delay-in-days":3691,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2001,12]]},"abstract":"<jats:p>Opioids are one of the standard therapies used in the management of chronic pain. They were first widely adopted for the treatment of chronic pain associated with cancer and are now considered important in the alleviation of non\u2010cancer and neuropathic pain. Around\u2010the\u2010clock (ATC) medication has been found to be an effective approach in treating chronic pain. Guidelines issued by the American Pain Society (1999) note that in most cases the preferred route of administering opioids is oral, because of convenience, flexibility, and relative steadiness of the opioid concentrations in the blood. The advantages of ATC therapy and oral medication are some of the reasons for the development of controlled\u2010release, oral formulations of opioids (e.g. morphine, oxycodone, hydromorphone, and hydrocodone). The reduced dosing frequency makes the oral medication more convenient for patients, making it easier for them to comply with the dosing regimen. ATC therapeutic coverage and the possible increased compliance afforded by controlled\u2010release formulations can make opioids even more effective in managing chronic pain.<\/jats:p>","DOI":"10.1053\/eujp.2001.0291","type":"journal-article","created":{"date-parts":[[2002,9,19]],"date-time":"2002-09-19T13:56:27Z","timestamp":1032443787000},"page":"109-111","source":"Crossref","is-referenced-by-count":28,"title":["Opioid formulations: tailoring to the needs in chronic pain"],"prefix":"10.1002","volume":"5","author":[{"given":"Robert F.","family":"Reder","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,1,9]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"1","volume-title":"Principles of Analgesic Use in the Treatment of Acute Pain and Cancer Pain","year":"1999"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.10.3222"},{"key":"e_1_2_1_4_1","first-page":"862","article-title":"Treatment of osteoarthritis pain with controlled release oxycodone or fixed combination oxycodone plus acetaminophen added to nonsteroidal antiinflammatory drugs: a double blind, randomized, multicenter, placebo controlled trial","volume":"26","author":"Caldwell JR","year":"1999","journal-title":"J Rheumatol"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/07357909809032886"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002280050651"},{"key":"e_1_2_1_7_1","first-page":"A175","article-title":"Controlled\u2010release oxycodone (OxyContin\u00ae) provides analgesia in painful diabetic neuropathy [abstract]","volume":"50","author":"Gimbel J.","year":"2001","journal-title":"Diabetes"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002508-199909000-00004"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(97)00072-9"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.10.3230"},{"key":"e_1_2_1_11_1","first-page":"S337","article-title":"Effectiveness of controlled\u2010released OxyContin in ostheoarthritis patients with uncontrolled pain measured by the WOMAC scale (abstract)","volume":"43","author":"Markenson J.","year":"2000","journal-title":"Arthr Rheum"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1090-3801(98)90020-9"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0885-3924(98)00064-5"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.6.853"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0885-3924(99)00079-2"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/00912700122010375"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1996.tb04223.x"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.6.1837"}],"container-title":["European Journal of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1053%2Feujp.2001.0291","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1053\/eujp.2001.0291","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T17:50:08Z","timestamp":1700416208000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1053\/eujp.2001.0291"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,12]]},"references-count":17,"journal-issue":{"issue":"SA","published-print":{"date-parts":[[2001,12]]}},"alternative-id":["10.1053\/eujp.2001.0291"],"URL":"https:\/\/doi.org\/10.1053\/eujp.2001.0291","archive":["Portico"],"relation":{},"ISSN":["1090-3801","1532-2149"],"issn-type":[{"value":"1090-3801","type":"print"},{"value":"1532-2149","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,12]]}}}